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Cooperation of genes in HPV16 E6/E7-dependent cervico-vaginal carcinogenesis trackable by endoscopy and independent of exogenous estrogens or carcinogens.

Böttinger P, Schreiber K, Hyjek E, Krausz T, Spiotto MT, Steiner M, Idel C, Booras H, Beck-Engeser G, Riederer J, Willimsky G, Wolf SP, Karrison T, Jensen E, Weichselbaum RR, Nakamura Y, Yew PY, Lambert PF, Kurita T, Kiyotani K, Leisegang M, Schreiber H.

Carcinogenesis. 2020 Mar 28. pii: bgaa027. doi: 10.1093/carcin/bgaa027. [Epub ahead of print]


Cell-penetrating peptide inhibits retromer-mediated human papillomavirus trafficking during virus entry.

Zhang P, Moreno R, Lambert PF, DiMaio D.

Proc Natl Acad Sci U S A. 2020 Mar 17;117(11):6121-6128. doi: 10.1073/pnas.1917748117. Epub 2020 Mar 2.


MmuPV1: A New Frontier in Animal Models of Papillomavirus Pathogenesis.

Spurgeon ME, Lambert PF.

J Virol. 2020 Feb 12. pii: JVI.00002-20. doi: 10.1128/JVI.00002-20. [Epub ahead of print] Review.


Stress keratin 17 enhances papillomavirus infection-induced disease by downregulating T cell recruitment.

Wang W, Uberoi A, Spurgeon M, Gronski E, Majerciak V, Lobanov A, Hayes M, Loke A, Zheng ZM, Lambert PF.

PLoS Pathog. 2020 Jan 22;16(1):e1008206. doi: 10.1371/journal.ppat.1008206. eCollection 2020 Jan.


The human papillomavirus 16 E5 gene potentiates MmuPV1-Dependent pathogenesis.

Torres AD, Spurgeon ME, Bilger A, Blaine-Sauer S, Uberoi A, Buehler D, McGregor SM, Ward-Shaw E, Lambert PF.

Virology. 2020 Feb;541:1-12. doi: 10.1016/j.virol.2019.12.002. Epub 2019 Dec 5.


Sexual transmission of murine papillomavirus (MmuPV1) in Mus musculus.

Spurgeon ME, Lambert PF.

Elife. 2019 Oct 17;8. pii: e50056. doi: 10.7554/eLife.50056.


A PI3K/AKT Scaffolding Protein, IQ Motif-Containing GTPase Associating Protein 1 (IQGAP1), Promotes Head and Neck Carcinogenesis.

Wei T, Choi S, Buehler D, Anderson RA, Lambert PF.

Clin Cancer Res. 2020 Jan 1;26(1):301-311. doi: 10.1158/1078-0432.CCR-19-1063. Epub 2019 Oct 9.


Effects of culture method on response to EGFR therapy in head and neck squamous cell carcinoma cells.

Ayuso JM, Vitek R, Swick AD, Skala MC, Wisinski KB, Kimple RJ, Lambert PF, Beebe DJ.

Sci Rep. 2019 Aug 28;9(1):12480. doi: 10.1038/s41598-019-48764-3.


Epstein-Barr Virus Infection Promotes Epithelial Cell Growth by Attenuating Differentiation-Dependent Exit from the Cell Cycle.

Eichelberg MR, Welch R, Guidry JT, Ali A, Ohashi M, Makielski KR, McChesney K, Van Sciver N, Lambert PF, Keleș S, Kenney SC, Scott RS, Johannsen E.

mBio. 2019 Aug 20;10(4). pii: e01332-19. doi: 10.1128/mBio.01332-19.


The Specificity of EGF-Stimulated IQGAP1 Scaffold Towards the PI3K-Akt Pathway is Defined by the IQ3 motif.

Chen M, Choi S, Jung O, Wen T, Baum C, Thapa N, Lambert PF, Rapraeger AC, Anderson RA.

Sci Rep. 2019 Jun 24;9(1):9126. doi: 10.1038/s41598-019-45671-5.


A Human Papillomavirus-Independent Cervical Cancer Animal Model Reveals Unconventional Mechanisms of Cervical Carcinogenesis.

He C, Lv X, Huang C, Angeletti PC, Hua G, Dong J, Zhou J, Wang Z, Ma B, Chen X, Lambert PF, Rueda BR, Davis JS, Wang C.

Cell Rep. 2019 Mar 5;26(10):2636-2650.e5. doi: 10.1016/j.celrep.2019.02.004.


A Novel In Vivo Infection Model To Study Papillomavirus-Mediated Disease of the Female Reproductive Tract.

Spurgeon ME, Uberoi A, McGregor SM, Wei T, Ward-Shaw E, Lambert PF.

mBio. 2019 Mar 5;10(2). pii: e00180-19. doi: 10.1128/mBio.00180-19.


Activating Mutations in Pik3ca Contribute to Anal Carcinogenesis in the Presence or Absence of HPV-16 Oncogenes.

Shin MK, Payne S, Bilger A, Matkowskyj KA, Carchman E, Meyer DS, Bentires-Alj M, Deming DA, Lambert PF.

Clin Cancer Res. 2019 Mar 15;25(6):1889-1900. doi: 10.1158/1078-0432.CCR-18-2843. Epub 2018 Dec 7.


Loss of Function of Canonical Notch Signaling Drives Head and Neck Carcinogenesis.

Nyman PE, Buehler D, Lambert PF.

Clin Cancer Res. 2018 Dec 15;24(24):6308-6318. doi: 10.1158/1078-0432.CCR-17-3535. Epub 2018 Aug 7.


Early synergistic interactions between the HPV16‑E7 oncoprotein and 17β-oestradiol for repressing the expression of Granzyme B in a cervical cancer model.

Munguía-Moreno JA, Díaz-Chavéz J, García-Villa E, Albino-Sanchez ME, Mendoza-Villanueva D, Ocadiz-Delgado R, Bonilla-Delgado J, Marín-Flores A, Cortés-Malagón EM, Alvarez-Rios E, Hidalgo-Miranda A, Üren A, Çelik H, Lambert PF, Gariglio P.

Int J Oncol. 2018 Aug;53(2):579-591. doi: 10.3892/ijo.2018.4432. Epub 2018 Jun 6.


HPV16-E6 Oncoprotein Activates TGF-β and Wnt/β-Catenin Pathways in the Epithelium-Mesenchymal Transition of Cataracts in a Transgenic Mouse Model.

Rodríguez-Uribe G, Serafín-Higuera N, Damian-Morales G, Cortés-Malagón EM, García-Hernández V, Verdejo-Torres O, Campos-Blázquez JP, Trejo-Muñoz CR, Contreras RG, Ocadiz-Delgado R, Palacios-Reyes C, Lambert PF, Griep AE, Mancilla-Percino T, Escobar-Herrera J, Álvarez-Ríos E, Ugarte-Briones C, Moreno J, Gariglio P, Bonilla-Delgado J.

Biomed Res Int. 2018 May 16;2018:2847873. doi: 10.1155/2018/2847873. eCollection 2018.


Inhibition of TGF-β and NOTCH Signaling by Cutaneous Papillomaviruses.

Meyers JM, Grace M, Uberoi A, Lambert PF, Munger K.

Front Microbiol. 2018 Mar 8;9:389. doi: 10.3389/fmicb.2018.00389. eCollection 2018. Review.


Lipidomic Profiling Links the Fanconi Anemia Pathway to Glycosphingolipid Metabolism in Head and Neck Cancer Cells.

Zhao X, Brusadelli MG, Sauter S, Butsch Kovacic M, Zhang W, Romick-Rosendale LE, Lambert PF, Setchell KDR, Wells SI.

Clin Cancer Res. 2018 Jun 1;24(11):2700-2709. doi: 10.1158/1078-0432.CCR-17-3686. Epub 2018 Mar 12.


Development of an in vivo infection model to study Mouse papillomavirus-1 (MmuPV1).

Uberoi A, Yoshida S, Lambert PF.

J Virol Methods. 2018 Mar;253:11-17. doi: 10.1016/j.jviromet.2017.12.002. Epub 2017 Dec 15.


Rodent Papillomaviruses.

Uberoi A, Lambert PF.

Viruses. 2017 Nov 27;9(12). pii: E362. doi: 10.3390/v9120362. Review.


The full transcription map of mouse papillomavirus type 1 (MmuPV1) in mouse wart tissues.

Xue XY, Majerciak V, Uberoi A, Kim BH, Gotte D, Chen X, Cam M, Lambert PF, Zheng ZM.

PLoS Pathog. 2017 Nov 27;13(11):e1006715. doi: 10.1371/journal.ppat.1006715. eCollection 2017 Nov.


Human papillomavirus oncogenes reprogram the cervical cancer microenvironment independently of and synergistically with estrogen.

Spurgeon ME, den Boon JA, Horswill M, Barthakur S, Forouzan O, Rader JS, Beebe DJ, Roopra A, Ahlquist P, Lambert PF.

Proc Natl Acad Sci U S A. 2017 Oct 24;114(43):E9076-E9085. doi: 10.1073/pnas.1712018114. Epub 2017 Oct 9.


Human Papillomavirus and the Stroma: Bidirectional Crosstalk during the Virus Life Cycle and Carcinogenesis.

Spurgeon ME, Lambert PF.

Viruses. 2017 Aug 9;9(8). pii: E219. doi: 10.3390/v9080219. Review.


Absence of γ-Chain in Keratinocytes Alters Chemokine Secretion, Resulting in Reduced Immune Cell Recruitment.

Nowak K, Linzner D, Thrasher AJ, Lambert PF, Di WL, Burns SO.

J Invest Dermatol. 2017 Oct;137(10):2120-2130. doi: 10.1016/j.jid.2017.05.024. Epub 2017 Jun 17.


Hypoxia-inducible factor-1α plays roles in Epstein-Barr virus's natural life cycle and tumorigenesis by inducing lytic infection through direct binding to the immediate-early BZLF1 gene promoter.

Kraus RJ, Yu X, Cordes BA, Sathiamoorthi S, Iempridee T, Nawandar DM, Ma S, Romero-Masters JC, McChesney KG, Lin Z, Makielski KR, Lee DL, Lambert PF, Johannsen EC, Kenney SC, Mertz JE.

PLoS Pathog. 2017 Jun 15;13(6):e1006404. doi: 10.1371/journal.ppat.1006404. eCollection 2017 Jun.


Overexpression of the human DEK oncogene reprograms cellular metabolism and promotes glycolysis.

Matrka MC, Watanabe M, Muraleedharan R, Lambert PF, Lane AN, Romick-Rosendale LE, Wells SI.

PLoS One. 2017 May 30;12(5):e0177952. doi: 10.1371/journal.pone.0177952. eCollection 2017.


Dissecting the regulation of EBV's BART miRNAs in carcinomas.

Yang YC, Liem A, Lambert PF, Sugden B.

Virology. 2017 May;505:148-154. doi: 10.1016/j.virol.2017.02.013. Epub 2017 Mar 1.


Differentiation-Dependent LMP1 Expression Is Required for Efficient Lytic Epstein-Barr Virus Reactivation in Epithelial Cells.

Nawandar DM, Ohashi M, Djavadian R, Barlow E, Makielski K, Ali A, Lee D, Lambert PF, Johannsen E, Kenney SC.

J Virol. 2017 Mar 29;91(8). pii: e02438-16. doi: 10.1128/JVI.02438-16. Print 2017 Apr 15.


Cutaneous HPV8 and MmuPV1 E6 Proteins Target the NOTCH and TGF-β Tumor Suppressors to Inhibit Differentiation and Sustain Keratinocyte Proliferation.

Meyers JM, Uberoi A, Grace M, Lambert PF, Munger K.

PLoS Pathog. 2017 Jan 20;13(1):e1006171. doi: 10.1371/journal.ppat.1006171. eCollection 2017 Jan.


Erratum to: Functional variants of human papillomavirus type 16 demonstrate host genome integration and transcriptional alterations corresponding to their unique cancer epidemiology.

Jackson R, Rosa BA, Lameiras S, Cuninghame S, Bernard J, Floriano WB, Lambert PF, Nicolas A, Zehbe I.

BMC Genomics. 2016 Dec 12;17(1):1018. No abstract available.


The Hidden Conundrum of Phosphoinositide Signaling in Cancer.

Thapa N, Tan X, Choi S, Lambert PF, Rapraeger AC, Anderson RA.

Trends Cancer. 2016 Jul;2(7):378-390. Epub 2016 Jun 20. Review.


Functional variants of human papillomavirus type 16 demonstrate host genome integration and transcriptional alterations corresponding to their unique cancer epidemiology.

Jackson R, Rosa BA, Lameiras S, Cuninghame S, Bernard J, Floriano WB, Lambert PF, Nicolas A, Zehbe I.

BMC Genomics. 2016 Nov 2;17(1):851. Erratum in: BMC Genomics. 2016 Dec 12;17 (1):1018.


Transgenic Mouse Models of Tumor Virus Action.

Lambert PF.

Annu Rev Virol. 2016 Sep 29;3(1):473-489. Review.


Dysregulation of Autophagy Contributes to Anal Carcinogenesis.

Carchman EH, Matkowskyj KA, Meske L, Lambert PF.

PLoS One. 2016 Oct 5;11(10):e0164273. doi: 10.1371/journal.pone.0164273. eCollection 2016.


The HPV16 E7 oncoprotein increases the expression of Oct3/4 and stemness-related genes and augments cell self-renewal.

Organista-Nava J, Gómez-Gómez Y, Ocadiz-Delgado R, García-Villa E, Bonilla-Delgado J, Lagunas-Martínez A, Tapia JS, Lambert PF, García-Carrancá A, Gariglio P.

Virology. 2016 Dec;499:230-242. doi: 10.1016/j.virol.2016.09.020. Epub 2016 Sep 29.


The HPV16 E7 Oncoprotein Disrupts Dendritic Cell Function and Induces the Systemic Expansion of CD11b(+)Gr1(+) Cells in a Transgenic Mouse Model.

Damian-Morales G, Serafín-Higuera N, Moreno-Eutimio MA, Cortés-Malagón EM, Bonilla-Delgado J, Rodríguez-Uribe G, Ocadiz-Delgado R, Lambert PF, Gariglio P.

Biomed Res Int. 2016;2016:8091353. doi: 10.1155/2016/8091353. Epub 2016 Jul 11.


A Mouse Model of Hyperproliferative Human Epithelium Validated by Keratin Profiling Shows an Aberrant Cytoskeletal Response to Injury.

Zhussupbekova S, Sinha R, Kuo P, Lambert PF, Frazer IH, Tuong ZK.

EBioMedicine. 2016 Jul;9:314-323. doi: 10.1016/j.ebiom.2016.06.011. Epub 2016 Jun 7.


The expression of miR-21 and miR-143 is deregulated by the HPV16 E7 oncoprotein and 17β-estradiol.

Gómez-Gómez Y, Organista-Nava J, Ocadiz-Delgado R, García-Villa E, Leyva-Vazquez MA, Illades-Aguiar B, Lambert PF, García-Carrancá A, Gariglio P.

Int J Oncol. 2016 Aug;49(2):549-58. doi: 10.3892/ijo.2016.3575. Epub 2016 Jun 9.


Role of Ultraviolet Radiation in Papillomavirus-Induced Disease.

Uberoi A, Yoshida S, Frazer IH, Pitot HC, Lambert PF.

PLoS Pathog. 2016 May 31;12(5):e1005664. doi: 10.1371/journal.ppat.1005664. eCollection 2016 May.


Identifying the Target Cells and Mechanisms of Merkel Cell Polyomavirus Infection.

Liu W, Yang R, Payne AS, Schowalter RM, Spurgeon ME, Lambert PF, Xu X, Buck CB, You J.

Cell Host Microbe. 2016 Jun 8;19(6):775-87. doi: 10.1016/j.chom.2016.04.024. Epub 2016 May 19.


Human papillomavirus promotes Epstein-Barr virus maintenance and lytic reactivation in immortalized oral keratinocytes.

Makielski KR, Lee D, Lorenz LD, Nawandar DM, Chiu YF, Kenney SC, Lambert PF.

Virology. 2016 Aug;495:52-62. doi: 10.1016/j.virol.2016.05.005. Epub 2016 May 11.


Using Organotypic Epithelial Tissue Culture to Study the Human Papillomavirus Life Cycle.

Lee D, Norby K, Hayes M, Chiu YF, Sugden B, Lambert PF.

Curr Protoc Microbiol. 2016 May 6;41:14B.8.1-14B.8.19. doi: 10.1002/cpmc.4.


Suppression of Antitumor Immune Responses by Human Papillomavirus through Epigenetic Downregulation of CXCL14.

Cicchini L, Westrich JA, Xu T, Vermeer DW, Berger JN, Clambey ET, Lee D, Song JI, Lambert PF, Greer RO, Lee JH, Pyeon D.

mBio. 2016 May 3;7(3). pii: e00270-16. doi: 10.1128/mBio.00270-16.


Stress-Induced EGFR Trafficking: Mechanisms, Functions, and Therapeutic Implications.

Tan X, Lambert PF, Rapraeger AC, Anderson RA.

Trends Cell Biol. 2016 May;26(5):352-366. doi: 10.1016/j.tcb.2015.12.006. Epub 2016 Jan 27. Review.


Defects in the Fanconi Anemia Pathway in Head and Neck Cancer Cells Stimulate Tumor Cell Invasion through DNA-PK and Rac1 Signaling.

Romick-Rosendale LE, Hoskins EE, Privette Vinnedge LM, Foglesong GD, Brusadelli MG, Potter SS, Komurov K, Brugmann SA, Lambert PF, Kimple RJ, Virts EL, Hanenberg H, Gillison ML, Wells SI.

Clin Cancer Res. 2016 Apr 15;22(8):2062-73. doi: 10.1158/1078-0432.CCR-15-2209. Epub 2015 Nov 24.


Key Characteristics of Carcinogens as a Basis for Organizing Data on Mechanisms of Carcinogenesis.

Smith MT, Guyton KZ, Gibbons CF, Fritz JM, Portier CJ, Rusyn I, DeMarini DM, Caldwell JC, Kavlock RJ, Lambert PF, Hecht SS, Bucher JR, Stewart BW, Baan RA, Cogliano VJ, Straif K.

Environ Health Perspect. 2016 Jun;124(6):713-21. doi: 10.1289/ehp.1509912. Epub 2015 Nov 24.


Differentiation-Dependent KLF4 Expression Promotes Lytic Epstein-Barr Virus Infection in Epithelial Cells.

Nawandar DM, Wang A, Makielski K, Lee D, Ma S, Barlow E, Reusch J, Jiang R, Wille CK, Greenspan D, Greenspan JS, Mertz JE, Hutt-Fletcher L, Johannsen EC, Lambert PF, Kenney SC.

PLoS Pathog. 2015 Oct 2;11(10):e1005195. doi: 10.1371/journal.ppat.1005195. eCollection 2015 Oct.


The Hippo/YAP pathway interacts with EGFR signaling and HPV oncoproteins to regulate cervical cancer progression.

He C, Mao D, Hua G, Lv X, Chen X, Angeletti PC, Dong J, Remmenga SW, Rodabaugh KJ, Zhou J, Lambert PF, Yang P, Davis JS, Wang C.

EMBO Mol Med. 2015 Nov;7(11):1426-49. doi: 10.15252/emmm.201404976.


Human papillomavirus type 16 E7 oncoprotein upregulates the retinoic acid receptor-beta expression in cervical cancer cell lines and K14E7 transgenic mice.

Gutiérrez J, García-Villa E, Ocadiz-Delgado R, Cortés-Malagón EM, Vázquez J, Roman-Rosales A, Alvarez-Rios E, Celik H, Romano MC, Üren A, Lambert PF, Gariglio P.

Mol Cell Biochem. 2015 Oct;408(1-2):261-72. doi: 10.1007/s11010-015-2504-1. Epub 2015 Jul 15.


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