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Loss-of-function of Endothelin receptor type A results in Oro-Oto-Cardiac syndrome.

Pritchard AB, Kanai SM, Krock B, Schindewolf E, Oliver-Krasinski J, Khalek N, Okashah N, Lambert NA, Tavares ALP, Zackai E, Clouthier DE.

Am J Med Genet A. 2020 Mar 5. doi: 10.1002/ajmg.a.61531. [Epub ahead of print]


Agonist-selective recruitment of engineered protein probes and of GRK2 by opioid receptors in living cells.

Stoeber M, Jullié D, Li J, Chakraborty S, Majumdar S, Lambert NA, Manglik A, von Zastrow M.

Elife. 2020 Feb 25;9. pii: e54208. doi: 10.7554/eLife.54208.


Components of the Gs signaling cascade exhibit distinct changes in mobility and membrane domain localization upon β2 -adrenergic receptor activation.

Bondar A, Jang W, Sviridova E, Lambert NA.

Traffic. 2020 Apr;21(4):324-332. doi: 10.1111/tra.12724.


Structure of formylpeptide receptor 2-Gi complex reveals insights into ligand recognition and signaling.

Zhuang Y, Liu H, Edward Zhou X, Kumar Verma R, de Waal PW, Jang W, Xu TH, Wang L, Meng X, Zhao G, Kang Y, Melcher K, Fan H, Lambert NA, Eric Xu H, Zhang C.

Nat Commun. 2020 Feb 14;11(1):885. doi: 10.1038/s41467-020-14728-9.


Common activation mechanism of class A GPCRs.

Zhou Q, Yang D, Wu M, Guo Y, Guo W, Zhong L, Cai X, Dai A, Jang W, Shakhnovich EI, Liu ZJ, Stevens RC, Lambert NA, Babu MM, Wang MW, Zhao S.

Elife. 2019 Dec 19;8. pii: e50279. doi: 10.7554/eLife.50279.


Variable G protein determinants of GPCR coupling selectivity.

Okashah N, Wan Q, Ghosh S, Sandhu M, Inoue A, Vaidehi N, Lambert NA.

Proc Natl Acad Sci U S A. 2019 Jun 11;116(24):12054-12059. doi: 10.1073/pnas.1905993116. Epub 2019 May 29.


A conserved molecular switch in Class F receptors regulates receptor activation and pathway selection.

Wright SC, Kozielewicz P, Kowalski-Jahn M, Petersen J, Bowin CF, Slodkowicz G, Marti-Solano M, Rodríguez D, Hot B, Okashah N, Strakova K, Valnohova J, Babu MM, Lambert NA, Carlsson J, Schulte G.

Nat Commun. 2019 Feb 8;10(1):667. doi: 10.1038/s41467-019-08630-2.


Mini G protein probes for active G protein-coupled receptors (GPCRs) in live cells.

Wan Q, Okashah N, Inoue A, Nehmé R, Carpenter B, Tate CG, Lambert NA.

J Biol Chem. 2018 May 11;293(19):7466-7473. doi: 10.1074/jbc.RA118.001975. Epub 2018 Mar 9.


Lipoma of the Palate: An Uncommon Finding.

Volpato LE, Vasconcelos AC, Lambert NA, de Souza Castro PH, Aburad A, Borges AH.

Open Dent J. 2016 Nov 29;10:643-646. doi: 10.2174/1874210601610010643. eCollection 2016.


RGS14 regulates the lifetime of Gα-GTP signaling but does not prolong Gβγ signaling following receptor activation in live cells.

Brown NE, Lambert NA, Hepler JR.

Pharmacol Res Perspect. 2016 Aug 18;4(5):e00249. eCollection 2016 Oct.


Activated G Protein Gαs Samples Multiple Endomembrane Compartments.

Martin BR, Lambert NA.

J Biol Chem. 2016 Sep 23;291(39):20295-20302. doi: 10.1074/jbc.M116.729731. Epub 2016 Aug 15.


Plasma membrane localization of the μ-opioid receptor controls spatiotemporal signaling.

Halls ML, Yeatman HR, Nowell CJ, Thompson GL, Gondin AB, Civciristov S, Bunnett NW, Lambert NA, Poole DP, Canals M.

Sci Signal. 2016 Feb 9;9(414):ra16. doi: 10.1126/scisignal.aac9177.


GGA3 Interacts with a G Protein-Coupled Receptor and Modulates Its Cell Surface Export.

Zhang M, Davis JE, Li C, Gao J, Huang W, Lambert NA, Terry AV Jr, Wu G.

Mol Cell Biol. 2016 Jan 25;36(7):1152-63. doi: 10.1128/MCB.00009-16.


Using Bioluminescence Resonance Energy Transfer (BRET) to Characterize Agonist-Induced Arrestin Recruitment to Modified and Unmodified G Protein-Coupled Receptors.

Donthamsetti P, Quejada JR, Javitch JA, Gurevich VV, Lambert NA.

Curr Protoc Pharmacol. 2015 Sep 1;70:2.14.1-2.14.14. doi: 10.1002/0471141755.ph0214s70.


Monitoring G Protein Activation in Cells with BRET.

Masuho I, Martemyanov KA, Lambert NA.

Methods Mol Biol. 2015;1335:107-13. doi: 10.1007/978-1-4939-2914-6_8.


Lateral diffusion contributes to FRET from lanthanide-tagged membrane proteins.

Lan TH, Wu G, Lambert NA.

Biochem Biophys Res Commun. 2015 Aug 14;464(1):244-8. doi: 10.1016/j.bbrc.2015.06.127. Epub 2015 Jun 25.


BRET evidence that β2 adrenergic receptors do not oligomerize in cells.

Lan TH, Liu Q, Li C, Wu G, Steyaert J, Lambert NA.

Sci Rep. 2015 May 8;5:10166. doi: 10.1038/srep10166.


A High-Throughput Drug Screening Strategy for Detecting Rhodopsin P23H Mutant Rescue and Degradation.

Chen Y, Tang H, Seibel W, Papoian R, Li X, Lambert NA, Palczewski K.

Invest Ophthalmol Vis Sci. 2015 Apr;56(4):2553-67. doi: 10.1167/iovs.14-16298.


Mutation of three residues in the third intracellular loop of the dopamine D2 receptor creates an internalization-defective receptor.

Clayton CC, Donthamsetti P, Lambert NA, Javitch JA, Neve KA.

J Biol Chem. 2014 Nov 28;289(48):33663-75. doi: 10.1074/jbc.M114.605378. Epub 2014 Oct 21.


HV1 acts as a sodium sensor and promotes superoxide production in medullary thick ascending limb of Dahl salt-sensitive rats.

Jin C, Sun J, Stilphen CA, Smith SM, Ocasio H, Bermingham B, Darji S, Guha A, Patel R, Geurts AM, Jacob HJ, Lambert NA, O'Connor PM.

Hypertension. 2014 Sep;64(3):541-50. doi: 10.1161/HYPERTENSIONAHA.114.03549. Epub 2014 Jun 16.


Rebuttal from Nevin A. Lambert and Jonathan A. Javitch.

Lambert NA, Javitch JA.

J Physiol. 2014 Jun 15;592(12):2449. doi: 10.1113/jphysiol.2014.274241. No abstract available.


CrossTalk opposing view: Weighing the evidence for class A GPCR dimers, the jury is still out.

Lambert NA, Javitch JA.

J Physiol. 2014 Jun 15;592(12):2443-5. doi: 10.1113/jphysiol.2014.272997. No abstract available.


Allosteric modulation of M1 muscarinic acetylcholine receptor internalization and subcellular trafficking.

Yeatman HR, Lane JR, Choy KH, Lambert NA, Sexton PM, Christopoulos A, Canals M.

J Biol Chem. 2014 May 30;289(22):15856-66. doi: 10.1074/jbc.M113.536672. Epub 2014 Apr 21.


L-2-oxothiazolidine-4-carboxylic acid attenuates oxidative stress and inflammation in retinal pigment epithelium.

Promsote W, Veeranan-Karmegam R, Ananth S, Shen D, Chan CC, Lambert NA, Ganapathy V, Martin PM.

Mol Vis. 2014 Jan 7;20:73-88. eCollection 2014.


The bile acid receptor TGR5 does not interact with β-arrestins or traffic to endosomes but transmits sustained signals from plasma membrane rafts.

Jensen DD, Godfrey CB, Niklas C, Canals M, Kocan M, Poole DP, Murphy JE, Alemi F, Cottrell GS, Korbmacher C, Lambert NA, Bunnett NW, Corvera CU.

J Biol Chem. 2013 Aug 9;288(32):22942-60. doi: 10.1074/jbc.M113.455774. Epub 2013 Jul 1.


Segregation of family A G protein-coupled receptor protomers in the plasma membrane.

Gavalas A, Lan TH, Liu Q, Corrêa IR Jr, Javitch JA, Lambert NA.

Mol Pharmacol. 2013 Sep;84(3):346-52. doi: 10.1124/mol.113.086868. Epub 2013 Jun 18.


Rab26 modulates the cell surface transport of α2-adrenergic receptors from the Golgi.

Li C, Fan Y, Lan TH, Lambert NA, Wu G.

J Biol Chem. 2012 Dec 14;287(51):42784-94. doi: 10.1074/jbc.M112.410936. Epub 2012 Oct 26.


Sensitive and high resolution localization and tracking of membrane proteins in live cells with BRET.

Lan TH, Liu Q, Li C, Wu G, Lambert NA.

Traffic. 2012 Nov;13(11):1450-6. doi: 10.1111/j.1600-0854.2012.01401.x. Epub 2012 Aug 5.


A triple arg motif mediates α(2B)-adrenergic receptor interaction with Sec24C/D and export.

Dong C, Nichols CD, Guo J, Huang W, Lambert NA, Wu G.

Traffic. 2012 Jun;13(6):857-68. doi: 10.1111/j.1600-0854.2012.01351.x. Epub 2012 Apr 12.


Inactive-state preassembly of G(q)-coupled receptors and G(q) heterotrimers.

Qin K, Dong C, Wu G, Lambert NA.

Nat Chem Biol. 2011 Aug 28;7(10):740-7. doi: 10.1038/nchembio.642.


Effects of chlorpyrifos and chlorpyrifos-oxon on the dynamics and movement of mitochondria in rat cortical neurons.

Middlemore-Risher ML, Adam BL, Lambert NA, Terry AV Jr.

J Pharmacol Exp Ther. 2011 Nov;339(2):341-9. doi: 10.1124/jpet.111.184762. Epub 2011 Jul 28.


Internalization dissociates β2-adrenergic receptors.

Lan TH, Kuravi S, Lambert NA.

PLoS One. 2011 Feb 22;6(2):e17361. doi: 10.1371/journal.pone.0017361.


Making structural sense of dimerization interfaces of delta opioid receptor homodimers.

Johnston JM, Aburi M, Provasi D, Bortolato A, Urizar E, Lambert NA, Javitch JA, Filizola M.

Biochemistry. 2011 Mar 15;50(10):1682-90. doi: 10.1021/bi101474v. Epub 2011 Feb 9.


Methods to detect cell surface expression and constitutive activity of GPR6.

Prasad BM, Hollins B, Lambert NA.

Methods Enzymol. 2010;484:179-95. doi: 10.1016/B978-0-12-381298-8.00010-1.


Blockade of dendritic cell development by bacterial fermentation products butyrate and propionate through a transporter (Slc5a8)-dependent inhibition of histone deacetylases.

Singh N, Thangaraju M, Prasad PD, Martin PM, Lambert NA, Boettger T, Offermanns S, Ganapathy V.

J Biol Chem. 2010 Sep 3;285(36):27601-8. doi: 10.1074/jbc.M110.102947. Epub 2010 Jul 2.


GPCR dimers fall apart.

Lambert NA.

Sci Signal. 2010 Mar 30;3(115):pe12. doi: 10.1126/scisignal.3115pe12.


Regulators of G-protein signaling accelerate GPCR signaling kinetics and govern sensitivity solely by accelerating GTPase activity.

Lambert NA, Johnston CA, Cappell SD, Kuravi S, Kimple AJ, Willard FS, Siderovski DP.

Proc Natl Acad Sci U S A. 2010 Apr 13;107(15):7066-71. doi: 10.1073/pnas.0912934107. Epub 2010 Mar 29. Erratum in: Proc Natl Acad Sci U S A. 2012 Feb 7;109(6):2175.


GPR109A is a G-protein-coupled receptor for the bacterial fermentation product butyrate and functions as a tumor suppressor in colon.

Thangaraju M, Cresci GA, Liu K, Ananth S, Gnanaprakasam JP, Browning DD, Mellinger JD, Smith SB, Digby GJ, Lambert NA, Prasad PD, Ganapathy V.

Cancer Res. 2009 Apr 1;69(7):2826-32. doi: 10.1158/0008-5472.CAN-08-4466. Epub 2009 Mar 10.


Instability of a class a G protein-coupled receptor oligomer interface.

Fonseca JM, Lambert NA.

Mol Pharmacol. 2009 Jun;75(6):1296-9. doi: 10.1124/mol.108.053876. Epub 2009 Mar 9.


The c-terminus of GRK3 indicates rapid dissociation of G protein heterotrimers.

Hollins B, Kuravi S, Digby GJ, Lambert NA.

Cell Signal. 2009 Jun;21(6):1015-21. doi: 10.1016/j.cellsig.2009.02.017. Epub 2009 Mar 1.


Uncoupling diffusion and binding in FRAP experiments.

Lambert NA.

Nat Methods. 2009 Mar;6(3):183; author reply 183-4. doi: 10.1038/nmeth0309-183a. No abstract available.


Activity-dependent regulation of the dopamine transporter is mediated by Ca(2+)/calmodulin-dependent protein kinase signaling.

Padmanabhan S, Lambert NA, Prasad BM.

Eur J Neurosci. 2008 Nov;28(10):2017-27. doi: 10.1111/j.1460-9568.2008.06496.x.


A point mutation to Galphai selectively blocks GoLoco motif binding: direct evidence for Galpha.GoLoco complexes in mitotic spindle dynamics.

Willard FS, Zheng Z, Guo J, Digby GJ, Kimple AJ, Conley JM, Johnston CA, Bosch D, Willard MD, Watts VJ, Lambert NA, Ikeda SR, Du Q, Siderovski DP.

J Biol Chem. 2008 Dec 26;283(52):36698-710. doi: 10.1074/jbc.M804936200. Epub 2008 Nov 4.


Three-dimensional neural constructs: a novel platform for neurophysiological investigation.

Irons HR, Cullen DK, Shapiro NP, Lambert NA, Lee RH, Laplaca MC.

J Neural Eng. 2008 Sep;5(3):333-41. doi: 10.1088/1741-2560/5/3/006. Epub 2008 Aug 28.


Dissociation of heterotrimeric g proteins in cells.

Lambert NA.

Sci Signal. 2008 Jun 24;1(25):re5. doi: 10.1126/scisignal.125re5. Review. Erratum in: Sci Signal. 2008 Jul 15;1(28):er3.


Differential dissociation of G protein heterotrimers.

Digby GJ, Sethi PR, Lambert NA.

J Physiol. 2008 Jul 15;586(14):3325-35. doi: 10.1113/jphysiol.2008.153965. Epub 2008 May 22.


Abundance and stability of complexes containing inactive G protein-coupled receptors and G proteins.

Qin K, Sethi PR, Lambert NA.

FASEB J. 2008 Aug;22(8):2920-7. doi: 10.1096/fj.08-105775. Epub 2008 Apr 23.


Rapid activation of inwardly rectifying potassium channels by immobile G-protein-coupled receptors.

Lober RM, Pereira MA, Lambert NA.

J Neurosci. 2006 Nov 29;26(48):12602-8.

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