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The Med31 Conserved Component of the Divergent Mediator Complex in Tetrahymena thermophila Participates in Developmental Regulation.

Garg J, Saettone A, Nabeel-Shah S, Cadorin M, Ponce M, Marquez S, Pu S, Greenblatt J, Lambert JP, Pearlman RE, Fillingham J.

Curr Biol. 2019 Jun 28. pii: S0960-9822(19)30779-1. doi: 10.1016/j.cub.2019.06.052. [Epub ahead of print]


Proteomics contribution to the elucidation of the steroid hormone receptors functions.

Agbo L, Lambert JP.

J Steroid Biochem Mol Biol. 2019 Jun 4;192:105387. doi: 10.1016/j.jsbmb.2019.105387. [Epub ahead of print] Review.


Measurement and Analysis of Lysine Acetylation by KAT Complexes In Vitro and In Vivo.

Lashgari A, Lambert JP, Côté J.

Methods Mol Biol. 2019;1983:57-77. doi: 10.1007/978-1-4939-9434-2_5.


Functional Proteomics of Nuclear Proteins in Tetrahymena thermophila: A Review.

Saettone A, Nabeel-Shah S, Garg J, Lambert JP, Pearlman RE, Fillingham J.

Genes (Basel). 2019 May 1;10(5). pii: E333. doi: 10.3390/genes10050333. Review.


Testing the ability of unmanned aerial systems and machine learning to map weeds at subfield scales: a test with the weed Alopecurus myosuroides (Huds).

Lambert JP, Childs DZ, Freckleton RP.

Pest Manag Sci. 2019 Aug;75(8):2283-2294. doi: 10.1002/ps.5444. Epub 2019 May 21.


BRN2 suppresses apoptosis, reprograms DNA damage repair, and is associated with a high somatic mutation burden in melanoma.

Herbert K, Binet R, Lambert JP, Louphrasitthiphol P, Kalkavan H, Sesma-Sanz L, Robles-Espinoza CD, Sarkar S, Suer E, Andrews S, Chauhan J, Roberts ND, Middleton MR, Gingras AC, Masson JY, Larue L, Falletta P, Goding CR.

Genes Dev. 2019 Mar 1;33(5-6):310-332. doi: 10.1101/gad.314633.118. Epub 2019 Feb 25.


Proteomic Analysis of Histones H2A/H2B and Variant Hv1 in Tetrahymena thermophila Reveals an Ancient Network of Chaperones.

Ashraf K, Nabeel-Shah S, Garg J, Saettone A, Derynck J, Gingras AC, Lambert JP, Pearlman RE, Fillingham J.

Mol Biol Evol. 2019 May 1;36(5):1037-1055. doi: 10.1093/molbev/msz039.


Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.

Lambert JP, Picaud S, Fujisawa T, Hou H, Savitsky P, Uusküla-Reimand L, Gupta GD, Abdouni H, Lin ZY, Tucholska M, Knight JDR, Gonzalez-Badillo B, St-Denis N, Newman JA, Stucki M, Pelletier L, Bandeira N, Wilson MD, Filippakopoulos P, Gingras AC.

Mol Cell. 2019 Feb 7;73(3):621-638.e17. doi: 10.1016/j.molcel.2018.11.006. Epub 2018 Dec 13.


Spatial Separation of Mitochondrial Calcium Uptake and Extrusion for Energy-Efficient Mitochondrial Calcium Signaling in the Heart.

De La Fuente S, Lambert JP, Nichtova Z, Fernandez Sanz C, Elrod JW, Sheu SS, Csordás G.

Cell Rep. 2018 Sep 18;24(12):3099-3107.e4. doi: 10.1016/j.celrep.2018.08.040.


Evaluating the potential of Unmanned Aerial Systems for mapping weeds at field scales: a case study with Alopecurus myosuroides.

Lambert JPT, Hicks HL, Childs DZ, Freckleton RP.

Weed Res. 2018 Feb;58(1):35-45. doi: 10.1111/wre.12275. Epub 2017 Nov 16.


The bromodomain-containing protein Ibd1 links multiple chromatin-related protein complexes to highly expressed genes in Tetrahymena thermophila.

Saettone A, Garg J, Lambert JP, Nabeel-Shah S, Ponce M, Burtch A, Thuppu Mudalige C, Gingras AC, Pearlman RE, Fillingham J.

Epigenetics Chromatin. 2018 Mar 9;11(1):10. doi: 10.1186/s13072-018-0180-6.


Targeted proteomics analyses of phosphorylation-dependent signalling networks.

Banerjee SL, Dionne U, Lambert JP, Bisson N.

J Proteomics. 2018 Oct 30;189:39-47. doi: 10.1016/j.jprot.2018.02.004. Epub 2018 Feb 7.


Ydj1 governs fungal morphogenesis and stress response, and facilitates mitochondrial protein import via Mas1 and Mas2.

Xie JL, Bohovych I, Wong EOY, Lambert JP, Gingras AC, Khalimonchuk O, Cowen LE, Leach MD.

Microb Cell. 2017 Oct 2;4(10):342-361. doi: 10.15698/mic2017.10.594.


Selective Targeting of Bromodomains of the Bromodomain-PHD Fingers Family Impairs Osteoclast Differentiation.

Meier JC, Tallant C, Fedorov O, Witwicka H, Hwang SY, van Stiphout RG, Lambert JP, Rogers C, Yapp C, Gerstenberger BS, Fedele V, Savitsky P, Heidenreich D, Daniels DL, Owen DR, Fish PV, Igoe NM, Bayle ED, Haendler B, Oppermann UCT, Buffa F, Brennan PE, Müller S, Gingras AC, Odgren PR, Birnbaum MJ, Knapp S.

ACS Chem Biol. 2017 Oct 20;12(10):2619-2630. doi: 10.1021/acschembio.7b00481. Epub 2017 Sep 12.


AIRE is a critical spindle-associated protein in embryonic stem cells.

Gu B, Lambert JP, Cockburn K, Gingras AC, Rossant J.

Elife. 2017 Jul 25;6. pii: e28131. doi: 10.7554/eLife.28131.


Exercise training provides cardioprotection by activating and coupling endothelial nitric oxide synthase via a β3-adrenergic receptor-AMP-activated protein kinase signaling pathway.

Barr LA, Lambert JP, Shimizu Y, Barouch LA, Naqvi N, Calvert JW.

Med Gas Res. 2017 Mar 30;7(1):1-8. doi: 10.4103/2045-9912.202904. eCollection 2017 Jan-Mar.


The mitochondrial Na+/Ca2+ exchanger is essential for Ca2+ homeostasis and viability.

Luongo TS, Lambert JP, Gross P, Nwokedi M, Lombardi AA, Shanmughapriya S, Carpenter AC, Kolmetzky D, Gao E, van Berlo JH, Tsai EJ, Molkentin JD, Chen X, Madesh M, Houser SR, Elrod JW.

Nature. 2017 May 4;545(7652):93-97. doi: 10.1038/nature22082. Epub 2017 Apr 26.


Multivalent Histone and DNA Engagement by a PHD/BRD/PWWP Triple Reader Cassette Recruits ZMYND8 to K14ac-Rich Chromatin.

Savitsky P, Krojer T, Fujisawa T, Lambert JP, Picaud S, Wang CY, Shanle EK, Krajewski K, Friedrichsen H, Kanapin A, Goding C, Schapira M, Samsonova A, Strahl BD, Gingras AC, Filippakopoulos P.

Cell Rep. 2016 Dec 6;17(10):2724-2737. doi: 10.1016/j.celrep.2016.11.014.


Acetylation of PCNA Sliding Surface by Eco1 Promotes Genome Stability through Homologous Recombination.

Billon P, Li J, Lambert JP, Chen Y, Tremblay V, Brunzelle JS, Gingras AC, Verreault A, Sugiyama T, Couture JF, Côté J.

Mol Cell. 2017 Jan 5;65(1):78-90. doi: 10.1016/j.molcel.2016.10.033. Epub 2016 Dec 1.


Proteomic analysis of the human KEOPS complex identifies C14ORF142 as a core subunit homologous to yeast Gon7.

Wan LC, Maisonneuve P, Szilard RK, Lambert JP, Ng TF, Manczyk N, Huang H, Laister R, Caudy AA, Gingras AC, Durocher D, Sicheri F.

Nucleic Acids Res. 2017 Jan 25;45(2):805-817. doi: 10.1093/nar/gkw1181. Epub 2016 Nov 29.


Data Independent Acquisition analysis in ProHits 4.0.

Liu G, Knight JD, Zhang JP, Tsou CC, Wang J, Lambert JP, Larsen B, Tyers M, Raught B, Bandeira N, Nesvizhskii AI, Choi H, Gingras AC.

J Proteomics. 2016 Oct 21;149:64-68. doi: 10.1016/j.jprot.2016.04.042. Epub 2016 Apr 29.


Promiscuous targeting of bromodomains by bromosporine identifies BET proteins as master regulators of primary transcription response in leukemia.

Picaud S, Leonards K, Lambert JP, Dovey O, Wells C, Fedorov O, Monteiro O, Fujisawa T, Wang CY, Lingard H, Tallant C, Nikbin N, Guetzoyan L, Ingham R, Ley SV, Brennan P, Muller S, Samsonova A, Gingras AC, Schwaller J, Vassiliou G, Knapp S, Filippakopoulos P.

Sci Adv. 2016 Oct 12;2(10):e1600760. eCollection 2016 Oct.


Angiotensin type 2-receptor (AT2R) activation induces hypotension in apolipoprotein E-deficient mice by activating peroxisome proliferator-activated receptor-γ.

Li M, Tejada T, Lambert JP, Nicholson CK, Yahiro E, Ambai VT, Ali SF, Bradley EW, Graham RM, Dell'Italia LJ, Calvert JW, Naqvi N.

Am J Cardiovasc Dis. 2016 Sep 15;6(3):118-28. eCollection 2016.


Dual action antifungal small molecule modulates multidrug efflux and TOR signaling.

Shekhar-Guturja T, Gunaherath GM, Wijeratne EM, Lambert JP, Averette AF, Lee SC, Kim T, Bahn YS, Tripodi F, Ammar R, Döhl K, Niewola-Staszkowska K, Schmitt L, Loewith RJ, Roth FP, Sanglard D, Andes D, Nislow C, Coccetti P, Gingras AC, Heitman J, Gunatilaka AA, Cowen LE.

Nat Chem Biol. 2016 Oct;12(10):867-75. doi: 10.1038/nchembio.2165. Epub 2016 Aug 29.


IGF-1 degradation by mouse mast cell protease 4 promotes cell death and adverse cardiac remodeling days after a myocardial infarction.

Tejada T, Tan L, Torres RA, Calvert JW, Lambert JP, Zaidi M, Husain M, Berce MD, Naib H, Pejler G, Abrink M, Graham RM, Lefer DJ, Naqvi N, Husain A.

Proc Natl Acad Sci U S A. 2016 Jun 21;113(25):6949-54. doi: 10.1073/pnas.1603127113. Epub 2016 Jun 6.


The TIP60 Complex Regulates Bivalent Chromatin Recognition by 53BP1 through Direct H4K20me Binding and H2AK15 Acetylation.

Jacquet K, Fradet-Turcotte A, Avvakumov N, Lambert JP, Roques C, Pandita RK, Paquet E, Herst P, Gingras AC, Pandita TK, Legube G, Doyon Y, Durocher D, Côté J.

Mol Cell. 2016 May 5;62(3):409-421. doi: 10.1016/j.molcel.2016.03.031.


SAINTq: Scoring protein-protein interactions in affinity purification - mass spectrometry experiments with fragment or peptide intensity data.

Teo G, Koh H, Fermin D, Lambert JP, Knight JD, Gingras AC, Choi H.

Proteomics. 2016 Aug;16(15-16):2238-45. doi: 10.1002/pmic.201500499. Epub 2016 May 27.


DJ-1 protects the heart against ischemia-reperfusion injury by regulating mitochondrial fission.

Shimizu Y, Lambert JP, Nicholson CK, Kim JJ, Wolfson DW, Cho HC, Husain A, Naqvi N, Chin LS, Li L, Calvert JW.

J Mol Cell Cardiol. 2016 Aug;97:56-66. doi: 10.1016/j.yjmcc.2016.04.008. Epub 2016 Apr 22.


Sodium Sulfide Attenuates Ischemic-Induced Heart Failure by Enhancing Proteasomal Function in an Nrf2-Dependent Manner.

Shimizu Y, Nicholson CK, Lambert JP, Barr LA, Kuek N, Herszenhaut D, Tan L, Murohara T, Hansen JM, Husain A, Naqvi N, Calvert JW.

Circ Heart Fail. 2016 Apr;9(4):e002368. doi: 10.1161/CIRCHEARTFAILURE.115.002368.


BRPF3-HBO1 regulates replication origin activation and histone H3K14 acetylation.

Feng Y, Vlassis A, Roques C, Lalonde ME, González-Aguilera C, Lambert JP, Lee SB, Zhao X, Alabert C, Johansen JV, Paquet E, Yang XJ, Gingras AC, Côté J, Groth A.

EMBO J. 2016 Jan 18;35(2):176-92. doi: 10.15252/embj.201591293. Epub 2015 Nov 30.


MSPLIT-DIA: sensitive peptide identification for data-independent acquisition.

Wang J, Tucholska M, Knight JD, Lambert JP, Tate S, Larsen B, Gingras AC, Bandeira N.

Nat Methods. 2015 Dec;12(12):1106-8. doi: 10.1038/nmeth.3655. No abstract available.


The Mitochondrial Calcium Uniporter Matches Energetic Supply with Cardiac Workload during Stress and Modulates Permeability Transition.

Luongo TS, Lambert JP, Yuan A, Zhang X, Gross P, Song J, Shanmughapriya S, Gao E, Jain M, Houser SR, Koch WJ, Cheung JY, Madesh M, Elrod JW.

Cell Rep. 2015 Jul 7;12(1):23-34. doi: 10.1016/j.celrep.2015.06.017. Epub 2015 Jun 25.


Hydrogen sulfide attenuates high fat diet-induced cardiac dysfunction via the suppression of endoplasmic reticulum stress.

Barr LA, Shimizu Y, Lambert JP, Nicholson CK, Calvert JW.

Nitric Oxide. 2015 Apr 30;46:145-56. doi: 10.1016/j.niox.2014.12.013. Epub 2015 Jan 6.


Hydrogen sulfide provides cardioprotection against myocardial/ischemia reperfusion injury in the diabetic state through the activation of the RISK pathway.

Lambert JP, Nicholson CK, Amin H, Amin S, Calvert JW.

Med Gas Res. 2014 Dec 12;4(1):20. doi: 10.1186/s13618-014-0020-0. eCollection 2014.


Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes.

Lambert JP, Tucholska M, Go C, Knight JD, Gingras AC.

J Proteomics. 2015 Apr 6;118:81-94. doi: 10.1016/j.jprot.2014.09.011. Epub 2014 Oct 2.


Cell cycle-regulated oscillator coordinates core histone gene transcription through histone acetylation.

Kurat CF, Lambert JP, Petschnigg J, Friesen H, Pawson T, Rosebrock A, Gingras AC, Fillingham J, Andrews B.

Proc Natl Acad Sci U S A. 2014 Sep 30;111(39):14124-9. doi: 10.1073/pnas.1414024111. Epub 2014 Sep 16.


(R)-PFI-2 is a potent and selective inhibitor of SETD7 methyltransferase activity in cells.

Barsyte-Lovejoy D, Li F, Oudhoff MJ, Tatlock JH, Dong A, Zeng H, Wu H, Freeman SA, Schapira M, Senisterra GA, Kuznetsova E, Marcellus R, Allali-Hassani A, Kennedy S, Lambert JP, Couzens AL, Aman A, Gingras AC, Al-Awar R, Fish PV, Gerstenberger BS, Roberts L, Benn CL, Grimley RL, Braam MJ, Rossi FM, Sudol M, Brown PJ, Bunnage ME, Owen DR, Zaph C, Vedadi M, Arrowsmith CH.

Proc Natl Acad Sci U S A. 2014 Sep 2;111(35):12853-8. doi: 10.1073/pnas.1407358111. Epub 2014 Aug 18.


Assessing cellular efficacy of bromodomain inhibitors using fluorescence recovery after photobleaching.

Philpott M, Rogers CM, Yapp C, Wells C, Lambert JP, Strain-Damerell C, Burgess-Brown NA, Gingras AC, Knapp S, Müller S.

Epigenetics Chromatin. 2014 Jul 13;7:14. doi: 10.1186/1756-8935-7-14. eCollection 2014.


A proliferative burst during preadolescence establishes the final cardiomyocyte number.

Naqvi N, Li M, Calvert JW, Tejada T, Lambert JP, Wu J, Kesteven SH, Holman SR, Matsuda T, Lovelock JD, Howard WW, Iismaa SE, Chan AY, Crawford BH, Wagner MB, Martin DI, Lefer DJ, Graham RM, Husain A.

Cell. 2014 May 8;157(4):795-807. doi: 10.1016/j.cell.2014.03.035.


Incorporating DNA shearing in standard affinity purification allows simultaneous identification of both soluble and chromatin-bound interaction partners.

Lambert JP, Tucholska M, Pawson T, Gingras AC.

J Proteomics. 2014 Apr 4;100:55-9. doi: 10.1016/j.jprot.2013.12.022. Epub 2014 Jan 9.


Molecular effects of autoimmune-risk promoter polymorphisms on expression, exon choice, and translational efficiency of interferon regulatory factor 5.

Clark DN, Lambert JP, Till RE, Argueta LB, Greenhalgh KE, Henrie B, Bills T, Hawkley TF, Roznik MG, Sloan JM, Mayhew V, Woodland L, Nelson EP, Tsai MH, Poole BD.

J Interferon Cytokine Res. 2014 May;34(5):354-65. doi: 10.1089/jir.2012.0105. Epub 2013 Dec 18.


Lnk adaptor suppresses radiation resistance and radiation-induced B-cell malignancies by inhibiting IL-11 signaling.

Louria-Hayon I, Frelin C, Ruston J, Gish G, Jin J, Kofler MM, Lambert JP, Adissu HA, Milyavsky M, Herrington R, Minden MD, Dick JE, Gingras AC, Iscove NN, Pawson T.

Proc Natl Acad Sci U S A. 2013 Dec 17;110(51):20599-604. doi: 10.1073/pnas.1319665110. Epub 2013 Dec 2.


Mapping differential interactomes by affinity purification coupled with data-independent mass spectrometry acquisition.

Lambert JP, Ivosev G, Couzens AL, Larsen B, Taipale M, Lin ZY, Zhong Q, Lindquist S, Vidal M, Aebersold R, Pawson T, Bonner R, Tate S, Gingras AC.

Nat Methods. 2013 Dec;10(12):1239-45. doi: 10.1038/nmeth.2702. Epub 2013 Oct 27.


Conserved Asf1-importin β physical interaction in growth and sexual development in the ciliate Tetrahymena thermophila.

Garg J, Lambert JP, Karsou A, Marquez S, Nabeel-Shah S, Bertucci V, Retnasothie DV, Radovani E, Pawson T, Gingras AC, Pearlman RE, Fillingham JS.

J Proteomics. 2013 Dec 6;94:311-26. doi: 10.1016/j.jprot.2013.09.018. Epub 2013 Oct 11.


Chronic exercise downregulates myocardial myoglobin and attenuates nitrite reductase capacity during ischemia-reperfusion.

Nicholson CK, Lambert JP, Chow CW, Lefer DJ, Calvert JW.

J Mol Cell Cardiol. 2013 Nov;64:1-10. doi: 10.1016/j.yjmcc.2013.08.002. Epub 2013 Aug 17.


The CRAPome: a contaminant repository for affinity purification-mass spectrometry data.

Mellacheruvu D, Wright Z, Couzens AL, Lambert JP, St-Denis NA, Li T, Miteva YV, Hauri S, Sardiu ME, Low TY, Halim VA, Bagshaw RD, Hubner NC, Al-Hakim A, Bouchard A, Faubert D, Fermin D, Dunham WH, Goudreault M, Lin ZY, Badillo BG, Pawson T, Durocher D, Coulombe B, Aebersold R, Superti-Furga G, Colinge J, Heck AJ, Choi H, Gstaiger M, Mohammed S, Cristea IM, Bennett KL, Washburn MP, Raught B, Ewing RM, Gingras AC, Nesvizhskii AI.

Nat Methods. 2013 Aug;10(8):730-6. doi: 10.1038/nmeth.2557. Epub 2013 Jul 7.


mChIP-KAT-MS, a method to map protein interactions and acetylation sites for lysine acetyltransferases.

Mitchell L, Huard S, Cotrut M, Pourhanifeh-Lemeri R, Steunou AL, Hamza A, Lambert JP, Zhou H, Ning Z, Basu A, Côté J, Figeys DA, Baetz K.

Proc Natl Acad Sci U S A. 2013 Apr 23;110(17):E1641-50. doi: 10.1073/pnas.1218515110. Epub 2013 Apr 9. Erratum in: Proc Natl Acad Sci U S A. 2014 Mar 18;111(11):4346.


Hydrogen sulfide preconditions the db/db diabetic mouse heart against ischemia-reperfusion injury by activating Nrf2 signaling in an Erk-dependent manner.

Peake BF, Nicholson CK, Lambert JP, Hood RL, Amin H, Amin S, Calvert JW.

Am J Physiol Heart Circ Physiol. 2013 May;304(9):H1215-24. doi: 10.1152/ajpheart.00796.2012. Epub 2013 Mar 11.


Thioredoxin 1 is essential for sodium sulfide-mediated cardioprotection in the setting of heart failure.

Nicholson CK, Lambert JP, Molkentin JD, Sadoshima J, Calvert JW.

Arterioscler Thromb Vasc Biol. 2013 Apr;33(4):744-51. doi: 10.1161/ATVBAHA.112.300484. Epub 2013 Jan 24.


An evaluation of pharmacists' expectations towards pharmacogenomics.

de Denus S, Letarte N, Hurlimann T, Lambert JP, Lavoie A, Robb L, Sheehan NL, Turgeon J, Vadnais B.

Pharmacogenomics. 2013 Jan;14(2):165-75. doi: 10.2217/pgs.12.197.


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