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Items: 1 to 50 of 156

1.

Treatment of Distal Femur Fractures with the Depuy-Synthes Variable Angle Locking Compression Plate.

McDonald TC, Lambert JJ, Hulick RM, Graves ML, Russell GV, Spitler CA, Bergin PF.

J Orthop Trauma. 2019 May 20. doi: 10.1097/BOT.0000000000001510. [Epub ahead of print]

PMID:
31259799
2.

Early-life stress influences acute and sensitized responses of adult mice to cocaine by interacting with GABAA α2 receptor expression.

Dixon CI, Walker SE, Swinny J, Belelli D, Lambert JJ, King SL, Stephens DN.

Behav Pharmacol. 2019 Apr;30(2 and 3 - Special Issue):272-281. doi: 10.1097/FBP.0000000000000466.

PMID:
30724801
3.

Metformin reverses early cortical network dysfunction and behavior changes in Huntington's disease.

Arnoux I, Willam M, Griesche N, Krummeich J, Watari H, Offermann N, Weber S, Narayan Dey P, Chen C, Monteiro O, Buettner S, Meyer K, Bano D, Radyushkin K, Langston R, Lambert JJ, Wanker E, Methner A, Krauss S, Schweiger S, Stroh A.

Elife. 2018 Sep 4;7. pii: e38744. doi: 10.7554/eLife.38744.

4.

Early-life adversity selectively impairs α2-GABAA receptor expression in the mouse nucleus accumbens and influences the behavioral effects of cocaine.

Mitchell SJ, Maguire EP, Cunningham L, Gunn BG, Linke M, Zechner U, Dixon CI, King SL, Stephens DN, Swinny JD, Belelli D, Lambert JJ.

Neuropharmacology. 2018 Oct;141:98-112. doi: 10.1016/j.neuropharm.2018.08.021. Epub 2018 Aug 21.

5.

Isotope Dilution-Based Targeted and Nontargeted Carbonyl Neurosteroid/Steroid Profiling.

Sharp S, Mitchell SJ, Vallée M, Kuzmanova E, Cooper M, Belelli D, Lambert JJ, Huang JT.

Anal Chem. 2018 Apr 17;90(8):5247-5255. doi: 10.1021/acs.analchem.8b00055. Epub 2018 Mar 28.

PMID:
29561593
6.

Role of GABAA receptor subtypes in the behavioural effects of intravenous general anaesthetics.

Weir CJ, Mitchell SJ, Lambert JJ.

Br J Anaesth. 2017 Dec 1;119(suppl_1):i167-i175. doi: 10.1093/bja/aex369. Review.

7.

Endogenous neurosteroids influence synaptic GABAA receptors during postnatal development.

Belelli D, Brown AR, Mitchell SJ, Gunn BG, Herd MB, Phillips GD, Seifi M, Swinny JD, Lambert JJ.

J Neuroendocrinol. 2018 Feb;30(2). doi: 10.1111/jne.12537. Review.

PMID:
28905487
8.

Morphine activation of mu opioid receptors causes disinhibition of neurons in the ventral tegmental area mediated by β-arrestin2 and c-Src.

Bull FA, Baptista-Hon DT, Lambert JJ, Walwyn W, Hales TG.

Sci Rep. 2017 Aug 30;7(1):9969. doi: 10.1038/s41598-017-10360-8.

9.

Selective inhibition of extra-synaptic α5-GABAA receptors by S44819, a new therapeutic agent.

Etherington LA, Mihalik B, Pálvölgyi A, Ling I, Pallagi K, Kertész S, Varga P, Gunn BG, Brown AR, Livesey MR, Monteiro O, Belelli D, Barkóczy J, Spedding M, Gacsályi I, Antoni FA, Lambert JJ.

Neuropharmacology. 2017 Oct;125:353-364. doi: 10.1016/j.neuropharm.2017.08.012. Epub 2017 Aug 12.

PMID:
28807671
10.

Behavioural pharmacology of the α5-GABAA receptor antagonist S44819: Enhancement and remediation of cognitive performance in preclinical models.

Gacsályi I, Móricz K, Gigler G, Wellmann J, Nagy K, Ling I, Barkóczy J, Haller J, Lambert JJ, Szénási G, Spedding M, Antoni FA.

Neuropharmacology. 2017 Oct;125:30-38. doi: 10.1016/j.neuropharm.2017.07.005. Epub 2017 Jul 8.

PMID:
28694097
11.

Nestorone® as a Novel Progestin for Nonoral Contraception: Structure-Activity Relationships and Brain Metabolism Studies.

Kumar N, Fagart J, Liere P, Mitchell SJ, Knibb AR, Petit-Topin I, Rame M, El-Etr M, Schumacher M, Lambert JJ, Rafestin-Oblin ME, Sitruk-Ware R.

Endocrinology. 2017 Jan 1;158(1):170-182. doi: 10.1210/en.2016-1426.

12.

GABAA receptor subtype involvement in addictive behaviour.

Stephens DN, King SL, Lambert JJ, Belelli D, Duka T.

Genes Brain Behav. 2017 Jan;16(1):149-184. doi: 10.1111/gbb.12321. Epub 2016 Sep 20. Review.

13.

During postnatal development endogenous neurosteroids influence GABA-ergic neurotransmission of mouse cortical neurons.

Brown AR, Mitchell SJ, Peden DR, Herd MB, Seifi M, Swinny JD, Belelli D, Lambert JJ.

Neuropharmacology. 2016 Apr;103:163-73. doi: 10.1016/j.neuropharm.2015.11.019. Epub 2015 Dec 2.

14.

A novel GABA(A) alpha 5 receptor inhibitor with therapeutic potential.

Ling I, Mihalik B, Etherington LA, Kapus G, Pálvölgyi A, Gigler G, Kertész S, Gaál A, Pallagi K, Kiricsi P, Szabó É, Szénási G, Papp L, Hársing LG, Lévay G, Spedding M, Lambert JJ, Belelli D, Barkóczy J, Volk B, Simig G, Gacsályi I, Antoni FA.

Eur J Pharmacol. 2015 Oct 5;764:497-507. doi: 10.1016/j.ejphar.2015.07.005. Epub 2015 Jul 11.

PMID:
26169564
15.

Developmentally regulated neurosteroid synthesis enhances GABAergic neurotransmission in mouse thalamocortical neurones.

Brown AR, Herd MB, Belelli D, Lambert JJ.

J Physiol. 2015 Jan 1;593(1):267-84. doi: 10.1113/jphysiol.2014.280263. Epub 2014 Dec 3.

16.

Molecular and functional diversity of GABA-A receptors in the enteric nervous system of the mouse colon.

Seifi M, Brown JF, Mills J, Bhandari P, Belelli D, Lambert JJ, Rudolph U, Swinny JD.

J Neurosci. 2014 Jul 30;34(31):10361-78. doi: 10.1523/JNEUROSCI.0441-14.2014.

17.

Localisation and stress-induced plasticity of GABAA receptor subunits within the cellular networks of the mouse dorsal raphe nucleus.

Corteen NL, Carter JA, Rudolph U, Belelli D, Lambert JJ, Swinny JD.

Brain Struct Funct. 2015 Sep;220(5):2739-63. doi: 10.1007/s00429-014-0824-7. Epub 2014 Jun 29.

PMID:
24973971
18.

GABAA receptor-acting neurosteroids: a role in the development and regulation of the stress response.

Gunn BG, Cunningham L, Mitchell SG, Swinny JD, Lambert JJ, Belelli D.

Front Neuroendocrinol. 2015 Jan;36:28-48. doi: 10.1016/j.yfrne.2014.06.001. Epub 2014 Jun 12. Review.

19.
20.

Control of Inhibition by the Direct Action of Cannabinoids on GABAA Receptors.

Golovko T, Min R, Lozovaya N, Falconer C, Yatsenko N, Tsintsadze T, Tsintsadze V, Ledent C, Harvey RJ, Belelli D, Lambert JJ, Rozov A, Burnashev N.

Cereb Cortex. 2015 Sep;25(9):2440-55. doi: 10.1093/cercor/bhu045. Epub 2014 Mar 18.

PMID:
24646614
21.

Tonic inhibition of accumbal spiny neurons by extrasynaptic α4βδ GABAA receptors modulates the actions of psychostimulants.

Maguire EP, Macpherson T, Swinny JD, Dixon CI, Herd MB, Belelli D, Stephens DN, King SL, Lambert JJ.

J Neurosci. 2014 Jan 15;34(3):823-38. doi: 10.1523/JNEUROSCI.3232-13.2014.

22.

Dysfunctional astrocytic and synaptic regulation of hypothalamic glutamatergic transmission in a mouse model of early-life adversity: relevance to neurosteroids and programming of the stress response.

Gunn BG, Cunningham L, Cooper MA, Corteen NL, Seifi M, Swinny JD, Lambert JJ, Belelli D.

J Neurosci. 2013 Dec 11;33(50):19534-54. doi: 10.1523/JNEUROSCI.1337-13.2013.

23.

Mutations in the Gabrb1 gene promote alcohol consumption through increased tonic inhibition.

Anstee QM, Knapp S, Maguire EP, Hosie AM, Thomas P, Mortensen M, Bhome R, Martinez A, Walker SE, Dixon CI, Ruparelia K, Montagnese S, Kuo YT, Herlihy A, Bell JD, Robinson I, Guerrini I, McQuillin A, Fisher EM, Ungless MA, Gurling HM, Morgan MY, Brown SD, Stephens DN, Belelli D, Lambert JJ, Smart TG, Thomas HC.

Nat Commun. 2013;4:2816. doi: 10.1038/ncomms3816.

24.

Extrasynaptic glycine receptors of rodent dorsal raphe serotonergic neurons: a sensitive target for ethanol.

Maguire EP, Mitchell EA, Greig SJ, Corteen N, Balfour DJ, Swinny JD, Lambert JJ, Belelli D.

Neuropsychopharmacology. 2014 Apr;39(5):1232-44. doi: 10.1038/npp.2013.326. Epub 2013 Nov 22.

25.

Mutagenic analysis of the intracellular portals of the human 5-HT3A receptor.

Carland JE, Cooper MA, Livesey MR, Hales TG, Peters JA, Lambert JJ.

J Biol Chem. 2013 Nov 1;288(44):31592-601. doi: 10.1074/jbc.M113.503300. Epub 2013 Sep 12.

26.

Extrasynaptic GABA(A) receptors couple presynaptic activity to postsynaptic inhibition in the somatosensory thalamus.

Herd MB, Brown AR, Lambert JJ, Belelli D.

J Neurosci. 2013 Sep 11;33(37):14850-68. doi: 10.1523/JNEUROSCI.1174-13.2013.

27.

The minimum M3-M4 loop length of neurotransmitter-activated pentameric receptors is critical for the structural integrity of cytoplasmic portals.

Baptista-Hon DT, Deeb TZ, Lambert JJ, Peters JA, Hales TG.

J Biol Chem. 2013 Jul 26;288(30):21558-68. doi: 10.1074/jbc.M113.481689. Epub 2013 Jun 5.

28.

5-Chloroindole: a potent allosteric modulator of the 5-HT₃ receptor.

Newman AS, Batis N, Grafton G, Caputo F, Brady CA, Lambert JJ, Peters JA, Gordon J, Brain KL, Powell AD, Barnes NM.

Br J Pharmacol. 2013 Jul;169(6):1228-38. doi: 10.1111/bph.12213.

29.

GABA-independent GABAA receptor openings maintain tonic currents.

Wlodarczyk AI, Sylantyev S, Herd MB, Kersanté F, Lambert JJ, Rusakov DA, Linthorst AC, Semyanov A, Belelli D, Pavlov I, Walker MC.

J Neurosci. 2013 Feb 27;33(9):3905-14. doi: 10.1523/JNEUROSCI.4193-12.2013.

30.

A study of subunit selectivity, mechanism and site of action of the delta selective compound 2 (DS2) at human recombinant and rodent native GABA(A) receptors.

Jensen ML, Wafford KA, Brown AR, Belelli D, Lambert JJ, Mirza NR.

Br J Pharmacol. 2013 Mar;168(5):1118-32. doi: 10.1111/bph.12001.

31.

Regulation of AMPA receptor surface trafficking and synaptic plasticity by a cognitive enhancer and antidepressant molecule.

Zhang H, Etherington LA, Hafner AS, Belelli D, Coussen F, Delagrange P, Chaouloff F, Spedding M, Lambert JJ, Choquet D, Groc L.

Mol Psychiatry. 2013 Apr;18(4):471-84. doi: 10.1038/mp.2012.80. Epub 2012 Jun 26.

32.

Neurosteroids and GABA(A) Receptor Interactions: A Focus on Stress.

Gunn BG, Brown AR, Lambert JJ, Belelli D.

Front Neurosci. 2011 Dec 5;5:131. doi: 10.3389/fnins.2011.00131. eCollection 2011.

33.

Distinct mechanisms regulate GABAA receptor and gephyrin clustering at perisomatic and axo-axonic synapses on CA1 pyramidal cells.

Panzanelli P, Gunn BG, Schlatter MC, Benke D, Tyagarajan SK, Scheiffele P, Belelli D, Lambert JJ, Rudolph U, Fritschy JM.

J Physiol. 2011 Oct 15;589(Pt 20):4959-80. doi: 10.1113/jphysiol.2011.216028. Epub 2011 Aug 8.

34.

Rings of charge within the extracellular vestibule influence ion permeation of the 5-HT3A receptor.

Livesey MR, Cooper MA, Lambert JJ, Peters JA.

J Biol Chem. 2011 May 6;286(18):16008-17. doi: 10.1074/jbc.M111.219618. Epub 2011 Mar 15.

35.

Cocaine effects on mouse incentive-learning and human addiction are linked to alpha2 subunit-containing GABAA receptors.

Dixon CI, Morris HV, Breen G, Desrivieres S, Jugurnauth S, Steiner RC, Vallada H, Guindalini C, Laranjeira R, Messas G, Rosahl TW, Atack JR, Peden DR, Belelli D, Lambert JJ, King SL, Schumann G, Stephens DN.

Proc Natl Acad Sci U S A. 2010 Feb 2;107(5):2289-94. doi: 10.1073/pnas.0910117107. Epub 2010 Jan 19.

36.

Novel structural determinants of single channel conductance and ion selectivity in 5-hydroxytryptamine type 3 and nicotinic acetylcholine receptors.

Peters JA, Cooper MA, Carland JE, Livesey MR, Hales TG, Lambert JJ.

J Physiol. 2010 Feb 15;588(Pt 4):587-96. doi: 10.1113/jphysiol.2009.183137. Epub 2009 Nov 23. Review.

37.

Neurosteroids: endogenous allosteric modulators of GABA(A) receptors.

Lambert JJ, Cooper MA, Simmons RD, Weir CJ, Belelli D.

Psychoneuroendocrinology. 2009 Dec;34 Suppl 1:S48-58. doi: 10.1016/j.psyneuen.2009.08.009.

PMID:
19758761
38.

Inhibition of thalamic excitability by 4,5,6,7-tetrahydroisoxazolo[4,5-c]pyridine-3-ol: a selective role for delta-GABA(A) receptors.

Herd MB, Foister N, Chandra D, Peden DR, Homanics GE, Brown VJ, Balfour DJ, Lambert JJ, Belelli D.

Eur J Neurosci. 2009 Mar;29(6):1177-87. doi: 10.1111/j.1460-9568.2009.06680.x.

39.

Bi-directional modulation of fast inhibitory synaptic transmission by leptin.

Solovyova N, Moult PR, Milojkovic B, Lambert JJ, Harvey J.

J Neurochem. 2009 Jan;108(1):190-201. doi: 10.1111/j.1471-4159.2008.05751.x.

40.

Characterization of the effects of charged residues in the intracellular loop on ion permeation in alpha1 glycine receptor channels.

Carland JE, Cooper MA, Sugiharto S, Jeong HJ, Lewis TM, Barry PH, Peters JA, Lambert JJ, Moorhouse AJ.

J Biol Chem. 2009 Jan 23;284(4):2023-30. doi: 10.1074/jbc.M806618200. Epub 2008 Dec 2.

41.

A transmembrane residue influences the interaction of propofol with the strychnine-sensitive glycine alpha1 and alpha1beta receptor.

Ahrens J, Leuwer M, Stachura S, Krampfl K, Belelli D, Lambert JJ, Haeseler G.

Anesth Analg. 2008 Dec;107(6):1875-83. doi: 10.1213/ane.0b013e3181875a31.

PMID:
19020133
42.

Novel compounds selectively enhance delta subunit containing GABA A receptors and increase tonic currents in thalamus.

Wafford KA, van Niel MB, Ma QP, Horridge E, Herd MB, Peden DR, Belelli D, Lambert JJ.

Neuropharmacology. 2009 Jan;56(1):182-9. doi: 10.1016/j.neuropharm.2008.08.004. Epub 2008 Aug 13.

PMID:
18762200
43.

Structural determinants of Ca2+ permeability and conduction in the human 5-hydroxytryptamine type 3A receptor.

Livesey MR, Cooper MA, Deeb TZ, Carland JE, Kozuska J, Hales TG, Lambert JJ, Peters JA.

J Biol Chem. 2008 Jul 11;283(28):19301-13. doi: 10.1074/jbc.M802406200. Epub 2008 May 12.

44.

The expression of GABAA beta subunit isoforms in synaptic and extrasynaptic receptor populations of mouse dentate gyrus granule cells.

Herd MB, Haythornthwaite AR, Rosahl TW, Wafford KA, Homanics GE, Lambert JJ, Belelli D.

J Physiol. 2008 Feb 15;586(4):989-1004. Epub 2007 Dec 13.

45.

Developmental maturation of synaptic and extrasynaptic GABAA receptors in mouse thalamic ventrobasal neurones.

Peden DR, Petitjean CM, Herd MB, Durakoglugil MS, Rosahl TW, Wafford K, Homanics GE, Belelli D, Fritschy JM, Lambert JJ.

J Physiol. 2008 Feb 15;586(4):965-87. Epub 2007 Dec 6.

46.

Neurosteroid modulation of GABAA receptors: molecular determinants and significance in health and disease.

Mitchell EA, Herd MB, Gunn BG, Lambert JJ, Belelli D.

Neurochem Int. 2008 Mar-Apr;52(4-5):588-95. Epub 2007 Oct 16. Review.

PMID:
18055067
47.

Synthesis, conformation and biological evaluation of the enantiomers of 3-fluoro-gamma-aminobutyric acid ((R)- and (S)-3F-GABA): an analogue of the neurotransmitter GABA.

Deniau G, Slawin AM, Lebl T, Chorki F, Issberner JP, van Mourik T, Heygate JM, Lambert JJ, Etherington LA, Sillar KT, O'Hagan D.

Chembiochem. 2007 Dec 17;8(18):2265-74.

PMID:
17990263
48.

Neurosteroid modulation of synaptic and extrasynaptic GABA(A) receptors.

Herd MB, Belelli D, Lambert JJ.

Pharmacol Ther. 2007 Oct;116(1):20-34. Epub 2007 Apr 21. Review.

PMID:
17531325
49.

How can drug discovery for psychiatric disorders be improved?

Agid Y, Buzsáki G, Diamond DM, Frackowiak R, Giedd J, Girault JA, Grace A, Lambert JJ, Manji H, Mayberg H, Popoli M, Prochiantz A, Richter-Levin G, Somogyi P, Spedding M, Svenningsson P, Weinberger D.

Nat Rev Drug Discov. 2007 Mar;6(3):189-201. doi: 10.1038/nrd2217. Review.

PMID:
17330070
50.

Dynamic modification of a mutant cytoplasmic cysteine residue modulates the conductance of the human 5-HT3A receptor.

Deeb TZ, Carland JE, Cooper MA, Livesey MR, Lambert JJ, Peters JA, Hales TG.

J Biol Chem. 2007 Mar 2;282(9):6172-82. Epub 2007 Jan 2.

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