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Mapping the physiological and molecular markers of stress and SSRI antidepressant treatment in S100a10 corticostriatal neurons.

Sargin D, Chottekalapanda RU, Perit KE, Yao V, Chu D, Sparks DW, Kalik S, Power SK, Troyanskaya OG, Schmidt EF, Greengard P, Lambe EK.

Mol Psychiatry. 2019 Aug 20. doi: 10.1038/s41380-019-0473-6. [Epub ahead of print]


Dual recombinase fate mapping reveals a transient cholinergic phenotype in multiple populations of developing glutamatergic neurons.

Nasirova N, Quina LA, Agosto-Marlin IM, Ramirez JM, Lambe EK, Turner EE.

J Comp Neurol. 2019 Aug 9. doi: 10.1002/cne.24753. [Epub ahead of print]


Serotonin Regulation of the Prefrontal Cortex: Cognitive Relevance and the Impact of Developmental Perturbation.

Sargin D, Jeoung HS, Goodfellow NM, Lambe EK.

ACS Chem Neurosci. 2019 Jul 17;10(7):3078-3093. doi: 10.1021/acschemneuro.9b00073. Epub 2019 Jul 1.


Apamin Improves Prefrontal Nicotinic Impairment in Mouse Model of Alzheimer's Disease.

Proulx É, Power SK, Oliver DK, Sargin D, McLaurin J, Lambe EK.

Cereb Cortex. 2019 Jun 12. pii: bhz107. doi: 10.1093/cercor/bhz107. [Epub ahead of print]


Dorsal raphe serotonin neurons inhibit operant responding for reward via inputs to the ventral tegmental area but not the nucleus accumbens: evidence from studies combining optogenetic stimulation and serotonin reuptake inhibition.

Browne CJ, Abela AR, Chu D, Li Z, Ji X, Lambe EK, Fletcher PJ.

Neuropsychopharmacology. 2019 Mar;44(4):793-804. doi: 10.1038/s41386-018-0271-x. Epub 2018 Nov 12.


Chrna5-Expressing Neurons in the Interpeduncular Nucleus Mediate Aversion Primed by Prior Stimulation or Nicotine Exposure.

Morton G, Nasirova N, Sparks DW, Brodsky M, Sivakumaran S, Lambe EK, Turner EE.

J Neurosci. 2018 Aug 1;38(31):6900-6920. doi: 10.1523/JNEUROSCI.0023-18.2018. Epub 2018 Jun 28.


Hippocampal 5-HT Input Regulates Memory Formation and Schaffer Collateral Excitation.

Teixeira CM, Rosen ZB, Suri D, Sun Q, Hersh M, Sargin D, Dincheva I, Morgan AA, Spivack S, Krok AC, Hirschfeld-Stoler T, Lambe EK, Siegelbaum SA, Ansorge MS.

Neuron. 2018 Jun 6;98(5):992-1004.e4. doi: 10.1016/j.neuron.2018.04.030. Epub 2018 May 10.


Ready, set, go: the bridging of attention to action by acetylcholine in prefrontal cortex.

Sparks DW, Proulx É, Lambe EK.

J Physiol. 2018 May 1;596(9):1539-1540. doi: 10.1113/JP275808. Epub 2018 Mar 26. No abstract available.


Opposing Cholinergic and Serotonergic Modulation of Layer 6 in Prefrontal Cortex.

Sparks DW, Tian MK, Sargin D, Venkatesan S, Intson K, Lambe EK.

Front Neural Circuits. 2018 Jan 4;11:107. doi: 10.3389/fncir.2017.00107. eCollection 2017.


Chronic social isolation reduces 5-HT neuronal activity via upregulated SK3 calcium-activated potassium channels.

Sargin D, Oliver DK, Lambe EK.

Elife. 2016 Nov 22;5. pii: e21416. doi: 10.7554/eLife.21416.


Serotonergic Suppression of Mouse Prefrontal Circuits Implicated in Task Attention.

Tian MK, Schmidt EF, Lambe EK.

eNeuro. 2016 Nov 8;3(5). pii: ENEURO.0269-16.2016. eCollection 2016 Sep-Oct.


Editorial: Neuromodulation of executive circuits.

Puig MV, Gulledge AT, Lambe EK, Gonzalez-Burgos G.

Front Neural Circuits. 2015 Oct 8;9:58. doi: 10.3389/fncir.2015.00058. eCollection 2015. No abstract available.


Dendritic spine density of prefrontal layer 6 pyramidal neurons in relation to apical dendrite sculpting by nicotinic acetylcholine receptors.

Kang L, Tian MK, Bailey CD, Lambe EK.

Front Cell Neurosci. 2015 Oct 8;9:398. doi: 10.3389/fncel.2015.00398. eCollection 2015.


Impaired Cholinergic Excitation of Prefrontal Attention Circuitry in the TgCRND8 Model of Alzheimer's Disease.

Proulx É, Fraser P, McLaurin J, Lambe EK.

J Neurosci. 2015 Sep 16;35(37):12779-91. doi: 10.1523/JNEUROSCI.4501-14.2015.


Enhanced 5-HT1A receptor-dependent feedback control over dorsal raphe serotonin neurons in the SERT knockout mouse.

Soiza-Reilly M, Goodfellow NM, Lambe EK, Commons KG.

Neuropharmacology. 2015 Feb;89:185-92. doi: 10.1016/j.neuropharm.2014.09.017. Epub 2014 Sep 28.


Postnatal day 2 to 11 constitutes a 5-HT-sensitive period impacting adult mPFC function.

Rebello TJ, Yu Q, Goodfellow NM, Caffrey Cagliostro MK, Teissier A, Morelli E, Demireva EY, Chemiakine A, Rosoklija GB, Dwork AJ, Lambe EK, Gingrich JA, Ansorge MS.

J Neurosci. 2014 Sep 10;34(37):12379-93. doi: 10.1523/JNEUROSCI.1020-13.2014.


Cholinergic excitation in mouse primary vs. associative cortex: region-specific magnitude and receptor balance.

Tian MK, Bailey CD, Lambe EK.

Eur J Neurosci. 2014 Aug;40(4):2608-18. doi: 10.1111/ejn.12622. Epub 2014 May 15.


Mice with compromised 5-HTT function lack phosphotyrosine-mediated inhibitory control over prefrontal 5-HT responses.

Goodfellow NM, Sargin D, Ansorge MS, Gingrich JA, Lambe EK.

J Neurosci. 2014 Apr 23;34(17):6107-11. doi: 10.1523/JNEUROSCI.3762-13.2014.


Early stress prevents the potentiation of muscarinic excitation by calcium release in adult prefrontal cortex.

Proulx É, Suri D, Heximer SP, Vaidya VA, Lambe EK.

Biol Psychiatry. 2014 Aug 15;76(4):315-23. doi: 10.1016/j.biopsych.2013.10.017. Epub 2013 Oct 28.


Nicotinic acetylcholine receptors in attention circuitry: the role of layer VI neurons of prefrontal cortex.

Proulx E, Piva M, Tian MK, Bailey CD, Lambe EK.

Cell Mol Life Sci. 2014 Apr;71(7):1225-44. Review.


Chrna5 genotype determines the long-lasting effects of developmental in vivo nicotine exposure on prefrontal attention circuitry.

Bailey CD, Tian MK, Kang L, O'Reilly R, Lambe EK.

Neuropharmacology. 2014 Feb;77:145-55. doi: 10.1016/j.neuropharm.2013.09.003. Epub 2013 Sep 18.


Plasticity of prefrontal attention circuitry: upregulated muscarinic excitability in response to decreased nicotinic signaling following deletion of α5 or β2 subunits.

Tian MK, Bailey CD, De Biasi M, Picciotto MR, Lambe EK.

J Neurosci. 2011 Nov 9;31(45):16458-63. doi: 10.1523/JNEUROSCI.3600-11.2011.


Nicotinic α5 subunits drive developmental changes in the activation and morphology of prefrontal cortex layer VI neurons.

Bailey CD, Alves NC, Nashmi R, De Biasi M, Lambe EK.

Biol Psychiatry. 2012 Jan 15;71(2):120-8. doi: 10.1016/j.biopsych.2011.09.011. Epub 2011 Oct 25.


Serotonin receptor expression in human prefrontal cortex: balancing excitation and inhibition across postnatal development.

Lambe EK, Fillman SG, Webster MJ, Shannon Weickert C.

PLoS One. 2011;6(7):e22799. doi: 10.1371/journal.pone.0022799. Epub 2011 Jul 29.


Schizophrenia susceptibility pathway neuregulin 1-ErbB4 suppresses Src upregulation of NMDA receptors.

Pitcher GM, Kalia LV, Ng D, Goodfellow NM, Yee KT, Lambe EK, Salter MW.

Nat Med. 2011 Apr;17(4):470-8. doi: 10.1038/nm.2315. Epub 2011 Mar 27.


Enhanced function of prefrontal serotonin 5-HT(2) receptors in a rat model of psychiatric vulnerability.

Benekareddy M, Goodfellow NM, Lambe EK, Vaidya VA.

J Neurosci. 2010 Sep 8;30(36):12138-50. doi: 10.1523/JNEUROSCI.3245-10.2010.


The nicotinic acetylcholine receptor alpha5 subunit plays a key role in attention circuitry and accuracy.

Bailey CD, De Biasi M, Fletcher PJ, Lambe EK.

J Neurosci. 2010 Jul 7;30(27):9241-52. doi: 10.1523/JNEUROSCI.2258-10.2010.


Enhanced prefrontal serotonin 5-HT(1A) currents in a mouse model of Williams-Beuren syndrome with low innate anxiety.

Proulx E, Young EJ, Osborne LR, Lambe EK.

J Neurodev Disord. 2010 Jun;2(2):99-108. Epub 2010 Mar 19.


Developmental sex differences in nicotinic currents of prefrontal layer VI neurons in mice and rats.

Alves NC, Bailey CD, Nashmi R, Lambe EK.

PLoS One. 2010 Feb 17;5(2):e9261. doi: 10.1371/journal.pone.0009261.


Layer II/III of the prefrontal cortex: Inhibition by the serotonin 5-HT1A receptor in development and stress.

Goodfellow NM, Benekareddy M, Vaidya VA, Lambe EK.

J Neurosci. 2009 Aug 12;29(32):10094-103. doi: 10.1523/JNEUROSCI.1960-09.2009.


Perspective: Translational studies on glutamate and dopamine neurocircuitry in addictions: implications for addiction treatment.

Lambe EK, George TP.

Neuropsychopharmacology. 2009 Jan;34(2):255-6. doi: 10.1038/npp.2008.196. Epub 2008 Nov 5.


Developmental excitation of corticothalamic neurons by nicotinic acetylcholine receptors.

Kassam SM, Herman PM, Goodfellow NM, Alves NC, Lambe EK.

J Neurosci. 2008 Aug 27;28(35):8756-64. doi: 10.1523/JNEUROSCI.2645-08.2008.


Schizophrenia, hypocretin (orexin), and the thalamocortical activating system.

Lambe EK, Liu RJ, Aghajanian GK.

Schizophr Bull. 2007 Nov;33(6):1284-90. Epub 2007 Jul 26. Review.


Severe deficits in 5-HT2A -mediated neurotransmission in BDNF conditional mutant mice.

Rios M, Lambe EK, Liu R, Teillon S, Liu J, Akbarian S, Roffler-Tarlov S, Jaenisch R, Aghajanian GK.

J Neurobiol. 2006 Mar;66(4):408-20.


Hallucinogen-induced UP states in the brain slice of rat prefrontal cortex: role of glutamate spillover and NR2B-NMDA receptors.

Lambe EK, Aghajanian GK.

Neuropsychopharmacology. 2006 Aug;31(8):1682-9. Epub 2005 Nov 2.


Hypocretin and nicotine excite the same thalamocortical synapses in prefrontal cortex: correlation with improved attention in rat.

Lambe EK, Olausson P, Horst NK, Taylor JR, Aghajanian GK.

J Neurosci. 2005 May 25;25(21):5225-9.


Nicotine induces glutamate release from thalamocortical terminals in prefrontal cortex.

Lambe EK, Picciotto MR, Aghajanian GK.

Neuropsychopharmacology. 2003 Feb;28(2):216-25.


Serotonin induces EPSCs preferentially in layer V pyramidal neurons of the frontal cortex in the rat.

Lambe EK, Goldman-Rakic PS, Aghajanian GK.

Cereb Cortex. 2000 Oct;10(10):974-80.


Dyslexia, gender, and brain imaging.

Lambe EK.

Neuropsychologia. 1999 May;37(5):521-36. Review.


MRI correlates of treatment response in first episode psychosis.

Zipursky RB, Zhang-Wong J, Lambe EK, Bean G, Beiser M.

Schizophr Res. 1998 Feb 27;30(1):81-90.


Cerebral gray matter volume deficits in first episode psychosis.

Zipursky RB, Lambe EK, Kapur S, Mikulis DJ.

Arch Gen Psychiatry. 1998 Jun;55(6):540-6.


A longitudinal magnetic resonance imaging study of brain changes in adolescents with anorexia nervosa.

Katzman DK, Zipursky RB, Lambe EK, Mikulis DJ.

Arch Pediatr Adolesc Med. 1997 Aug;151(8):793-7.


Cerebral gray matter volume deficits after weight recovery from anorexia nervosa.

Lambe EK, Katzman DK, Mikulis DJ, Kennedy SH, Zipursky RB.

Arch Gen Psychiatry. 1997 Jun;54(6):537-42.


Cerebral gray matter and white matter volume deficits in adolescent girls with anorexia nervosa.

Katzman DK, Lambe EK, Mikulis DJ, Ridgley JN, Goldbloom DS, Zipursky RB.

J Pediatr. 1996 Dec;129(6):794-803.


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