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Items: 1 to 50 of 91

1.

A single-cell transcriptome atlas of the adult human retina.

Lukowski SW, Lo CY, Sharov AA, Nguyen Q, Fang L, Hung SS, Zhu L, Zhang T, Grünert U, Nguyen T, Senabouth A, Jabbari JS, Welby E, Sowden JC, Waugh HS, Mackey A, Pollock G, Lamb TD, Wang PY, Hewitt AW, Gillies MC, Powell JE, Wong RC.

EMBO J. 2019 Sep 16;38(18):e100811. doi: 10.15252/embj.2018100811. Epub 2019 Aug 22.

PMID:
31436334
2.

Topographic Rod Recovery Profiles after a Prolonged Dark Adaptation in Subjects with Reticular Pseudodrusen.

Luu CD, Tan R, Caruso E, Fletcher EL, Lamb TD, Guymer RH.

Ophthalmol Retina. 2018 Dec;2(12):1206-1217. doi: 10.1016/j.oret.2018.06.016. Epub 2018 Aug 18.

PMID:
31047193
3.

Phototransduction gain at the G-protein, transducin, and effector protein, phosphodiesterase-6, stages in retinal rods.

Heck M, Hofmann KP, Kraft TW, Lamb TD.

Proc Natl Acad Sci U S A. 2019 Apr 30;116(18):8653-8654. doi: 10.1073/pnas.1904017116. No abstract available.

PMID:
31040258
4.

Evolution of the calcium feedback steps of vertebrate phototransduction.

Lamb TD, Hunt DM.

Open Biol. 2018 Sep 26;8(9). pii: 180119. doi: 10.1098/rsob.180119.

5.

Implications of dimeric activation of PDE6 for rod phototransduction.

Lamb TD, Heck M, Kraft TW.

Open Biol. 2018 Aug;8(8). pii: 180076. doi: 10.1098/rsob.180076.

6.

It takes two transducins to activate the cGMP-phosphodiesterase 6 in retinal rods.

Qureshi BM, Behrmann E, Schöneberg J, Loerke J, Bürger J, Mielke T, Giesebrecht J, Noé F, Lamb TD, Hofmann KP, Spahn CMT, Heck M.

Open Biol. 2018 Aug;8(8). pii: 180075. doi: 10.1098/rsob.180075.

7.

Evolution of the shut-off steps of vertebrate phototransduction.

Lamb TD, Patel HR, Chuah A, Hunt DM.

Open Biol. 2018 Jan;8(1). pii: 170232. doi: 10.1098/rsob.170232.

8.

Evolution of the vertebrate phototransduction cascade activation steps.

Lamb TD, Hunt DM.

Dev Biol. 2017 Nov 1;431(1):77-92. doi: 10.1016/j.ydbio.2017.03.018. Epub 2017 Mar 25.

9.
10.

Evolution of Vertebrate Phototransduction: Cascade Activation.

Lamb TD, Patel H, Chuah A, Natoli RC, Davies WI, Hart NS, Collin SP, Hunt DM.

Mol Biol Evol. 2016 Aug;33(8):2064-87. doi: 10.1093/molbev/msw095. Epub 2016 May 11.

11.

Why rods and cones?

Lamb TD.

Eye (Lond). 2016 Feb;30(2):179-85. doi: 10.1038/eye.2015.236. Epub 2015 Nov 13. Review.

12.

The kinetics of regeneration of rhodopsin under enzyme-limited availability of 11-cis retinoid.

Lamb TD, Corless RM, Pananos AD.

Vision Res. 2015 May;110(Pt A):23-33. doi: 10.1016/j.visres.2015.02.014. Epub 2015 Mar 10.

13.

Evolution of Phototransduction, Vertebrate Photoreceptors and Retina.

Lamb TD.

In: Kolb H, Fernandez E, Nelson R, editors. Webvision: The Organization of the Retina and Visual System [Internet]. Salt Lake City (UT): University of Utah Health Sciences Center; 1995-.
2013 May 14 [updated 2013 Jul 10].

14.

Evolution of phototransduction, vertebrate photoreceptors and retina.

Lamb TD.

Prog Retin Eye Res. 2013 Sep;36:52-119. doi: 10.1016/j.preteyeres.2013.06.001. Epub 2013 Jun 19. Review.

15.

Slowed recovery of human photopic ERG a-wave amplitude following intense bleaches: a slowing of cone pigment regeneration?

Mahroo OA, Lamb TD.

Doc Ophthalmol. 2012 Oct;125(2):137-47. doi: 10.1007/s10633-012-9344-z. Epub 2012 Jul 20.

PMID:
22814870
16.

Modelling the initial phase of the human rod photoreceptor response to the onset of steady illumination.

Mahroo OA, Ban VS, Bussmann BM, Copley HC, Hammond CJ, Lamb TD.

Doc Ophthalmol. 2012 Apr;124(2):125-31. doi: 10.1007/s10633-012-9316-3. Epub 2012 Feb 19.

PMID:
22350929
17.

Human scotopic dark adaptation: Comparison of recoveries of psychophysical threshold and ERG b-wave sensitivity.

Ruseckaite R, Lamb TD, Pianta MJ, Cameron AM.

J Vis. 2011 Jul 6;11(8). pii: 2. doi: 10.1167/11.8.2.

PMID:
21733908
18.
19.

Ectopic expression of cone-specific G-protein-coupled receptor kinase GRK7 in zebrafish rods leads to lower photosensitivity and altered responses.

Vogalis F, Shiraki T, Kojima D, Wada Y, Nishiwaki Y, Jarvinen JL, Sugiyama J, Kawakami K, Masai I, Kawamura S, Fukada Y, Lamb TD.

J Physiol. 2011 May 1;589(Pt 9):2321-48. doi: 10.1113/jphysiol.2010.204156. Epub 2011 Mar 8.

20.

Evolution of vertebrate retinal photoreception.

Lamb TD.

Philos Trans R Soc Lond B Biol Sci. 2009 Oct 12;364(1531):2911-24. doi: 10.1098/rstb.2009.0102. Review.

21.

The evolution of phototransduction and eyes.

Lamb TD, Arendt D, Collin SP.

Philos Trans R Soc Lond B Biol Sci. 2009 Oct 12;364(1531):2791-3. doi: 10.1098/rstb.2009.0106. No abstract available.

22.

Dark adaptation recovery of human rod bipolar cell response kinetics estimated from scotopic b-wave measurements.

Cameron AM, Miao L, Ruseckaite R, Pianta MJ, Lamb TD.

J Physiol. 2008 Nov 15;586(22):5419-36. doi: 10.1113/jphysiol.2008.160028. Epub 2008 Sep 18.

23.

Evolution of the vertebrate eye: opsins, photoreceptors, retina and eye cup.

Lamb TD, Collin SP, Pugh EN Jr.

Nat Rev Neurosci. 2007 Dec;8(12):960-76. Review.

24.

Phototransduction, dark adaptation, and rhodopsin regeneration the proctor lecture.

Lamb TD, Pugh EN Jr.

Invest Ophthalmol Vis Sci. 2006 Dec;47(12):5137-52. No abstract available.

PMID:
17122096
25.

Dark adaptation of human rod bipolar cells measured from the b-wave of the scotopic electroretinogram.

Cameron AM, Mahroo OA, Lamb TD.

J Physiol. 2006 Sep 1;575(Pt 2):507-26. Epub 2006 Jun 15.

26.

The photocurrent response of human cones is fast and monophasic.

van Hateren JH, Lamb TD.

BMC Neurosci. 2006 Apr 20;7:34.

27.

Toward a unified model of vertebrate rod phototransduction.

Hamer RD, Nicholas SC, Tranchina D, Lamb TD, Jarvinen JL.

Vis Neurosci. 2005 Jul-Aug;22(4):417-36.

28.

The retinal G protein-coupled receptor (RGR) enhances isomerohydrolase activity independent of light.

Wenzel A, Oberhauser V, Pugh EN Jr, Lamb TD, Grimm C, Samardzija M, Fahl E, Seeliger MW, Remé CE, von Lintig J.

J Biol Chem. 2005 Aug 19;280(33):29874-84. Epub 2005 Jun 16.

29.

Extremely rapid recovery of human cone circulating current at the extinction of bleaching exposures.

Kenkre JS, Moran NA, Lamb TD, Mahroo OA.

J Physiol. 2005 Aug 15;567(Pt 1):95-112. Epub 2005 Jun 2.

30.
31.

Dark adaptation and the retinoid cycle of vision.

Lamb TD, Pugh EN Jr.

Prog Retin Eye Res. 2004 May;23(3):307-80. Review.

PMID:
15177205
32.

Contribution of cone photoreceptors and post-receptoral mechanisms to the human photopic electroretinogram.

Friedburg C, Allen CP, Mason PJ, Lamb TD.

J Physiol. 2004 May 1;556(Pt 3):819-34. Epub 2004 Feb 27.

33.
34.

Multiple steps of phosphorylation of activated rhodopsin can account for the reproducibility of vertebrate rod single-photon responses.

Hamer RD, Nicholas SC, Tranchina D, Liebman PA, Lamb TD.

J Gen Physiol. 2003 Oct;122(4):419-44. Epub 2003 Sep 15.

35.

G proteins and phototransduction.

Arshavsky VY, Lamb TD, Pugh EN Jr.

Annu Rev Physiol. 2002;64:153-87. Review.

PMID:
11826267
36.
37.

Human cone photoreceptor responses measured by the electroretinogram [correction of electoretinogram] a-wave during and after exposure to intense illumination.

Paupoo AA, Mahroo OA, Friedburg C, Lamb TD.

J Physiol. 2000 Dec 1;529 Pt 2:469-82. Erratum in: J Physiol 2001 May 1;532(Pt 3):893.

38.

The role of steady phosphodiesterase activity in the kinetics and sensitivity of the light-adapted salamander rod photoresponse.

Nikonov S, Lamb TD, Pugh EN Jr.

J Gen Physiol. 2000 Dec;116(6):795-824. Erratum in: J Gen Physiol 2001 Apr;117(4):367.

39.

The gain of rod phototransduction: reconciliation of biochemical and electrophysiological measurements.

Leskov IB, Klenchin VA, Handy JW, Whitlock GG, Govardovskii VI, Bownds MD, Lamb TD, Pugh EN Jr, Arshavsky VY.

Neuron. 2000 Sep;27(3):525-37.

40.

Molecular mechanisms of vertebrate photoreceptor light adaptation.

Pugh EN Jr, Nikonov S, Lamb TD.

Curr Opin Neurobiol. 1999 Aug;9(4):410-8. Review.

PMID:
10448166
42.
43.

Molecular basis of dark adaptation in rod photoreceptors.

Leibrock CS, Reuter T, Lamb TD.

Eye (Lond). 1998;12 ( Pt 3b):511-20. Review.

PMID:
9775211
44.
45.

Rod plateaux during dark adaptation in Sorsby's fundus dystrophy and vitamin A deficiency.

Cideciyan AV, Pugh EN Jr, Lamb TD, Huang Y, Jacobson SG.

Invest Ophthalmol Vis Sci. 1997 Aug;38(9):1786-94.

PMID:
9286267
46.
47.
48.

Ida Mann Lecture. Transduction in human photoreceptors.

Lamb TD.

Aust N Z J Ophthalmol. 1996 May;24(2):105-10.

PMID:
9199739
49.

Gain and kinetics of activation in the G-protein cascade of phototransduction.

Lamb TD.

Proc Natl Acad Sci U S A. 1996 Jan 23;93(2):566-70.

50.

Transduction and adaptation in sensory receptor cells.

Torre V, Ashmore JF, Lamb TD, Menini A.

J Neurosci. 1995 Dec;15(12):7757-68. Review.

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