Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 31

1.

Oncogene-Selective Sensitivity to Synchronous Cell Death following Modulation of the Amino Acid Nutrient Cystine.

Poursaitidis I, Wang X, Crighton T, Labuschagne C, Mason D, Cramer SL, Triplett K, Roy R, Pardo OE, Seckl MJ, Rowlinson SW, Stone E, Lamb RF.

Cell Rep. 2017 Mar 14;18(11):2547-2556. doi: 10.1016/j.celrep.2017.02.054.

2.

The impact of diabetes mellitus on survival following resection and adjuvant chemotherapy for pancreatic cancer.

Kleeff J, Costello E, Jackson R, Halloran C, Greenhalf W, Ghaneh P, Lamb RF, Lerch MM, Mayerle J, Palmer D, Cox T, Rawcliffe CL, Strobel O, Büchler MW, Neoptolemos JP.

Br J Cancer. 2016 Sep 27;115(7):887-94. doi: 10.1038/bjc.2016.277. Epub 2016 Sep 1.

3.

T cell exit from quiescence and differentiation into Th2 cells depend on Raptor-mTORC1-mediated metabolic reprogramming.

Yang K, Shrestha S, Zeng H, Karmaus PW, Neale G, Vogel P, Guertin DA, Lamb RF, Chi H.

Immunity. 2013 Dec 12;39(6):1043-56. doi: 10.1016/j.immuni.2013.09.015. Epub 2013 Dec 5.

4.

Mammalian target of rapamycin complex I (mTORC1) activity in ras homologue enriched in brain (Rheb)-deficient mouse embryonic fibroblasts.

Groenewoud MJ, Goorden SM, Kassies J, Pellis-van Berkel W, Lamb RF, Elgersma Y, Zwartkruis FJ.

PLoS One. 2013 Nov 26;8(11):e81649. doi: 10.1371/journal.pone.0081649. eCollection 2013.

5.

Pancreatic cancer hENT1 expression and survival from gemcitabine in patients from the ESPAC-3 trial.

Greenhalf W, Ghaneh P, Neoptolemos JP, Palmer DH, Cox TF, Lamb RF, Garner E, Campbell F, Mackey JR, Costello E, Moore MJ, Valle JW, McDonald AC, Carter R, Tebbutt NC, Goldstein D, Shannon J, Dervenis C, Glimelius B, Deakin M, Charnley RM, Lacaine F, Scarfe AG, Middleton MR, Anthoney A, Halloran CM, Mayerle J, Oláh A, Jackson R, Rawcliffe CL, Scarpa A, Bassi C, Büchler MW; European Study Group for Pancreatic Cancer.

J Natl Cancer Inst. 2014 Jan;106(1):djt347. doi: 10.1093/jnci/djt347. Epub 2013 Dec 3.

PMID:
24301456
6.

Tuberous sclerosis 1 (Tsc1)-dependent metabolic checkpoint controls development of dendritic cells.

Wang Y, Huang G, Zeng H, Yang K, Lamb RF, Chi H.

Proc Natl Acad Sci U S A. 2013 Dec 10;110(50):E4894-903. doi: 10.1073/pnas.1308905110. Epub 2013 Nov 26.

7.

Amino acid sensing mechanisms: an Achilles heel in cancer?

Lamb RF.

FEBS J. 2012 Aug;279(15):2624-31. doi: 10.1111/j.1742-4658.2012.08659.x. Epub 2012 Jul 3. Review.

8.

Negative feedback loops: nutrient starvation employs a new tr(IKK) to inhibit PI3K.

Lamb RF.

Mol Cell. 2012 Mar 30;45(6):705-6. doi: 10.1016/j.molcel.2012.03.015.

9.

Amino acid sensing and regulation of mTORC1.

Yan L, Lamb RF.

Semin Cell Dev Biol. 2012 Aug;23(6):621-5. doi: 10.1016/j.semcdb.2012.02.001. Epub 2012 Feb 10. Review.

PMID:
22342805
10.

[Arginine and innate immune response].

Mieulet V, Lamb RF.

Med Sci (Paris). 2011 May;27(5):461-3. doi: 10.1051/medsci/2011275005. Epub 2011 May 25. French. No abstract available.

11.

Signalling by amino acid nutrients.

Yan L, Lamb RF.

Biochem Soc Trans. 2011 Apr;39(2):443-5. doi: 10.1042/BST0390443. Review.

PMID:
21428916
12.

TPL-2-mediated activation of MAPK downstream of TLR4 signaling is coupled to arginine availability.

Mieulet V, Yan L, Choisy C, Sully K, Procter J, Kouroumalis A, Krywawych S, Pende M, Ley SC, Moinard C, Lamb RF.

Sci Signal. 2010 Aug 17;3(135):ra61. doi: 10.1126/scisignal.2000934.

13.

Tuberous sclerosis complex: linking cancer to metabolism.

Mieulet V, Lamb RF.

Trends Mol Med. 2010 Jul;16(7):329-35. doi: 10.1016/j.molmed.2010.05.001. Epub 2010 Jun 3. Review.

PMID:
20605525
14.

Nutrient regulation of mTORC1 and cell growth.

Yan L, Mieulet V, Lamb RF.

Cell Cycle. 2010 Jul 1;9(13):2473-4. No abstract available.

PMID:
20543582
15.

PP2A T61 epsilon is an inhibitor of MAP4K3 in nutrient signaling to mTOR.

Yan L, Mieulet V, Burgess D, Findlay GM, Sully K, Procter J, Goris J, Janssens V, Morrice NA, Lamb RF.

Mol Cell. 2010 Mar 12;37(5):633-42. doi: 10.1016/j.molcel.2010.01.031.

16.

mTORC2 is the hydrophobic motif kinase for SGK1.

Yan L, Mieulet V, Lamb RF.

Biochem J. 2008 Dec 15;416(3):e19-21. doi: 10.1042/BJ20082202.

PMID:
19025518
17.

Shooting the messenger: CULLIN' insulin signaling with Fbw8.

Mieulet V, Lamb RF.

Dev Cell. 2008 Jun;14(6):816-7. doi: 10.1016/j.devcel.2008.05.010.

18.

A MAP4 kinase related to Ste20 is a nutrient-sensitive regulator of mTOR signalling.

Findlay GM, Yan L, Procter J, Mieulet V, Lamb RF.

Biochem J. 2007 Apr 1;403(1):13-20.

19.

Hyperactivation of mammalian target of rapamycin (mTOR) signaling by a gain-of-function mutant of the Rheb GTPase.

Yan L, Findlay GM, Jones R, Procter J, Cao Y, Lamb RF.

J Biol Chem. 2006 Jul 21;281(29):19793-7. Epub 2006 May 25.

20.

TSC1-2 tumour suppressor and regulation of mTOR signalling: linking cell growth and proliferation?

Findlay GM, Harrington LS, Lamb RF.

Curr Opin Genet Dev. 2005 Feb;15(1):69-76.

PMID:
15661536
21.

Restraining PI3K: mTOR signalling goes back to the membrane.

Harrington LS, Findlay GM, Lamb RF.

Trends Biochem Sci. 2005 Jan;30(1):35-42. Review.

PMID:
15653324
22.

The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins.

Harrington LS, Findlay GM, Gray A, Tolkacheva T, Wigfield S, Rebholz H, Barnett J, Leslie NR, Cheng S, Shepherd PR, Gout I, Downes CP, Lamb RF.

J Cell Biol. 2004 Jul 19;166(2):213-23. Epub 2004 Jul 12.

23.

The TSC1 tumour suppressor hamartin regulates cell adhesion through ERM proteins and the GTPase Rho.

Lamb RF, Roy C, Diefenbach TJ, Vinters HV, Johnson MW, Jay DG, Hall A.

Nat Cell Biol. 2000 May;2(5):281-7.

PMID:
10806479
24.

The transcription factor AP-1 is required for EGF-induced activation of rho-like GTPases, cytoskeletal rearrangements, motility, and in vitro invasion of A431 cells.

Malliri A, Symons M, Hennigan RF, Hurlstone AF, Lamb RF, Wheeler T, Ozanne BW.

J Cell Biol. 1998 Nov 16;143(4):1087-99.

25.

Essential functions of ezrin in maintenance of cell shape and lamellipodial extension in normal and transformed fibroblasts.

Lamb RF, Ozanne BW, Roy C, McGarry L, Stipp C, Mangeat P, Jay DG.

Curr Biol. 1997 Sep 1;7(9):682-8.

26.

AP-1-mediated invasion requires increased expression of the hyaluronan receptor CD44.

Lamb RF, Hennigan RF, Turnbull K, Katsanakis KD, MacKenzie ED, Birnie GD, Ozanne BW.

Mol Cell Biol. 1997 Feb;17(2):963-76.

27.

Practical histological microdissection for PCR analysis.

Going JJ, Lamb RF.

J Pathol. 1996 May;179(1):121-4.

PMID:
8691336
29.

Functional expression and molecular characterization of the thyrotrophin-releasing hormone receptor from the rat anterior pituitary gland.

Sellar RE, Taylor PL, Lamb RF, Zabavnik J, Anderson L, Eidne KA.

J Mol Endocrinol. 1993 Apr;10(2):199-206.

PMID:
8387312
30.

Differentiation stage-specific expression of a gene during granulopoiesis.

Wiedemann LM, Francis GE, Lamb RF, Burns JH, Winnie JN, MacKenzie ED, Birnie GD.

Leukemia. 1989 Mar;3(3):227-34.

PMID:
2918759
31.

Editorial. The name of the game--communication.

Lamb RF.

Bull Monmouth Ocean Cty Dent Soc. 1971 Feb;27(4):4-6. No abstract available.

PMID:
5313360

Supplemental Content

Support Center