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Items: 46


Crystal structure of NucB, a biofilm-degrading endonuclease.

Baslé A, Hewitt L, Koh A, Lamb HK, Thompson P, Burgess JG, Hall MJ, Hawkins AR, Murray H, Lewis RJ.

Nucleic Acids Res. 2018 Jan 9;46(1):473-484. doi: 10.1093/nar/gkx1170.


Matriptase Induction of Metalloproteinase-Dependent Aggrecanolysis In Vitro and In Vivo: Promotion of Osteoarthritic Cartilage Damage by Multiple Mechanisms.

Wilkinson DJ, Wang H, Habgood A, Lamb HK, Thompson P, Hawkins AR, Désilets A, Leduc R, Steinmetzer T, Hammami M, Lee MS, Craik CS, Watson S, Lin H, Milner JM, Rowan AD.

Arthritis Rheumatol. 2017 Aug;69(8):1601-1611. doi: 10.1002/art.40133. Epub 2017 Jul 5. Erratum in: Arthritis Rheumatol. 2018 Oct;70(10):1596.


Inducing apoptosis of cancer cells using small-molecule plant compounds that bind to GRP78.

Martin S, Lamb HK, Brady C, Lefkove B, Bonner MY, Thompson P, Lovat PE, Arbiser JL, Hawkins AR, Redfern CP.

Br J Cancer. 2013 Jul 23;109(2):433-43. doi: 10.1038/bjc.2013.325. Epub 2013 Jun 27.


Crystal structure of the dimer of two essential Salmonella typhimurium proteins, YgjD & YeaZ and calorimetric evidence for the formation of a ternary YgjD-YeaZ-YjeE complex.

Nichols CE, Lamb HK, Thompson P, El Omari K, Lockyer M, Charles I, Hawkins AR, Stammers DK.

Protein Sci. 2013 May;22(5):628-40. doi: 10.1002/pro.2247. Epub 2013 Mar 26.


Interaction between relaxase MbeA and accessory protein MbeC of the conjugally mobilizable plasmid ColE1.

Varsaki A, Lamb HK, Eleftheriadou O, Vandera E, Thompson P, Moncalián G, de la Cruz F, Hawkins AR, Drainas C.

FEBS Lett. 2012 Mar 23;586(6):675-9. doi: 10.1016/j.febslet.2012.01.060. Epub 2012 Feb 14.


Crystallographic and microcalorimetric analyses reveal the structural basis for high arginine specificity in the Salmonella enterica serovar Typhimurium periplasmic binding protein STM4351.

Stamp AL, Owen P, El Omari K, Lockyer M, Lamb HK, Charles IG, Hawkins AR, Stammers DK.

Proteins. 2011 Jul;79(7):2352-7. doi: 10.1002/prot.23060. Epub 2011 May 10. No abstract available.


Structural and functional characterization of Salmonella enterica serovar Typhimurium YcbL: an unusual Type II glyoxalase.

Stamp AL, Owen P, El Omari K, Nichols CE, Lockyer M, Lamb HK, Charles IG, Hawkins AR, Stammers DK.

Protein Sci. 2010 Oct;19(10):1897-905. doi: 10.1002/pro.475.


The transcription repressor NmrA is subject to proteolysis by three Aspergillus nidulans proteases.

Zhao X, Hume SL, Johnson C, Thompson P, Huang J, Gray J, Lamb HK, Hawkins AR.

Protein Sci. 2010 Jul;19(7):1405-19. doi: 10.1002/pro.421.


Dinucleotide-sensing proteins: linking signaling networks and regulating transcription.

Lamb HK, Stammers DK, Hawkins AR.

Sci Signal. 2008 Aug 19;1(33):pe38. doi: 10.1126/scisignal.133pe38.


Structural analysis of the recognition of the negative regulator NmrA and DNA by the zinc finger from the GATA-type transcription factor AreA.

Kotaka M, Johnson C, Lamb HK, Hawkins AR, Ren J, Stammers DK.

J Mol Biol. 2008 Aug 29;381(2):373-82. doi: 10.1016/j.jmb.2008.05.077. Epub 2008 Jun 5.


Structure of the ribosomal interacting GTPase YjeQ from the enterobacterial species Salmonella typhimurium.

Nichols CE, Johnson C, Lamb HK, Lockyer M, Charles IG, Hawkins AR, Stammers DK.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Nov 1;63(Pt 11):922-8. Epub 2007 Oct 24.


Functional analysis of the GTPases EngA and YhbZ encoded by Salmonella typhimurium.

Lamb HK, Thompson P, Elliott C, Charles IG, Richards J, Lockyer M, Watkins N, Nichols C, Stammers DK, Bagshaw CR, Cooper A, Hawkins AR.

Protein Sci. 2007 Nov;16(11):2391-402. Epub 2007 Sep 28.


Characterization of Salmonella typhimurium YegS, a putative lipid kinase homologous to eukaryotic sphingosine and diacylglycerol kinases.

Nichols CE, Lamb HK, Lockyer M, Charles IG, Pyne S, Hawkins AR, Stammers DK.

Proteins. 2007 Jul 1;68(1):13-25.


Immunogenicity of a Yersinia pestis vaccine antigen monomerized by circular permutation.

Chalton DA, Musson JA, Flick-Smith H, Walker N, McGregor A, Lamb HK, Williamson ED, Miller J, Robinson JH, Lakey JH.

Infect Immun. 2006 Dec;74(12):6624-31. Epub 2006 Sep 18.


Structural characterization of Salmonella typhimurium YeaZ, an M22 O-sialoglycoprotein endopeptidase homolog.

Nichols CE, Johnson C, Lockyer M, Charles IG, Lamb HK, Hawkins AR, Stammers DK.

Proteins. 2006 Jul 1;64(1):111-23.


The affinity of a major Ca2+ binding site on GRP78 is differentially enhanced by ADP and ATP.

Lamb HK, Mee C, Xu W, Liu L, Blond S, Cooper A, Charles IG, Hawkins AR.

J Biol Chem. 2006 Mar 31;281(13):8796-805. Epub 2006 Jan 17.


GTP cyclohydrolase II structure and mechanism.

Ren J, Kotaka M, Lockyer M, Lamb HK, Hawkins AR, Stammers DK.

J Biol Chem. 2005 Nov 4;280(44):36912-9. Epub 2005 Aug 22.


Modulation of the ligand binding properties of the transcription repressor NmrA by GATA-containing DNA and site-directed mutagenesis.

Lamb HK, Ren J, Park A, Johnson C, Leslie K, Cocklin S, Thompson P, Mee C, Cooper A, Stammers DK, Hawkins AR.

Protein Sci. 2004 Dec;13(12):3127-38. Epub 2004 Nov 10.


Biophysical and kinetic analysis of wild-type and site-directed mutants of the isolated and native dehydroquinate synthase domain of the AROM protein.

Park A, Lamb HK, Nichols C, Moore JD, Brown KA, Cooper A, Charles IG, Stammers DK, Hawkins AR.

Protein Sci. 2004 Aug;13(8):2108-19.


The negative transcriptional regulator NmrA discriminates between oxidized and reduced dinucleotides.

Lamb HK, Leslie K, Dodds AL, Nutley M, Cooper A, Johnson C, Thompson P, Stammers DK, Hawkins AR.

J Biol Chem. 2003 Aug 22;278(34):32107-14. Epub 2003 May 22.


Ligand-induced conformational changes and a mechanism for domain closure in Aspergillus nidulans dehydroquinate synthase.

Nichols CE, Ren J, Lamb HK, Hawkins AR, Stammers DK.

J Mol Biol. 2003 Mar 14;327(1):129-44.


PDZ domains facilitate binding of high temperature requirement protease A (HtrA) and tail-specific protease (Tsp) to heterologous substrates through recognition of the small stable RNA A (ssrA)-encoded peptide.

Spiers A, Lamb HK, Cocklin S, Wheeler KA, Budworth J, Dodds AL, Pallen MJ, Maskell DJ, Charles IG, Hawkins AR.

J Biol Chem. 2002 Oct 18;277(42):39443-9. Epub 2002 Aug 12.


Kinetic analysis of the interaction between the QutA and QutR transcription-regulating proteins.

Watts C, Si-Hoe SM, Lamb HK, Levett LJ, Coggins JR, Hawkins AR.

Proteins. 2002 Aug 1;48(2):161-8.


The structure of the negative transcriptional regulator NmrA reveals a structural superfamily which includes the short-chain dehydrogenase/reductases.

Stammers DK, Ren J, Leslie K, Nichols CE, Lamb HK, Cocklin S, Dodds A, Hawkins AR.

EMBO J. 2001 Dec 3;20(23):6619-26.


Identification of domains responsible for signal recognition and transduction within the QUTR transcription repressor protein.

Levett LJ, Si-Hoe SM, Liddle S, Wheeler K, Smith D, Lamb HK, Newton GH, Coggins JR, Hawkins AR.

Biochem J. 2000 Aug 15;350 Pt 1:189-97.


Differential expression of ryanodine receptor RyR2 mRNA in the non-pregnant and pregnant human myometrium.

Awad SS, Lamb HK, Morgan JM, Dunlop W, Gillespie JI.

Biochem J. 1997 Mar 15;322 ( Pt 3):777-83.


The QUTA activator and QUTR repressor proteins of Aspergillus nidulans interact to regulate transcription of the quinate utilization pathway genese.

Lamb HK, Newton GH, Levett LJ, Cairns E, Roberts CF, Hawkins AR.

Microbiology. 1996 Jun;142 ( Pt 6):1477-90. Erratum in: Microbiology 1996 Oct;142(Pt 10):2983.


Control of metabolic flux through the quinate pathway in Aspergillus nidulans.

Wheeler KA, Lamb HK, Hawkins AR.

Biochem J. 1996 Apr 1;315 ( Pt 1):195-205.


Comparative analysis of the QUTR transcription repressor protein and the three C-terminal domains of the pentafunctional AROM enzyme.

Lamb HK, Moore JD, Lakey JH, Levett LJ, Wheeler KA, Lago H, Coggins JR, Hawkins AR.

Biochem J. 1996 Feb 1;313 ( Pt 3):941-50.


Domain structure and function within the QUTA protein of Aspergillus nidulans: implications for the control of transcription.

Levesley I, Newton GH, Lamb HK, van Schothorst E, Dalgleish RW, Samson AC, Roberts CF, Hawkins AR.

Microbiology. 1996 Jan;142 ( Pt 1):87-98. Erratum in: Microbiology 1996 Jul;142(Pt 7):1909.


The molecular biology of multidomain proteins. Selected examples.

Hawkins AR, Lamb HK.

Eur J Biochem. 1995 Aug 15;232(1):7-18. Review.


Control of metabolic flux in the shikimate and quinate pathways.

Hawkins AR, Lamb HK, Roberts CF.

Prog Ind Microbiol. 1994;29:195-220. Review. No abstract available.


Genesis of eukaryotic transcriptional activator and repressor proteins by splitting a multidomain anabolic enzyme.

Hawkins AR, Lamb HK, Moore JD, Roberts CF.

Gene. 1993 Dec 22;136(1-2):49-54.


The pre-chorismate (shikimate) and quinate pathways in filamentous fungi: theoretical and practical aspects.

Hawkins AR, Lamb HK, Moore JD, Charles IG, Roberts CF.

J Gen Microbiol. 1993 Dec;139(12):2891-9. Review. No abstract available.


The molecular biology of the pentafunctional AROM protein.

Hawkins AR, Moore JD, Lamb HK.

Biochem Soc Trans. 1993 Feb;21(1):181-6. Review. No abstract available.


Differential flux through the quinate and shikimate pathways. Implications for the channelling hypothesis.

Lamb HK, van den Hombergh JP, Newton GH, Moore JD, Roberts CF, Hawkins AR.

Biochem J. 1992 May 15;284 ( Pt 1):181-7.


Spatial and biological characterisation of the complete quinic acid utilisation gene cluster in Aspergillus nidulans.

Lamb HK, Hawkins AR, Smith M, Harvey IJ, Brown J, Turner G, Roberts CF.

Mol Gen Genet. 1990 Aug;223(1):17-23.


Isolation, characterization and nucleotide sequences of the aroC genes encoding chorismate synthase from Salmonella typhi and Escherichia coli.

Charles IG, Lamb HK, Pickard D, Dougan G, Hawkins AR.

J Gen Microbiol. 1990 Feb;136(2):353-8.


Molecular organisation of the quinic acid utilization (QUT) gene cluster in Aspergillus nidulans.

Hawkins AR, Lamb HK, Smith M, Keyte JW, Roberts CF.

Mol Gen Genet. 1988 Oct;214(2):224-31.


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