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Biological and clinical impact of imbalanced progesterone receptor isoform ratios in breast cancer.

Lamb CA, Fabris VT, Jacobsen B, Molinolo AA, Lanari C.

Endocr Relat Cancer. 2018 Jul 10. pii: ERC-18-0179. doi: 10.1530/ERC-18-0179. [Epub ahead of print]


Increased High Molecular Weight FGF2 in Endocrine-Resistant Breast Cancer.

Sahores A, Figueroa V, May M, Liguori M, Rubstein A, Fuentes C, Jacobsen BM, Elía A, Rojas P, Sequeira GR, Álvarez MM, González P, Gass H, Hewitt S, Molinolo A, Lanari C, Lamb CA.

Horm Cancer. 2018 Jun 28. doi: 10.1007/s12672-018-0339-4. [Epub ahead of print]


AlphaE Integrin Expression Is Increased in the Ileum Relative to the Colon and Unaffected by Inflammation.

Ichikawa R, Lamb CA, Eastham-Anderson J, Scherl A, Raffals L, Faubion WA, Bennett MR, Long AK, Mansfield JC, Kirby JA, Keir ME.

J Crohns Colitis. 2018 Jun 15. doi: 10.1093/ecco-jcc/jjy084. [Epub ahead of print]


Gut-selective integrin-targeted therapies for inflammatory bowel disease.

Lamb CA, O'Byrne S, Keir ME, Butcher EC.

J Crohns Colitis. 2018 May 15. doi: 10.1093/ecco-jcc/jjy060. [Epub ahead of print]


The Impact of NOD2 Variants on Fecal Microbiota in Crohn's Disease and Controls Without Gastrointestinal Disease.

Kennedy NA, Lamb CA, Berry SH, Walker AW, Mansfield J, Parkes M, Simpkins R, Tremelling M, Nutland S; UK IBD Genetics Consortium, Parkhill J, Probert C, Hold GL, Lees CW.

Inflamm Bowel Dis. 2018 Feb 15;24(3):583-592. doi: 10.1093/ibd/izx061.


SNX18 regulates ATG9A trafficking from recycling endosomes by recruiting Dynamin-2.

Søreng K, Munson MJ, Lamb CA, Bjørndal GT, Pankiv S, Carlsson SR, Tooze SA, Simonsen A.

EMBO Rep. 2018 Apr;19(4). pii: e44837. doi: 10.15252/embr.201744837. Epub 2018 Feb 7.


Donor intravascular monocyte trafficking: a potential therapeutic target for primary graft dysfunction following lung transplantation?

Lamb CA, Kirby JA.

Thorax. 2018 Apr;73(4):303-304. doi: 10.1136/thoraxjnl-2017-210274. Epub 2018 Jan 31. No abstract available.


Targeting FGFR with BGJ398 in breast cancer: Effect on tumor growth and metastasis.

Sahores A, May M, Sequeira G, Fuentes C, Jacobsen B, Lanari C, Lamb CA.

Curr Cancer Drug Targets. 2017 Dec 13. doi: 10.2174/1568009618666171214114706. [Epub ahead of print]


T Lymphocytes Expressing AlphaE Beta7 Integrin in Ulcerative Colitis: Associations With Cellular Lineage and Phenotype.

Lamb CA, Kirby JA, Keir ME, Mansfield JC.

J Crohns Colitis. 2017 Dec 4;11(12):1504-1505. doi: 10.1093/ecco-jcc/jjx097. No abstract available.


Mechanisms Affecting the Gut of Preterm Infants in Enteral Feeding Trials.

Embleton ND, Berrington JE, Dorling J, Ewer AK, Juszczak E, Kirby JA, Lamb CA, Lanyon CV, McGuire W, Probert CS, Rushton SP, Shirley MD, Stewart CJ, Cummings SP.

Front Nutr. 2017 May 8;4:14. doi: 10.3389/fnut.2017.00014. eCollection 2017.


αEβ7 Integrin Identifies Subsets of Pro-Inflammatory Colonic CD4+ T Lymphocytes in Ulcerative Colitis.

Lamb CA, Mansfield JC, Tew GW, Gibbons D, Long AK, Irving P, Diehl L, Eastham-Anderson J, Price MB, O'Boyle G, Jones DEJ, O'Byrne S, Hayday A, Keir ME, Egen JG, Kirby JA.

J Crohns Colitis. 2017 May 1;11(5):610-620. doi: 10.1093/ecco-jcc/jjw189.


Quantifying Autophagic Structures in Mammalian Cells Using Confocal Microscopy.

Lamb CA, Joachim J, Tooze SA.

Methods Enzymol. 2017;587:21-42. doi: 10.1016/bs.mie.2016.09.051. Epub 2016 Nov 12.


Exploring the genetic architecture of inflammatory bowel disease by whole-genome sequencing identifies association at ADCY7.

Luo Y, de Lange KM, Jostins L, Moutsianas L, Randall J, Kennedy NA, Lamb CA, McCarthy S, Ahmad T, Edwards C, Serra EG, Hart A, Hawkey C, Mansfield JC, Mowat C, Newman WG, Nichols S, Pollard M, Satsangi J, Simmons A, Tremelling M, Uhlig H, Wilson DC, Lee JC, Prescott NJ, Lees CW, Mathew CG, Parkes M, Barrett JC, Anderson CA.

Nat Genet. 2017 Feb;49(2):186-192. doi: 10.1038/ng.3761. Epub 2017 Jan 9.


Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease.

de Lange KM, Moutsianas L, Lee JC, Lamb CA, Luo Y, Kennedy NA, Jostins L, Rice DL, Gutierrez-Achury J, Ji SG, Heap G, Nimmo ER, Edwards C, Henderson P, Mowat C, Sanderson J, Satsangi J, Simmons A, Wilson DC, Tremelling M, Hart A, Mathew CG, Newman WG, Parkes M, Lees CW, Uhlig H, Hawkey C, Prescott NJ, Ahmad T, Mansfield JC, Anderson CA, Barrett JC.

Nat Genet. 2017 Feb;49(2):256-261. doi: 10.1038/ng.3760. Epub 2017 Jan 9.


Rabs and GAPs in starvation-induced autophagy.

Lamb CA, Longatti A, Tooze SA.

Small GTPases. 2016 Oct;7(4):265-269. Epub 2016 Sep 26. Review.


Implementation of a 'care bundle' improves the management of patients admitted to hospital with decompensated cirrhosis.

Dyson JK, Rajasekhar P, Wetten A, Ashraf HH, Ng S, Paremal S, Baqai MF, Lamb CA, Masson S, Hudson M, Dipper C, Cowlam S, Hussaini H, McPherson S.

Aliment Pharmacol Ther. 2016 Nov;44(10):1030-1038. doi: 10.1111/apt.13806. Epub 2016 Sep 26. Erratum in: Aliment Pharmacol Ther. 2017 Feb;45(4):579.


TBC1D14 sets the TRAPP for ATG9.

Lamb CA, Tooze SA.

Autophagy. 2016 Jul 2;12(7):1212-3. doi: 10.1080/15548627.2016.1177696. Epub 2016 May 12. Review.


TBC1D14 and TRAPP - Regulating autophagy through ATG9.

Lamb CA, Tooze SA.

Cell Cycle. 2016 Jul 17;15(14):1797-8. doi: 10.1080/15384101.2016.1176400. Epub 2016 Apr 22. No abstract available.


Clec16a is Critical for Autolysosome Function and Purkinje Cell Survival.

Redmann V, Lamb CA, Hwang S, Orchard RC, Kim S, Razi M, Milam A, Park S, Yokoyama CC, Kambal A, Kreamalmeyer D, Bosch MK, Xiao M, Green K, Kim J, Pruett-Miller SM, Ornitz DM, Allen PM, Beatty WL, Schmidt RE, DiAntonio A, Tooze SA, Virgin HW.

Sci Rep. 2016 Mar 18;6:23326. doi: 10.1038/srep23326.


16K Fractionation of 3T3-L1 Adipocytes to Produce a Crude GLUT4-Containing Vesicle Fraction.

Sadler JB, Lamb CA, Gould GW, Bryant NJ.

Cold Spring Harb Protoc. 2016 Mar 1;2016(3):pdb.prot083683. doi: 10.1101/pdb.prot083683.


Preparation of a Total Membrane Fraction from 3T3-L1 Adipocytes.

Sadler JB, Lamb CA, Gould GW, Bryant NJ.

Cold Spring Harb Protoc. 2016 Mar 1;2016(3):pdb.prot083675. doi: 10.1101/pdb.prot083675.


Relapse after withdrawal from anti-TNF therapy for inflammatory bowel disease: an observational study, plus systematic review and meta-analysis.

Kennedy NA, Warner B, Johnston EL, Flanders L, Hendy P, Ding NS, Harris R, Fadra AS, Basquill C, Lamb CA, Cameron FL, Murray CD, Parkes M, Gooding I, Ahmad T, Gaya DR, Mann S, Lindsay JO, Gordon J, Satsangi J, Hart A, McCartney S, Irving P; UK Anti-TNF withdrawal study group, Lees CW.

Aliment Pharmacol Ther. 2016 Apr;43(8):910-923. doi: 10.1111/apt.13547. Epub 2016 Feb 19. Review.


Iodixanol Gradient Centrifugation to Separate Components of the Low-Density Membrane Fraction from 3T3-L1 Adipocytes.

Sadler JB, Lamb CA, Gould GW, Bryant NJ.

Cold Spring Harb Protoc. 2016 Feb 1;2016(2):pdb.prot083709. doi: 10.1101/pdb.prot083709.


Complete Membrane Fractionation of 3T3-L1 Adipocytes.

Sadler JB, Lamb CA, Gould GW, Bryant NJ.

Cold Spring Harb Protoc. 2016 Feb 1;2016(2):pdb.prot083691. doi: 10.1101/pdb.prot083691.


TBC1D14 regulates autophagy via the TRAPP complex and ATG9 traffic.

Lamb CA, Nühlen S, Judith D, Frith D, Snijders AP, Behrends C, Tooze SA.

EMBO J. 2016 Feb 1;35(3):281-301. doi: 10.15252/embj.201592695. Epub 2015 Dec 28.


Association Between Response to Etrolizumab and Expression of Integrin αE and Granzyme A in Colon Biopsies of Patients With Ulcerative Colitis.

Tew GW, Hackney JA, Gibbons D, Lamb CA, Luca D, Egen JG, Diehl L, Eastham Anderson J, Vermeire S, Mansfield JC, Feagan BG, Panes J, Baumgart DC, Schreiber S, Dotan I, Sandborn WJ, Kirby JA, Irving PM, De Hertogh G, Van Assche GA, Rutgeerts P, O'Byrne S, Hayday A, Keir ME.

Gastroenterology. 2016 Feb;150(2):477-87.e9. doi: 10.1053/j.gastro.2015.10.041. Epub 2015 Oct 30.


Assessing mammalian autophagy.

Tooze SA, Dooley HC, Jefferies HB, Joachim J, Judith D, Lamb CA, Razi M, Wirth M.

Methods Mol Biol. 2015;1270:155-65. doi: 10.1007/978-1-4939-2309-0_12.


Top Differential Diagnosis Should Be Microscopic Polyangiitis in ANCA-Positive Patient with Diffuse Pulmonary Hemorrhage and Hemosiderosis.

Ward ND, Cosner DE, Lamb CA, Li W, Macknis JK, Rooney MT, Zhang PL.

Case Rep Pathol. 2014;2014:286030. doi: 10.1155/2014/286030. Epub 2014 Nov 30.


Fatigue in primary sclerosing cholangitis is associated with sympathetic over-activity and increased cardiac output.

Dyson JK, Elsharkawy AM, Lamb CA, Al-Rifai A, Newton JL, Jones DE, Hudson M.

Liver Int. 2015 May;35(5):1633-41. doi: 10.1111/liv.12709. Epub 2014 Dec 4.


Thiopurine withdrawal during sustained clinical remission in inflammatory bowel disease: relapse and recapture rates, with predictive factors in 237 patients.

Kennedy NA, Kalla R, Warner B, Gambles CJ, Musy R, Reynolds S, Dattani R, Nayee H, Felwick R, Harris R, Marriott S, Senanayake SM, Lamb CA, Al-Hilou H, Gaya DR, Irving PM, Mansfield J, Parkes M, Ahmad T, Cummings JR, Arnott ID, Satsangi J, Lobo AJ, Smith M, Lindsay JO, Lees CW.

Aliment Pharmacol Ther. 2014 Dec;40(11-12):1313-23. doi: 10.1111/apt.12980. Epub 2014 Oct 6.


Breast cancer metastasis: demonstration that FOXP3 regulates CXCR4 expression and the response to CXCL12.

Douglass S, Meeson AP, Overbeck-Zubrzycka D, Brain JG, Bennett MR, Lamb CA, Lennard TW, Browell D, Ali S, Kirby JA.

J Pathol. 2014 Sep;234(1):74-85. doi: 10.1002/path.4381. Epub 2014 Jul 9.


Etrolizumab as induction therapy for ulcerative colitis: a randomised, controlled, phase 2 trial.

Vermeire S, O'Byrne S, Keir M, Williams M, Lu TT, Mansfield JC, Lamb CA, Feagan BG, Panes J, Salas A, Baumgart DC, Schreiber S, Dotan I, Sandborn WJ, Tew GW, Luca D, Tang MT, Diehl L, Eastham-Anderson J, De Hertogh G, Perrier C, Egen JG, Kirby JA, van Assche G, Rutgeerts P.

Lancet. 2014 Jul 26;384(9940):309-18. doi: 10.1016/S0140-6736(14)60661-9. Epub 2014 May 9.


The autophagosome: origins unknown, biogenesis complex.

Lamb CA, Yoshimori T, Tooze SA.

Nat Rev Mol Cell Biol. 2013 Dec;14(12):759-74. Epub 2013 Nov 8. Review.


Sexually transmitted infections manifesting as proctitis.

Lamb CA, Lamb EI, Mansfield JC, Sankar KN.

Frontline Gastroenterol. 2013 Jan;4(1):32-40.


Developing an endoscopic mucosal resection service in a district general hospital.

Lamb CA, Barbour JA.

Frontline Gastroenterol. 2012 Oct;3(4):272-277. Epub 2012 Aug 11.


Novel, low cost, highly effective, handmade steroid pellets for experimental studies.

Sahores A, Luque GM, Wargon V, May M, Molinolo A, Becu-Villalobos D, Lanari C, Lamb CA.

PLoS One. 2013 May 15;8(5):e64049. doi: 10.1371/journal.pone.0064049. Print 2013.


Endosomal sorting of GLUT4 and Gap1 is conserved between yeast and insulin-sensitive cells.

Shewan AM, McCann RK, Lamb CA, Stirrat L, Kioumourtzoglou D, Adamson IS, Verma S, James DE, Bryant NJ.

J Cell Sci. 2013 Apr 1;126(Pt 7):1576-82. doi: 10.1242/jcs.114371. Epub 2013 Feb 19.


Endocytosis and autophagy: Shared machinery for degradation.

Lamb CA, Dooley HC, Tooze SA.

Bioessays. 2013 Jan;35(1):34-45. doi: 10.1002/bies.201200130. Epub 2012 Nov 13. Review.


TBC1D14 regulates autophagosome formation via Rab11- and ULK1-positive recycling endosomes.

Longatti A, Lamb CA, Razi M, Yoshimura S, Barr FA, Tooze SA.

J Cell Biol. 2012 May 28;197(5):659-75. doi: 10.1083/jcb.201111079. Epub 2012 May 21.


Estrogen receptor alpha mediates progestin-induced mammary tumor growth by interacting with progesterone receptors at the cyclin D1/MYC promoters.

Giulianelli S, Vaqué JP, Soldati R, Wargon V, Vanzulli SI, Martins R, Zeitlin E, Molinolo AA, Helguero LA, Lamb CA, Gutkind JS, Lanari C.

Cancer Res. 2012 May 1;72(9):2416-27. doi: 10.1158/0008-5472.CAN-11-3290. Epub 2012 Mar 6.


Chemokine receptor CXCR3 agonist prevents human T-cell migration in a humanized model of arthritic inflammation.

O'Boyle G, Fox CR, Walden HR, Willet JD, Mavin ER, Hine DW, Palmer JM, Barker CE, Lamb CA, Ali S, Kirby JA.

Proc Natl Acad Sci U S A. 2012 Mar 20;109(12):4598-603. doi: 10.1073/pnas.1118104109. Epub 2012 Mar 5. Erratum in: Proc Natl Acad Sci U S A. 2012 May 15;109(20):7948.


Associated expressions of FGFR-2 and FGFR-3: from mouse mammary gland physiology to human breast cancer.

Cerliani JP, Vanzulli SI, Piñero CP, Bottino MC, Sahores A, Nuñez M, Varchetta R, Martins R, Zeitlin E, Hewitt SM, Molinolo AA, Lanari C, Lamb CA.

Breast Cancer Res Treat. 2012 Jun;133(3):997-1008. doi: 10.1007/s10549-011-1883-6. Epub 2011 Nov 29.


Unusual endocervical adenocarcinomas: an immunohistochemical analysis with molecular detection of human papillomavirus.

Park KJ, Kiyokawa T, Soslow RA, Lamb CA, Oliva E, Zivanovic O, Juretzka MM, Pirog EC.

Am J Surg Pathol. 2011 May;35(5):633-46. doi: 10.1097/PAS.0b013e31821534b9.


Interaction between FGFR-2, STAT5, and progesterone receptors in breast cancer.

Cerliani JP, Guillardoy T, Giulianelli S, Vaque JP, Gutkind JS, Vanzulli SI, Martins R, Zeitlin E, Lamb CA, Lanari C.

Cancer Res. 2011 May 15;71(10):3720-31. doi: 10.1158/0008-5472.CAN-10-3074. Epub 2011 Apr 4. Erratum in: Cancer Res. 2011 Sep 1;71(17):5941.


BIM(EL), an intrinsically disordered protein, is degraded by 20S proteasomes in the absence of poly-ubiquitylation.

Wiggins CM, Tsvetkov P, Johnson M, Joyce CL, Lamb CA, Bryant NJ, Komander D, Shaul Y, Cook SJ.

J Cell Sci. 2011 Mar 15;124(Pt 6):969-77. doi: 10.1242/jcs.058438.


Measurement of faecal calprotectin and lactoferrin in inflammatory bowel disease.

Lamb CA, Mansfield JC.

Frontline Gastroenterol. 2011 Jan;2(1):13-18. Epub 2010 Nov 3.


MPA-induced gene expression and stromal and parenchymal gene expression profiles in luminal murine mammary carcinomas with different hormonal requirements.

Giulianelli S, Herschkowitz JI, Patel V, Lamb CA, Gutkind JS, Molinolo A, Perou CM, Lanari C.

Breast Cancer Res Treat. 2011 Aug;129(1):49-67. doi: 10.1007/s10549-010-1185-4. Epub 2010 Oct 2.


Insulin-regulated trafficking of GLUT4 requires ubiquitination.

Lamb CA, McCann RK, Stöckli J, James DE, Bryant NJ.

Traffic. 2010 Nov;11(11):1445-54. doi: 10.1111/j.1600-0854.2010.01113.x. Epub 2010 Sep 20.


Inoculated mammary carcinoma-associated fibroblasts: contribution to hormone independent tumor growth.

Fabris VT, Sahores A, Vanzulli SI, Colombo L, Molinolo AA, Lanari C, Lamb CA.

BMC Cancer. 2010 Jun 16;10:293. doi: 10.1186/1471-2407-10-293.


The diagnosis of primary eosinophilic oesophagitis in adults: missed or misinterpreted?

Kanakala V, Lamb CA, Haigh C, Stirling RW, Attwood SE.

Eur J Gastroenterol Hepatol. 2010 Jul;22(7):848-55. doi: 10.1097/MEG.0b013e32832c7709.


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