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Structure based design of macrocyclic factor XIa inhibitors: Discovery of cyclic P1 linker moieties with improved oral bioavailability.

Clark CG, Rossi KA, Corte JR, Fang T, Smallheer JM, De Lucca I, Nirschl DS, Orwat MJ, Pinto DJP, Hu Z, Wang Y, Yang W, Jeon Y, Ewing WR, Myers JE Jr, Sheriff S, Lou Z, Bozarth JM, Wu Y, Rendina A, Harper T, Zheng J, Xin B, Xiang Q, Luettgen JM, Seiffert DA, Wexler RR, Lam PYS.

Bioorg Med Chem Lett. 2019 Oct 1;29(19):126604. doi: 10.1016/j.bmcl.2019.08.008. Epub 2019 Aug 16.


OsCAldOMT1 is a bifunctional O-methyltransferase involved in the biosynthesis of tricin-lignins in rice cell walls.

Lam PY, Tobimatsu Y, Matsumoto N, Suzuki S, Lan W, Takeda Y, Yamamura M, Sakamoto M, Ralph J, Lo C, Umezawa T.

Sci Rep. 2019 Aug 12;9(1):11597. doi: 10.1038/s41598-019-47957-0.


Changes on the electrocardiogram in anorexia nervosa: A case control study.

Janzen M, Cheung CC, Steinberg C, Lam PY, Krahn AD.

J Electrocardiol. 2019 Sep - Oct;56:64-69. doi: 10.1016/j.jelectrocard.2019.07.006. Epub 2019 Jul 8.


IL13RA2 is differentially regulated in Papillary Thyroid Carcinoma versus Follicular Thyroid Carcinoma.

Chong ST, Tan KM, Kok CYL, Guan SP, Lai SH, Lim C, Hu J, Sturgis C, Eng C, Lam PYP, Ngeow J.

J Clin Endocrinol Metab. 2019 Jul 10. pii: jc.2019-00040. doi: 10.1210/jc.2019-00040. [Epub ahead of print]


NKT Cell-Driven Enhancement of Antitumor Immunity Induced by Clec9a-Targeted Tailorable Nanoemulsion.

Lam PY, Kobayashi T, Soon M, Zeng B, Dolcetti R, Leggatt G, Thomas R, Mattarollo SR.

Cancer Immunol Res. 2019 Jun;7(6):952-962. doi: 10.1158/2326-6066.CIR-18-0650. Epub 2019 May 3.


Efficient Front-Rear Coupling in Neutrophil Chemotaxis by Dynamic Myosin II Localization.

Tsai TY, Collins SR, Chan CK, Hadjitheodorou A, Lam PY, Lou SS, Yang HW, Jorgensen J, Ellett F, Irimia D, Davidson MW, Fischer RS, Huttenlocher A, Meyer T, Ferrell JE Jr, Theriot JA.

Dev Cell. 2019 Apr 22;49(2):189-205.e6. doi: 10.1016/j.devcel.2019.03.025.


Developing zebrafish disease models for in vivo small molecule screens.

Lam PY, Peterson RT.

Curr Opin Chem Biol. 2019 Jun;50:37-44. doi: 10.1016/j.cbpa.2019.02.005. Epub 2019 Mar 28. Review.


Recruitment of specific flavonoid B-ring hydroxylases for two independent biosynthesis pathways of flavone-derived metabolites in grasses.

Lam PY, Lui ACW, Yamamura M, Wang L, Takeda Y, Suzuki S, Liu H, Zhu FY, Chen MX, Zhang J, Umezawa T, Tobimatsu Y, Lo C.

New Phytol. 2019 Jul;223(1):204-219. doi: 10.1111/nph.15795. Epub 2019 Apr 13.


Echocardiographic Assessment of Ventricular Function During Exercise in Adolescent Female Patients With Anorexia Nervosa.

Escudero CA, Potts JE, Lam PY, De Souza AM, Duff K, Mugford GJ, Sandor GGS.

J Am Soc Echocardiogr. 2019 Mar;32(3):394-403.e3. doi: 10.1016/j.echo.2018.10.014. Epub 2019 Jan 9.


Eating disorders in biological males: clinical presentation and consideration of sex differences in a pediatric sample.

Coelho JS, Lee T, Karnabi P, Burns A, Marshall S, Geller J, Lam PY.

J Eat Disord. 2018 Nov 26;6:40. doi: 10.1186/s40337-018-0226-y. eCollection 2018.


Intra-patient and inter-patient comparisons of DNA damage response biomarkers in Nasopharynx Cancer (NPC): analysis of NCC0901 randomised controlled trial of induction chemotherapy in locally advanced NPC.

Chua KLM, Yeo ELL, Shihabudeen WA, Tan SH, Shwe TT, Ong EHW, Lam PYP, Soo KC, Soong YL, Fong KW, Tan TWK, Wee JTS, Chua MLK.

BMC Cancer. 2018 Nov 12;18(1):1095. doi: 10.1186/s12885-018-5005-2.


Ultrafast Single-Cell Level Enzymatic Tumor Profiling.

Ng EX, Sun G, Wei SC, Miller MA, DasGupta R, Lam PYP, Chen CH.

Anal Chem. 2019 Jan 15;91(2):1277-1285. doi: 10.1021/acs.analchem.8b02576. Epub 2018 Nov 2.


Therapeutic vaccination with 4-1BB co-stimulation eradicates mouse acute myeloid leukemia.

Kerage D, Soon MSF, Doff BL, Kobayashi T, Nissen MD, Lam PY, Leggatt GR, Mattarollo SR.

Oncoimmunology. 2018 Jul 26;7(10):e1486952. doi: 10.1080/2162402X.2018.1486952. eCollection 2018.


Filopodia and focal adhesions: An integrated system driving branching morphogenesis in neuronal pathfinding and angiogenesis.

Fischer RS, Lam PY, Huttenlocher A, Waterman CM.

Dev Biol. 2019 Jul 1;451(1):86-95. doi: 10.1016/j.ydbio.2018.08.015. Epub 2018 Sep 5. Review.


Noncanonical translation via deadenylated 3' UTRs maintains primordial germ cells.

Jin YN, Schlueter PJ, Jurisch-Yaksi N, Lam PY, Jin S, Hwang WY, Yeh JJ, Yoshigi M, Ong SE, Schenone M, Hartigan CR, Carr SA, Peterson RT.

Nat Chem Biol. 2018 Sep;14(9):844-852. doi: 10.1038/s41589-018-0098-0. Epub 2018 Jul 9.


The dimer-dependent catalytic activity of RAF family kinases is revealed through characterizing their oncogenic mutants.

Yuan J, Ng WH, Lam PYP, Wang Y, Xia H, Yap J, Guan SP, Lee ASG, Wang M, Baccarini M, Hu J.

Oncogene. 2018 Oct;37(43):5719-5734. doi: 10.1038/s41388-018-0365-2. Epub 2018 Jun 21.


Doppler Echocardiography Assessment of Aortic Stiffness in Female Adolescents with Anorexia Nervosa.

Escudero CA, Potts JE, Lam PY, De Souza AM, Mugford GJ, Sandor GGS.

J Am Soc Echocardiogr. 2018 Jul;31(7):784-790. doi: 10.1016/j.echo.2018.01.003. Epub 2018 Mar 17.


Glucocorticoids promote apoptosis of proinflammatory monocytes by inhibiting ERK activity.

Achuthan A, Aslam ASM, Nguyen Q, Lam PY, Fleetwood AJ, Frye AT, Louis C, Lee MC, Smith JE, Cook AD, Olshansky M, Turner SJ, Hamilton JA.

Cell Death Dis. 2018 Feb 15;9(3):267. doi: 10.1038/s41419-018-0332-4.


Oral Health Indicators for Risk of Malnutrition in Elders.

Wu LL, Cheung KY, Lam PYP, Gao XL.

J Nutr Health Aging. 2018;22(2):254-261. doi: 10.1007/s12603-017-0887-2.


Matrix metalloproteinase-1 facilitates MSC migration via cleavage of IGF-2/IGFBP2 complex.

Guan SP, Lam ATL, Newman JP, Chua KLM, Kok CYL, Chong ST, Chua MLK, Lam PYP.

FEBS Open Bio. 2017 Nov 23;8(1):15-26. doi: 10.1002/2211-5463.12330. eCollection 2018 Jan.


Erratum to "Changes in Lower Limb Strength and Function Following Lumbar Spinal Mobilization" [J Manipulative Physiol Ther. 2017;40(8):587-596].

Yuen TS, Ng J, Lam PY, Lau MY, Siu WL, Yu KM, Lo CN.

J Manipulative Physiol Ther. 2018 Feb;41(2):174. doi: 10.1016/j.jmpt.2017.12.001. Epub 2018 Jan 6. No abstract available.


B cell lymphoma progression promotes the accumulation of circulating Ly6Clo monocytes with immunosuppressive activity.

McKee SJ, Tuong ZK, Kobayashi T, Doff BL, Soon MS, Nissen M, Lam PY, Keane C, Vari F, Moi D, Mazzieri R, Leggatt G, Gandhi MK, Mattarollo SR.

Oncoimmunology. 2017 Dec 18;7(2):e1393599. doi: 10.1080/2162402X.2017.1393599. eCollection 2018.


Interleukin-13 receptor alpha 2 cooperates with EGFRvIII signaling to promote glioblastoma multiforme.

Newman JP, Wang GY, Arima K, Guan SP, Waters MR, Cavenee WK, Pan E, Aliwarga E, Chong ST, Kok CYL, Endaya BB, Habib AA, Horibe T, Ng WH, Ho IAW, Hui KM, Kordula T, Lam PYP.

Nat Commun. 2017 Dec 4;8(1):1913. doi: 10.1038/s41467-017-01392-9.


Changes in Lower Limb Strength and Function Following Lumbar Spinal Mobilization.

Yuen TS, Lam PY, Lau MY, Siu WL, Yu KM, Lo CN, Ng J.

J Manipulative Physiol Ther. 2017 Oct;40(8):587-596. doi: 10.1016/j.jmpt.2017.07.003. Erratum in: J Manipulative Physiol Ther. 2018 Jan 6;:.


Invariant Natural Killer T Cells in Immune Regulation of Blood Cancers: Harnessing Their Potential in Immunotherapies.

Lam PY, Nissen MD, Mattarollo SR.

Front Immunol. 2017 Oct 23;8:1355. doi: 10.3389/fimmu.2017.01355. eCollection 2017. Review.


Discovery of a Parenteral Small Molecule Coagulation Factor XIa Inhibitor Clinical Candidate (BMS-962212).

Pinto DJP, Orwat MJ, Smith LM 2nd, Quan ML, Lam PYS, Rossi KA, Apedo A, Bozarth JM, Wu Y, Zheng JJ, Xin B, Toussaint N, Stetsko P, Gudmundsson O, Maxwell B, Crain EJ, Wong PC, Lou Z, Harper TW, Chacko SA, Myers JE Jr, Sheriff S, Zhang H, Hou X, Mathur A, Seiffert DA, Wexler RR, Luettgen JM, Ewing WR.

J Med Chem. 2017 Dec 14;60(23):9703-9723. doi: 10.1021/acs.jmedchem.7b01171. Epub 2017 Nov 17.


Bottom-Up Two-Dimensional Electron-Capture Dissociation Mass Spectrometry of Calmodulin.

Floris F, van Agthoven MA, Chiron L, Wootton CA, Lam PYY, Barrow MP, Delsuc MA, O'Connor PB.

J Am Soc Mass Spectrom. 2018 Jan;29(1):207-210. doi: 10.1007/s13361-017-1812-y. Epub 2017 Oct 3.


Live imaging reveals distinct modes of neutrophil and macrophage migration within interstitial tissues.

Barros-Becker F, Lam PY, Fisher R, Huttenlocher A.

J Cell Sci. 2017 Nov 15;130(22):3801-3808. doi: 10.1242/jcs.206128. Epub 2017 Sep 28.


A high-conductance chemo-optogenetic system based on the vertebrate channel Trpa1b.

Lam PY, Mendu SK, Mills RW, Zheng B, Padilla H, Milan DJ, Desai BN, Peterson RT.

Sci Rep. 2017 Sep 19;7(1):11839. doi: 10.1038/s41598-017-11791-z.


Exploiting molecular genomics in precision radiation oncology: a marriage of biological and physical precision.

Tan JSH, Lin X, Chua KLM, Lam PY, Soo KC, Chua MLK.

Chin Clin Oncol. 2017 Sep;6(Suppl 2):S19. doi: 10.21037/cco.2017.06.31. Review.


Human mesenchymal stem cells preferentially migrate toward highly oncogenic human hepatocellular carcinoma cells with activated EpCAM signaling.

Endaya B, Guan SP, Newman JP, Huynh H, Sia KC, Chong ST, Kok CYL, Chung AYF, Liu BB, Hui KM, Lam PYP.

Oncotarget. 2017 May 5;8(33):54629-54639. doi: 10.18632/oncotarget.17633. eCollection 2017 Aug 15.


Macrocyclic inhibitors of Factor XIa: Discovery of alkyl-substituted macrocyclic amide linkers with improved potency.

Corte JR, Yang W, Fang T, Wang Y, Osuna H, Lai A, Ewing WR, Rossi KA, Myers JE Jr, Sheriff S, Lou Z, Zheng JJ, Harper TW, Bozarth JM, Wu Y, Luettgen JM, Seiffert DA, Quan ML, Wexler RR, Lam PYS.

Bioorg Med Chem Lett. 2017 Aug 15;27(16):3833-3839. doi: 10.1016/j.bmcl.2017.06.058. Epub 2017 Jun 23.


Disrupting Flavone Synthase II Alters Lignin and Improves Biomass Digestibility.

Lam PY, Tobimatsu Y, Takeda Y, Suzuki S, Yamamura M, Umezawa T, Lo C.

Plant Physiol. 2017 Jun;174(2):972-985. doi: 10.1104/pp.16.01973. Epub 2017 Apr 6.


Copper(ii)-catalyzed Chan-Lam cross-coupling: chemoselective N-arylation of aminophenols.

Siva Reddy A, Ranjith Reddy K, Nageswar Rao D, Jaladanki CK, Bharatam PV, Lam PY, Das P.

Org Biomol Chem. 2017 Jan 25;15(4):801-806. doi: 10.1039/c6ob02444k.


Translating research into clinical practice across the developmental spectrum: Examining the clinical utility of the short treatment allocation tool for eating disorders.

Geller J, Coelho JS, Srikameswaran S, Lam PY, Iyar M, Norris ML.

Int J Eat Disord. 2017 Mar;50(3):235-238. doi: 10.1002/eat.22654. Epub 2016 Dec 19. No abstract available.


Recent discoveries concerning the tumor - mesenchymal stem cell interactions.

Lazennec G, Lam PY.

Biochim Biophys Acta. 2016 Dec;1866(2):290-299. doi: 10.1016/j.bbcan.2016.10.004. Epub 2016 Oct 14. Review.


Synthesis and evaluation of an 18 F-labeled derivative of F3 for targeting surface-expressed nucleolin in cancer and tumor endothelial cells.

Lam PY, Hillyar CR, Able S, Vallis KA.

J Labelled Comp Radiopharm. 2016 Oct;59(12):492-499. doi: 10.1002/jlcr.3439. Epub 2016 Sep 4.


Granulocyte macrophage colony-stimulating factor induces CCL17 production via IRF4 to mediate inflammation.

Achuthan A, Cook AD, Lee MC, Saleh R, Khiew HW, Chang MW, Louis C, Fleetwood AJ, Lacey DC, Christensen AD, Frye AT, Lam PY, Kusano H, Nomura K, Steiner N, Förster I, Nutt SL, Olshansky M, Turner SJ, Hamilton JA.

J Clin Invest. 2016 Sep 1;126(9):3453-66. doi: 10.1172/JCI87828. Epub 2016 Aug 15.


Pinch, cinch or step: Evaluating the effectiveness and acceptability of mid upper arm circumference measurements in adolescents with eating disorders.

Lam PY, Marshall SK, Devi Harjit G, Coelho JS, Cairns J.

Eat Behav. 2016 Aug;22:72-75. doi: 10.1016/j.eatbeh.2016.03.023. Epub 2016 Apr 10.


Amyloid Hydrogen Bonding Polymorphism Evaluated by (15)N{(17)O}REAPDOR Solid-State NMR and Ultra-High Resolution Fourier Transform Ion Cyclotron Resonance Mass Spectrometry.

Wei J, Antzutkin ON, Filippov AV, Iuga D, Lam PY, Barrow MP, Dupree R, Brown SP, O'Connor PB.

Biochemistry. 2016 Apr 12;55(14):2065-8. doi: 10.1021/acs.biochem.5b01095. Epub 2016 Apr 1.


Characterization of Myocardial Repolarization Reserve in Adolescent Females With Anorexia Nervosa.

Padfield GJ, Escudero CA, DeSouza AM, Steinberg C, Gibbs K, Puyat JH, Lam PY, Sanatani S, Sherwin E, Potts JE, Sandor G, Krahn AD.

Circulation. 2016 Feb 9;133(6):557-65. doi: 10.1161/CIRCULATIONAHA.115.016697. Epub 2016 Jan 14.


Novel phenylalanine derived diamides as Factor XIa inhibitors.

Smith LM 2nd, Orwat MJ, Hu Z, Han W, Wang C, Rossi KA, Gilligan PJ, Pabbisetty KB, Osuna H, Corte JR, Rendina AR, Luettgen JM, Wong PC, Narayanan R, Harper TW, Bozarth JM, Crain EJ, Wei A, Ramamurthy V, Morin PE, Xin B, Zheng J, Seiffert DA, Quan ML, Lam PYS, Wexler RR, Pinto DJP.

Bioorg Med Chem Lett. 2016 Jan 15;26(2):472-478. doi: 10.1016/j.bmcl.2015.11.089. Epub 2015 Nov 26.


Uncoiling collagen: a multidimensional mass spectrometry study.

Simon HJ, van Agthoven MA, Lam PY, Floris F, Chiron L, Delsuc MA, Rolando C, Barrow MP, O'Connor PB.

Analyst. 2016 Jan 7;141(1):157-65. doi: 10.1039/c5an01757b. Epub 2015 Nov 16.


Macrophages mediate flagellin induced inflammasome activation and host defense in zebrafish.

Vincent WJ, Freisinger CM, Lam PY, Huttenlocher A, Sauer JD.

Cell Microbiol. 2016 Apr;18(4):591-604. doi: 10.1111/cmi.12536. Epub 2015 Nov 4.


Redox-Active Mn Porphyrin-based Potent SOD Mimic, MnTnBuOE-2-PyP(5+), Enhances Carbenoxolone-Mediated TRAIL-Induced Apoptosis in Glioblastoma Multiforme.

Yulyana Y, Tovmasyan A, Ho IA, Sia KC, Newman JP, Ng WH, Guo CM, Hui KM, Batinic-Haberle I, Lam PY.

Stem Cell Rev Rep. 2016 Feb;12(1):140-55. doi: 10.1007/s12015-015-9628-2.


An Echocardiographic Study of Left Ventricular Size and Cardiac Function in Adolescent Females with Anorexia Nervosa.

Escudero CA, Potts JE, Lam PY, De Souza AM, Mugford GJ, Sandor GG.

Eur Eat Disord Rev. 2016 Jan;24(1):26-33. doi: 10.1002/erv.2409. Epub 2015 Oct 8.


Isolating dividing neural and brain tumour cells for gene expression profiling.

Endaya B, Cavanagh B, Alowaidi F, Walker T, de Pennington N, Ng JM, Lam PY, Mackay-Sim A, Neuzil J, Meedeniya AC.

J Neurosci Methods. 2016 Jan 15;257:121-33. doi: 10.1016/j.jneumeth.2015.09.020. Epub 2015 Oct 9.


Transcriptional profiling of dividing tumor cells detects intratumor heterogeneity linked to cell proliferation in a brain tumor model.

Endaya BB, Lam PY, Meedeniya AC, Neuzil J.

Mol Oncol. 2016 Jan;10(1):126-37. doi: 10.1016/j.molonc.2015.09.001. Epub 2015 Sep 10.


Correction to "Synthesis of Biologically Active Piperidine Metabolites of Clopidogrel: Determination of Structure and Analyte Development".

Shaw SA, Balasubramanian B, Bonacorsi S, Caceres Cortes J, Cao K, Chen BC, Dai J, Decicco C, Goswami A, Guo Z, Hanson R, Humphreys WG, Lam PY, Li W, Mathur A, Maxwell BD, Michaudel Q, Peng L, Pudzianowski A, Qiu F, Su S, Sun D, Tymiak AA, Vokits BP, Wang B, Wexler R, Wu DR, Zhang Y, Zhao R, Baran PS.

J Org Chem. 2015 Sep 18;80(18):9370. doi: 10.1021/acs.joc.5b02011. Epub 2015 Sep 2. No abstract available.


Synthesis of Biologically Active Piperidine Metabolites of Clopidogrel: Determination of Structure and Analyte Development.

Shaw SA, Balasubramanian B, Bonacorsi S, Cortes JC, Cao K, Chen BC, Dai J, Decicco C, Goswami A, Guo Z, Hanson R, Humphreys WG, Lam PY, Li W, Mathur A, Maxwell BD, Michaudel Q, Peng L, Pudzianowski A, Qiu F, Su S, Sun D, Tymiak AA, Vokits BP, Wang B, Wexler R, Wu DR, Zhang Y, Zhao R, Baran PS.

J Org Chem. 2015 Jul 17;80(14):7019-32. doi: 10.1021/acs.joc.5b00632. Epub 2015 Jul 7. Erratum in: J Org Chem. 2015 Sep 18;80(18):9370.


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