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Items: 43

1.

Molecular basis of action of a small molecule positive allosteric modulator (PAM)-agonist at the type 1 cholecystokinin holoreceptor.

Desai AJ, Mechin I, Nagarajan K, Valant C, Wootten D, Lam PCH, Orry A, Abagyan R, Nair A, Sexton PM, Christopoulos A, Miller LJ.

Mol Pharmacol. 2018 Dec 27. pii: mol.118.114082. doi: 10.1124/mol.118.114082. [Epub ahead of print]

2.

Hybrid receptor structure/ligand-based docking and activity prediction in ICM: development and evaluation in D3R Grand Challenge 3.

Lam PC, Abagyan R, Totrov M.

J Comput Aided Mol Des. 2018 Aug 9. doi: 10.1007/s10822-018-0139-5. [Epub ahead of print]

PMID:
30094533
3.

Ligand-biased ensemble receptor docking (LigBEnD): a hybrid ligand/receptor structure-based approach.

Lam PC, Abagyan R, Totrov M.

J Comput Aided Mol Des. 2018 Jan;32(1):187-198. doi: 10.1007/s10822-017-0058-x. Epub 2017 Sep 8.

4.

Crystal structure of acetylcholinesterase catalytic subunits of the malaria vector Anopheles gambiae.

Han Q, Wong DM, Robinson H, Ding H, Lam PCH, Totrov MM, Carlier PR, Li J.

Insect Sci. 2017 Mar 1. doi: 10.1111/1744-7917.12450. [Epub ahead of print] No abstract available.

5.

Feasibility, acceptability and clinical utility of the Cultural Formulation Interview: mixed-methods results from the DSM-5 international field trial.

Lewis-Fernández R, Aggarwal NK, Lam PC, Galfalvy H, Weiss MG, Kirmayer LJ, Paralikar V, Deshpande SN, Díaz E, Nicasio AV, Boiler M, Alarcón RD, Rohlof H, Groen S, van Dijk RC, Jadhav S, Sarmukaddam S, Ndetei D, Scalco MZ, Bassiri K, Aguilar-Gaxiola S, Ton H, Westermeyer J, Vega-Dienstmaier JM.

Br J Psychiatry. 2017 Apr;210(4):290-297. doi: 10.1192/bjp.bp.116.193862. Epub 2017 Jan 19.

PMID:
28104738
6.

Bivalent Carbamates as Novel Control Agents of the Malaria Mosquito, Anopheles gambiae.

Mutunga JM, Chen QH, Wong DM, Lam PC, Li J, Totrov MM, Gross AD, Carlier PR, Bloomquist JR.

Chimia (Aarau). 2016 Oct;70(10):704-708.

PMID:
27779928
7.

Use of Cysteine Trapping to Map Spatial Approximations between Residues Contributing to the Helix N-capping Motif of Secretin and Distinct Residues within Each of the Extracellular Loops of Its Receptor.

Dong M, Lam PC, Orry A, Sexton PM, Christopoulos A, Abagyan R, Miller LJ.

J Biol Chem. 2016 Mar 4;291(10):5172-84. doi: 10.1074/jbc.M115.706010. Epub 2016 Jan 6.

8.

Molecular Mechanism of Action of Triazolobenzodiazepinone Agonists of the Type 1 Cholecystokinin Receptor. Possible Cooperativity across the Receptor Homodimeric Complex.

Desai AJ, Lam PC, Orry A, Abagyan R, Christopoulos A, Sexton PM, Miller LJ.

J Med Chem. 2015 Dec 24;58(24):9562-77. doi: 10.1021/acs.jmedchem.5b01110. Epub 2015 Dec 10.

9.

3-Oxoisoxazole-2(3H)-carboxamides and isoxazol-3-yl carbamates: Resistance-breaking acetylcholinesterase inhibitors targeting the malaria mosquito, Anopheles gambiae.

Verma A, Wong DM, Islam R, Tong F, Ghavami M, Mutunga JM, Slebodnick C, Li J, Viayna E, Lam PC, Totrov MM, Bloomquist JR, Carlier PR.

Bioorg Med Chem. 2015 Mar 15;23(6):1321-40. doi: 10.1016/j.bmc.2015.01.026. Epub 2015 Jan 22.

10.

Ways of coping of Chinese caregivers for family members with schizophrenia in two metropolitan cities: Guangzhou and Hong Kong, China.

Lam PC, Ng P, Pan J, Young DK.

Int J Soc Psychiatry. 2015 Sep;61(6):591-9. doi: 10.1177/0020764014565797. Epub 2015 Jan 9.

PMID:
25575577
11.

Development of a highly selective allosteric antagonist radioligand for the type 1 cholecystokinin receptor and elucidation of its molecular basis of binding.

Dong M, Vattelana AM, Lam PC, Orry AJ, Abagyan R, Christopoulos A, Sexton PM, Haines DR, Miller LJ.

Mol Pharmacol. 2015 Jan;87(1):130-40. doi: 10.1124/mol.114.095430. Epub 2014 Oct 15.

12.

Inhibitor profile of bis(n)-tacrines and N-methylcarbamates on acetylcholinesterase from Rhipicephalus (Boophilus) microplus and Phlebotomus papatasi.

Swale DR, Tong F, Temeyer KB, Li A, Lam PC, Totrov MM, Carlier PR, Pérez de León AA, Bloomquist JR.

Pestic Biochem Physiol. 2013 Jul 1;106(3). doi: 10.1016/j.pestbp.2013.03.005.

13.

Identification of a new class of FtsZ inhibitors by structure-based design and in vitro screening.

Chan FY, Sun N, Neves MA, Lam PC, Chung WH, Wong LK, Chow HY, Ma DL, Chan PH, Leung YC, Chan TH, Abagyan R, Wong KY.

J Chem Inf Model. 2013 Aug 26;53(8):2131-40. doi: 10.1021/ci400203f. Epub 2013 Jul 25.

PMID:
23848971
14.

Molecular basis for benzodiazepine agonist action at the type 1 cholecystokinin receptor.

Harikumar KG, Cawston EE, Lam PC, Patil A, Orry A, Henke BR, Abagyan R, Christopoulos A, Sexton PM, Miller LJ.

J Biol Chem. 2013 Jul 19;288(29):21082-95. doi: 10.1074/jbc.M113.480715. Epub 2013 Jun 10.

15.

Neurotoxicology of bis(n)-tacrines on Blattella germanica and Drosophila melanogaster acetylcholinesterase.

Mutunga JM, Boina DR, Anderson TD, Bloomquist JR, Carlier PR, Wong DM, Lam PC, Totrov MM.

Arch Insect Biochem Physiol. 2013 Aug;83(4):180-94. doi: 10.1002/arch.21104. Epub 2013 Jun 5.

16.

Select small core structure carbamates exhibit high contact toxicity to "carbamate-resistant" strain malaria mosquitoes, Anopheles gambiae (Akron).

Wong DM, Li J, Chen QH, Han Q, Mutunga JM, Wysinski A, Anderson TD, Ding H, Carpenetti TL, Verma A, Islam R, Paulson SL, Lam PC, Totrov M, Bloomquist JR, Carlier PR.

PLoS One. 2012;7(10):e46712. doi: 10.1371/journal.pone.0046712. Epub 2012 Oct 1.

17.

Aryl methylcarbamates: potency and selectivity towards wild-type and carbamate-insensitive (G119S) Anopheles gambiae acetylcholinesterase, and toxicity to G3 strain An. gambiae.

Wong DM, Li J, Lam PC, Hartsel JA, Mutunga JM, Totrov M, Bloomquist JR, Carlier PR.

Chem Biol Interact. 2013 Mar 25;203(1):314-8. doi: 10.1016/j.cbi.2012.09.001. Epub 2012 Sep 16.

18.

Mapping spatial approximations between the amino terminus of secretin and each of the extracellular loops of its receptor using cysteine trapping.

Dong M, Xu X, Ball AM, Makhoul JA, Lam PC, Pinon DI, Orry A, Sexton PM, Abagyan R, Miller LJ.

FASEB J. 2012 Dec;26(12):5092-105. doi: 10.1096/fj.12-212399. Epub 2012 Sep 10.

19.

Re-engineering aryl methylcarbamates to confer high selectivity for inhibition of Anopheles gambiae versus human acetylcholinesterase.

Hartsel JA, Wong DM, Mutunga JM, Ma M, Anderson TD, Wysinski A, Islam R, Wong EA, Paulson SL, Li J, Lam PC, Totrov MM, Bloomquist JR, Carlier PR.

Bioorg Med Chem Lett. 2012 Jul 15;22(14):4593-8. doi: 10.1016/j.bmcl.2012.05.103. Epub 2012 Jun 6. Erratum in: Bioorg Med Chem Lett. 2013 Oct 15;23(20):5752.

20.

Molecular basis for binding and subtype selectivity of 1,4-benzodiazepine antagonist ligands of the cholecystokinin receptor.

Cawston EE, Lam PC, Harikumar KG, Dong M, Ball AM, Augustine ML, Akgün E, Portoghese PS, Orry A, Abagyan R, Sexton PM, Miller LJ.

J Biol Chem. 2012 May 25;287(22):18618-35. doi: 10.1074/jbc.M111.335646. Epub 2012 Mar 30.

21.

Triazole-linked reduced amide isosteres: an approach for the fragment-based drug discovery of anti-Alzheimer's BACE1 inhibitors.

Monceaux CJ, Hirata-Fukae C, Lam PC, Totrov MM, Matsuoka Y, Carlier PR.

Bioorg Med Chem Lett. 2011 Jul 1;21(13):3992-6. doi: 10.1016/j.bmcl.2011.05.007. Epub 2011 May 8.

PMID:
21621412
22.

Molecular basis of secretin docking to its intact receptor using multiple photolabile probes distributed throughout the pharmacophore.

Dong M, Lam PC, Pinon DI, Hosohata K, Orry A, Sexton PM, Abagyan R, Miller LJ.

J Biol Chem. 2011 Jul 8;286(27):23888-99. doi: 10.1074/jbc.M111.245969. Epub 2011 May 12.

23.

Refinement of glucagon-like peptide 1 docking to its intact receptor using mid-region photolabile probes and molecular modeling.

Miller LJ, Chen Q, Lam PC, Pinon DI, Sexton PM, Abagyan R, Dong M.

J Biol Chem. 2011 May 6;286(18):15895-907. doi: 10.1074/jbc.M110.217901. Epub 2011 Mar 16.

24.

Secretin occupies a single protomer of the homodimeric secretin receptor complex: insights from photoaffinity labeling studies using dual sites of covalent attachment.

Dong M, Lam PC, Pinon DI, Orry A, Sexton PM, Abagyan R, Miller LJ.

J Biol Chem. 2010 Mar 26;285(13):9919-31. doi: 10.1074/jbc.M109.089730. Epub 2010 Jan 25.

25.

GPCR 3D homology models for ligand screening: lessons learned from blind predictions of adenosine A2a receptor complex.

Katritch V, Rueda M, Lam PC, Yeager M, Abagyan R.

Proteins. 2010 Jan;78(1):197-211. doi: 10.1002/prot.22507.

26.

Complete mapping of the stereochemical course of retentive deprotonation/alkylation of 1H-benzo[e][1,4]diazepin-2(3H)-ones.

Hsu DC, Lam PC, Slebodnick C, Carlier PR.

J Am Chem Soc. 2009 Dec 23;131(50):18168-76. doi: 10.1021/ja907507j.

PMID:
19921816
27.
28.

Functional importance of a structurally distinct homodimeric complex of the family B G protein-coupled secretin receptor.

Gao F, Harikumar KG, Dong M, Lam PC, Sexton PM, Christopoulos A, Bordner A, Abagyan R, Miller LJ.

Mol Pharmacol. 2009 Aug;76(2):264-74. doi: 10.1124/mol.109.055756. Epub 2009 May 8.

29.

Towards a species-selective acetylcholinesterase inhibitor to control the mosquito vector of malaria, Anopheles gambiae.

Carlier PR, Anderson TD, Wong DM, Hsu DC, Hartsel J, Ma M, Wong EA, Choudhury R, Lam PC, Totrov MM, Bloomquist JR.

Chem Biol Interact. 2008 Sep 25;175(1-3):368-75. doi: 10.1016/j.cbi.2008.04.037. Epub 2008 May 4.

PMID:
18554580
30.

Spatial approximation between secretin residue five and the third extracellular loop of its receptor provides new insight into the molecular basis of natural agonist binding.

Dong M, Lam PC, Pinon DI, Sexton PM, Abagyan R, Miller LJ.

Mol Pharmacol. 2008 Aug;74(2):413-22. doi: 10.1124/mol.108.047209. Epub 2008 May 8.

31.
32.

Molecular approximations between residues 21 and 23 of secretin and its receptor: development of a model for peptide docking with the amino terminus of the secretin receptor.

Dong M, Lam PC, Gao F, Hosohata K, Pinon DI, Sexton PM, Abagyan R, Miller LJ.

Mol Pharmacol. 2007 Aug;72(2):280-90. Epub 2007 May 2.

34.

Genetic heterogeneity in paroxysmal nonkinesigenic dyskinesia.

Spacey SD, Adams PJ, Lam PC, Materek LA, Stoessl AJ, Snutch TP, Hsiung GY.

Neurology. 2006 May 23;66(10):1588-90.

PMID:
16717228
36.

Enantioselective synthesis of "quaternary" 1,4-benzodiazepin-2-one scaffolds via memory of chirality.

Carlier PR, Zhao H, DeGuzman J, Lam PC.

J Am Chem Soc. 2003 Sep 24;125(38):11482-3.

PMID:
13129335
38.

Catalytic asymmetric synthesis of protected tryptophan regioisomers.

Carlier PR, Lam PC, Wong DM.

J Org Chem. 2002 Aug 23;67(17):6256-9.

PMID:
12182675
39.

A study of antagonist/agonist isokinetic work ratios of shoulder rotators in men who play badminton.

Ng GY, Lam PC.

J Orthop Sports Phys Ther. 2002 Aug;32(8):399-404.

PMID:
12168958
40.
41.

Calcification in oligodendroglioma.

Chen WY, Liu HC, Lam PC.

Zhonghua Yi Xue Za Zhi (Taipei). 1990 Mar;45(3):143-6.

PMID:
2168257
43.

Venous outflow of the hormones secreted by the rat pituitary autotransplanted beneath the kidney capsule.

Lam PC, Morishige WK, Rothchild I.

Proc Soc Exp Biol Med. 1976 Sep;152(4):615-7.

PMID:
987591

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