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Development of a Novel Quinoline Derivative as a P-Glycoprotein Inhibitor to Reverse Multidrug Resistance in Cancer Cells.

Zhou Y, Chung PY, Ma JY, Lam AK, Law S, Chan KW, Chan AS, Li X, Lam KH, Chui CH, Tang JC.

Biology (Basel). 2019 Oct 1;8(4). pii: E75. doi: 10.3390/biology8040075.


Defining Protein Pattern Differences Among Molecular Subtypes of Diffuse Gliomas Using Mass Spectrometry.

Djuric U, Lam KHB, Kao J, Batruch I, Jevtic S, Papaioannou MD, Diamandis P.

Mol Cell Proteomics. 2019 Oct;18(10):2029-2043. doi: 10.1074/mcp.RA119.001521. Epub 2019 Jul 28.


Non-contact High-frequency Ultrasound Microbeam Stimulation: A Novel Finding and Potential Causes of Cell Responses.

Qi L, Zhang Q, Tan Y, Lam KH, Zheng H, Qian M.

IEEE Trans Biomed Eng. 2019 Jul 16. doi: 10.1109/TBME.2019.2929008. [Epub ahead of print]


Structure of the full-length Clostridium difficile toxin B.

Chen P, Lam KH, Liu Z, Mindlin FA, Chen B, Gutierrez CB, Huang L, Zhang Y, Hamza T, Feng H, Matsui T, Bowen ME, Perry K, Jin R.

Nat Struct Mol Biol. 2019 Aug;26(8):712-719. doi: 10.1038/s41594-019-0268-0. Epub 2019 Jul 15.


Rituximab-PECC induction followed by 90 Y-ibritumomab tiuxetan consolidation in relapsed or refractory DLBCL patients who are ineligible for or have failed ASCT: results from a phase II HOVON study.

Lugtenburg PJ, Zijlstra JM, Doorduijn JK, Böhmer LH, Hoogendoorn M, Berenschot HW, Beeker A, van der Burg-de Graauw NC, Schouten HC, Bilgin YM, Kersten MJ, Koene HR, Herbers AHE, de Jong D, Hijmering N, Lam KH, Chiţu D, Brouwer RE, van Imhoff GW; Dutch HOVON group.

Br J Haematol. 2019 Jul 10. doi: 10.1111/bjh.16087. [Epub ahead of print]


Effect of a two-stage intervention package on the cesarean section rate in Guangzhou, China: A before-and-after study.

Xia X, Zhou Z, Shen S, Lu J, Zhang L, Huang P, Yu J, Yang L, Wang P, Lam KH, Jacobsson B, Mol BW, Xia H, Qiu X.

PLoS Med. 2019 Jul 8;16(7):e1002846. doi: 10.1371/journal.pmed.1002846. eCollection 2019 Jul.


Miniature Transducer Using PNN-PZT-based Ceramic for Intravascular Ultrasound.

Zhang Q, Pang X, Zhang Z, Su M, Hong J, Zheng H, Qiu W, Lam KH.

IEEE Trans Ultrason Ferroelectr Freq Control. 2019 Mar 25. doi: 10.1109/TUFFC.2019.2906652. [Epub ahead of print]


The Effect of Microfluidic Geometry on Myoblast Migration.

Atmaramani R, Black BJ, Lam KH, Sheth VM, Pancrazio JJ, Schmidtke DW, Alsmadi NZ.

Micromachines (Basel). 2019 Feb 21;10(2). pii: E143. doi: 10.3390/mi10020143.


A viral-fusion-peptide-like molecular switch drives membrane insertion of botulinum neurotoxin A1.

Lam KH, Guo Z, Krez N, Matsui T, Perry K, Weisemann J, Rummel A, Bowen ME, Jin R.

Nat Commun. 2018 Dec 18;9(1):5367. doi: 10.1038/s41467-018-07789-4.


Targeting DNA Binding for NF-κB as an Anticancer Approach in Hepatocellular Carcinoma.

Chung PY, Lam PL, Zhou YY, Gasparello J, Finotti A, Chilin A, Marzaro G, Gambari R, Bian ZX, Kwok WM, Wong WY, Wang X, Lam AK, Chan AS, Li X, Ma JY, Chui CH, Lam KH, Tang JC.

Cells. 2018 Oct 22;7(10). pii: E177. doi: 10.3390/cells7100177.


An In Vitro Model for Assessing Corneal Keratocyte Spreading and Migration on Aligned Fibrillar Collagen.

Kivanany PB, Grose KC, Yonet-Tanyeri N, Manohar S, Sunkara Y, Lam KH, Schmidtke DW, Varner VD, Petroll WM.

J Funct Biomater. 2018 Sep 21;9(4). pii: E54. doi: 10.3390/jfb9040054.


Expression of Insulin-Like Growth Factor Binding Protein-5 (IGFBP5) Reverses Cisplatin-Resistance in Esophageal Carcinoma.

Chan D, Zhou Y, Chui CH, Lam KH, Law S, Chan AS, Li X, Lam AK, Tang JCO.

Cells. 2018 Sep 20;7(10). pii: E143. doi: 10.3390/cells7100143.


Swelling of the breast after cosmetic augmentation.

van 't Hart W, Jansen AJG, Lam KH, Lugtenburg PJ, Vasilic D.

Neth J Med. 2018 Sep;76(7):345. No abstract available.


Building professionals' intention to use smart and sustainable building technologies - An empirical study.

To WM, Lee PKC, Lam KH.

PLoS One. 2018 Aug 1;13(8):e0201625. doi: 10.1371/journal.pone.0201625. eCollection 2018.


Three SpoA-domain proteins interact in the creation of the flagellar type III secretion system in Helicobacter pylori.

Lam KH, Xue C, Sun K, Zhang H, Lam WWL, Zhu Z, Ng JTY, Sause WE, Lertsethtakarn P, Lau KF, Ottemann KM, Au SWN.

J Biol Chem. 2018 Sep 7;293(36):13961-13973. doi: 10.1074/jbc.RA118.002263. Epub 2018 Jul 10.


Loss of water from protonated polyglycines: interconversion and dissociation of the product imidazolone ions.

Lam KHB, Lau JK, Lai CK, Chu IK, Martens J, Berden G, Oomens J, Hopkinson AC, Siu KWM.

Phys Chem Chem Phys. 2018 Jul 11;20(27):18688-18698. doi: 10.1039/c8cp02543f.


Functional cargo delivery into mouse and human fibroblasts using a versatile microfluidic device.

Lam KH, Fernandez-Perez A, Schmidtke DW, Munshi NV.

Biomed Microdevices. 2018 Jun 25;20(3):52. doi: 10.1007/s10544-018-0292-6.


Structural basis for recognition of frizzled proteins by Clostridium difficile toxin B.

Chen P, Tao L, Wang T, Zhang J, He A, Lam KH, Liu Z, He X, Perry K, Dong M, Jin R.

Science. 2018 May 11;360(6389):664-669. doi: 10.1126/science.aar1999.


Flow cytometry shows added value in diagnosing lymphoma in brain biopsies.

van der Meulen M, Bromberg JEC, Lam KH, Dammers R, Langerak AW, Doorduijn JK, Kros JM, van den Bent MJ, van der Velden VHJ.

Cytometry B Clin Cytom. 2018 Nov;94(6):928-934. doi: 10.1002/cyto.b.21641. Epub 2018 Sep 3.


Excellent rate capability and cycling stability in Li+-conductive Li2SnO3-coated LiNi0.5Mn1.5O4 cathode materials for lithium-ion batteries.

Mou J, Deng Y, Song Z, Zheng Q, Lam KH, Lin D.

Dalton Trans. 2018 May 22;47(20):7020-7028. doi: 10.1039/c8dt00014j.


Structural and biochemical characterization of the protease domain of the mosaic botulinum neurotoxin type HA.

Lam KH, Sikorra S, Weisemann J, Maatsch H, Perry K, Rummel A, Binz T, Jin R.

Pathog Dis. 2018 Jun 1;76(4). doi: 10.1093/femspd/fty044.


Association of Solid Fuel Use With Risk of Cardiovascular and All-Cause Mortality in Rural China.

Yu K, Qiu G, Chan KH, Lam KH, Kurmi OP, Bennett DA, Yu C, Pan A, Lv J, Guo Y, Bian Z, Yang L, Chen Y, Hu FB, Chen Z, Li L, Wu T.

JAMA. 2018 Apr 3;319(13):1351-1361. doi: 10.1001/jama.2018.2151.


Preparation of Nanofibrous Silver/Poly(vinylidene fluoride) Composite Membrane with Enhanced Infrared Extinction and Controllable Wetting Property.

Ren DM, Huang HK, Yu Y, Li ZT, Jiang LW, Chen SM, Lam KH, Lin B, Shi B, He FA, Wu HJ.

J Nanosci Nanotechnol. 2018 May 1;18(5):3274-3282. doi: 10.1166/jnn.2018.14545.


Structures and disulfide cross-linking of de novo designed therapeutic mini-proteins.

Silva DA, Stewart L, Lam KH, Jin R, Baker D.

FEBS J. 2018 May;285(10):1783-1785. doi: 10.1111/febs.14394. Epub 2018 Mar 6. Review.


Characterization of Endothelial Cells Associated with Hematopoietic Niche Formation in Humans Identifies IL-33 As an Anabolic Factor.

Kenswil KJG, Jaramillo AC, Ping Z, Chen S, Hoogenboezem RM, Mylona MA, Adisty MN, Bindels EMJ, Bos PK, Stoop H, Lam KH, van Eerden B, Cupedo T, Raaijmakers MHGP.

Cell Rep. 2018 Jan 16;22(3):666-678. doi: 10.1016/j.celrep.2017.12.070.


EBV-encoded miRNAs target ATM-mediated response in nasopharyngeal carcinoma.

Lung RW, Hau PM, Yu KH, Yip KY, Tong JH, Chak WP, Chan AW, Lam KH, Lo AK, Tin EK, Chau SL, Pang JC, Kwan JS, Busson P, Young LS, Yap LF, Tsao SW, To KF, Lo KW.

J Pathol. 2018 Apr;244(4):394-407. doi: 10.1002/path.5018. Epub 2018 Feb 16.


Crystal structure of the FliF-FliG complex from Helicobacter pylori yields insight into the assembly of the motor MS-C ring in the bacterial flagellum.

Xue C, Lam KH, Zhang H, Sun K, Lee SH, Chen X, Au SWN.

J Biol Chem. 2018 Feb 9;293(6):2066-2078. doi: 10.1074/jbc.M117.797936. Epub 2017 Dec 11.


A Portable Ultrasound System for Non-Invasive Ultrasonic Neuro-Stimulation.

Qiu W, Zhou J, Chen Y, Su M, Li G, Zhao H, Gu X, Meng, Wang C, Xiao Y, Lam KH, Dai J, Zheng H.

IEEE Trans Neural Syst Rehabil Eng. 2017 Dec;25(12):2509-2515. doi: 10.1109/TNSRE.2017.2765001.


Preparation of ZnS@In2S3 Core@shell Composite for Enhanced Photocatalytic Degradation of Gaseous o-Dichlorobenzene under Visible Light.

Liu B, Hu X, Li X, Li Y, Chen C, Lam KH.

Sci Rep. 2017 Nov 27;7(1):16396. doi: 10.1038/s41598-017-16732-4.


The hypothetical protein P47 of Clostridium botulinum E1 strain Beluga has a structural topology similar to bactericidal/permeability-increasing protein.

Lam KH, Qi R, Liu S, Kroh A, Yao G, Perry K, Rummel A, Jin R.

Toxicon. 2018 Jun 1;147:19-26. doi: 10.1016/j.toxicon.2017.10.012. Epub 2017 Oct 16.


Ficus virens proanthocyanidins induced apoptosis in breast cancer cells concomitantly ameliorated 5-fluorouracil induced intestinal mucositis in rats.

Chen XX, Lam KH, Chen QX, Leung GP, Tang SCW, Sze SC, Xiao JB, Feng F, Wang Y, Zhang KY, Zhang ZJ.

Food Chem Toxicol. 2017 Dec;110:49-61. doi: 10.1016/j.fct.2017.10.017. Epub 2017 Oct 10.


Massively parallel de novo protein design for targeted therapeutics.

Chevalier A, Silva DA, Rocklin GJ, Hicks DR, Vergara R, Murapa P, Bernard SM, Zhang L, Lam KH, Yao G, Bahl CD, Miyashita SI, Goreshnik I, Fuller JT, Koday MT, Jenkins CM, Colvin T, Carter L, Bohn A, Bryan CM, Fernández-Velasco DA, Stewart L, Dong M, Huang X, Jin R, Wilson IA, Fuller DH, Baker D.

Nature. 2017 Oct 5;550(7674):74-79. doi: 10.1038/nature23912. Epub 2017 Sep 27.


Interconversion between 4-Imidazolone Ions; Isomers of [b4]+ Derived from Protonated Tetraglycine.

Lam KHB, Lau JK, Lai CK, Hopkinson AC, Siu KWM.

J Phys Chem B. 2017 Oct 19;121(41):9541-9547. doi: 10.1021/acs.jpcb.7b07586. Epub 2017 Oct 6.


A putative spermidine synthase interacts with flagellar switch protein FliM and regulates motility in Helicobacter pylori.

Zhang H, Lam KH, Lam WWL, Wong SYY, Chan VSF, Au SWN.

Mol Microbiol. 2017 Dec;106(5):690-703. doi: 10.1111/mmi.13829. Epub 2017 Sep 21.


A camelid single-domain antibody neutralizes botulinum neurotoxin A by blocking host receptor binding.

Yao G, Lam KH, Weisemann J, Peng L, Krez N, Perry K, Shoemaker CB, Dong M, Rummel A, Jin R.

Sci Rep. 2017 Aug 7;7(1):7438. doi: 10.1038/s41598-017-07457-5.


An adjustable multi-scale single beam acoustic tweezers based on ultrahigh frequency ultrasonic transducer.

Chen X, Lam KH, Chen R, Chen Z, Yu P, Chen Z, Shung KK, Zhou Q.

Biotechnol Bioeng. 2017 Nov;114(11):2637-2647. doi: 10.1002/bit.26365. Epub 2017 Jul 18.


Reinforcement of the colon anastomosis with cyanoacrylate glue: a porcine model.

Boersema GSA, Vennix S, Wu Z, Te Lintel Hekkert M, Duncker DGM, Lam KH, Menon AG, Kleinrensink GJ, Lange JF.

J Surg Res. 2017 Sep;217:84-91. doi: 10.1016/j.jss.2017.05.001. Epub 2017 May 10.


Biosorption Performance of Encapsulated Candida krusei for the removal of Copper(II).

Luk CHJ, Yip J, Yuen CWM, Pang SK, Lam KH, Kan CW.

Sci Rep. 2017 May 19;7(1):2159. doi: 10.1038/s41598-017-02350-7.


The Born in Guangzhou Cohort Study (BIGCS).

Qiu X, Lu JH, He JR, Lam KH, Shen SY, Guo Y, Kuang YS, Yuan MY, Qiu L, Chen NN, Lu MS, Li WD, Xing YF, Zhou FJ, Bartington S, Cheng KK, Xia HM.

Eur J Epidemiol. 2017 Apr;32(4):337-346. doi: 10.1007/s10654-017-0239-x. Epub 2017 Mar 20.


Crystal Structure of the Receptor-Binding Domain of Botulinum Neurotoxin Type HA, Also Known as Type FA or H.

Yao G, Lam KH, Perry K, Weisemann J, Rummel A, Jin R.

Toxins (Basel). 2017 Mar 8;9(3). pii: E93. doi: 10.3390/toxins9030093.


Multifunctional single beam acoustic tweezer for non-invasive cell/organism manipulation and tissue imaging.

Lam KH, Li Y, Li Y, Lim HG, Zhou Q, Shung KK.

Sci Rep. 2016 Nov 22;6:37554. doi: 10.1038/srep37554.


Development of a 20-MHz wide-bandwidth PMN-PT single crystal phased-array ultrasound transducer.

Wong CM, Chen Y, Luo H, Dai J, Lam KH, Chan HL.

Ultrasonics. 2017 Jan;73:181-186. doi: 10.1016/j.ultras.2016.09.012. Epub 2016 Sep 12.


Chronic signs of memory B cell activation in patients with Behçet's disease are partially restored by anti-tumour necrosis factor treatment.

van der Houwen TB, van Hagen PM, Timmermans WM, Bartol SJ, Lam KH, Kappen JH, van Zelm MC, van Laar JA.

Rheumatology (Oxford). 2017 Jan;56(1):134-144. doi: 10.1093/rheumatology/kew366. Epub 2016 Oct 15.


Synthesis of platinum(II) and palladium(II) complexes with 9,9-dihexyl-4,5-diazafluorene and their in vivo antitumour activity against Hep3B xenografted mice.

Wang QW, Lam PL, Wong RS, Cheng GY, Lam KH, Bian ZX, Ho CL, Feng YH, Gambari R, Lo YH, Wong WY, Chui CH.

Eur J Med Chem. 2016 Nov 29;124:537-543. doi: 10.1016/j.ejmech.2016.08.033. Epub 2016 Aug 18.


Sutureless closure of colonic defects with tissue adhesives: an in vivo study in the rat.

Vakalopoulos KA, Wu Z, Kroese LF, Jeekel J, Kleinrensink GJ, Dodou D, Lam KH, Lange JF.

Am J Surg. 2017 Jan;213(1):151-158. doi: 10.1016/j.amjsurg.2016.05.009. Epub 2016 Jun 16.


B-Cell Dysregulation in Crohn's Disease Is Partially Restored with Infliximab Therapy.

Timmermans WM, van Laar JA, van der Houwen TB, Kamphuis LS, Bartol SJ, Lam KH, Ouwendijk RJ, Sparrow MP, Gibson PR, van Hagen PM, van Zelm MC.

PLoS One. 2016 Jul 28;11(7):e0160103. doi: 10.1371/journal.pone.0160103. eCollection 2016.


Anti-cancer Effects of a Novel Quinoline Derivative 83b1 on Human Esophageal Squamous Cell Carcinoma through Down-Regulation of COX-2 mRNA and PGE2.

Pun IH, Chan D, Chan SH, Chung PY, Zhou YY, Law S, Lam AK, Chui CH, Chan AS, Lam KH, Tang JC.

Cancer Res Treat. 2017 Jan;49(1):219-229. doi: 10.4143/crt.2016.190. Epub 2016 Jul 18.


N-linked glycosylation of SV2 is required for binding and uptake of botulinum neurotoxin A.

Yao G, Zhang S, Mahrhold S, Lam KH, Stern D, Bagramyan K, Perry K, Kalkum M, Rummel A, Dong M, Jin R.

Nat Struct Mol Biol. 2016 Jul;23(7):656-62. doi: 10.1038/nsmb.3245. Epub 2016 Jun 13.


Effects of shear on P-selectin deposition in microfluidic channels.

Shimp EA, Alsmadi NZ, Cheng T, Lam KH, Lewis CS, Schmidtke DW.

Biomicrofluidics. 2016 Apr 27;10(2):024128. doi: 10.1063/1.4944823. eCollection 2016 Mar.

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