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Tumors with TSC mutations are sensitive to CDK7 inhibition through NRF2 and glutathione depletion.

Zarei M, Du H, Nassar AH, Yan RE, Giannikou K, Johnson SH, Lam HC, Henske EP, Wang Y, Zhang T, Asara J, Kwiatkowski DJ.

J Exp Med. 2019 Sep 10. pii: jem.20190251. doi: 10.1084/jem.20190251. [Epub ahead of print]


Time-Series Study of Associations between Rates of People Affected by Disasters and the El Niño Southern Oscillation (ENSO) Cycle.

Lam HCY, Haines A, McGregor G, Chan EYY, Hajat S.

Int J Environ Res Public Health. 2019 Aug 28;16(17). pii: E3146. doi: 10.3390/ijerph16173146.


Rapamycin-upregulated miR-29b promotes mTORC1-hyperactive cell growth in TSC2-deficient cells by downregulating tumor suppressor retinoic acid receptor β (RARβ).

Liu HJ, Lam HC, Baglini CV, Nijmeh J, Cottrill AA, Chan SY, Henske EP.

Oncogene. 2019 Aug 16. doi: 10.1038/s41388-019-0957-5. [Epub ahead of print]


Short-term Association Between Meteorological Factors and Childhood Pneumonia Hospitalization in Hong Kong: A Time-series Study.

Lam HCY, Chan EYY, Goggins WB 3rd.

Epidemiology. 2019 Jul;30 Suppl 1:S107-S114. doi: 10.1097/EDE.0000000000000998.


Health impact of climate change in cities of middle-income countries: the case of China.

Chan EYY, Ho JY, Hung HHY, Liu S, Lam HCY.

Br Med Bull. 2019 Jun 19;130(1):5-24. doi: 10.1093/bmb/ldz011.


Is "Perceived Water Insecurity" Associated with Disaster Risk Perception, Preparedness Attitudes, and Coping Ability in Rural China? (A Health-EDRM Pilot Study).

Ho JY, Chan EYY, Lam HCY, Yeung MPS, Wong CKP, Yung TKC.

Int J Environ Res Public Health. 2019 Apr 8;16(7). pii: E1254. doi: 10.3390/ijerph16071254.


Next generation sequencing for clinical diagnostics: Five year experience of an academic laboratory.

Hartman P, Beckman K, Silverstein K, Yohe S, Schomaker M, Henzler C, Onsongo G, Lam HC, Munro S, Daniel J, Billstein B, Deshpande A, Hauge A, Mroz P, Lee W, Holle J, Wiens K, Karnuth K, Kemmer T, Leary M, Michel S, Pohlman L, Thayanithy V, Nelson A, Bower M, Thyagarajan B.

Mol Genet Metab Rep. 2019 Mar 1;19:100464. doi: 10.1016/j.ymgmr.2019.100464. eCollection 2019 Jun.


Evolution of rotavirus C in humans and several domestic animal species.

Trovão NS, Shepherd FK, Herzberg K, Jarvis MC, Lam HC, Rovira A, Culhane MR, Nelson MI, Marthaler DG.

Zoonoses Public Health. 2019 Aug;66(5):546-557. doi: 10.1111/zph.12575. Epub 2019 Mar 7.


Is Urban Household Emergency Preparedness Associated with Short-Term Impact Reduction after a Super Typhoon in Subtropical City?

Chan EYY, Man AYT, Lam HCY, Chan GKW, Hall BJ, Hung KKC.

Int J Environ Res Public Health. 2019 Feb 19;16(4). pii: E596. doi: 10.3390/ijerph16040596.


Scientific evidence on natural disasters and health emergency and disaster risk management in Asian rural-based area.

Chan EYY, Man AYT, Lam HCY.

Br Med Bull. 2019 Mar 1;129(1):91-105. doi: 10.1093/bmb/ldz002. Review.


Health Vulnerability Index for Disaster Risk Reduction: Application in Belt and Road Initiative (BRI) Region.

Chan EYY, Huang Z, Lam HCY, Wong CKP, Zou Q.

Int J Environ Res Public Health. 2019 Jan 29;16(3). pii: E380. doi: 10.3390/ijerph16030380.


Health Emergency Disaster Risk Management of Public Transport Systems: A Population-Based Study after the 2017 Subway Fire in Hong Kong, China.

Chan EYY, Huang Z, Hung KKC, Chan GKW, Lam HCY, Lo ESK, Yeung MPS.

Int J Environ Res Public Health. 2019 Jan 15;16(2). pii: E228. doi: 10.3390/ijerph16020228.


Different sensitivities to ambient temperature between first- and re-admission childhood asthma cases in Hong Kong - A time series study.

Lam HCY, Hajat S, Chan EYY, Goggins WB 3rd.

Environ Res. 2019 Mar;170:487-492. doi: 10.1016/j.envres.2018.12.002. Epub 2018 Dec 4.


Biomimetic and Biocatalytic Synthesis of Bruceol.

Day AJ, Lee JHZ, Phan QD, Lam HC, Ametovski A, Sumby CJ, Bell SG, George JH.

Angew Chem Int Ed Engl. 2019 Jan 28;58(5):1427-1431. doi: 10.1002/anie.201812432. Epub 2018 Dec 28.


Vps34-mediated macropinocytosis in Tuberous Sclerosis Complex 2-deficient cells supports tumorigenesis.

Filippakis H, Belaid A, Siroky B, Wu C, Alesi N, Hougard T, Nijmeh J, Lam HC, Henske EP.

Sci Rep. 2018 Sep 21;8(1):14161. doi: 10.1038/s41598-018-32256-x.


Renal disease in tuberous sclerosis complex: pathogenesis and therapy.

Lam HC, Siroky BJ, Henske EP.

Nat Rev Nephrol. 2018 Nov;14(11):704-716. doi: 10.1038/s41581-018-0059-6. Review.


Short-term association between ambient temperature and acute myocardial infarction hospitalizations for diabetes mellitus patients: A time series study.

Lam HCY, Chan JCN, Luk AOY, Chan EYY, Goggins WB.

PLoS Med. 2018 Jul 17;15(7):e1002612. doi: 10.1371/journal.pmed.1002612. eCollection 2018 Jul.


Comparison of short-term associations with meteorological variables between COPD and pneumonia hospitalization among the elderly in Hong Kong-a time-series study.

Lam HC, Chan EY, Goggins WB 3rd.

Int J Biometeorol. 2018 Aug;62(8):1447-1460. doi: 10.1007/s00484-018-1542-2. Epub 2018 May 5.


Duration of Bisphosphonate Therapy.

Lam HC, Thomas CM, Shaver JM.

Am Fam Physician. 2018 Apr 1;97(7):Online. No abstract available.


TSC2-deficient tumors have evidence of T cell exhaustion and respond to anti-PD-1/anti-CTLA-4 immunotherapy.

Liu HJ, Lizotte PH, Du H, Speranza MC, Lam HC, Vaughan S, Alesi N, Wong KK, Freeman GJ, Sharpe AH, Henske EP.

JCI Insight. 2018 Apr 19;3(8). pii: 98674. doi: 10.1172/jci.insight.98674. eCollection 2018 Apr 19.


Association between Ambient Temperatures and Mental Disorder Hospitalizations in a Subtropical City: A Time-Series Study of Hong Kong Special Administrative Region.

Chan EYY, Lam HCY, So SHW, Goggins WB, Ho JY, Liu S, Chung PPW.

Int J Environ Res Public Health. 2018 Apr 14;15(4). pii: E754. doi: 10.3390/ijerph15040754.


TSC2 regulates microRNA biogenesis via mTORC1 and GSK3β.

Ogórek B, Lam HC, Khabibullin D, Liu HJ, Nijmeh J, Triboulet R, Kwiatkowski DJ, Gregory RI, Henske EP.

Hum Mol Genet. 2018 May 1;27(9):1654-1663. doi: 10.1093/hmg/ddy073.


Management of gout and hyperuricemia: Multidisciplinary consensus in Taiwan.

Yu KH, Chen DY, Chen JH, Chen SY, Chen SM, Cheng TT, Hsieh SC, Hsieh TY, Hsu PF, Kuo CF, Kuo MC, Lam HC, Lee IT, Liang TH, Lin HY, Lin SC, Tsai WP, Tsay GJ, Wei JC, Yang CH, Tsai WC.

Int J Rheum Dis. 2018 Apr;21(4):772-787. doi: 10.1111/1756-185X.13266. Epub 2018 Jan 24. Review.


Ten-eleven translocation 1 dysfunction reduces 5-hydroxymethylcytosine expression levels in gastric cancer cells.

Wang KC, Kang CH, Tsai CY, Chou NH, Tu YT, Li GC, Lam HC, Liu SI, Chang PM, Lin YH, Tsai KW.

Oncol Lett. 2018 Jan;15(1):278-284. doi: 10.3892/ol.2017.7264. Epub 2017 Oct 25.


mTORC1 Couples Nucleotide Synthesis to Nucleotide Demand Resulting in a Targetable Metabolic Vulnerability.

Valvezan AJ, Turner M, Belaid A, Lam HC, Miller SK, McNamara MC, Baglini C, Housden BE, Perrimon N, Kwiatkowski DJ, Asara JM, Henske EP, Manning BD.

Cancer Cell. 2017 Nov 13;32(5):624-638.e5. doi: 10.1016/j.ccell.2017.09.013. Epub 2017 Oct 19.


Rapamycin-induced miR-21 promotes mitochondrial homeostasis and adaptation in mTORC1 activated cells.

Lam HC, Liu HJ, Baglini CV, Filippakis H, Alesi N, Nijmeh J, Du H, Lope AL, Cottrill KA, Handen A, Asara JM, Kwiatkowski DJ, Ben-Sahra I, Oldham WM, Chan SY, Henske EP.

Oncotarget. 2017 Aug 4;8(39):64714-64727. doi: 10.18632/oncotarget.19947. eCollection 2017 Sep 12.


Evolution and Vaccination of Influenza Virus.

Lam HC, Bi X, Sreevatsan S, Boley D.

J Comput Biol. 2017 Aug;24(8):787-798. doi: 10.1089/cmb.2017.0025. Epub 2017 Jul 7.


Biosynthetically-inspired oxidations of capillobenzopyranol.

Pepper HP, Lam HC, George JH.

Org Biomol Chem. 2017 Jun 7;15(22):4811-4815. doi: 10.1039/c7ob00868f.


p62/SQSTM1 Cooperates with Hyperactive mTORC1 to Regulate Glutathione Production, Maintain Mitochondrial Integrity, and Promote Tumorigenesis.

Lam HC, Baglini CV, Lope AL, Parkhitko AA, Liu HJ, Alesi N, Malinowska IA, Ebrahimi-Fakhari D, Saffari A, Yu JJ, Pereira A, Khabibullin D, Ogorek B, Nijmeh J, Kavanagh T, Handen A, Chan SY, Asara JM, Oldham WM, Diaz-Meco MT, Moscat J, Sahin M, Priolo C, Henske EP.

Cancer Res. 2017 Jun 15;77(12):3255-3267. doi: 10.1158/0008-5472.CAN-16-2458. Epub 2017 May 16.


Biomimetic Total Synthesis of Rhodonoids C and D, and Murrayakonine D.

Day AJ, Lam HC, Sumby CJ, George JH.

Org Lett. 2017 May 19;19(10):2463-2465. doi: 10.1021/acs.orglett.7b00779. Epub 2017 May 3.


Biomimetic Total Synthesis of (±)-Verrubenzospirolactone.

Lam HC, Pepper HP, Sumby CJ, George JH.

Angew Chem Int Ed Engl. 2017 Jul 10;56(29):8532-8535. doi: 10.1002/anie.201700114. Epub 2017 Feb 22.


MicroRNA-324 in Human Cancer: miR-324-5p and miR-324-3p Have Distinct Biological Functions in Human Cancer.

Kuo WT, Yu SY, Li SC, Lam HC, Chang HT, Chen WS, Yeh CY, Hung SF, Liu TC, Wu T, Yu CC, Tsai KW.

Anticancer Res. 2016 Oct;36(10):5189-5196.


Inactivation of Tsc2 in Mesoderm-Derived Cells Causes Polycystic Kidney Lesions and Impairs Lung Alveolarization.

Ren S, Luo Y, Chen H, Warburton D, Lam HC, Wang LL, Chen P, Henske EP, Shi W.

Am J Pathol. 2016 Dec;186(12):3261-3272. doi: 10.1016/j.ajpath.2016.08.013. Epub 2016 Oct 18.


New developments in the genetics and pathogenesis of tumours in tuberous sclerosis complex.

Lam HC, Nijmeh J, Henske EP.

J Pathol. 2017 Jan;241(2):219-225. doi: 10.1002/path.4827. Epub 2016 Nov 29. Review.


Isocitrate Dehydrogenase 2 Dysfunction Contributes to 5-hydroxymethylcytosine Depletion in Gastric Cancer Cells.

Chou NH, Tsai CY, Tu YT, Wang KC, Kang CH, Chang PM, Li GC, Lam HC, Liu SI, Tsai KW.

Anticancer Res. 2016 Aug;36(8):3983-90.


Biomimetic Total Synthesis of Hyperjapones A-E and Hyperjaponols A and C.

Lam HC, Spence JT, George JH.

Angew Chem Int Ed Engl. 2016 Aug 22;55(35):10368-71. doi: 10.1002/anie.201606091. Epub 2016 Jul 27.


Risk of skin cancer in patients with diabetes mellitus: A nationwide retrospective cohort study in Taiwan.

Tseng HW, Shiue YL, Tsai KW, Huang WC, Tang PL, Lam HC.

Medicine (Baltimore). 2016 Jun;95(26):e4070. doi: 10.1097/MD.0000000000004070.


The short-term association between asthma hospitalisations, ambient temperature, other meteorological factors and air pollutants in Hong Kong: a time-series study.

Lam HC, Li AM, Chan EY, Goggins WB 3rd.

Thorax. 2016 Dec;71(12):1097-1109. doi: 10.1136/thoraxjnl-2015-208054. Epub 2016 Jun 24.


Arm Selection Preference of MicroRNA-193a Varies in Breast Cancer.

Tsai KW, Leung CM, Lo YH, Chen TW, Chan WC, Yu SY, Tu YT, Lam HC, Li SC, Ger LP, Liu WS, Chang HT.

Sci Rep. 2016 Jun 16;6:28176. doi: 10.1038/srep28176.


Complete Genome Sequence of Porcine Epidemic Diarrhea Virus Strain COL/Cundinamarca/2014 from Colombia.

Jarvis MC, Lam HC, Rovira A, Marthaler DG.

Genome Announc. 2016 Apr 21;4(2). pii: e00239-16. doi: 10.1128/genomeA.00239-16.


Mushroom poisoning in Hong Kong: a ten-year review.

Chan CK, Lam HC, Chiu SW, Tse ML, Lau FL.

Hong Kong Med J. 2016 Apr;22(2):124-30. doi: 10.12809/hkmj154706. Epub 2016 Mar 11.


Characterization and evolution of porcine deltacoronavirus in the United States.

Homwong N, Jarvis MC, Lam HC, Diaz A, Rovira A, Nelson M, Marthaler D.

Prev Vet Med. 2016 Jan 1;123:168-174. doi: 10.1016/j.prevetmed.2015.11.001. Epub 2015 Nov 10.


Genomic and evolutionary inferences between American and global strains of porcine epidemic diarrhea virus.

Jarvis MC, Lam HC, Zhang Y, Wang L, Hesse RA, Hause BM, Vlasova A, Wang Q, Zhang J, Nelson MI, Murtaugh MP, Marthaler D.

Prev Vet Med. 2016 Jan 1;123:175-184. doi: 10.1016/j.prevetmed.2015.10.020. Epub 2015 Nov 10.


Comparative In Vitro and In Vivo Studies of Porcine Rotavirus G9P[13] and Human Rotavirus Wa G1P[8].

Shao L, Fischer DD, Kandasamy S, Rauf A, Langel SN, Wentworth DE, Stucker KM, Halpin RA, Lam HC, Marthaler D, Saif LJ, Vlasova AN.

J Virol. 2015 Oct 14;90(1):142-51. doi: 10.1128/JVI.02401-15. Print 2016 Jan 1.


The role of human papillomavirus in head and neck squamous cell carcinoma: A case control study on a southern Chinese population.

Chor JS, Vlantis AC, Chow TL, Fung SC, Ng FY, Lau CH, Chan AB, Ho LC, Kwong WH, Fung MN, Lam EW, Mak KL, Lam HC, Kok AS, Ho WC, Yeung AC, Chan PK.

J Med Virol. 2016 May;88(5):877-87. doi: 10.1002/jmv.24405. Epub 2015 Nov 3.


Online coupling of hydrophilic interaction/strong cation exchange/reversed-phase liquid chromatography with porous graphitic carbon liquid chromatography for simultaneous proteomics and N-glycomics analysis.

Zhao Y, Law HC, Zhang Z, Lam HC, Quan Q, Li G, Chu IK.

J Chromatogr A. 2015 Oct 9;1415:57-66. doi: 10.1016/j.chroma.2015.08.017. Epub 2015 Aug 19.


Identification and Complete Genome of Seneca Valley Virus in Vesicular Fluid and Sera of Pigs Affected with Idiopathic Vesicular Disease, Brazil.

Vannucci FA, Linhares DC, Barcellos DE, Lam HC, Collins J, Marthaler D.

Transbound Emerg Dis. 2015 Dec;62(6):589-93. doi: 10.1111/tbed.12410. Epub 2015 Sep 7.


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