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Structural abnormalities in the temporalis musculo-aponeurotic complex in chronic muscular temporomandibular disorders.

Moayedi M, Krishnamoorthy G, He PT, Agur A, Weissman-Fogel I, Tenenbaum HC, Lam EWN, Davis KD, Henderson L, Cioffi I.

Pain. 2020 Mar 9. doi: 10.1097/j.pain.0000000000001864. [Epub ahead of print]


Multifaceted Oncogenic Role of Adipocytes in the Tumour Microenvironment.

Jiramongkol Y, Lam EW.

Adv Exp Med Biol. 2020;1219:125-142. doi: 10.1007/978-3-030-34025-4_7.


A Splice Variant of NCOR2, BQ323636.1, Confers Chemoresistance in Breast Cancer by Altering the Activity of NRF2.

Leung MH, Tsoi H, Gong C, Man EP, Zona S, Yao S, Lam EW, Khoo US.

Cancers (Basel). 2020 Feb 26;12(3). pii: E533. doi: 10.3390/cancers12030533.


Phosphorylation independent eIF4E translational reprogramming of selective mRNAs determines tamoxifen resistance in breast cancer.

Gong C, Tsoi H, Mok KC, Cheung J, Man EPS, Fujino K, Wong A, Lam EWF, Khoo US.

Oncogene. 2020 Feb 17. doi: 10.1038/s41388-020-1210-y. [Epub ahead of print]


ZRANB2 and SYF2-mediated splicing programs converging on ECT2 are involved in breast cancer cell resistance to doxorubicin.

Tanaka I, Chakraborty A, Saulnier O, Benoit-Pilven C, Vacher S, Labiod D, Lam EWF, Bièche I, Delattre O, Pouzoulet F, Auboeuf D, Vagner S, Dutertre M.

Nucleic Acids Res. 2020 Mar 18;48(5):2676-2693. doi: 10.1093/nar/gkz1213.


Associations between demographic factors and psychological distress among Chinese residents in Hong Kong: beyond socioeconomic classes.

Sun KS, Lam TP, Lam KF, Chan HY, Lo TL, Chao DVK, Yu YTT, Lam EWW.

Psychol Health Med. 2020 Jan 15:1-13. doi: 10.1080/13548506.2020.1714063. [Epub ahead of print]


The human oral cavity microbiota composition during acute tonsillitis: a cross-sectional survey.

Yeoh YK, Chan MH, Chen Z, Lam EWH, Wong PY, Ngai CM, Chan PKS, Hui M.

BMC Oral Health. 2019 Dec 5;19(1):275. doi: 10.1186/s12903-019-0956-5.


Lapatinib sensitivity in nasopharyngeal carcinoma is modulated by SIRT2-mediated FOXO3 deacetylation.

Aimjongjun S, Mahmud Z, Jiramongkol Y, Alasiri G, Yao S, Yagüe E, Janvilisri T, Lam EW.

BMC Cancer. 2019 Nov 14;19(1):1106. doi: 10.1186/s12885-019-6308-7.


Targeting amphiregulin (AREG) derived from senescent stromal cells diminishes cancer resistance and averts programmed cell death 1 ligand (PD-L1)-mediated immunosuppression.

Xu Q, Long Q, Zhu D, Fu D, Zhang B, Han L, Qian M, Guo J, Xu J, Cao L, Chin YE, Coppé JP, Lam EW, Campisi J, Sun Y.

Aging Cell. 2019 Dec;18(6):e13027. doi: 10.1111/acel.13027. Epub 2019 Sep 7.


EP300 and SIRT1/6 Co-Regulate Lapatinib Sensitivity Via Modulating FOXO3-Acetylation and Activity in Breast Cancer.

Mahmud Z, Gomes AR, Lee HJ, Aimjongjun S, Jiramongkol Y, Yao S, Zona S, Alasiri G, Gong G, Yagüe E, Lam EW.

Cancers (Basel). 2019 Jul 28;11(8). pii: E1067. doi: 10.3390/cancers11081067.


Molecular mechanism of Forkhead box M1 inhibition by thiostrepton in breast cancer cells.

Kongsema M, Wongkhieo S, Khongkow M, Lam EW, Boonnoy P, Vongsangnak W, Wong-Ekkabut J.

Oncol Rep. 2019 Sep;42(3):953-962. doi: 10.3892/or.2019.7225. Epub 2019 Jul 8.


Regulation of PERK expression by FOXO3: a vulnerability of drug-resistant cancer cells.

Alasiri G, Jiramongkol Y, Zona S, Fan LY, Mahmud Z, Gong G, Lee HJ, Lam EW.

Oncogene. 2019 Sep;38(36):6382-6398. doi: 10.1038/s41388-019-0890-7. Epub 2019 Jul 16.


Activation of Aurora A kinase increases YAP stability via blockage of autophagy.

Wang P, Gong Y, Guo T, Li M, Fang L, Yin S, Kamran M, Liu Y, Xu J, Xu L, Peng F, Xue X, Yang M, Hung MC, Lam EW, Gu C, Wang C, Zhan Q, Liu Q.

Cell Death Dis. 2019 Jun 3;10(6):432. doi: 10.1038/s41419-019-1664-4.


The Critical Role of Dysregulated RhoB Signaling Pathway in Radioresistance of Colorectal Cancer.

Liu N, Cui W, Jiang X, Zhang Z, Gnosa S, Ali Z, Jensen L, Jönsson JI, Blockhuys S, Lam EW, Zhao Z, Ping J, Xie N, Kopsida M, Wang X, Sun XF.

Int J Radiat Oncol Biol Phys. 2019 Aug 1;104(5):1153-1164. doi: 10.1016/j.ijrobp.2019.04.021. Epub 2019 Apr 27.


Promyelocytic leukemia protein (PML) controls breast cancer cell proliferation by modulating Forkhead transcription factors.

Sachini N, Arampatzi P, Klonizakis A, Nikolaou C, Makatounakis T, Lam EW, Kretsovali A, Papamatheakis J.

Mol Oncol. 2019 Jun;13(6):1369-1387. doi: 10.1002/1878-0261.12486. Epub 2019 May 16.


Extracellular vesicles in the tumor microenvironment: old stories, but new tales.

Han L, Lam EW, Sun Y.

Mol Cancer. 2019 Mar 30;18(1):59. doi: 10.1186/s12943-019-0980-8. Review.


FOXK2 Transcription Factor and Its Emerging Roles in Cancer.

Nestal de Moraes G, Carneiro LDT, Maia RC, Lam EW, Sharrocks AD.

Cancers (Basel). 2019 Mar 20;11(3). pii: E393. doi: 10.3390/cancers11030393. Review.


Correction: FOXO3a represses VEGF expression through FOXM1-dependent and -independent mechanisms in breast cancer.

Karadedou CT, Gomes AR, Chen J, Petkovic M, Ho KK, Zwolinska AK, Feltes A, Wong SY, Chan KYK, Cheung YN, Tsang JWH, Brosens JJ, Khoo US, Lam EW.

Oncogene. 2019 Jun;38(25):5111-5112. doi: 10.1038/s41388-019-0770-1.


Oncogenic EP300 can be targeted with inhibitors of aldo-keto reductases.

Mahmud Z, Asaduzzaman M, Kumar U, Masrour N, Jugov R, Coombes RC, Shousha S, Hu Y, Lam EW, Yagüe E.

Biochem Pharmacol. 2019 May;163:391-403. doi: 10.1016/j.bcp.2019.03.009. Epub 2019 Mar 9.


The prognostic landscape of interactive biological processes presents treatment responses in cancer.

He B, Gao R, Lv D, Wen Y, Song L, Wang X, Lin S, Huang Q, Deng Z, Wang Z, Yan M, Zheng F, Lam EW, Kelley KW, Li Z, Liu Q.

EBioMedicine. 2019 Mar;41:120-133. doi: 10.1016/j.ebiom.2019.01.064. Epub 2019 Feb 22.


FOXM1 modulates 5-FU resistance in colorectal cancer through regulating TYMS expression.

Varghese V, Magnani L, Harada-Shoji N, Mauri F, Szydlo RM, Yao S, Lam EW, Kenny LM.

Sci Rep. 2019 Feb 6;9(1):1505. doi: 10.1038/s41598-018-38017-0.


Stress-induced epinephrine enhances lactate dehydrogenase A and promotes breast cancer stem-like cells.

Cui B, Luo Y, Tian P, Peng F, Lu J, Yang Y, Su Q, Liu B, Yu J, Luo X, Yin L, Cheng W, An F, He B, Liang D, Wu S, Chu P, Song L, Liu X, Luo H, Xu J, Pan Y, Wang Y, Li D, Huang P, Yang Q, Zhang L, Zhou BP, Liu S, Xu G, Lam EW, Kelley KW, Liu Q.

J Clin Invest. 2019 Mar 1;129(3):1030-1046. doi: 10.1172/JCI121685. Epub 2019 Jan 28.


The coordinated action of VCP/p97 and GCN2 regulates cancer cell metabolism and proteostasis during nutrient limitation.

Parzych K, Saavedra-García P, Valbuena GN, Al-Sadah HA, Robinson ME, Penfold L, Kuzeva DM, Ruiz-Tellez A, Loaiza S, Holzmann V, Caputo V, Johnson DC, Kaiser MF, Karadimitris A, Lam EW, Chevet E, Feldhahn N, Keun HC, Auner HW.

Oncogene. 2019 Apr;38(17):3216-3231. doi: 10.1038/s41388-018-0651-z. Epub 2019 Jan 9.


FOXM1 modulates 5-fluorouracil sensitivity in cholangiocarcinoma through thymidylate synthase (TYMS): implications of FOXM1-TYMS axis uncoupling in 5-FU resistance.

Intuyod K, Saavedra-García P, Zona S, Lai CF, Jiramongkol Y, Vaeteewoottacharn K, Pairojkul C, Yao S, Yong JS, Trakansuebkul S, Waraasawapati S, Luvira V, Wongkham S, Pinlaor S, Lam EW.

Cell Death Dis. 2018 Dec 11;9(12):1185. doi: 10.1038/s41419-018-1235-0.


Global transcriptional analysis identifies a novel role for SOX4 in tumor-induced angiogenesis.

Vervoort SJ, de Jong OG, Roukens MG, Frederiks CL, Vermeulen JF, Lourenço AR, Bella L, Vidakovic AT, Sandoval JL, Moelans C, van Amersfoort M, Dallman MJ, Bruna A, Caldas C, Nieuwenhuis E, van der Wall E, Derksen P, van Diest P, Verhaar MC, Lam EW, Mokry M, Coffer PJ.

Elife. 2018 Dec 3;7. pii: e27706. doi: 10.7554/eLife.27706.


Senescent cells: A new Achilles' heel to exploit for cancer medicine?

Zhang B, Lam EW, Sun Y.

Aging Cell. 2019 Feb;18(1):e12875. doi: 10.1111/acel.12875. Epub 2018 Nov 19.


Characterization of FOXO Acetylation.

Yao S, Mahmud Z, Sachini N, Aimjongjun S, Saavedra-García P, Lam EW.

Methods Mol Biol. 2019;1890:77-90. doi: 10.1007/978-1-4939-8900-3_7.


Estrogen receptor β upregulated by lncRNA-H19 to promote cancer stem-like properties in papillary thyroid carcinoma.

Li M, Chai HF, Peng F, Meng YT, Zhang LZ, Zhang L, Zou H, Liang QL, Li MM, Mao KG, Sun DX, Tong MY, Deng ZQ, Hou ZJ, Zhao Y, Li J, Wang XC, Lv SS, Zhang QQ, Yu X, Lam EW, Liu Q, Cui XN, Xu J.

Cell Death Dis. 2018 Nov 2;9(11):1120. doi: 10.1038/s41419-018-1077-9.


Views of Hong Kong Chinese primary care attenders on psychological distress: causes, management and recovery.

Sun KS, Lam TP, Lam KF, Lo TL, Chao DVK, Lam EWW, Chan HY.

Fam Pract. 2019 Jan 25;36(1):84-90. doi: 10.1093/fampra/cmy102.


Targeting SPINK1 in the damaged tumour microenvironment alleviates therapeutic resistance.

Chen F, Long Q, Fu D, Zhu D, Ji Y, Han L, Zhang B, Xu Q, Liu B, Li Y, Wu S, Yang C, Qian M, Xu J, Liu S, Cao L, Chin YE, Lam EW, Coppé JP, Sun Y.

Nat Commun. 2018 Oct 17;9(1):4315. doi: 10.1038/s41467-018-06860-4.


Chemotherapy-induced apoptosis, autophagy and cell cycle arrest are key drivers of synergy in chemo-immunotherapy of epithelial ovarian cancer.

Wahba J, Natoli M, Whilding LM, Parente-Pereira AC, Jung Y, Zona S, Lam EW, Smith JR, Maher J, Ghaem-Maghami S.

Cancer Immunol Immunother. 2018 Nov;67(11):1753-1765. doi: 10.1007/s00262-018-2199-8. Epub 2018 Aug 24.


Cellular Senescence: The Sought or the Unwanted?

Sun Y, Coppé JP, Lam EW.

Trends Mol Med. 2018 Oct;24(10):871-885. doi: 10.1016/j.molmed.2018.08.002. Epub 2018 Aug 25. Review.


Do patients with and without a regular primary care physician have their psychological distress looked after differently?

Sun KS, Lam TP, Lam KF, Lo TL, Chao DVK, Lam EWW, Wu D.

J Public Health (Oxf). 2019 Jun 1;41(2):399-404. doi: 10.1093/pubmed/fdy112.


O-GlcNAcylation mediates metastasis of cholangiocarcinoma through FOXO3 and MAN1A1.

Phoomak C, Silsirivanit A, Park D, Sawanyawisuth K, Vaeteewoottacharn K, Wongkham C, Lam EW, Pairojkul C, Lebrilla CB, Wongkham S.

Oncogene. 2018 Oct;37(42):5648-5665. doi: 10.1038/s41388-018-0366-1. Epub 2018 Jun 18.


Cyclin D1 depletion interferes with oxidative balance and promotes cancer cell senescence.

Laphanuwat P, Likasitwatanakul P, Sittithumcharee G, Thaphaengphan A, Chomanee N, Suppramote O, Ketaroonrut N, Charngkaew K, Lam EW, Okada S, Panich U, Sampattavanich S, Jirawatnotai S.

J Cell Sci. 2018 Jun 25;131(12). pii: jcs214726. doi: 10.1242/jcs.214726.


Reduced FOXM1 Expression Limits Trophoblast Migration and Angiogenesis and Is Associated With Preeclampsia.

Monteiro LJ, Cubillos S, Sanchez M, Acuña-Gallardo S, Venegas P, Herrera V, Lam EW, Varas-Godoy M, Illanes SE.

Reprod Sci. 2019 May;26(5):580-590. doi: 10.1177/1933719118778798. Epub 2018 May 30.


The senescence-associated secretory phenotype is potentiated by feedforward regulatory mechanisms involving Zscan4 and TAK1.

Zhang B, Fu D, Xu Q, Cong X, Wu C, Zhong X, Ma Y, Lv Z, Chen F, Han L, Qian M, Chin YE, Lam EW, Chiao P, Sun Y.

Nat Commun. 2018 Apr 30;9(1):1723. doi: 10.1038/s41467-018-04010-4.


Enablers to seeking professional help for psychological distress-a study on Chinese primary care attenders.

Sun KS, Lam TP, Lam KF, Lo TL, Chao DVK, Lam EWW.

Psychiatry Res. 2018 Jun;264:9-14. doi: 10.1016/j.psychres.2018.03.056. Epub 2018 Mar 24.


A Novel Method for Characterizing Beam Hardening Artifacts in Cone-beam Computed Tomographic Images.

Fox A, Basrani B, Kishen A, Lam EWN.

J Endod. 2018 May;44(5):869-874. doi: 10.1016/j.joen.2018.02.005. Epub 2018 Mar 20.


SUMOylation modulates FOXK2-mediated paclitaxel sensitivity in breast cancer cells.

Nestal de Moraes G, Ji Z, Fan LY, Yao S, Zona S, Sharrocks AD, Lam EW.

Oncogenesis. 2018 Mar 13;7(3):29. doi: 10.1038/s41389-018-0038-6.


The role of human papillomavirus in laryngeal cancer in Southern China.

Lam EWH, Chan MMH, Wai CKC, Ngai CM, Chen Z, Wong MCS, Yeung ACM, Tong JHM, Chan ABW, To KF, Chan PKS.

J Med Virol. 2018 Jun;90(6):1150-1159. doi: 10.1002/jmv.25058. Epub 2018 Mar 6.


BQ323636.1, a Novel Splice Variant to NCOR2, as a Predictor for Tamoxifen-Resistant Breast Cancer.

Gong C, Man EPS, Tsoi H, Lee TKW, Lee P, Ma ST, Wong LS, Luk MY, Rakha EA, Green AR, Ellis IO, Lam EW, Cheung KL, Khoo US.

Clin Cancer Res. 2018 Aug 1;24(15):3681-3691. doi: 10.1158/1078-0432.CCR-17-2259. Epub 2018 Feb 2.


Correction to: Tumour suppressor EP300, a modulator of paclitaxel resistance and stemness, is downregulated in metaplastic breast cancer.

Asaduzzaman M, Constantinou S, Min H, Gallon J, Lin ML, Singh P, Raguz S, Ali S, Shousha S, Charles Coombes R, Lam EW, Hu Y, Yagüe E.

Breast Cancer Res Treat. 2018 Jan;167(2):605-606. doi: 10.1007/s10549-017-4633-6.


Metabolomics reveals novel blood plasma biomarkers associated to the BRCA1-mutated phenotype of human breast cancer.

Roig B, Rodríguez-Balada M, Samino S, Lam EW, Guaita-Esteruelas S, Gomes AR, Correig X, Borràs J, Yanes O, Gumà J.

Sci Rep. 2017 Dec 19;7(1):17831. doi: 10.1038/s41598-017-17897-8.


Glycolysis gatekeeper PDK1 reprograms breast cancer stem cells under hypoxia.

Peng F, Wang JH, Fan WJ, Meng YT, Li MM, Li TT, Cui B, Wang HF, Zhao Y, An F, Guo T, Liu XF, Zhang L, Lv L, Lv DK, Xu LZ, Xie JJ, Lin WX, Lam EW, Xu J, Liu Q.

Oncogene. 2018 Feb 22;37(8):1119. doi: 10.1038/onc.2017.407. Epub 2017 Dec 18.


In Response.

Lam EWK, Chung F, Wong J.

Anesth Analg. 2018 Jan;126(1):369-370. doi: 10.1213/ANE.0000000000002627. No abstract available.


The FOXO3-FOXM1 axis: A key cancer drug target and a modulator of cancer drug resistance.

Yao S, Fan LY, Lam EW.

Semin Cancer Biol. 2018 Jun;50:77-89. doi: 10.1016/j.semcancer.2017.11.018. Epub 2017 Nov 24. Review.


Glycolysis gatekeeper PDK1 reprograms breast cancer stem cells under hypoxia.

Peng F, Wang JH, Fan WJ, Meng YT, Li MM, Li TT, Cui B, Wang HF, Zhao Y, An F, Guo T, Liu XF, Zhang L, Lv L, Lv DK, Xu LZ, Xie JJ, Lin WX, Lam EW, Xu J, Liu Q.

Oncogene. 2018 Feb 22;37(8):1062-1074. doi: 10.1038/onc.2017.368. Epub 2017 Nov 6. Erratum in: Oncogene. 2017 Dec 18;:.


p62/SQSTM1 interacts with vimentin to enhance breast cancer metastasis.

Li SS, Xu LZ, Zhou W, Yao S, Wang CL, Xia JL, Wang HF, Kamran M, Xue XY, Dong L, Wang J, Ding XD, Bella L, Bugeon L, Xu J, Zheng FM, Dallman MJ, Lam EWF, Liu Q.

Carcinogenesis. 2017 Oct 26;38(11):1092-1103. doi: 10.1093/carcin/bgx099.

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