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Targeting SPINK1 in the damaged tumour microenvironment alleviates therapeutic resistance.

Chen F, Long Q, Fu D, Zhu D, Ji Y, Han L, Zhang B, Xu Q, Liu B, Li Y, Wu S, Yang C, Qian M, Xu J, Liu S, Cao L, Chin YE, Lam EW, Coppé JP, Sun Y.

Nat Commun. 2018 Oct 17;9(1):4315. doi: 10.1038/s41467-018-06860-4.


Phase II Trial of Acai Juice Product in Biochemically Recurrent Prostate Cancer.

Kessler ER, Su LJ, Gao D, Torkko KC, Wacker M, Anduha M, Chronister N, Maroni P, Crawford ED, Flaig TW, Glode LM, Lam ET.

Integr Cancer Ther. 2018 Oct 5:1534735418803755. doi: 10.1177/1534735418803755. [Epub ahead of print]


Patient preference survey: are patients willing to delay surgery if obstructive sleep apnea is suspected?

Ho G, Cozowicz C, Wong J, Singh M, Lam E, Mörwald EE, Hasan N, Memtsoudis SG, Chung F.

BMC Anesthesiol. 2018 Sep 12;18(1):128. doi: 10.1186/s12871-018-0594-5.


Sequence-guided approach to genotyping plant clones and species using polymorphic NB-ARC-related genes.

Chu P, Wilson GM, Michael TP, Vaiciunas J, Honig J, Lam E.

Plant Mol Biol. 2018 Sep 6. doi: 10.1007/s11103-018-0774-1. [Epub ahead of print]


Fast and robust misalignment correction of Fourier ptychographic microscopy for full field of view reconstruction.

Zhou A, Wang W, Chen N, Lam EY, Lee B, Situ G.

Opt Express. 2018 Sep 3;26(18):23661-23674. doi: 10.1364/OE.26.023661.


Domain Swap Between two Type II Metacaspases Defines Key Elements for Their Biochemical Properties.

Fortin J, Lam E.

Plant J. 2018 Sep 3. doi: 10.1111/tpj.14079. [Epub ahead of print]


Chemotherapy-induced apoptosis, autophagy and cell cycle arrest are key drivers of synergy in chemo-immunotherapy of epithelial ovarian cancer.

Wahba J, Natoli M, Whilding LM, Parente-Pereira AC, Jung Y, Zona S, Lam EW, Smith JR, Maher J, Ghaem-Maghami S.

Cancer Immunol Immunother. 2018 Nov;67(11):1753-1765. doi: 10.1007/s00262-018-2199-8. Epub 2018 Aug 24.


Cellular Senescence: The Sought or the Unwanted?

Sun Y, Coppé JP, Lam EW.

Trends Mol Med. 2018 Oct;24(10):871-885. doi: 10.1016/j.molmed.2018.08.002. Epub 2018 Aug 25. Review.


C-H Activation and Proton Transfer Initiate Alkene Metathesis Activity of the Tungsten(IV)-Oxo Complex.

Chan KW, Lam E, D'Anna V, Allouche F, Michel C, Safonova OV, Sautet P, Copéret C.

J Am Chem Soc. 2018 Sep 12;140(36):11395-11401. doi: 10.1021/jacs.8b06603. Epub 2018 Aug 29.


Correlation of Apiose Levels and Growth Rates in Duckweeds.

Pagliuso D, Grandis A, Igarashi ES, Lam E, Buckeridge MS.

Front Chem. 2018 Jul 20;6:291. doi: 10.3389/fchem.2018.00291. eCollection 2018.


Generating a high-confidence reference genome map of the Greater Duckweed by integration of cytogenomic, optical mapping, and Oxford Nanopore technologies.

Hoang PNT, Michael TP, Gilbert S, Chu P, Motley ST, Appenroth KJ, Schubert I, Lam E.

Plant J. 2018 Jul 28. doi: 10.1111/tpj.14049. [Epub ahead of print]


Bacterial Production of Indole Related Compounds Reveals Their Role in Association Between Duckweeds and Endophytes.

Gilbert S, Xu J, Acosta K, Poulev A, Lebeis S, Lam E.

Front Chem. 2018 Jul 12;6:265. doi: 10.3389/fchem.2018.00265. eCollection 2018.


A 30-year monitoring of changes in coral community structure following anthropogenic disturbances in Tolo Harbour and Channel, Hong Kong.

Wong KT, Chui APY, Lam EKY, Ang P Jr.

Mar Pollut Bull. 2018 Aug;133:900-910. doi: 10.1016/j.marpolbul.2018.06.049. Epub 2018 Jun 28.


Structural Variation Detection and Analysis Using Bionano Optical Mapping.

Chan S, Lam E, Saghbini M, Bocklandt S, Hastie A, Cao H, Holmlin E, Borodkin M.

Methods Mol Biol. 2018;1833:193-203. doi: 10.1007/978-1-4939-8666-8_16.


Isolated Zr Surface Sites on Silica Promote Hydrogenation of CO2 to CH3OH in Supported Cu Catalysts.

Lam E, Larmier K, Wolf P, Tada S, Safonova OV, Copéret C.

J Am Chem Soc. 2018 Aug 22;140(33):10530-10535. doi: 10.1021/jacs.8b05595. Epub 2018 Aug 8.


Do patients with and without a regular primary care physician have their psychological distress looked after differently?

Sun KS, Lam TP, Lam KF, Lo TL, Chao DVK, Lam EWW, Wu D.

J Public Health (Oxf). 2018 Jul 4. doi: 10.1093/pubmed/fdy112. [Epub ahead of print]


O-GlcNAcylation mediates metastasis of cholangiocarcinoma through FOXO3 and MAN1A1.

Phoomak C, Silsirivanit A, Park D, Sawanyawisuth K, Vaeteewoottacharn K, Wongkham C, Lam EW, Pairojkul C, Lebrilla CB, Wongkham S.

Oncogene. 2018 Oct;37(42):5648-5665. doi: 10.1038/s41388-018-0366-1. Epub 2018 Jun 18.


High-resolution comparative analysis of great ape genomes.

Kronenberg ZN, Fiddes IT, Gordon D, Murali S, Cantsilieris S, Meyerson OS, Underwood JG, Nelson BJ, Chaisson MJP, Dougherty ML, Munson KM, Hastie AR, Diekhans M, Hormozdiari F, Lorusso N, Hoekzema K, Qiu R, Clark K, Raja A, Welch AE, Sorensen M, Baker C, Fulton RS, Armstrong J, Graves-Lindsay TA, Denli AM, Hoppe ER, Hsieh P, Hill CM, Pang AWC, Lee J, Lam ET, Dutcher SK, Gage FH, Warren WC, Shendure J, Haussler D, Schneider VA, Cao H, Ventura M, Wilson RK, Paten B, Pollen A, Eichler EE.

Science. 2018 Jun 8;360(6393). pii: eaar6343. doi: 10.1126/science.aar6343.


Cyclin D1 depletion interferes with oxidative balance and promotes cancer cell senescence.

Laphanuwat P, Likasitwatanakul P, Sittithumcharee G, Thaphaengphan A, Chomanee N, Suppramote O, Ketaroonrut N, Charngkaew K, Lam EW, Okada S, Panich U, Sampattavanich S, Jirawatnotai S.

J Cell Sci. 2018 Jun 25;131(12). pii: jcs214726. doi: 10.1242/jcs.214726.


A Comparison of Endoscopic Ultrasound-Guided Fine-Needle Aspiration and Fine-Needle Biopsy in the Diagnosis of Solid Pancreatic Lesions.

Ayres LR, Kmiotek EK, Lam E, Telford JJ.

Can J Gastroenterol Hepatol. 2018 Apr 19;2018:1415062. doi: 10.1155/2018/1415062. eCollection 2018.


Reduced FOXM1 Expression Limits Trophoblast Migration and Angiogenesis and Is Associated With Preeclampsia.

Monteiro LJ, Cubillos S, Sanchez M, Acuña-Gallardo S, Venegas P, Herrera V, Lam EW, Varas-Godoy M, Illanes SE.

Reprod Sci. 2018 Jan 1:1933719118778798. doi: 10.1177/1933719118778798. [Epub ahead of print]


Roles of Plant-Associated Microbiota in Traditional Herbal Medicine.

Huang W, Long C, Lam E.

Trends Plant Sci. 2018 Jul;23(7):559-562. doi: 10.1016/j.tplants.2018.05.003. Epub 2018 May 22.


Biofeedback interventions for individuals with cerebral palsy: a systematic review.

MacIntosh A, Lam E, Vigneron V, Vignais N, Biddiss E.

Disabil Rehabil. 2018 May 12:1-23. doi: 10.1080/09638288.2018.1468933. [Epub ahead of print]


New autofocus and reconstruction method based on a connected domain.

Ou H, Wu Y, Lam EY, Wang BZ.

Opt Lett. 2018 May 1;43(9):2201-2203. doi: 10.1364/OL.43.002201.


The senescence-associated secretory phenotype is potentiated by feedforward regulatory mechanisms involving Zscan4 and TAK1.

Zhang B, Fu D, Xu Q, Cong X, Wu C, Zhong X, Ma Y, Lv Z, Chen F, Han L, Qian M, Chin YE, Lam EW, Chiao P, Sun Y.

Nat Commun. 2018 Apr 30;9(1):1723. doi: 10.1038/s41467-018-04010-4.


A digital microfluidic system for serological immunoassays in remote settings.

Ng AHC, Fobel R, Fobel C, Lamanna J, Rackus DG, Summers A, Dixon C, Dryden MDM, Lam C, Ho M, Mufti NS, Lee V, Asri MAM, Sykes EA, Chamberlain MD, Joseph R, Ope M, Scobie HM, Knipes A, Rota PA, Marano N, Chege PM, Njuguna M, Nzunza R, Kisangau N, Kiogora J, Karuingi M, Burton JW, Borus P, Lam E, Wheeler AR.

Sci Transl Med. 2018 Apr 25;10(438). pii: eaar6076. doi: 10.1126/scitranslmed.aar6076.


Enablers to seeking professional help for psychological distress-a study on Chinese primary care attenders.

Sun KS, Lam TP, Lam KF, Lo TL, Chao DVK, Lam EWW.

Psychiatry Res. 2018 Jun;264:9-14. doi: 10.1016/j.psychres.2018.03.056. Epub 2018 Mar 24.


A Novel Method for Characterizing Beam Hardening Artifacts in Cone-beam Computed Tomographic Images.

Fox A, Basrani B, Kishen A, Lam EWN.

J Endod. 2018 May;44(5):869-874. doi: 10.1016/j.joen.2018.02.005. Epub 2018 Mar 20.


Renal cell carcinoma: a review of biology and pathophysiology.

Nabi S, Kessler ER, Bernard B, Flaig TW, Lam ET.

F1000Res. 2018 Mar 12;7:307. doi: 10.12688/f1000research.13179.1. eCollection 2018. Review.


Broad-spectrum antiviral activity of the deubiquitinase inhibitor HBX against human adenoviruses.

Kosulin K, Lam E, Heim A, Dobner T, Rodríguez E.

Antivir Ther. 2018 Mar 20. doi: 10.3851/IMP3230. [Epub ahead of print]


Multiplexed Proteome Dynamics Profiling Reveals Mechanisms Controlling Protein Homeostasis.

Savitski MM, Zinn N, Faelth-Savitski M, Poeckel D, Gade S, Becher I, Muelbaier M, Wagner AJ, Strohmer K, Werner T, Melchert S, Petretich M, Rutkowska A, Vappiani J, Franken H, Steidel M, Sweetman GM, Gilan O, Lam EYN, Dawson MA, Prinjha RK, Grandi P, Bergamini G, Bantscheff M.

Cell. 2018 Mar 22;173(1):260-274.e25. doi: 10.1016/j.cell.2018.02.030. Epub 2018 Mar 15.


SUMOylation modulates FOXK2-mediated paclitaxel sensitivity in breast cancer cells.

Nestal de Moraes G, Ji Z, Fan LY, Yao S, Zona S, Sharrocks AD, Lam EW.

Oncogenesis. 2018 Mar 13;7(3):29. doi: 10.1038/s41389-018-0038-6.


The H2B deubiquitinase Usp22 promotes antibody class switch recombination by facilitating non-homologous end joining.

Li C, Irrazabal T, So CC, Berru M, Du L, Lam E, Ling AK, Gommerman JL, Pan-Hammarström Q, Martin A.

Nat Commun. 2018 Mar 8;9(1):1006. doi: 10.1038/s41467-018-03455-x.


Axial localization using time reversal multiple signal classification in optical scanning holography.

Ou H, Wu Y, Lam EY, Wang BZ.

Opt Express. 2018 Feb 19;26(4):3756-3771. doi: 10.1364/OE.26.003756.


102-nm, 44.5-MHz inertial-free swept source by mode-locked fiber laser and time stretch technique for optical coherence tomography.

Kang J, Feng P, Wei X, Lam EY, Tsia KK, Wong KKY.

Opt Express. 2018 Feb 19;26(4):4370-4381. doi: 10.1364/OE.26.004370.


The role of human papillomavirus in laryngeal cancer in Southern China.

Lam EWH, Chan MMH, Wai CKC, Ngai CM, Chen Z, Wong MCS, Yeung ACM, Tong JHM, Chan ABW, To KF, Chan PKS.

J Med Virol. 2018 Jun;90(6):1150-1159. doi: 10.1002/jmv.25058. Epub 2018 Mar 6.


BQ323636.1, a Novel Splice Variant to NCOR2, as a Predictor for Tamoxifen-Resistant Breast Cancer.

Gong C, Man EPS, Tsoi H, Lee TKW, Lee P, Ma ST, Wong LS, Luk MY, Rakha EA, Green AR, Ellis IO, Lam EW, Cheung KL, Khoo US.

Clin Cancer Res. 2018 Aug 1;24(15):3681-3691. doi: 10.1158/1078-0432.CCR-17-2259. Epub 2018 Feb 2.


Mixing genomes alters nuclear architecture.

Lam E.

Nat Plants. 2018 Feb;4(2):65-66. doi: 10.1038/s41477-018-0103-3. No abstract available.


Hypermethylation of NF-κB-Activating Protein-Like (NKAPL) Promoter in Hepatocellular Carcinoma Suppresses Its Expression and Predicts a Poor Prognosis.

Ng PKS, Lau CPY, Lam EKY, Li SSK, Lui VWY, Yeo W, Ng YK, Lai PBS, Tsui SKW.

Dig Dis Sci. 2018 Mar;63(3):676-686. doi: 10.1007/s10620-018-4929-3. Epub 2018 Jan 20.


High-Resolution Sequencing of Viral Populations during Early Simian Immunodeficiency Virus Infection Reveals Evolutionary Strategies for Rapid Escape from Emerging Env-Specific Antibody Responses.

Ita S, Hill AK, Lam EC, Dufort FJ, Yang X, Newman R, Leviyang S, Fofana IB, Johnson WE.

J Virol. 2018 Mar 14;92(7). pii: e01574-17. doi: 10.1128/JVI.01574-17. Print 2018 Apr 1.


Can the Syndesmosis Procedure Prevent Metatarsus Primus Varus and Hallux Valgus Deformity Recurrence? A 5-Year Prospective Study.

Wu DY, Lam EKF.

J Foot Ankle Surg. 2018 Mar - Apr;57(2):316-324. doi: 10.1053/j.jfas.2017.10.012. Epub 2018 Jan 12.


Basal insulin peglispro increases lipid oxidation, metabolic flexibility, thermogenesis and ketone bodies compared to insulin glargine in subjects with type 1 diabetes mellitus.

Porksen NK, Linnebjerg H, Lam ECQ, Garhyan P, Pachori A, Pratley RE, Smith SR.

Diabetes Obes Metab. 2018 May;20(5):1193-1201. doi: 10.1111/dom.13215. Epub 2018 Feb 4.


Correction to: Tumour suppressor EP300, a modulator of paclitaxel resistance and stemness, is downregulated in metaplastic breast cancer.

Asaduzzaman M, Constantinou S, Min H, Gallon J, Lin ML, Singh P, Raguz S, Ali S, Shousha S, Charles Coombes R, Lam EW, Hu Y, Yagüe E.

Breast Cancer Res Treat. 2018 Jan;167(2):605-606. doi: 10.1007/s10549-017-4633-6.


Utility of Serum IgG4 Levels in a Multiethnic Population.

Qi R, Chen LYC, Park S, Irvine R, Seidman MA, Kelsall JT, Collins D, Yin V, Slack GW, Mattman A, Lam E, Carruthers MN.

Am J Med Sci. 2018 Jan;355(1):61-66. doi: 10.1016/j.amjms.2017.08.014. Epub 2017 Aug 24.


Metabolomics reveals novel blood plasma biomarkers associated to the BRCA1-mutated phenotype of human breast cancer.

Roig B, Rodríguez-Balada M, Samino S, Lam EW, Guaita-Esteruelas S, Gomes AR, Correig X, Borràs J, Yanes O, Gumà J.

Sci Rep. 2017 Dec 19;7(1):17831. doi: 10.1038/s41598-017-17897-8.


Phase I Dose-Escalation Trial of PT2385, a First-in-Class Hypoxia-Inducible Factor-2α Antagonist in Patients With Previously Treated Advanced Clear Cell Renal Cell Carcinoma.

Courtney KD, Infante JR, Lam ET, Figlin RA, Rini BI, Brugarolas J, Zojwalla NJ, Lowe AM, Wang K, Wallace EM, Josey JA, Choueiri TK.

J Clin Oncol. 2018 Mar 20;36(9):867-874. doi: 10.1200/JCO.2017.74.2627. Epub 2017 Dec 19.


Glycolysis gatekeeper PDK1 reprograms breast cancer stem cells under hypoxia.

Peng F, Wang JH, Fan WJ, Meng YT, Li MM, Li TT, Cui B, Wang HF, Zhao Y, An F, Guo T, Liu XF, Zhang L, Lv L, Lv DK, Xu LZ, Xie JJ, Lin WX, Lam EW, Xu J, Liu Q.

Oncogene. 2018 Feb 22;37(8):1119. doi: 10.1038/onc.2017.407. Epub 2017 Dec 18.


OMSV enables accurate and comprehensive identification of large structural variations from nanochannel-based single-molecule optical maps.

Li L, Leung AK, Kwok TP, Lai YYY, Pang IK, Chung GT, Mak ACY, Poon A, Chu C, Li M, Wu JJK, Lam ET, Cao H, Lin C, Sibert J, Yiu SM, Xiao M, Lo KW, Kwok PY, Chan TF, Yip KY.

Genome Biol. 2017 Dec 1;18(1):230. doi: 10.1186/s13059-017-1356-2.


In Response.

Lam EWK, Chung F, Wong J.

Anesth Analg. 2018 Jan;126(1):369-370. doi: 10.1213/ANE.0000000000002627. No abstract available.


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