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A Novel DPYD Variant Associated With Severe Toxicity of Fluoropyrimidines: Role of Pre-emptive DPYD Genotype Screening.

Tong CC, Lam CW, Lam KO, Lee VHF, Luk MY.

Front Oncol. 2018 Jul 24;8:279. doi: 10.3389/fonc.2018.00279. eCollection 2018.


Anti-Allergic Inflammatory Activity of Interleukin-37 Is Mediated by Novel Signaling Cascades in Human Eosinophils.

Zhu J, Dong J, Ji L, Jiang P, Leung TF, Liu D, Ng LG, Tsang MS, Jiao D, Lam CW, Wong CK.

Front Immunol. 2018 Jun 22;9:1445. doi: 10.3389/fimmu.2018.01445. eCollection 2018.


Auditory-based cognitive training programme for attention and memory in older people at risk of progressive cognitive decline: a randomised controlled trial.

Lee TM, Chan FH, Chu LW, Kwok TC, Lam LC, Tam HM, Woo J.

Hong Kong Med J. 2017 Jun;23 Suppl 2(3):12-15. No abstract available.


The first pilot study of expanded newborn screening for inborn errors of metabolism and survey of related knowledge and opinions of health care professionals in Hong Kong.

Mak CM, Law EC, Lee HH, Siu WK, Chow KM, Au Yeung SK, Ngan HY, Tse NK, Kwong NS, Chan GC, Lee KW, Chan WP, Wong SF, Tang MH, Kan AS, Hui AP, So PL, Shek CC, Lee RS, Wong KY, Yau EK, Poon KH, Siu S, Poon GW, Kwok AM, Ng JW, Yim VC, Ma GG, Chu CH, Tong TY, Chong YK, Chen SP, Ching CK, Chan AO, Tam S, Lau RL, Ng WF, Lee KC, Chan AY, Lam CW.

Hong Kong Med J. 2018 Jun;24(3):226-237. doi: 10.12809/hkmj176939. Epub 2018 Jun 4.


ZH-1 enhances the anticancer activity of gemcitabine via deoxyribonucleotide synthesis and apoptotic pathway against A549 cells.

Guo J, Li Y, Lam CWK, Wang C, Yao M, Zhang W.

Food Chem Toxicol. 2018 Sep;119:222-230. doi: 10.1016/j.fct.2018.04.019. Epub 2018 Apr 10.


Sophora flavescens protects against mycobacterial Trehalose Dimycolate-induced lung granuloma by inhibiting inflammation and infiltration of macrophages.

Liu D, Chan BC, Cheng L, Tsang MS, Zhu J, Wong CW, Jiao D, Chan HY, Leung PC, Lam CW, Wong CK.

Sci Rep. 2018 Mar 2;8(1):3903. doi: 10.1038/s41598-018-22286-w.


Genetic basis of channelopathies and cardiomyopathies in Hong Kong Chinese patients: a 10-year regional laboratory experience.

Mak CM, Chen SP, Mok NS, Siu WK, Lee HH, Ching CK, Tsui PT, Fong NC, Yuen YP, Poon WT, Law CY, Chong YK, Chan YW, Yung TC, Fan KY, Lam CW.

Hong Kong Med J. 2018 Aug;24(4):340-349. doi: 10.12809/hkmj176870. Epub 2018 Mar 2.


Population-Wide Genetic Risk Prediction of Complex Diseases: A Pilot Feasibility Study in Macau Population for Precision Public Healthcare Planning.

Tsui NBY, Cheng G, Chung T, Lam CWK, Yee A, Chung PKC, Kwan TK, Ko E, He D, Wong WT, Lau JYN, Lau LT, Fok M.

Sci Rep. 2018 Jan 30;8(1):1853. doi: 10.1038/s41598-017-19017-y.


A tricyclic pyrrolobenzodiazepine produced by Klebsiella oxytoca is associated with cytotoxicity in antibiotic-associated hemorrhagic colitis.

Tse H, Gu Q, Sze KH, Chu IK, Kao RY, Lee KC, Lam CW, Yang D, Tai SS, Ke Y, Chan E, Chan WM, Dai J, Leung SP, Leung SY, Yuen KY.

J Biol Chem. 2017 Nov 24;292(47):19503-19520. doi: 10.1074/jbc.M117.791558. Epub 2017 Sep 26.


Bioconcentration and Metabolism of Emodin in Zebrafish Eleutheroembryos.

Chen J, Li S, Liu M, Lam CWK, Li Z, Xu X, Chen Z, Zhang W, Yao M.

Front Pharmacol. 2017 Jul 11;8:453. doi: 10.3389/fphar.2017.00453. eCollection 2017.


Activation of Eosinophils Interacting with Bronchial Epithelial Cells by Antimicrobial Peptide LL-37: Implications in Allergic Asthma.

Jiao D, Wong CK, Tsang MS, Chu IM, Liu D, Zhu J, Chu M, Lam CW.

Sci Rep. 2017 May 12;7(1):1848. doi: 10.1038/s41598-017-02085-5.


Clinical and Molecular Epidemiology of Carbapenem-Resistant Enterobacteriaceae Among Adult Inpatients in Singapore.

Marimuthu K, Venkatachalam I, Khong WX, Koh TH, Cherng BPZ, Van La M, De PP, Krishnan PU, Tan TY, Choon RFK, Pada SK, Lam CW, Ooi ST, Deepak RN, Smitasin N, Tan EL, Lee JJ, Kurup A, Young B, Sim NTW, Thoon KC, Fisher D, Ling ML, Peng BAS, Teo YY, Hsu LY, Lin RTP, Ong RT, Teo J, Ng OT; Carbapenemase-Producing Enterobacteriaceae in Singapore (CaPES) Study Group.

Clin Infect Dis. 2017 May 15;64(suppl_2):S68-S75. doi: 10.1093/cid/cix113.


The Young's Modulus, Fracture Stress, and Fracture Strain of Gellan Hydrogels Filled with Whey Protein Microparticles.

Lam CWY, Ikeda S.

J Food Sci. 2017 May;82(5):1157-1162. doi: 10.1111/1750-3841.13714. Epub 2017 Apr 25.


Validation of an Instrument to Assess the Mental Capacity to Sign an Enduring Power of Attorney.

Ko RS, Lui VW, Lai KC, Chiu CC, Lam LC.

East Asian Arch Psychiatry. 2017 Mar;27(1):11-7.


Validation of the Chinese Version of the Revised Clinical Interview Schedule: Findings from Hong Kong Mental Morbidity Survey.

Chan WC, Wong CS, Chen EY, Ng RM, Hung SF, Cheung EF, Sham PC, Chiu HF, Lam M, Chang WC, Lee EH, Chiang TP, Lau JT, van Os J, Lewis G, Bebbington P, Lam LC.

East Asian Arch Psychiatry. 2017 Mar;27(1):3-10.


Global developmental delay and intellectual disability associated with a de novo TOP2B mutation.

Lam CW, Yeung WL, Law CY.

Clin Chim Acta. 2017 Jun;469:63-68. doi: 10.1016/j.cca.2017.03.022. Epub 2017 Mar 23.


Clinical Signs, Staphylococcus and Atopic Eczema-Related Seromarkers.

Hon KL, Tsang KY, Kung JS, Leung TF, Lam CW, Wong CK.

Molecules. 2017 Feb 14;22(2). pii: E291. doi: 10.3390/molecules22020291.


Identification of the cell binding domain in Nipah virus G glycoprotein using a phage display system.

Lam CW, AbuBakar S, Chang LY.

J Virol Methods. 2017 May;243:1-9. doi: 10.1016/j.jviromet.2017.01.004. Epub 2017 Jan 9.


Limb girdle myasthenia with digenic RAPSN and a novel disease gene AK9 mutations.

Lam CW, Wong KS, Leung HW, Law CY.

Eur J Hum Genet. 2017 Feb;25(2):192-199. doi: 10.1038/ejhg.2016.162. Epub 2016 Dec 14.


A common PRRT2 mutation in familial paroxysmal kinesigenic dyskinesia in Hong Kong: a case series of 16 patients.

Law CY, Yeung WL, Cheung YF, Chan HF, Fung E, Hui J, Yung IO, Yuen YP, Chan AO, Lam CW.

Hong Kong Med J. 2016 Dec;22(6):619-22. doi: 10.12809/hkmj154579. No abstract available.


Effect of Rorrico, extracted from group of Chinese medicines, on influenza A and H1N1 infections.

Chui SH, Wong YH, Fong MY, Chiu YM, Lam CWK.

J Tradit Chin Med. 2016 Dec;36(6):701-5.


Profiling ribonucleotide and deoxyribonucleotide pools perturbed by gemcitabine in human non-small cell lung cancer cells.

Guo JR, Chen QQ, Lam CW, Wang CY, Wong VK, Chang ZF, Zhang W.

Sci Rep. 2016 Nov 15;6:37250. doi: 10.1038/srep37250.


Physical health and lifestyle predictors for significant cognitive impairment in community-dwelling Chinese older adults in Hong Kong.

Lee AT, Chan WC, Chiu HF, Richards M, Hui LY, Ng SP, Chan WM, Lam LC.

Hong Kong Med J. 2016 Dec;22 Suppl 6(6):37-39. No abstract available.


Isoliquiritigenin suppresses human T Lymphocyte activation via covalently binding cysteine 46 of IκB kinase.

Yan F, Yang F, Wang R, Yao XJ, Bai L, Zeng X, Huang J, Wong VKW, Lam CWK, Zhou H, Su X, Liu J, Li T, Liu L.

Oncotarget. 2017 May 23;8(21):34223-34235. doi: 10.18632/oncotarget.11934.


Effects of resistance training on cardiovascular health in non-obese active adolescents.

Yu CC, McManus AM, So HK, Chook P, Au CT, Li AM, Kam JT, So RC, Lam CW, Chan IH, Sung RY.

World J Clin Pediatr. 2016 Aug 8;5(3):293-300. doi: 10.5409/wjcp.v5.i3.293. eCollection 2016 Aug 8.


A new mechanism for increasing the oral bioavailability of scutellarin with Cremophor EL: Activation of MRP3 with concurrent inhibition of MRP2 and BCRP.

Xiao L, Yi T, Chen M, Lam CW, Zhou H.

Eur J Pharm Sci. 2016 Oct 10;93:456-67. doi: 10.1016/j.ejps.2016.08.054. Epub 2016 Aug 29.


Overcoming chemoresistance in prostate cancer with Chinese medicine Tripterygium wilfordii via multiple mechanisms.

Wang Z, Ravula R, Shi L, Song Y, Yeung S, Liu M, Lau B, Hao J, Wang J, Lam CW, Chow MS, Huang Y.

Oncotarget. 2016 Sep 20;7(38):61246-61261. doi: 10.18632/oncotarget.10868.


Aberrant Expression of Novel Cytokine IL-38 and Regulatory T Lymphocytes in Childhood Asthma.

Chu M, Chu IM, Yung EC, Lam CW, Leung TF, Wong GW, Wong CK.

Molecules. 2016 Jul 18;21(7). pii: E933. doi: 10.3390/molecules21070933.


Precision or Personalized Medicine for Cancer Chemotherapy: Is there a Role for Herbal Medicine.

Wang Z, Liu X, Ho RL, Lam CW, Chow MS.

Molecules. 2016 Jul 7;21(7). pii: E889. doi: 10.3390/molecules21070889. Review.


Non-linear pharmacokinetics of piperine and its herb-drug interactions with docetaxel in Sprague-Dawley rats.

Li C, Wang Q, Ren T, Zhang Y, Lam CWK, Chow MSS, Zuo Z.

J Pharm Biomed Anal. 2016 Sep 5;128:286-293. doi: 10.1016/j.jpba.2016.05.041. Epub 2016 May 24.


Diagnostic yield of array CGH in patients with autism spectrum disorder in Hong Kong.

Siu WK, Lam CW, Mak CM, Lau ET, Tang MH, Tang WF, Poon-Mak RS, Lee CC, Hung SF, Leung PW, Kwong KL, Yau EK, Ng GS, Fong NC, Chan KY.

Clin Transl Med. 2016 Dec;5(1):18. doi: 10.1186/s40169-016-0098-1. Epub 2016 May 16.


Serum from Nipah Virus Patients Recognises Recombinant Viral Proteins Produced in Escherichia coli.

Tiong V, Lam CW, Phoon WH, AbuBakar S, Chang LY.

Jpn J Infect Dis. 2017 Jan 24;70(1):26-31. doi: 10.7883/yoken.JJID.2015.501. Epub 2016 May 9.


Anti-inflammatory activities of Ganoderma lucidum (Lingzhi) and San-Miao-San supplements in MRL/lpr mice for the treatment of systemic lupus erythematosus.

Cai Z, Wong CK, Dong J, Jiao D, Chu M, Leung PC, Lau CBS, Lau CP, Tam LS, Lam CWK.

Chin Med. 2016 Apr 29;11:23. doi: 10.1186/s13020-016-0093-x. eCollection 2016.


Lipid metabolites as potential diagnostic and prognostic biomarkers for acute community acquired pneumonia.

To KK, Lee KC, Wong SS, Sze KH, Ke YH, Lui YM, Tang BS, Li IW, Lau SK, Hung IF, Law CY, Lam CW, Yuen KY.

Diagn Microbiol Infect Dis. 2016 Jun;85(2):249-54. doi: 10.1016/j.diagmicrobio.2016.03.012. Epub 2016 Mar 14.


Anti-Inflammatory Activities of Pentaherbs Formula, Berberine, Gallic Acid and Chlorogenic Acid in Atopic Dermatitis-Like Skin Inflammation.

Tsang MS, Jiao D, Chan BC, Hon KL, Leung PC, Lau CB, Wong EC, Cheng L, Chan CK, Lam CW, Wong CK.

Molecules. 2016 Apr 20;21(4):519. doi: 10.3390/molecules21040519.


Aberrant Expression of Bacterial Pattern Recognition Receptor NOD2 of Basophils and Microbicidal Peptides in Atopic Dermatitis.

Wong CK, Chu IM, Hon KL, Tsang MS, Lam CW.

Molecules. 2016 Apr 11;21(4):471. doi: 10.3390/molecules21040471.


Expanding genotype/phenotype of neuromuscular diseases by comprehensive target capture/NGS.

Tian X, Liang WC, Feng Y, Wang J, Zhang VW, Chou CH, Huang HD, Lam CW, Hsu YY, Lin TS, Chen WT, Wong LJ, Jong YJ.

Neurol Genet. 2015 Aug 13;1(2):e14. doi: 10.1212/NXG.0000000000000015. eCollection 2015 Aug.


Differential changes in gene expression in human neutrophils following TNF-α stimulation: Up-regulation of anti-apoptotic proteins and down-regulation of proteins involved in death receptor signaling.

Chiewchengchol D, Wright HL, Thomas HB, Lam CW, Roberts KJ, Hirankarn N, Beresford MW, Moots RJ, Edwards SW.

Immun Inflamm Dis. 2015 Dec 2;4(1):35-44. doi: 10.1002/iid3.90. eCollection 2016 Mar.


New Potential Pharmacological Functions of Chinese Herbal Medicines via Regulation of Autophagy.

Law BY, Mok SW, Wu AG, Lam CW, Yu MX, Wong VK.

Molecules. 2016 Mar 17;21(3):359. doi: 10.3390/molecules21030359. Review.


Metabolomic Profiling of Plasma from Melioidosis Patients Using UHPLC-QTOF MS Reveals Novel Biomarkers for Diagnosis.

Lau SK, Lee KC, Lo GC, Ding VS, Chow WN, Ke TY, Curreem SO, To KK, Ho DT, Sridhar S, Wong SC, Chan JF, Hung IF, Sze KH, Lam CW, Yuen KY, Woo PC.

Int J Mol Sci. 2016 Feb 27;17(3):307. doi: 10.3390/ijms17030307.


Natural Products from Chinese Medicines with Potential Benefits to Bone Health.

Che CT, Wong MS, Lam CW.

Molecules. 2016 Feb 27;21(3):239. doi: 10.3390/molecules21030239. Review.


Novel large deletion in AVPR2 gene causing copy number variation in a patient with X-linked nephrogenic diabetes insipidus.

Cho SY, Law CY, Ng KL, Lam CW.

Clin Chim Acta. 2016 Apr 1;455:84-6. doi: 10.1016/j.cca.2016.01.032. Epub 2016 Jan 29.


Genetic diversity of Aspergillus species isolated from onychomycosis and Aspergillus hongkongensis sp. nov., with implications to antifungal susceptibility testing.

Tsang CC, Hui TW, Lee KC, Chen JH, Ngan AH, Tam EW, Chan JF, Wu AL, Cheung M, Tse BP, Wu AK, Lai CK, Tsang DN, Que TL, Lam CW, Yuen KY, Lau SK, Woo PC.

Diagn Microbiol Infect Dis. 2016 Feb;84(2):125-34. doi: 10.1016/j.diagmicrobio.2015.10.027. Epub 2015 Nov 3.


Application of artificial neural network to investigate the effects of 5-fluorouracil on ribonucleotides and deoxyribonucleotides in HepG2 cells.

Guo J, Chen Q, Lam CW, Wang C, Wong VK, Xu F, Jiang Z, Zhang W.

Sci Rep. 2015 Nov 18;5:16861. doi: 10.1038/srep16861.


Unmasking a novel disease gene NEO1 associated with autism spectrum disorders by a hemizygous deletion on chromosome 15 and a functional polymorphism.

Siu WK, Lam CW, Gao WW, Vincent Tang HM, Jin DY, Mak CM.

Behav Brain Res. 2016 Mar 1;300:135-42. doi: 10.1016/j.bbr.2015.10.041. Epub 2015 Oct 27.


Elevated Expression and Pro-Inflammatory Activity of IL-36 in Patients with Systemic Lupus Erythematosus.

Chu M, Wong CK, Cai Z, Dong J, Jiao D, Kam NW, Lam CW, Tam LS.

Molecules. 2015 Oct 27;20(10):19588-604. doi: 10.3390/molecules201019588.


Clinical whole-exome sequencing reveals a novel missense pathogenic variant of GNAO1 in a patient with infantile-onset epilepsy.

Law CY, Chang ST, Cho SY, Yau EK, Ng GS, Fong NC, Lam CW.

Clin Chim Acta. 2015 Dec 7;451(Pt B):292-6. doi: 10.1016/j.cca.2015.10.011. Epub 2015 Oct 17.


NOD2 and TLR2 ligands trigger the activation of basophils and eosinophils by interacting with dermal fibroblasts in atopic dermatitis-like skin inflammation.

Jiao D, Wong CK, Qiu HN, Dong J, Cai Z, Chu M, Hon KL, Tsang MS, Lam CW.

Cell Mol Immunol. 2016 Jul;13(4):535-50. doi: 10.1038/cmi.2015.77. Epub 2015 Sep 21.


Metabolomic Profiling of Plasma from Patients with Tuberculosis by Use of Untargeted Mass Spectrometry Reveals Novel Biomarkers for Diagnosis.

Lau SK, Lee KC, Curreem SO, Chow WN, To KK, Hung IF, Ho DT, Sridhar S, Li IW, Ding VS, Koo EW, Wong CF, Tam S, Lam CW, Yuen KY, Woo PC.

J Clin Microbiol. 2015 Dec;53(12):3750-9. doi: 10.1128/JCM.01568-15. Epub 2015 Sep 16.

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