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Harmonizing brain magnetic resonance imaging methods for vascular contributions to neurodegeneration.

Smith EE, Biessels GJ, De Guio F, de Leeuw FE, Duchesne S, Düring M, Frayne R, Ikram MA, Jouvent E, MacIntosh BJ, Thrippleton MJ, Vernooij MW, Adams H, Backes WH, Ballerini L, Black SE, Chen C, Corriveau R, DeCarli C, Greenberg SM, Gurol ME, Ingrisch M, Job D, Lam BYK, Launer LJ, Linn J, McCreary CR, Mok VCT, Pantoni L, Pike GB, Ramirez J, Reijmer YD, Romero JR, Ropele S, Rost NS, Sachdev PS, Scott CJM, Seshadri S, Sharma M, Sourbron S, Steketee RME, Swartz RH, van Oostenbrugge R, van Osch M, van Rooden S, Viswanathan A, Werring D, Dichgans M, Wardlaw JM.

Alzheimers Dement (Amst). 2019 Feb 26;11:191-204. doi: 10.1016/j.dadm.2019.01.002. eCollection 2019 Dec. Review.


Risk of intracerebral haemorrhage in Chinese patients with atrial fibrillation on warfarin with cerebral microbleeds: the IPAAC-Warfarin study.

Soo Y, Abrigo JM, Leung KT, Tsang SF, Ip HL, Ma SH, Ma K, Fong WC, Li SH, Li R, Ng PW, Wong KK, Liu W, Lam BYK, Wong KSL, Mok V, Chu WCW, Leung TW; IPAAC study group.

J Neurol Neurosurg Psychiatry. 2018 Dec 15. pii: jnnp-2018-319104. doi: 10.1136/jnnp-2018-319104. [Epub ahead of print]


p53 in AgRP neurons is required for protection against diet-induced obesity via JNK1.

Quiñones M, Al-Massadi O, Folgueira C, Bremser S, Gallego R, Torres-Leal L, Haddad-Tóvolli R, García-Caceres C, Hernandez-Bautista R, Lam BYH, Beiroa D, Sanchez-Rebordelo E, Senra A, Malagon JA, Valerio P, Fondevila MF, Fernø J, Malagon MM, Contreras R, Pfluger P, Brüning JC, Yeo G, Tschöp M, Diéguez C, López M, Claret M, Kloppenburg P, Sabio G, Nogueiras R.

Nat Commun. 2018 Aug 24;9(1):3432. doi: 10.1038/s41467-018-05711-6.


Mapping the contribution and strategic distribution patterns of neuroimaging features of small vessel disease in poststroke cognitive impairment.

Shi L, Zhao L, Yeung FK, Wong SY, Chan RKT, Tse MF, Chan SC, Kwong YC, Li KC, Liu K, Abrigo JM, Lau AYL, Wong A, Lam BYK, Leung TWH, Fu J, Chu WCW, Mok VCT.

J Neurol Neurosurg Psychiatry. 2018 Sep;89(9):918-926. doi: 10.1136/jnnp-2017-317817. Epub 2018 Apr 17.


Hypothalamic loss of Snord116 recapitulates the hyperphagia of Prader-Willi syndrome.

Polex-Wolf J, Lam BY, Larder R, Tadross J, Rimmington D, Bosch F, Cenzano VJ, Ayuso E, Ma MK, Rainbow K, Coll AP, O'Rahilly S, Yeo GS.

J Clin Invest. 2018 Mar 1;128(3):960-969. doi: 10.1172/JCI97007. Epub 2018 Jan 29.


Converting MMSE to MoCA and MoCA 5-minute protocol in an educationally heterogeneous sample with stroke or transient ischemic attack.

Wong A, Black SE, Yiu SYP, Au LWC, Lau AYL, Soo YOY, Chan AYY, Leung TWH, Wong LKS, Kwok TCY, Cheung TCK, Leung KT, Lam BYK, Kwan JSK, Mok VCT.

Int J Geriatr Psychiatry. 2018 May;33(5):729-734. doi: 10.1002/gps.4846. Epub 2018 Jan 2.


Psychopathy Moderates the Relationship between Orbitofrontal and Striatal Alterations and Violence: The Investigation of Individuals Accused of Homicide.

Lam BYH, Yang Y, Schug RA, Han C, Liu J, Lee TMC.

Front Hum Neurosci. 2017 Dec 1;11:579. doi: 10.3389/fnhum.2017.00579. eCollection 2017.


Is vascular cognitive impairment more common in Asia?

Lam BYK, Mok VCT.

Asian J Psychiatr. 2017 Apr 5. pii: S1876-2018(16)30009-0. doi: 10.1016/j.ajp.2017.03.043. [Epub ahead of print] No abstract available.


Development and validation of a risk score (CHANGE) for cognitive impairment after ischemic stroke.

Chander RJ, Lam BYK, Lin X, Ng AYT, Wong APL, Mok VCT, Kandiah N.

Sci Rep. 2017 Sep 29;7(1):12441. doi: 10.1038/s41598-017-12755-z.


Selective rab11 transport and the intrinsic regenerative ability of CNS axons.

Koseki H, Donegá M, Lam BY, Petrova V, van Erp S, Yeo GS, Kwok JC, Ffrench-Constant C, Eva R, Fawcett JW.

Elife. 2017 Aug 8;6. pii: e26956. doi: 10.7554/eLife.26956.


Obesity-associated gene TMEM18 has a role in the central control of appetite and body weight regulation.

Larder R, Sim MFM, Gulati P, Antrobus R, Tung YCL, Rimmington D, Ayuso E, Polex-Wolf J, Lam BYH, Dias C, Logan DW, Virtue S, Bosch F, Yeo GSH, Saudek V, O'Rahilly S, Coll AP.

Proc Natl Acad Sci U S A. 2017 Aug 29;114(35):9421-9426. doi: 10.1073/pnas.1707310114. Epub 2017 Aug 15.


Genetically improved BarraCUDA.

Langdon WB, Lam BYH.

BioData Min. 2017 Aug 2;10:28. doi: 10.1186/s13040-017-0149-1. eCollection 2017.


Adult-onset hyperinsulinaemic hypoglycaemia in clinical practice: diagnosis, aetiology and management.

Challis BG, Powlson AS, Casey RT, Pearson C, Lam BY, Ma M, Pitfield D, Yeo GSH, Godfrey E, Cheow HK, Chatterjee VK, Carroll NR, Shaw A, Buscombe JR, Simpson HL.

Endocr Connect. 2017 Oct;6(7):540-548. doi: 10.1530/EC-17-0076. Epub 2017 Aug 7.


Serine peptidase inhibitor Kazal type 1 (SPINK1) as novel downstream effector of the cadherin-17/β-catenin axis in hepatocellular carcinoma.

Shek FH, Luo R, Lam BYH, Sung WK, Lam TW, Luk JM, Leung MS, Chan KT, Wang HK, Chan CM, Poon RT, Lee NP.

Cell Oncol (Dordr). 2017 Oct;40(5):443-456. doi: 10.1007/s13402-017-0332-x. Epub 2017 Jun 19.


Thyroid Hormone Receptor Beta in the Ventromedial Hypothalamus Is Essential for the Physiological Regulation of Food Intake and Body Weight.

Hameed S, Patterson M, Dhillo WS, Rahman SA, Ma Y, Holton C, Gogakos A, Yeo GSH, Lam BYH, Polex-Wolf J, Fenske W, Bell J, Anastasovska J, Samarut J, Bloom SR, Bassett JHD, Williams GR, Gardiner JV.

Cell Rep. 2017 Jun 13;19(11):2202-2209. doi: 10.1016/j.celrep.2017.05.066.


Heterogeneity of hypothalamic pro-opiomelanocortin-expressing neurons revealed by single-cell RNA sequencing.

Lam BYH, Cimino I, Polex-Wolf J, Nicole Kohnke S, Rimmington D, Iyemere V, Heeley N, Cossetti C, Schulte R, Saraiva LR, Logan DW, Blouet C, O'Rahilly S, Coll AP, Yeo GSH.

Mol Metab. 2017 Mar 1;6(5):383-392. doi: 10.1016/j.molmet.2017.02.007. eCollection 2017 May.


Marginal zone B cells control the response of follicular helper T cells to a high-cholesterol diet.

Nus M, Sage AP, Lu Y, Masters L, Lam BYH, Newland S, Weller S, Tsiantoulas D, Raffort J, Marcus D, Finigan A, Kitt L, Figg N, Schirmbeck R, Kneilling M, Yeo GSH, Binder CJ, de la Pompa JL, Mallat Z.

Nat Med. 2017 May;23(5):601-610. doi: 10.1038/nm.4315. Epub 2017 Apr 17.


Early-onset and delayed-onset poststroke dementia - revisiting the mechanisms.

Mok VC, Lam BY, Wong A, Ko H, Markus HS, Wong LK.

Nat Rev Neurol. 2017 Mar;13(3):148-159. doi: 10.1038/nrneurol.2017.16. Epub 2017 Feb 17. Review.


STROKOG (stroke and cognition consortium): An international consortium to examine the epidemiology, diagnosis, and treatment of neurocognitive disorders in relation to cerebrovascular disease.

Sachdev PS, Lo JW, Crawford JD, Mellon L, Hickey A, Williams D, Bordet R, Mendyk AM, Gelé P, Deplanque D, Bae HJ, Lim JS, Brodtmann A, Werden E, Cumming T, Köhler S, Verhey FR, Dong YH, Tan HH, Chen C, Xin X, Kalaria RN, Allan LM, Akinyemi RO, Ogunniyi A, Klimkowicz-Mrowiec A, Dichgans M, Wollenweber FA, Zietemann V, Hoffmann M, Desmond DW, Linden T, Blomstrand C, Fagerberg B, Skoog I, Godefroy O, Barbay M, Roussel M, Lee BC, Yu KH, Wardlaw J, Makin SJ, Doubal FN, Chappell FM, Srikanth VK, Thrift AG, Donnan GA, Kandiah N, Chander RJ, Lin X, Cordonnier C, Moulin S, Rossi C, Sabayan B, Stott DJ, Jukema JW, Melkas S, Jokinen H, Erkinjuntti T, Mok VC, Wong A, Lam BY, Leys D, Hénon H, Bombois S, Lipnicki DM, Kochan NA; STROKOG.

Alzheimers Dement (Amst). 2016 Nov 18;7:11-23. doi: 10.1016/j.dadm.2016.10.006. eCollection 2017.


Neuropsychiatric Symptom Clusters in Stroke and Transient Ischemic Attack by Cognitive Status and Stroke Subtype: Frequency and Relationships with Vascular Lesions, Brain Atrophy and Amyloid.

Wong A, Lau AY, Yang J, Wang Z, Liu W, Lam BY, Au L, Shi L, Wang D, Chu WC, Xiong YY, Lo ES, Law LS, Leung TW, Lam LC, Chan AY, Soo YO, Leung EY, Wong LK, Mok VC.

PLoS One. 2016 Sep 15;11(9):e0162846. doi: 10.1371/journal.pone.0162846. eCollection 2016.


Relations between Recent Past Leisure Activities with Risks of Dementia and Cognitive Functions after Stroke.

Wong A, Lau AY, Lo E, Tang M, Wang Z, Liu W, Tanner N, Chau N, Law L, Shi L, Chu WC, Yang J, Xiong YY, Lam BY, Au L, Chan AY, Soo Y, Leung TW, Wong LK, Lam LC, Mok VC.

PLoS One. 2016 Jul 25;11(7):e0159952. doi: 10.1371/journal.pone.0159952. eCollection 2016.


Transcriptomic profiling of pancreatic alpha, beta and delta cell populations identifies delta cells as a principal target for ghrelin in mouse islets.

Adriaenssens AE, Svendsen B, Lam BY, Yeo GS, Holst JJ, Reimann F, Gribble FM.

Diabetologia. 2016 Oct;59(10):2156-65. doi: 10.1007/s00125-016-4033-1. Epub 2016 Jul 7.


Effect of theory of mind and peer victimization on the schizotypy-aggression relationship.

Lam BY, Raine A, Lee TM.

NPJ Schizophr. 2016 Mar 23;2:16001. doi: 10.1038/npjschz.2016.1. eCollection 2016.


Delayed-onset dementia after stroke or transient ischemic attack.

Mok VCT, Lam BYK, Wang Z, Liu W, Au L, Leung EYL, Chen S, Yang J, Chu WCW, Lau AYL, Chan AYY, Shi L, Fan F, Ma SH, Ip V, Soo YOY, Leung TWH, Kwok TCY, Ho CL, Wong LKS, Wong A.

Alzheimers Dement. 2016 Nov;12(11):1167-1176. doi: 10.1016/j.jalz.2016.05.007. Epub 2016 Jun 18.


Chronic Activation of γ2 AMPK Induces Obesity and Reduces β Cell Function.

Yavari A, Stocker CJ, Ghaffari S, Wargent ET, Steeples V, Czibik G, Pinter K, Bellahcene M, Woods A, Martínez de Morentin PB, Cansell C, Lam BY, Chuster A, Petkevicius K, Nguyen-Tu MS, Martinez-Sanchez A, Pullen TJ, Oliver PL, Stockenhuber A, Nguyen C, Lazdam M, O'Dowd JF, Harikumar P, Tóth M, Beall C, Kyriakou T, Parnis J, Sarma D, Katritsis G, Wortmann DD, Harper AR, Brown LA, Willows R, Gandra S, Poncio V, de Oliveira Figueiredo MJ, Qi NR, Peirson SN, McCrimmon RJ, Gereben B, Tretter L, Fekete C, Redwood C, Yeo GS, Heisler LK, Rutter GA, Smith MA, Withers DJ, Carling D, Sternick EB, Arch JR, Cawthorne MA, Watkins H, Ashrafian H.

Cell Metab. 2016 May 10;23(5):821-36. doi: 10.1016/j.cmet.2016.04.003. Epub 2016 Apr 28.


Facial emotion perception impairments in schizophrenia patients with comorbid antisocial personality disorder.

Tang DYY, Liu ACY, Lui SSY, Lam BYH, Siu BWM, Lee TMC, Cheung EFC.

Psychiatry Res. 2016 Feb 28;236:22-27. doi: 10.1016/j.psychres.2016.01.005. Epub 2016 Jan 6.


Neural mediator of the schizotypy-antisocial behavior relationship.

Lam BY, Yang Y, Raine A, Lee TM.

Transl Psychiatry. 2015 Nov 3;5:e669. doi: 10.1038/tp.2015.162.


A Transcriptome-Led Exploration of Molecular Mechanisms Regulating Somatostatin-Producing D-Cells in the Gastric Epithelium.

Adriaenssens A, Lam BY, Billing L, Skeffington K, Sewing S, Reimann F, Gribble F.

Endocrinology. 2015 Nov;156(11):3924-36. doi: 10.1210/en.2015-1301. Epub 2015 Aug 4.


Grey and white matter correlates of recent and remote autobiographical memory retrieval--insights from the dementias.

Irish M, Hornberger M, El Wahsh S, Lam BY, Lah S, Miller L, Hsieh S, Hodges JR, Piguet O.

PLoS One. 2014 Nov 14;9(11):e113081. doi: 10.1371/journal.pone.0113081. eCollection 2014.


Longitudinal white matter changes in frontotemporal dementia subtypes.

Lam BY, Halliday GM, Irish M, Hodges JR, Piguet O.

Hum Brain Mapp. 2014 Jul;35(7):3547-57. Epub 2013 Nov 25.


The relationship between neurocognition and symptomatology in people with schizophrenia: social cognition as the mediator.

Lam BY, Raine A, Lee TM.

BMC Psychiatry. 2014 May 13;14:138. doi: 10.1186/1471-244X-14-138.


DEFLATE compression algorithm corrects for overestimation of phylogenetic diversity by Grantham approach to single-nucleotide polymorphism classification.

Schlosberg A, Lam BY, Yeo GS, Clifton-Bligh RJ.

Int J Mol Sci. 2014 May 13;15(5):8491-508. doi: 10.3390/ijms15058491.


Longitudinal grey and white matter changes in frontotemporal dementia and Alzheimer's disease.

Frings L, Yew B, Flanagan E, Lam BY, Hüll M, Huppertz HJ, Hodges JR, Hornberger M.

PLoS One. 2014 Mar 3;9(3):e90814. doi: 10.1371/journal.pone.0090814. eCollection 2014.


Microarray, qPCR, and KCNJ5 sequencing of aldosterone-producing adenomas reveal differences in genotype and phenotype between zona glomerulosa- and zona fasciculata-like tumors.

Azizan EA, Lam BY, Newhouse SJ, Zhou J, Kuc RE, Clarke J, Happerfield L, Marker A, Hoffman GJ, Brown MJ.

J Clin Endocrinol Metab. 2012 May;97(5):E819-29. doi: 10.1210/jc.2011-2965. Epub 2012 Mar 22.


BarraCUDA - a fast short read sequence aligner using graphics processing units.

Klus P, Lam S, Lyberg D, Cheung MS, Pullan G, McFarlane I, Yeo GSh, Lam BY.

BMC Res Notes. 2012 Jan 13;5:27. doi: 10.1186/1756-0500-5-27.


Peer victimization partially mediates the schizotypy-aggression relationship in children and adolescents.

Raine A, Fung AL, Lam BY.

Schizophr Bull. 2011 Sep;37(5):937-45. doi: 10.1093/schbul/sbr082. Epub 2011 Jul 27.


Transcriptome analysis of embryonic and adult sensory axons reveals changes in mRNA repertoire localization.

Gumy LF, Yeo GS, Tung YC, Zivraj KH, Willis D, Coppola G, Lam BY, Twiss JL, Holt CE, Fawcett JW.

RNA. 2011 Jan;17(1):85-98. doi: 10.1261/rna.2386111. Epub 2010 Nov 23.


Developmental control of the Nlrp6 inflammasome and a substrate, IL-18, in mammalian intestine.

Kempster SL, Belteki G, Forhead AJ, Fowden AL, Catalano RD, Lam BY, McFarlane I, Charnock-Jones DS, Smith GC.

Am J Physiol Gastrointest Liver Physiol. 2011 Feb;300(2):G253-63. doi: 10.1152/ajpgi.00397.2010. Epub 2010 Nov 18.


Recovery knowledge and recovery-oriented services in Hong Kong.

Mak WW, Lam BY, Yau SS.

Psychiatr Serv. 2010 Nov;61(11):1164. doi: 10.1176/ps.2010.61.11.1164. No abstract available.


microRNA-122 as a regulator of mitochondrial metabolic gene network in hepatocellular carcinoma.

Burchard J, Zhang C, Liu AM, Poon RT, Lee NP, Wong KF, Sham PC, Lam BY, Ferguson MD, Tokiwa G, Smith R, Leeson B, Beard R, Lamb JR, Lim L, Mao M, Dai H, Luk JM.

Mol Syst Biol. 2010 Aug 24;6:402. doi: 10.1038/msb.2010.58.


Identification of the global transcriptomic response of the hypothalamic arcuate nucleus to fasting and leptin.

Jovanovic Z, Tung YC, Lam BY, O'Rahilly S, Yeo GS.

J Neuroendocrinol. 2010 Aug;22(8):915-25. doi: 10.1111/j.1365-2826.2010.02026.x. Epub 2010 Jun 9.


CREB-dependent Nur77 induction following depolarization in PC12 cells and neurons is modulated by MEF2 transcription factors.

Lam BY, Zhang W, Ng DC, Maruthappu M, Roderick HL, Chawla S.

J Neurochem. 2010 Feb;112(4):1065-73. doi: 10.1111/j.1471-4159.2009.06521.x. Epub 2009 Dec 3.


Consequences of long-term oral administration of the mitochondria-targeted antioxidant MitoQ to wild-type mice.

Rodriguez-Cuenca S, Cochemé HM, Logan A, Abakumova I, Prime TA, Rose C, Vidal-Puig A, Smith AC, Rubinsztein DC, Fearnley IM, Jones BA, Pope S, Heales SJ, Lam BY, Neogi SG, McFarlane I, James AM, Smith RA, Murphy MP.

Free Radic Biol Med. 2010 Jan 1;48(1):161-72. doi: 10.1016/j.freeradbiomed.2009.10.039. Epub 2009 Oct 23.


Inverse regulation of plasticity-related immediate early genes by calcineurin in hippocampal neurons.

Lam BY, Zhang W, Enticknap N, Haggis E, Cader MZ, Chawla S.

J Biol Chem. 2009 May 1;284(18):12562-71. doi: 10.1074/jbc.M901121200. Epub 2009 Mar 6.


Comparative proteomic analysis of mouse livers from embryo to adult reveals an association with progression of hepatocellular carcinoma.

Lee NP, Leung KW, Cheung N, Lam BY, Xu MZ, Sham PC, Lau GK, Poon RT, Fan ST, Luk JM.

Proteomics. 2008 May;8(10):2136-49. doi: 10.1002/pmic.200700590.


Laparoscopic intragastric approach for stromal tumours located at the posterior gastric wall.

Li VK, Hung WK, Chung CK, Ying MW, Lam BY, Kan DM, Chan MC.

Asian J Surg. 2008 Jan;31(1):6-10. doi: 10.1016/S1015-9584(08)60047-0.


A novel vessel segmentation algorithm for pathological retina images based on the divergence of vector fields.

Lam BY, Yan H.

IEEE Trans Med Imaging. 2008 Feb;27(2):237-46. doi: 10.1109/TMI.2007.909827.


Artificial neural networks and decision tree model analysis of liver cancer proteomes.

Luk JM, Lam BY, Lee NP, Ho DW, Sham PC, Chen L, Peng J, Leng X, Day PJ, Fan ST.

Biochem Biophys Res Commun. 2007 Sep 14;361(1):68-73. Epub 2007 Jul 10.


Randomized trial comparing pantoprazole infusion, bolus and no treatment on gastric pH and recurrent bleeding in peptic ulcers.

Hung WK, Li VK, Chung CK, Ying MW, Loo CK, Liu CK, Lam BY, Chan MC.

ANZ J Surg. 2007 Aug;77(8):677-81.


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