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Items: 1 to 50 of 228

1.

Preclinical Characterization of NVR 3-778, a First-in-Class Capsid Assembly Modulator against Hepatitis B Virus.

Lam AM, Espiritu C, Vogel R, Ren S, Lau V, Kelly M, Kuduk SD, Hartman GD, Flores OA, Klumpp K.

Antimicrob Agents Chemother. 2018 Dec 21;63(1). pii: e01734-18. doi: 10.1128/AAC.01734-18. Print 2019 Jan.

2.

Efficacy of NVR 3-778, Alone and In Combination With Pegylated Interferon, vs Entecavir In uPA/SCID Mice With Humanized Livers and HBV Infection.

Klumpp K, Shimada T, Allweiss L, Volz T, Lütgehetmann M, Hartman G, Flores OA, Lam AM, Dandri M.

Gastroenterology. 2018 Feb;154(3):652-662.e8. doi: 10.1053/j.gastro.2017.10.017. Epub 2017 Oct 24.

PMID:
29079518
3.

Hepatitis B Virus Capsid Assembly Modulators, but Not Nucleoside Analogs, Inhibit the Production of Extracellular Pregenomic RNA and Spliced RNA Variants.

Lam AM, Ren S, Espiritu C, Kelly M, Lau V, Zheng L, Hartman GD, Flores OA, Klumpp K.

Antimicrob Agents Chemother. 2017 Jul 25;61(8). pii: e00680-17. doi: 10.1128/AAC.00680-17. Print 2017 Aug.

4.

"Wave" of the Future in Neuroanesthesiology Too!

Schmidt BE, Lam AM.

Anesth Analg. 2017 Jan;124(1):371. No abstract available.

PMID:
27984312
5.

CagY Is an Immune-Sensitive Regulator of the Helicobacter pylori Type IV Secretion System.

Barrozo RM, Hansen LM, Lam AM, Skoog EC, Martin ME, Cai LP, Lin Y, Latoscha A, Suerbaum S, Canfield DR, Solnick JV.

Gastroenterology. 2016 Dec;151(6):1164-1175.e3. doi: 10.1053/j.gastro.2016.08.014. Epub 2016 Aug 26.

6.

High-resolution crystal structure of a hepatitis B virus replication inhibitor bound to the viral core protein.

Klumpp K, Lam AM, Lukacs C, Vogel R, Ren S, Espiritu C, Baydo R, Atkins K, Abendroth J, Liao G, Efimov A, Hartman G, Flores OA.

Proc Natl Acad Sci U S A. 2015 Dec 8;112(49):15196-201. doi: 10.1073/pnas.1513803112. Epub 2015 Nov 23.

7.

Monitoring for carotid endarterectomy: more or less?

Lam AM, Kianpour D.

Anesth Analg. 2015 Jun;120(6):1186-8. doi: 10.1213/ANE.0000000000000734. No abstract available.

PMID:
25988628
8.

Molecular and structural basis for the roles of hepatitis C virus polymerase NS5B amino acids 15, 223, and 321 in viral replication and drug resistance.

Lam AM, Edwards TE, Mosley RT, Murakami E, Bansal S, Lugo C, Bao H, Otto MJ, Sofia MJ, Furman PA.

Antimicrob Agents Chemother. 2014 Nov;58(11):6861-9. doi: 10.1128/AAC.03847-14. Epub 2014 Sep 2.

9.

Plagiarism by any other name (author)?

Lam AM.

Anesth Analg. 2014 Sep;119(3):749. doi: 10.1213/ANE.0000000000000271. No abstract available.

PMID:
25137008
10.

Discovery of a novel class of potent HCV NS4B inhibitors: SAR studies on piperazinone derivatives.

Kakarla R, Liu J, Naduthambi D, Chang W, Mosley RT, Bao D, Steuer HM, Keilman M, Bansal S, Lam AM, Seibel W, Neilson S, Furman PA, Sofia MJ.

J Med Chem. 2014 Mar 13;57(5):2136-60. doi: 10.1021/jm4012643. Epub 2014 Jan 29.

PMID:
24476391
11.

An epidural blood patch causing acute neurologic dysfunction necessitating a decompressive laminectomy.

Mehta SP, Keogh BP, Lam AM.

Reg Anesth Pain Med. 2014 Jan-Feb;39(1):78-80. doi: 10.1097/AAP.0000000000000025.

PMID:
24310044
12.

Use of 2'-spirocyclic ethers in HCV nucleoside design.

Du J, Chun BK, Mosley RT, Bansal S, Bao H, Espiritu C, Lam AM, Murakami E, Niu C, Micolochick Steuer HM, Furman PA, Sofia MJ.

J Med Chem. 2014 Mar 13;57(5):1826-35. doi: 10.1021/jm401224y. Epub 2013 Oct 18.

PMID:
24079820
13.

Functional plasticity in the type IV secretion system of Helicobacter pylori.

Barrozo RM, Cooke CL, Hansen LM, Lam AM, Gaddy JA, Johnson EM, Cariaga TA, Suarez G, Peek RM Jr, Cover TL, Solnick JV.

PLoS Pathog. 2013 Feb;9(2):e1003189. doi: 10.1371/journal.ppat.1003189. Epub 2013 Feb 28.

14.

β-D-2'-α-F-2'-β-C-Methyl-6-O-substituted 3',5'-cyclic phosphate nucleotide prodrugs as inhibitors of hepatitis C virus replication: a structure-activity relationship study.

Du J, Bao D, Chun BK, Jiang Y, Reddy PG, Zhang HR, Ross BS, Bansal S, Bao H, Espiritu C, Lam AM, Murakami E, Niu C, Micolochick Steuer HM, Furman PA, Otto MJ, Sofia MJ.

Bioorg Med Chem Lett. 2012 Sep 15;22(18):5924-9. doi: 10.1016/j.bmcl.2012.07.066. Epub 2012 Jul 27.

PMID:
22892115
15.

Blood pressure and adverse perioperative neurologic outcomes: an uncomfortable position.

Lam AM, Baldwin G.

Anesth Analg. 2012 Jun;114(6):1156-9. doi: 10.1213/ANE.0b013e318252ec92. No abstract available.

PMID:
22615443
16.

Metabolic activation of the anti-hepatitis C virus nucleotide prodrug PSI-352938.

Niu C, Tolstykh T, Bao H, Park Y, Babusis D, Lam AM, Bansal S, Du J, Chang W, Reddy PG, Zhang HR, Woolley J, Wang LQ, Chao PB, Ray AS, Otto MJ, Sofia MJ, Furman PA, Murakami E.

Antimicrob Agents Chemother. 2012 Jul;56(7):3767-75. doi: 10.1128/AAC.00530-12. Epub 2012 Apr 23.

17.

Structure of hepatitis C virus polymerase in complex with primer-template RNA.

Mosley RT, Edwards TE, Murakami E, Lam AM, Grice RL, Du J, Sofia MJ, Furman PA, Otto MJ.

J Virol. 2012 Jun;86(12):6503-11. doi: 10.1128/JVI.00386-12. Epub 2012 Apr 11.

18.

Genotype and subtype profiling of PSI-7977 as a nucleotide inhibitor of hepatitis C virus.

Lam AM, Espiritu C, Bansal S, Micolochick Steuer HM, Niu C, Zennou V, Keilman M, Zhu Y, Lan S, Otto MJ, Furman PA.

Antimicrob Agents Chemother. 2012 Jun;56(6):3359-68. doi: 10.1128/AAC.00054-12. Epub 2012 Mar 19.

19.

Inhibition of hepatitis C virus NS5A by fluoro-olefin based γ-turn mimetics.

Chang W, Mosley RT, Bansal S, Keilman M, Lam AM, Furman PA, Otto MJ, Sofia MJ.

Bioorg Med Chem Lett. 2012 Apr 15;22(8):2938-42. doi: 10.1016/j.bmcl.2012.02.051. Epub 2012 Feb 28.

PMID:
22425564
20.

Hepatitis C virus nucleotide inhibitors PSI-352938 and PSI-353661 exhibit a novel mechanism of resistance requiring multiple mutations within replicon RNA.

Lam AM, Espiritu C, Bansal S, Micolochick Steuer HM, Zennou V, Otto MJ, Furman PA.

J Virol. 2011 Dec;85(23):12334-42. doi: 10.1128/JVI.05639-11. Epub 2011 Sep 28.

21.

Activity and the metabolic activation pathway of the potent and selective hepatitis C virus pronucleotide inhibitor PSI-353661.

Furman PA, Murakami E, Niu C, Lam AM, Espiritu C, Bansal S, Bao H, Tolstykh T, Micolochick Steuer H, Keilman M, Zennou V, Bourne N, Veselenak RL, Chang W, Ross BS, Du J, Otto MJ, Sofia MJ.

Antiviral Res. 2011 Aug;91(2):120-32. doi: 10.1016/j.antiviral.2011.05.003. Epub 2011 May 12.

22.

Inhibition of hepatitis C virus replicon RNA synthesis by PSI-352938, a cyclic phosphate prodrug of β-D-2'-deoxy-2'-α-fluoro-2'-β-C-methylguanosine.

Lam AM, Espiritu C, Murakami E, Zennou V, Bansal S, Micolochick Steuer HM, Niu C, Keilman M, Bao H, Bourne N, Veselenak RL, Reddy PG, Chang W, Du J, Nagarathnam D, Sofia MJ, Otto MJ, Furman PA.

Antimicrob Agents Chemother. 2011 Jun;55(6):2566-75. doi: 10.1128/AAC.00032-11. Epub 2011 Mar 28.

23.

Cerebral blood flow and the injured brain: how should we monitor and manipulate it?

Dagal A, Lam AM.

Curr Opin Anaesthesiol. 2011 Apr;24(2):131-7. doi: 10.1097/ACO.0b013e3283445898. Review.

PMID:
21386665
24.

Discovery of PSI-353661, a Novel Purine Nucleotide Prodrug for the Treatment of HCV Infection.

Chang W, Bao D, Chun BK, Naduthambi D, Nagarathnam D, Rachakonda S, Reddy PG, Ross BS, Zhang HR, Bansal S, Espiritu CL, Keilman M, Lam AM, Niu C, Steuer HM, Furman PA, Otto MJ, Sofia MJ.

ACS Med Chem Lett. 2010 Dec 17;2(2):130-5. doi: 10.1021/ml100209f. eCollection 2011 Feb 10.

25.

2'-deoxy-2'-α-fluoro-2'-β-C-methyl 3',5'-cyclic phosphate nucleotide prodrug analogs as inhibitors of HCV NS5B polymerase: discovery of PSI-352938.

Reddy PG, Bao D, Chang W, Chun BK, Du J, Nagarathnam D, Rachakonda S, Ross BS, Zhang HR, Bansal S, Espiritu CL, Keilman M, Lam AM, Niu C, Steuer HM, Furman PA, Otto MJ, Sofia MJ.

Bioorg Med Chem Lett. 2010 Dec 15;20(24):7376-80. doi: 10.1016/j.bmcl.2010.10.035. Epub 2010 Oct 15.

PMID:
21050754
26.

Discovery of a β-d-2'-deoxy-2'-α-fluoro-2'-β-C-methyluridine nucleotide prodrug (PSI-7977) for the treatment of hepatitis C virus.

Sofia MJ, Bao D, Chang W, Du J, Nagarathnam D, Rachakonda S, Reddy PG, Ross BS, Wang P, Zhang HR, Bansal S, Espiritu C, Keilman M, Lam AM, Steuer HM, Niu C, Otto MJ, Furman PA.

J Med Chem. 2010 Oct 14;53(19):7202-18. doi: 10.1021/jm100863x.

PMID:
20845908
27.

Mechanism of activation of PSI-7851 and its diastereoisomer PSI-7977.

Murakami E, Tolstykh T, Bao H, Niu C, Steuer HM, Bao D, Chang W, Espiritu C, Bansal S, Lam AM, Otto MJ, Sofia MJ, Furman PA.

J Biol Chem. 2010 Nov 5;285(45):34337-47. doi: 10.1074/jbc.M110.161802. Epub 2010 Aug 26.

28.

Adenosine-induced transient asystole for intracranial aneurysm surgery: a retrospective review.

Guinn NR, McDonagh DL, Borel CO, Wright DR, Zomorodi AR, Powers CJ, Warner DS, Lam AM, Britz GW.

J Neurosurg Anesthesiol. 2011 Jan;23(1):35-40. doi: 10.1097/ANA.0b013e3181ef2b11.

PMID:
20706138
29.

Clinical experience with transcranial Doppler ultrasonography as a confirmatory test for brain death: a retrospective analysis.

Sharma D, Souter MJ, Moore AE, Lam AM.

Neurocrit Care. 2011 Jun;14(3):370-6. doi: 10.1007/s12028-010-9415-5.

PMID:
20694525
30.

PSI-7851, a pronucleotide of beta-D-2'-deoxy-2'-fluoro-2'-C-methyluridine monophosphate, is a potent and pan-genotype inhibitor of hepatitis C virus replication.

Lam AM, Murakami E, Espiritu C, Steuer HM, Niu C, Keilman M, Bao H, Zennou V, Bourne N, Julander JG, Morrey JD, Smee DF, Frick DN, Heck JA, Wang P, Nagarathnam D, Ross BS, Sofia MJ, Otto MJ, Furman PA.

Antimicrob Agents Chemother. 2010 Aug;54(8):3187-96. doi: 10.1128/AAC.00399-10. Epub 2010 Jun 1.

31.

A method to simultaneously monitor hepatitis C virus NS3 helicase and protease activities.

Frick DN, Ginzburg O, Lam AM.

Methods Mol Biol. 2010;587:223-33. doi: 10.1007/978-1-60327-355-8_16.

32.

Paradoxical emboli secondary to hepatic pathology: common or coincidental?

Gabikian P, Walker M, Chowdhary AM, Lam AM, Britz GW.

Case Rep Med. 2009;2009:184192. doi: 10.1155/2009/184192. Epub 2009 Nov 22.

33.

Nucleoside analog inhibitors of hepatitis C viral replication: recent advances, challenges and trends.

Furman PA, Lam AM, Murakami E.

Future Med Chem. 2009 Nov;1(8):1429-52. doi: 10.4155/fmc.09.88. Review.

PMID:
21426058
34.

Postoperative cognitive dysfunction in the elderly.

Ramaiah R, Lam AM.

Anesthesiol Clin. 2009 Sep;27(3):485-96, table of contents. doi: 10.1016/j.anclin.2009.07.011. Review.

PMID:
19825488
35.

Prolonged propofol anesthesia is not associated with an increase in blood lactate.

Rozet I, Tontisirin N, Vavilala MS, Treggiari MM, Lee LA, Lam AM.

Anesth Analg. 2009 Oct;109(4):1105-10. doi: 10.1213/ANE.0b013e3181b5a220. Epub 2009 Jul 29.

PMID:
19641048
36.

Cerebral autoregulation and anesthesia.

Dagal A, Lam AM.

Curr Opin Anaesthesiol. 2009 Oct;22(5):547-52. doi: 10.1097/ACO.0b013e32833020be. Review.

PMID:
19620861
37.

Esmolol blunts postoperative hemodynamic changes after propofol-remifentanil total intravenous fast-track neuroanesthesia for intracranial surgery.

Bilotta F, Lam AM, Doronzio A, Cuzzone V, Delfini R, Rosa G.

J Clin Anesth. 2008 Sep;20(6):426-30. doi: 10.1016/j.jclinane.2008.04.006.

PMID:
18929282
38.

Accuracy of transcranial Doppler ultrasonography and single-photon emission computed tomography in the diagnosis of angiographically demonstrated cerebral vasospasm.

Kincaid MS, Souter MJ, Treggiari MM, Yanez ND, Moore A, Lam AM.

J Neurosurg. 2009 Jan;110(1):67-72. doi: 10.3171/2008.4.17520.

PMID:
18821830
39.

Editorial comment. Neuroanesthesia and neurocritical care.

Lam AM.

Curr Opin Anaesthesiol. 2008 Oct;21(5):529. doi: 10.1097/ACO.0b013e32830f4514. No abstract available.

PMID:
18784474
40.

Effects of mutagenic and chain-terminating nucleotide analogs on enzymes isolated from hepatitis C virus strains of various genotypes.

Heck JA, Lam AM, Narayanan N, Frick DN.

Antimicrob Agents Chemother. 2008 Jun;52(6):1901-11. doi: 10.1128/AAC.01496-07. Epub 2008 Apr 7.

41.

Propofol infusion syndrome or probable overinterpretation syndrome?

Rozet I, Lam AM.

Anesthesiology. 2008 Feb;108(2):330; author reply 331-2. doi: 10.1097/01.anes.0000300041.04742.66. No abstract available.

PMID:
18212580
42.

Hemispheric differences in cerebral autoregulation in children with moderate and severe traumatic brain injury.

Vavilala MS, Tontisirin N, Udomphorn Y, Armstead W, Zimmerman JJ, Chesnut R, Lam AM.

Neurocrit Care. 2008;9(1):45-54.

PMID:
18084727
43.

Effect of equiosmolar solutions of mannitol versus hypertonic saline on intraoperative brain relaxation and electrolyte balance.

Rozet I, Tontisirin N, Muangman S, Vavilala MS, Souter MJ, Lee LA, Kincaid MS, Britz GW, Lam AM.

Anesthesiology. 2007 Nov;107(5):697-704.

PMID:
18073543
44.

Subarachnoid lumbar drains: a case series of fractured catheters and a near miss.

Olivar H, Bramhall JS, Rozet I, Vavilala MS, Souter MJ, Lee LA, Lam AM.

Can J Anaesth. 2007 Oct;54(10):829-34.

PMID:
17934165
45.

Pain and the craniotomy.

Kincaid MS, Lam AM.

J Neurosurg. 2007 Jun;106(6):1136-7; author reply 1137. No abstract available.

PMID:
17564193
46.

Early childhood gender differences in anterior and posterior cerebral blood flow velocity and autoregulation.

Tontisirin N, Muangman SL, Suz P, Pihoker C, Fisk D, Moore A, Lam AM, Vavilala MS.

Pediatrics. 2007 Mar;119(3):e610-5. Epub 2007 Feb 5.

PMID:
17283178
47.

Neurointensive care; impaired cerebral autoregulation in infants and young children early after inflicted traumatic brain injury: a preliminary report.

Vavilala MS, Muangman S, Waitayawinyu P, Roscigno C, Jaffe K, Mitchell P, Kirkness C, Zimmerman JJ, Ellenbogen R, Lam AM.

J Neurotrauma. 2007 Jan;24(1):87-96.

PMID:
17263672
48.

Dexmedetomidine sedation during awake craniotomy for seizure resection: effects on electrocorticography.

Souter MJ, Rozet I, Ojemann JG, Souter KJ, Holmes MD, Lee L, Lam AM.

J Neurosurg Anesthesiol. 2007 Jan;19(1):38-44.

PMID:
17198099
49.

Clinical experience with dexmedetomidine for implantation of deep brain stimulators in Parkinson's disease.

Rozet I, Muangman S, Vavilala MS, Lee LA, Souter MJ, Domino KJ, Slimp JC, Goodkin R, Lam AM.

Anesth Analg. 2006 Nov;103(5):1224-8.

PMID:
17056959
50.

Improving outcome for the injured brain and spinal cord.

Fletcher S, Lam AM.

Curr Opin Anaesthesiol. 2000 Apr;13(2):155-60.

PMID:
17016295

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