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Understanding How BCG Vaccine Protects Against Mycobacterium tuberculosis Infection: Lessons From Household Contact Studies.

Lalvani A, Seshadri C.

J Infect Dis. 2019 Jul 12. pii: jiz261. doi: 10.1093/infdis/jiz261. [Epub ahead of print] No abstract available.


Interferon gamma release assays for Diagnostic Evaluation of Active tuberculosis (IDEA): test accuracy study and economic evaluation.

Takwoingi Y, Whitworth H, Rees-Roberts M, Badhan A, Partlett C, Green N, Boakye A, Lambie H, Marongiu L, Jit M, White P, Deeks JJ, Kon OM, Lalvani A.

Health Technol Assess. 2019 May;23(23):1-152. doi: 10.3310/hta23230.


Immunodiagnosis of active tuberculosis.

Halliday A, Masonou T, Tolosa-Wright M, Mandagere V, Lalvani A.

Expert Rev Respir Med. 2019 Jun;13(6):521-532. doi: 10.1080/17476348.2019.1615888. Epub 2019 May 28.


Predicting progression to active tuberculosis: A rate-limiting step on the path to elimination.

Lalvani A, Berrocal-Almanza LC, Halliday A.

PLoS Med. 2019 May 24;16(5):e1002814. doi: 10.1371/journal.pmed.1002814. eCollection 2019 May.


CD4+ T cell cytokine responses to the DAR-901 booster vaccine in BCG-primed adults: A randomized, placebo-controlled trial.

Masonou T, Hokey DA, Lahey T, Halliday A, Berrocal-Almanza LC, Wieland-Alter WF, Arbeit RD, Lalvani A, von Reyn CF.

PLoS One. 2019 May 23;14(5):e0217091. doi: 10.1371/journal.pone.0217091. eCollection 2019.


Engaging with civil society to improve access to LTBI screening for new migrants in England: a qualitative study.

Berrocal-Almanza LC, Botticello J, Piotrowski H, Karnani N, Kon OM, Lalvani A, Zenner D.

Int J Tuberc Lung Dis. 2019 May 1;23(5):563-570. doi: 10.5588/ijtld.18.0230.


Clinical utility of existing and second-generation interferon-γ release assays for diagnostic evaluation of tuberculosis: an observational cohort study.

Whitworth HS, Badhan A, Boakye AA, Takwoingi Y, Rees-Roberts M, Partlett C, Lambie H, Innes J, Cooke G, Lipman M, Conlon C, Macallan D, Chua F, Post FA, Wiselka M, Woltmann G, Deeks JJ, Kon OM, Lalvani A; Interferon-γ Release Assays for Diagnostic Evaluation of Active Tuberculosis study group.

Lancet Infect Dis. 2019 Feb;19(2):193-202. doi: 10.1016/S1473-3099(18)30613-3. Epub 2019 Jan 14. Erratum in: Lancet Infect Dis. 2019 Feb;19(2):e39. Lancet Infect Dis. 2019 Mar;19(3):e64.


Discordance in latent tuberculosis (TB) test results in patients with end-stage renal disease.

Southern J, Sridhar S, Tsou CY, Hopkins S, Collier S, Nikolayevskyy V, Lozewicz S, Lalvani A, Abubakar I, Lipman M.

Public Health. 2019 Jan;166:34-39. doi: 10.1016/j.puhe.2018.09.023. Epub 2018 Nov 12.


Two interferon gamma release assays for predicting active tuberculosis: the UK PREDICT TB prognostic test study.

Abubakar I, Lalvani A, Southern J, Sitch A, Jackson C, Onyimadu O, Lipman M, Deeks JJ, Griffiths C, Bothamley G, Kon OM, Hayward A, Lord J, Drobniewski F.

Health Technol Assess. 2018 Oct;22(56):1-96. doi: 10.3310/hta22560.


Prognostic value of interferon-γ release assays and tuberculin skin test in predicting the development of active tuberculosis (UK PREDICT TB): a prospective cohort study.

Abubakar I, Drobniewski F, Southern J, Sitch AJ, Jackson C, Lipman M, Deeks JJ, Griffiths C, Bothamley G, Lynn W, Burgess H, Mann B, Imran A, Sridhar S, Tsou CY, Nikolayevskyy V, Rees-Roberts M, Whitworth H, Kon OM, Haldar P, Kunst H, Anderson S, Hayward A, Watson JM, Milburn H, Lalvani A; PREDICT Study Team.

Lancet Infect Dis. 2018 Oct;18(10):1077-1087. doi: 10.1016/S1473-3099(18)30355-4. Epub 2018 Aug 30.


Diabetes mellitus and latent tuberculosis infection: baseline analysis of a large UK cohort.

Jackson C, Southern J, Lalvani A, Drobniewski F, Griffiths CJ, Lipman M, Bothamley GH, Deeks JJ, Imran A, Kon OM, Mpofu S, Nikolayevskyy V, Rees-Roberts M, Sitch A, Sridhar S, Tsou CY, Whitworth H, Abubakar I.

Thorax. 2019 Jan;74(1):91-94. doi: 10.1136/thoraxjnl-2017-211124. Epub 2018 May 15.


Can defective interfering RNAs affect the live attenuated influenza vaccine? - Authors' reply.

Singanayagam A, Zambon M, Lalvani A, Barclay W.

Lancet Infect Dis. 2017 Dec;17(12):1235-1236. doi: 10.1016/S1473-3099(17)30638-2. No abstract available.


Innate activation of human primary epithelial cells broadens the host response to Mycobacterium tuberculosis in the airways.

Reuschl AK, Edwards MR, Parker R, Connell DW, Hoang L, Halliday A, Jarvis H, Siddiqui N, Wright C, Bremang S, Newton SM, Beverley P, Shattock RJ, Kon OM, Lalvani A.

PLoS Pathog. 2017 Sep 1;13(9):e1006577. doi: 10.1371/journal.ppat.1006577. eCollection 2017 Sep.


Urgent challenges in implementing live attenuated influenza vaccine.

Singanayagam A, Zambon M, Lalvani A, Barclay W.

Lancet Infect Dis. 2018 Jan;18(1):e25-e32. doi: 10.1016/S1473-3099(17)30360-2. Epub 2017 Aug 2. Review.


Stratification of Latent Mycobacterium tuberculosis Infection by Cellular Immune Profiling.

Halliday A, Whitworth H, Kottoor SH, Niazi U, Menzies S, Kunst H, Bremang S, Badhan A, Beverley P, Kon OM, Lalvani A.

J Infect Dis. 2017 May 1;215(9):1480-1487. doi: 10.1093/infdis/jix107.


Novel interferon-gamma assays for diagnosing tuberculosis in young children in India.

Shaikh N, Gupte A, Dharmshale S, Pokkali S, Thakar M, Upadhye VJ, Ordonez AA, Kinikar A, Gupte N, Mave V, Kagal A, Gupta A, Lalvani A, Paranjpe R, Bharadwaj R, Jain SK.

Int J Tuberc Lung Dis. 2017 Apr 1;21(4):412-419. doi: 10.5588/ijtld.16.0428.


Proteomic Analysis of Kveim Reagent Identifies Targets of Cellular Immunity in Sarcoidosis.

Eberhardt C, Thillai M, Parker R, Siddiqui N, Potiphar L, Goldin R, Timms JF, Wells AU, Kon OM, Wickremasinghe M, Mitchell D, Weeks ME, Lalvani A.

PLoS One. 2017 Jan 23;12(1):e0170285. doi: 10.1371/journal.pone.0170285. eCollection 2017.


Evaluation of serum inflammatory biomarkers as predictors of treatment outcome in pulmonary tuberculosis.

Singanayagam A, Manalan K, Connell DW, Chalmers JD, Sridhar S, Ritchie AI, Lalvani A, Wickremasinghe M, Kon OM.

Int J Tuberc Lung Dis. 2016 Dec;20(12):1653-1660.


Influenza A Virus Challenge Models in Cynomolgus Macaques Using the Authentic Inhaled Aerosol and Intra-Nasal Routes of Infection.

Marriott AC, Dennis M, Kane JA, Gooch KE, Hatch G, Sharpe S, Prevosto C, Leeming G, Zekeng EG, Staples KJ, Hall G, Ryan KA, Bate S, Moyo N, Whittaker CJ, Hallis B, Silman NJ, Lalvani A, Wilkinson TM, Hiscox JA, Stewart JP, Carroll MW.

PLoS One. 2016 Jun 16;11(6):e0157887. doi: 10.1371/journal.pone.0157887. eCollection 2016.


PD-1 Expression and Cytokine Secretion Profiles of Mycobacterium tuberculosis-Specific CD4+ T-Cell Subsets; Potential Correlates of Containment in HIV-TB Co-Infection.

Pollock KM, Montamat-Sicotte DJ, Grass L, Cooke GS, Kapembwa MS, Kon OM, Sampson RD, Taylor GP, Lalvani A.

PLoS One. 2016 Jan 12;11(1):e0146905. doi: 10.1371/journal.pone.0146905. eCollection 2016.


Differences in antigen-specific CD4+ responses to opportunistic infections in HIV infection.

Pollock KM, Montamat-Sicotte DJ, Cooke GS, Kapembwa MS, Kon OM, Grass L, Sampson RD, Taylor GP, Lalvani A.

Immun Inflamm Dis. 2015 Sep;3(3):141-53. doi: 10.1002/iid3.50. Epub 2015 Apr 29.


Vitamin D deficiency and TB disease phenotype.

Pareek M, Innes J, Sridhar S, Grass L, Connell D, Woltmann G, Wiselka M, Martineau AR, Kon OM, Dedicoat M, Lalvani A.

Thorax. 2015 Dec;70(12):1171-80. doi: 10.1136/thoraxjnl-2014-206617. Epub 2015 Sep 23.


Reply: To PMID 25105895.

Sridhar S, Lalvani A.

Pediatr Infect Dis J. 2015 Oct;34(10):1138. doi: 10.1097/INF.0000000000000842. No abstract available.


Viral hepatitis prevalence in patients with active and latent tuberculosis.

Nooredinvand HA, Connell DW, Asgheddi M, Abdullah M, O'Donoghue M, Campbell L, Wickremasinghe MI, Lalvani A, Kon OM, Khan SA.

World J Gastroenterol. 2015 Aug 7;21(29):8920-6. doi: 10.3748/wjg.v21.i29.8920.


Pre-entry screening for tuberculosis: the need for better evidence.

Lalvani A, Pareek M, Berrocal Almanza LC.

Pathog Glob Health. 2015 Mar;109(2):44-5. doi: 10.1179/2047772415Z.000000000254. No abstract available.


Longevity and determinants of protective humoral immunity after pandemic influenza infection.

Sridhar S, Begom S, Hoschler K, Bermingham A, Adamson W, Carman W, Riley S, Lalvani A.

Am J Respir Crit Care Med. 2015 Feb 1;191(3):325-32. doi: 10.1164/rccm.201410-1798OC.


Authors' reply to Turner and colleagues.

Abubakar I, Sridhar S, Eisenhut M, Roy A, Harris RJ, Rodrigues LC, Mangtani P, Adetifa I, Lalvani A.

BMJ. 2014 Sep 9;349:g5441. doi: 10.1136/bmj.g5441. No abstract available.


Increased risk of Mycobacterium tuberculosis infection in household child contacts exposed to passive tobacco smoke.

Sridhar S, Karnani N, Connell DW, Millington KA, Dosanjh D, Bakir M, Soysal A, Deeks J, Lalvani A.

Pediatr Infect Dis J. 2014 Dec;33(12):1303-6. doi: 10.1097/INF.0000000000000506.


Effect of BCG vaccination against Mycobacterium tuberculosis infection in children: systematic review and meta-analysis.

Roy A, Eisenhut M, Harris RJ, Rodrigues LC, Sridhar S, Habermann S, Snell L, Mangtani P, Adetifa I, Lalvani A, Abubakar I.

BMJ. 2014 Aug 5;349:g4643. doi: 10.1136/bmj.g4643. Review.


ESX1-dependent fractalkine mediates chemotaxis and Mycobacterium tuberculosis infection in humans.

Hingley-Wilson SM, Connell D, Pollock K, Hsu T, Tchilian E, Sykes A, Grass L, Potiphar L, Bremang S, Kon OM, Jacobs WR Jr, Lalvani A.

Tuberculosis (Edinb). 2014 May;94(3):262-70. doi: 10.1016/ Epub 2014 Feb 3.


Performance of Xpert MTB/RIF in the diagnosis of tuberculous mediastinal lymphadenopathy by endobronchial ultrasound.

Dhasmana DJ, Ross C, Bradley CJ, Connell DW, George PM, Singanayagam A, Jepson A, Craig C, Wright C, Molyneaux PL, Wickremasinghe M, Lalvani A, Cooke GS, Kon OM.

Ann Am Thorac Soc. 2014 Mar;11(3):392-6. doi: 10.1513/AnnalsATS.201308-250OC.


Utility of T-cell interferon-γ release assays for diagnosing tuberculous serositis: a prospective study in Beijing, China.

Zhang L, Zhang Y, Shi X, Zhang Y, Deng G, Lalvani A, Liu X.

PLoS One. 2014 Jan 9;9(1):e85030. doi: 10.1371/journal.pone.0085030. eCollection 2014.


Pediatric tuberculosis in young children in India: a prospective study.

Jain SK, Ordonez A, Kinikar A, Gupte N, Thakar M, Mave V, Jubulis J, Dharmshale S, Desai S, Hatolkar S, Kagal A, Lalvani A, Gupta A, Bharadwaj R.

Biomed Res Int. 2013;2013:783698. doi: 10.1155/2013/783698. Epub 2013 Dec 10.


Interferon-gamma release assays for tuberculosis: current and future applications.

Thillai M, Pollock K, Pareek M, Lalvani A.

Expert Rev Respir Med. 2014 Feb;8(1):67-78. doi: 10.1586/17476348.2014.852471. Epub 2013 Dec 2. Review.


Harnessing local and systemic immunity for vaccines against tuberculosis.

Beverley PC, Sridhar S, Lalvani A, Tchilian EZ.

Mucosal Immunol. 2014 Jan;7(1):20-6. doi: 10.1038/mi.2013.99. Epub 2013 Nov 20. Review.


Incidence of influenza A(H1N1)pdm09 infection, United Kingdom, 2009-2011.

Sridhar S, Begom S, Bermingham A, Hoschler K, Adamson W, Carman W, Van Kerkhove MD, Lalvani A.

Emerg Infect Dis. 2013 Nov;19(11):1866-9. doi: 10.3201/eid1911.130295.


Cellular immune correlates of protection against symptomatic pandemic influenza.

Sridhar S, Begom S, Bermingham A, Hoschler K, Adamson W, Carman W, Bean T, Barclay W, Deeks JJ, Lalvani A.

Nat Med. 2013 Oct;19(10):1305-12. doi: 10.1038/nm.3350. Epub 2013 Sep 22.


Evaluation of screening methods for identification of patients with chronic rheumatological disease requiring tuberculosis chemoprophylaxis prior to commencement of TNF-α antagonist therapy.

Singanayagam A, Manalan K, Sridhar S, Molyneaux PL, Connell DW, George PM, Kindelerer A, Seneviratne S, Lalvani A, Wickremasinghe M, Kon OM.

Thorax. 2013 Oct;68(10):955-61. doi: 10.1136/thoraxjnl-2013-203436. Epub 2013 Aug 23.


T-cell immunophenotyping distinguishes active from latent tuberculosis.

Pollock KM, Whitworth HS, Montamat-Sicotte DJ, Grass L, Cooke GS, Kapembwa MS, Kon OM, Sampson RD, Taylor GP, Lalvani A.

J Infect Dis. 2013 Sep;208(6):952-68. doi: 10.1093/infdis/jit265.


High rates of Mycobacterium tuberculosis among socially marginalized immigrants in low-incidence area, 1991-2010, Italy.

Baussano I, Mercadante S, Pareek M, Lalvani A, Bugiani M.

Emerg Infect Dis. 2013;19(9):1437-45. doi: 10.3201/eid1909.120200.


Undetected multidrug-resistant tuberculosis amplified by first-line therapy in mixed infection.

Hingley-Wilson SM, Casey R, Connell D, Bremang S, Evans JT, Hawkey PM, Smith GE, Jepson A, Philip S, Kon OM, Lalvani A.

Emerg Infect Dis. 2013 Jul;19(7):1138-41. doi: 10.3201/1907.130313.


Tuberculosis vaccines: time to reset the paradigm?

Lalvani A, Sridhar S, von Reyn CF.

Thorax. 2013 Dec;68(12):1092-4. doi: 10.1136/thoraxjnl-2013-203456. Epub 2013 Jun 7. No abstract available.


Biomarkers of tuberculosis: a research roadmap.

Whitworth HS, Aranday-Cortes E, Lalvani A.

Biomark Med. 2013 Jun;7(3):349-62. doi: 10.2217/bmm.13.53. Review.


How should I interpret an interferon gamma release assay result for tuberculosis infection?

Abubakar I, Stagg HR, Whitworth H, Lalvani A.

Thorax. 2013 Mar;68(3):298-301. doi: 10.1136/thoraxjnl-2013-203247.


Tuberculosis immunodiagnosis: delving below the surface.

Lalvani A, Connell DW.

Thorax. 2013 Mar;68(3):204-6. doi: 10.1136/thoraxjnl-2012-202481. No abstract available.


IGRAs--the gateway to T cell based TB diagnosis.

Whitworth HS, Scott M, Connell DW, Dongés B, Lalvani A.

Methods. 2013 May 15;61(1):52-62. doi: 10.1016/j.ymeth.2012.12.012. Epub 2013 Jan 4.


Dissecting the immunological, antimicrobial and clinical effects of vitamin D therapy in tuberculosis.

Lalvani A, Connell DW.

Pathog Glob Health. 2012 Nov;106(7):378-9. doi: 10.1179/2047772412Z.00000000087. No abstract available.


Ethnicity and mycobacterial lineage as determinants of tuberculosis disease phenotype.

Pareek M, Evans J, Innes J, Smith G, Hingley-Wilson S, Lougheed KE, Sridhar S, Dedicoat M, Hawkey P, Lalvani A.

Thorax. 2013 Mar;68(3):221-9. doi: 10.1136/thoraxjnl-2012-201824. Epub 2012 Sep 27.


Evaluation of immigrant tuberculosis screening in industrialized countries.

Pareek M, Baussano I, Abubakar I, Dye C, Lalvani A.

Emerg Infect Dis. 2012 Sep;18(9):1422-9. doi: 10.3201/eid1809.120128.

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