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Platelet GPIbα is a mediator and potential interventional target for NASH and subsequent liver cancer.

Malehmir M, Pfister D, Gallage S, Szydlowska M, Inverso D, Kotsiliti E, Leone V, Peiseler M, Surewaard BGJ, Rath D, Ali A, Wolf MJ, Drescher H, Healy ME, Dauch D, Kroy D, Krenkel O, Kohlhepp M, Engleitner T, Olkus A, Sijmonsma T, Volz J, Deppermann C, Stegner D, Helbling P, Nombela-Arrieta C, Rafiei A, Hinterleitner M, Rall M, Baku F, Borst O, Wilson CL, Leslie J, O'Connor T, Weston CJ, Adams DH, Sheriff L, Teijeiro A, Prinz M, Bogeska R, Anstee N, Bongers MN, Notohamiprodjo M, Geisler T, Withers DJ, Ware J, Mann DA, Augustin HG, Vegiopoulos A, Milsom MD, Rose AJ, Lalor PF, Llovet JM, Pinyol R, Tacke F, Rad R, Matter M, Djouder N, Kubes P, Knolle PA, Unger K, Zender L, Nieswandt B, Gawaz M, Weber A, Heikenwalder M.

Nat Med. 2019 Apr;25(4):641-655. doi: 10.1038/s41591-019-0379-5. Epub 2019 Apr 1.


A framework for tracer-based metabolism in mammalian cells by NMR.

Saborano R, Eraslan Z, Roberts J, Khanim FL, Lalor PF, Reed MAC, Günther UL.

Sci Rep. 2019 Feb 21;9(1):2520. doi: 10.1038/s41598-018-37525-3.


Liver sinusoidal endothelial cells - gatekeepers of hepatic immunity.

Shetty S, Lalor PF, Adams DH.

Nat Rev Gastroenterol Hepatol. 2018 Sep;15(9):555-567. doi: 10.1038/s41575-018-0020-y. Review.


Could endothelial TGFβ signaling be a promising new target for liver disease?

Adams DH, Shepherd EL, Lalor PF.

Expert Rev Gastroenterol Hepatol. 2018 Jul;12(7):637-639. doi: 10.1080/17474124.2018.1477587. Epub 2018 May 30. No abstract available.


Centrobin controls primary ciliogenesis in vertebrates.

Ogungbenro YA, Tena TC, Gaboriau D, Lalor P, Dockery P, Philipp M, Morrison CG.

J Cell Biol. 2018 Apr 2;217(4):1205-1215. doi: 10.1083/jcb.201706095. Epub 2018 Feb 13.


Employing mesenchymal stem cells to support tumor-targeted delivery of extracellular vesicle (EV)-encapsulated microRNA-379.

O'Brien KP, Khan S, Gilligan KE, Zafar H, Lalor P, Glynn C, O'Flatharta C, Ingoldsby H, Dockery P, De Bhulbh A, Schweber JR, St John K, Leahy M, Murphy JM, Gallagher WM, O'Brien T, Kerin MJ, Dwyer RM.

Oncogene. 2018 Apr;37(16):2137-2149. doi: 10.1038/s41388-017-0116-9. Epub 2018 Jan 25.


Dynamic regulation of canonical TGFβ signalling by endothelial transcription factor ERG protects from liver fibrogenesis.

Dufton NP, Peghaire CR, Osuna-Almagro L, Raimondi C, Kalna V, Chuahan A, Webb G, Yang Y, Birdsey GM, Lalor P, Mason JC, Adams DH, Randi AM.

Nat Commun. 2017 Oct 12;8(1):895. doi: 10.1038/s41467-017-01169-0.


Phytochrome A and B Regulate Primary Metabolism in Arabidopsis Leaves in Response to Light.

Han X, Tohge T, Lalor P, Dockery P, Devaney N, Esteves-Ferreira AA, Fernie AR, Sulpice R.

Front Plant Sci. 2017 Aug 9;8:1394. doi: 10.3389/fpls.2017.01394. eCollection 2017.


Fortifying the Bone-Implant Interface Part 2: An In Vivo Evaluation of 3D-Printed and TPS-Coated Triangular Implants.

MacBarb RF, Lindsey DP, Woods SA, Lalor PA, Gundanna MI, Yerby SA.

Int J Spine Surg. 2017 Jun 1;11:16. doi: 10.14444/4016. eCollection 2017.


Tandem Amplification of the Staphylococcal Cassette Chromosome mec Element Can Drive High-Level Methicillin Resistance in Methicillin-Resistant Staphylococcus aureus.

Gallagher LA, Coughlan S, Black NS, Lalor P, Waters EM, Wee B, Watson M, Downing T, Fitzgerald JR, Fleming GTA, O'Gara JP.

Antimicrob Agents Chemother. 2017 Aug 24;61(9). pii: e00869-17. doi: 10.1128/AAC.00869-17. Print 2017 Sep.


Changes in human hepatic metabolism in steatosis and cirrhosis.

Schofield Z, Reed MA, Newsome PN, Adams DH, Günther UL, Lalor PF.

World J Gastroenterol. 2017 Apr 21;23(15):2685-2695. doi: 10.3748/wjg.v23.i15.2685.


In Vitro and Ex Vivo Models to Study T Cell Migration Through the Human Liver Parenchyma.

Wiggins BG, Aliazis K, Davies SP, Hirschfield G, Lalor PF, Reynolds G, Stamataki Z.

Methods Mol Biol. 2017;1591:195-214. doi: 10.1007/978-1-4939-6931-9_14.


Using Ex Vivo Liver Organ Cultures to Measure Lymphocyte Trafficking.

Wiggins BG, Stamataki Z, Lalor PF.

Methods Mol Biol. 2017;1591:177-194. doi: 10.1007/978-1-4939-6931-9_13.


Introduction to Lymphocyte Trafficking in Disease.

Lalor PF, Hepburn EA.

Methods Mol Biol. 2017;1591:169-176. doi: 10.1007/978-1-4939-6931-9_12. Review.


Screening of exosomal microRNAs from colorectal cancer cells.

Clancy C, Khan S, Glynn CL, Holian E, Dockery P, Lalor P, Brown JA, Joyce MR, Kerin MJ, Dwyer RM.

Cancer Biomark. 2016;17(4):427-435. doi: 10.3233/CBM-160659.


Platelets: No longer bystanders in liver disease.

Chauhan A, Adams DH, Watson SP, Lalor PF.

Hepatology. 2016 Nov;64(5):1774-1784. doi: 10.1002/hep.28526. Epub 2016 Apr 7. Review.


Ulk4 Is Essential for Ciliogenesis and CSF Flow.

Liu M, Guan Z, Shen Q, Lalor P, Fitzgerald U, O'Brien T, Dockery P, Shen S.

J Neurosci. 2016 Jul 20;36(29):7589-600. doi: 10.1523/JNEUROSCI.0621-16.2016.


CEP164-null cells generated by genome editing show a ciliation defect with intact DNA repair capacity.

Daly OM, Gaboriau D, Karakaya K, King S, Dantas TJ, Lalor P, Dockery P, Krämer A, Morrison CG.

J Cell Sci. 2016 May 1;129(9):1769-74. doi: 10.1242/jcs.186221. Epub 2016 Mar 10.


Human intrahepatic regulatory T cells are functional, require IL-2 from effector cells for survival, and are susceptible to Fas ligand-mediated apoptosis.

Chen YY, Jeffery HC, Hunter S, Bhogal R, Birtwistle J, Braitch MK, Roberts S, Ming M, Hannah J, Thomas C, Adali G, Hübscher SG, Syn WK, Afford S, Lalor PF, Adams DH, Oo YH.

Hepatology. 2016 Jul;64(1):138-50. doi: 10.1002/hep.28517. Epub 2016 Apr 15.


Murine Models of Acute Alcoholic Hepatitis and Their Relevance to Human Disease.

Wilkin RJ, Lalor PF, Parker R, Newsome PN.

Am J Pathol. 2016 Apr;186(4):748-60. doi: 10.1016/j.ajpath.2015.12.003. Epub 2016 Feb 1. Review.


Dysregulated hepatic expression of glucose transporters in chronic disease: contribution of semicarbazide-sensitive amine oxidase to hepatic glucose uptake.

Karim S, Liaskou E, Fear J, Garg A, Reynolds G, Claridge L, Adams DH, Newsome PN, Lalor PF.

Am J Physiol Gastrointest Liver Physiol. 2014 Dec 15;307(12):G1180-90. doi: 10.1152/ajpgi.00377.2013. Epub 2014 Oct 23.


Three-Dimensional Microgel Platform for the Production of Cell Factories Tailored for the Nucleus Pulposus.

Fontana G, Srivastava A, Thomas D, Lalor P, Dockery P, Pandit A.

Bioconjug Chem. 2015 Jul 15;26(7):1297-306. doi: 10.1021/bc5004247. Epub 2014 Oct 20.


Top-down and bottom-up identification of proteins by liquid extraction surface analysis mass spectrometry of healthy and diseased human liver tissue.

Sarsby J, Martin NJ, Lalor PF, Bunch J, Cooper HJ.

J Am Soc Mass Spectrom. 2014 Nov;25(11):1953-61. doi: 10.1007/s13361-014-0967-z. Epub 2014 Sep 3.


Comment on: Is esophagogastroduodenoscopy before Roux-en-Y gastric bypass or sleeve gastrectomy mandatory?

Lalor PF.

Surg Obes Relat Dis. 2014 May-Jun;10(3):417-8. doi: 10.1016/j.soard.2014.02.024. Epub 2014 Feb 28. No abstract available.


Development of hepatocellular carcinoma in a murine model of nonalcoholic steatohepatitis induced by use of a high-fat/fructose diet and sedentary lifestyle.

Dowman JK, Hopkins LJ, Reynolds GM, Nikolaou N, Armstrong MJ, Shaw JC, Houlihan DD, Lalor PF, Tomlinson JW, Hübscher SG, Newsome PN.

Am J Pathol. 2014 May;184(5):1550-61. doi: 10.1016/j.ajpath.2014.01.034. Epub 2014 Mar 17.


Non-enzymatic dissociation of human mesenchymal stromal cells improves chemokine-dependent migration and maintains immunosuppressive function.

Garg A, Houlihan DD, Aldridge V, Suresh S, Li KK, King AL, Sutaria R, Fear J, Bhogal RH, Lalor PF, Newsome PN.

Cytotherapy. 2014 Apr;16(4):545-59. doi: 10.1016/j.jcyt.2013.10.003.


A chondromimetic microsphere for in situ spatially controlled chondrogenic differentiation of human mesenchymal stem cells.

Ansboro S, Hayes JS, Barron V, Browne S, Howard L, Greiser U, Lalor P, Shannon F, Barry FP, Pandit A, Murphy JM.

J Control Release. 2014 Apr 10;179:42-51. doi: 10.1016/j.jconrel.2014.01.023. Epub 2014 Jan 31.


Commonly used disinfectants fail to eradicate Salmonella enterica biofilms from food contact surface materials.

Corcoran M, Morris D, De Lappe N, O'Connor J, Lalor P, Dockery P, Cormican M.

Appl Environ Microbiol. 2014 Feb;80(4):1507-14. doi: 10.1128/AEM.03109-13. Epub 2013 Dec 20.


Ultrastructure of the ciliated cells of the free-swimming larva, and sessile stages, of the marine sponge Haliclona indistincta (Demospongiae: Haplosclerida).

Stephens KM, Ereskovsky A, Lalor P, McCormack GP.

J Morphol. 2013 Nov;274(11):1263-76. doi: 10.1002/jmor.20177. Epub 2013 Sep 11.


Formal lithium fixation improves direct analysis of lipids in tissue by mass spectrometry.

Griffiths RL, Sarsby J, Guggenheim EJ, Race AM, Steven RT, Fear J, Lalor PF, Bunch J.

Anal Chem. 2013 Aug 6;85(15):7146-53. doi: 10.1021/ac400737z. Epub 2013 Jul 23.


Abnormal centrosomal structure and duplication in Cep135-deficient vertebrate cells.

Inanç B, Pütz M, Lalor P, Dockery P, Kuriyama R, Gergely F, Morrison CG.

Mol Biol Cell. 2013 Sep;24(17):2645-54. doi: 10.1091/mbc.E13-03-0149. Epub 2013 Jul 17.


Calcium-binding capacity of centrin2 is required for linear POC5 assembly but not for nucleotide excision repair.

Dantas TJ, Daly OM, Conroy PC, Tomas M, Wang Y, Lalor P, Dockery P, Ferrando-May E, Morrison CG.

PLoS One. 2013 Jul 2;8(7):e68487. doi: 10.1371/journal.pone.0068487. Print 2013.


Mapping the extracellular and membrane proteome associated with the vasculature and the stroma in the embryo.

Soulet F, Kilarski WW, Roux-Dalvai F, Herbert JM, Sacewicz I, Mouton-Barbosa E, Bicknell R, Lalor P, Monsarrat B, Bikfalvi A.

Mol Cell Proteomics. 2013 Aug;12(8):2293-312. doi: 10.1074/mcp.M112.024075. Epub 2013 May 14.


The regulation of T-cell recruitment to the human liver during acute liver failure.

Tuncer C, Oo YH, Murphy N, Adams DH, Lalor PF.

Liver Int. 2013 Jul;33(6):852-63. doi: 10.1111/liv.12182. Epub 2013 Apr 25.


Salmonella enterica biofilm formation and density in the Centers for Disease Control and Prevention's biofilm reactor model is related to serovar and substratum.

Corcoran M, Morris D, De Lappe N, O'Connor J, Lalor P, Dockery P, Cormican M.

J Food Prot. 2013 Apr;76(4):662-7. doi: 10.4315/0362-028X.JFP-12-303.


Promoter hijack reveals pericentrin functions in mitosis and the DNA damage response.

Wang Y, Dantas TJ, Lalor P, Dockery P, Morrison CG.

Cell Cycle. 2013 Feb 15;12(4):635-46. doi: 10.4161/cc.23516. Epub 2013 Jan 16.


An in vitro model of human acute ethanol exposure that incorporates CXCR3- and CXCR4-dependent recruitment of immune cells.

Karim S, Liaskou E, Hadley S, Youster J, Faint J, Adams DH, Lalor PF.

Toxicol Sci. 2013 Mar;132(1):131-41. doi: 10.1093/toxsci/kfs337. Epub 2013 Jan 8.


Hepatic sinusoidal endothelium avidly binds platelets in an integrin-dependent manner, leading to platelet and endothelial activation and leukocyte recruitment.

Lalor PF, Herbert J, Bicknell R, Adams DH.

Am J Physiol Gastrointest Liver Physiol. 2013 Mar 1;304(5):G469-78. doi: 10.1152/ajpgi.00407.2012. Epub 2012 Dec 20.


Hyperspectral visualization of mass spectrometry imaging data.

Fonville JM, Carter CL, Pizarro L, Steven RT, Palmer AD, Griffiths RL, Lalor PF, Lindon JC, Nicholson JK, Holmes E, Bunch J.

Anal Chem. 2013 Feb 5;85(3):1415-23. doi: 10.1021/ac302330a. Epub 2013 Jan 15.


Hepatic expression and cellular distribution of the glucose transporter family.

Karim S, Adams DH, Lalor PF.

World J Gastroenterol. 2012 Dec 14;18(46):6771-81. doi: 10.3748/wjg.v18.i46.6771. Review.


Loss of plakophilin 2 disrupts heart development in zebrafish.

Moriarty MA, Ryan R, Lalor P, Dockery P, Byrnes L, Grealy M.

Int J Dev Biol. 2012;56(9):711-8. doi: 10.1387/ijdb.113390mm.


C-NAP1 and rootletin restrain DNA damage-induced centriole splitting and facilitate ciliogenesis.

Conroy PC, Saladino C, Dantas TJ, Lalor P, Dockery P, Morrison CG.

Cell Cycle. 2012 Oct 15;11(20):3769-78. doi: 10.4161/cc.21986.


Monocyte subsets in human liver disease show distinct phenotypic and functional characteristics.

Liaskou E, Zimmermann HW, Li KK, Oo YH, Suresh S, Stamataki Z, Qureshi O, Lalor PF, Shaw J, Syn WK, Curbishley SM, Adams DH.

Hepatology. 2013 Jan;57(1):385-98. doi: 10.1002/hep.26016. Epub 2012 Dec 4.


Recruitment mechanisms of primary and malignant B cells to the human liver.

Shetty S, Bruns T, Weston CJ, Stamataki Z, Oo YH, Long HM, Reynolds GM, Pratt G, Moss P, Jalkanen S, Hubscher SG, Lalor PF, Adams DH.

Hepatology. 2012 Oct;56(4):1521-31. doi: 10.1002/hep.25790.


Human mesenchymal stem cells are recruited to injured liver in a β1-integrin and CD44 dependent manner.

Aldridge V, Garg A, Davies N, Bartlett DC, Youster J, Beard H, Kavanagh DP, Kalia N, Frampton J, Lalor PF, Newsome PN.

Hepatology. 2012 Sep;56(3):1063-73. doi: 10.1002/hep.25716. Epub 2012 Jul 12.


Functional consequences of human lymphocyte cryopreservation: implications for subsequent interactions of cells with endothelium.

Faint JM, Tuncer C, Garg A, Adams DH, Lalor PF.

J Immunother. 2011 Oct;34(8):588-96. doi: 10.1097/CJI.0b013e31822bc3d0.


Defective nucleotide excision repair with normal centrosome structures and functions in the absence of all vertebrate centrins.

Dantas TJ, Wang Y, Lalor P, Dockery P, Morrison CG.

J Cell Biol. 2011 Apr 18;193(2):307-18. doi: 10.1083/jcb.201012093. Epub 2011 Apr 11.


Common lymphatic endothelial and vascular endothelial receptor-1 mediates the transmigration of regulatory T cells across human hepatic sinusoidal endothelium.

Shetty S, Weston CJ, Oo YH, Westerlund N, Stamataki Z, Youster J, Hubscher SG, Salmi M, Jalkanen S, Lalor PF, Adams DH.

J Immunol. 2011 Apr 1;186(7):4147-55. doi: 10.4049/jimmunol.1002961. Epub 2011 Mar 2.


Regulation of mucosal addressin cell adhesion molecule 1 expression in human and mice by vascular adhesion protein 1 amine oxidase activity.

Liaskou E, Karikoski M, Reynolds GM, Lalor PF, Weston CJ, Pullen N, Salmi M, Jalkanen S, Adams DH.

Hepatology. 2011 Feb;53(2):661-72. doi: 10.1002/hep.24085. Epub 2011 Jan 10.

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