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Items: 37


Creating a web-based electronic tool to aid tuberculosis (TB) cluster investigation: data integration in TB surveillance activities in the United Kingdom, 2013 to 2016.

Davidson JA, Anderson LF, Adebisi V, de Jongh L, Burkitt A, Lalor MK.

Euro Surveill. 2018 Nov;23(44). doi: 10.2807/1560-7917.ES.2018.23.44.1700794.


The Changing Landscape of Childhood Tuberculosis in the United Kingdom: A Retrospective Cohort (2000 to 2015).

Mohiyuddin T, Seddon JA, Thomas HL, Lalor MK.

Pediatr Infect Dis J. 2018 Sep 25. doi: 10.1097/INF.0000000000002200. [Epub ahead of print]


Delay from symptom onset to treatment start among tuberculosis patients in England, 2012-2015.

Loutet MG, Sinclair C, Whitehead N, Cosgrove C, Lalor MK, Thomas HL.

Epidemiol Infect. 2018 Sep;146(12):1511-1518. doi: 10.1017/S095026881800167X. Epub 2018 Jun 20.


Trends in, and factors associated with, HIV infection amongst tuberculosis patients in the era of anti-retroviral therapy: a retrospective study in England, Wales and Northern Ireland.

Winter JR, Stagg HR, Smith CJ, Lalor MK, Davidson JA, Brown AE, Brown J, Zenner D, Lipman M, Pozniak A, Abubakar I, Delpech V.

BMC Med. 2018 Jun 7;16(1):85. doi: 10.1186/s12916-018-1070-2.


Understanding Tuberculosis Transmission in the United Kingdom: Findings From 6 Years of Mycobacterial Interspersed Repetitive Unit-Variable Number Tandem Repeats Strain Typing, 2010-2015.

Davidson JA, Thomas HL, Maguire H, Brown T, Burkitt A, Macdonald N, Campbell CNJ, Lalor MK.

Am J Epidemiol. 2018 Oct 1;187(10):2233-2242. doi: 10.1093/aje/kwy119.


The use of whole-genome sequencing in cluster investigation of a multidrug-resistant tuberculosis outbreak.

Lalor MK, Casali N, Walker TM, Anderson LF, Davidson JA, Ratna N, Mullarkey C, Gent M, Foster K, Brown T, Magee J, Barrett A, Crook DW, Drobniewski F, Thomas HL, Abubakar I.

Eur Respir J. 2018 Jun 21;51(6). pii: 1702313. doi: 10.1183/13993003.02313-2017. Print 2018 Jun.


Reduction in tuberculosis incidence in the UK from 2011 to 2015: a population-based study.

Thomas HL, Harris RJ, Muzyamba MC, Davidson JA, Lalor MK, Campbell CNJ, Anderson SR, Zenner D.

Thorax. 2018 Aug;73(8):769-775. doi: 10.1136/thoraxjnl-2017-211074. Epub 2018 Apr 19.


The challenge of estimating tuberculosis mortality accurately in England and Wales.

Lalor MK, Mohiyuddin T, Uddin T, Thomas HL, Lipman M, Campbell CNJ.

Int J Tuberc Lung Dis. 2018 May 1;22(5):572-578. doi: 10.5588/ijtld.17.0695.


Investigating a tuberculosis cluster among Filipino health care workers in a low-incidence country.

Davidson JA, Fulton N, Thomas HL, Lalor MK, Zenner D, Brown T, Murphy S, Anderson LF.

Int J Tuberc Lung Dis. 2018 Mar 1;22(3):252-257. doi: 10.5588/ijtld.17.0620.


Acquired Resistance to Antituberculosis Drugs in England, Wales, and Northern Ireland, 2000-2015.

Loutet MG, Davidson JA, Brown T, Dedicoat M, Thomas HL, Lalor MK.

Emerg Infect Dis. 2018 Mar;24(3):524-533. doi: 10.3201/eid2403.171362.


Injecting drug use predicts active tuberculosis in a national cohort of people living with HIV.

Winter JR, Stagg HR, Smith CJ, Brown AE, Lalor MK, Lipman M, Pozniak A, Skingsley A, Kirwan P, Yin Z, Thomas HL, Delpech V, Abubakar I.

AIDS. 2017 Nov 13;31(17):2403-2413. doi: 10.1097/QAD.0000000000001635.


Recent household transmission of tuberculosis in England, 2010-2012: retrospective national cohort study combining epidemiological and molecular strain typing data.

Lalor MK, Anderson LF, Hamblion EL, Burkitt A, Davidson JA, Maguire H, Abubakar I, Thomas HL.

BMC Med. 2017 Jun 13;15(1):105. doi: 10.1186/s12916-017-0864-y.


Twenty years and counting: epidemiology of an outbreak of isoniazid-resistant tuberculosis in England and Wales, 1995 to 2014.

Smith CM, Trienekens SC, Anderson C, Lalor MK, Brown T, Story A, Fry H, Hayward AC, Maguire H.

Euro Surveill. 2017 Feb 23;22(8). pii: 30467. doi: 10.2807/1560-7917.ES.2017.22.8.30467.


Epidemiology of Mycobacterium bovis Disease in Humans in England, Wales, and Northern Ireland, 2002-2014.

Davidson JA, Loutet MG, O'Connor C, Kearns C, Smith RM, Lalor MK, Thomas HL, Abubakar I, Zenner D.

Emerg Infect Dis. 2017 Mar;23(3):377-386. doi: 10.3201/eid2303.161408.


Insidious Risk of Severe Mycobacterium chimaera Infection in Cardiac Surgery Patients.

Chand M, Lamagni T, Kranzer K, Hedge J, Moore G, Parks S, Collins S, Del Ojo Elias C, Ahmed N, Brown T, Smith EG, Hoffman P, Kirwan P, Mason B, Smith-Palmer A, Veal P, Lalor MK, Bennett A, Walker J, Yeap A, Isidro Carrion Martin A, Dolan G, Bhatt S, Skingsley A, Charlett A, Pearce D, Russell K, Kendall S, Klein AA, Robins S, Schelenz S, Newsholme W, Thomas S, Collyns T, Davies E, McMenamin J, Doherty L, Peto TE, Crook D, Zambon M, Phin N.

Clin Infect Dis. 2017 Feb 1;64(3):335-342. doi: 10.1093/cid/ciw754. Epub 2016 Dec 7.


Tuberculosis in migrants moving from high-incidence to low-incidence countries: a population-based cohort study of 519 955 migrants screened before entry to England, Wales, and Northern Ireland.

Aldridge RW, Zenner D, White PJ, Williamson EJ, Muzyamba MC, Dhavan P, Mosca D, Thomas HL, Lalor MK, Abubakar I, Hayward AC.

Lancet. 2016 Nov 19;388(10059):2510-2518. doi: 10.1016/S0140-6736(16)31008-X. Epub 2016 Oct 11.


Recent TB transmission, clustering and predictors of large clusters in London, 2010-2012: results from first 3 years of universal MIRU-VNTR strain typing.

Hamblion EL, Le Menach A, Anderson LF, Lalor MK, Brown T, Abubakar I, Anderson C, Maguire H, Anderson SR; Public Health England Strain Typing Project Board.

Thorax. 2016 Aug;71(8):749-56. doi: 10.1136/thoraxjnl-2014-206608.


Pulmonary Mycobacterium avium-intracellulare is the main driver of the rise in non-tuberculous mycobacteria incidence in England, Wales and Northern Ireland, 2007-2012.

Shah NM, Davidson JA, Anderson LF, Lalor MK, Kim J, Thomas HL, Lipman M, Abubakar I.

BMC Infect Dis. 2016 May 6;16:195. doi: 10.1186/s12879-016-1521-3.


Towards better guidance on caseload thresholds to promote positive tuberculosis treatment outcomes: a cohort study.

Stagg HR, Abubakar I, Brown J, Lalor MK, Thomas HL, Mohiyuddin T, Pedrazzoli D, Merle CS.

BMC Med. 2016 Mar 23;14:52. doi: 10.1186/s12916-016-0592-8.


TB in healthcare workers in the UK: a cohort analysis 2009-2013.

Davidson JA, Lalor MK, Anderson LF, Tamne S, Abubakar I, Thomas HL.

Thorax. 2017 Jul;72(7):654-659. doi: 10.1136/thoraxjnl-2015-208026. Epub 2016 Feb 17.


Assessment of Mycobacterium tuberculosis transmission in Oxfordshire, UK, 2007-12, with whole pathogen genome sequences: an observational study.

Walker TM, Lalor MK, Broda A, Ortega LS, Morgan M, Parker L, Churchill S, Bennett K, Golubchik T, Giess AP, Del Ojo Elias C, Jeffery KJ, Bowler ICJW, Laurenson IF, Barrett A, Drobniewski F, McCarthy ND, Anderson LF, Abubakar I, Thomas HL, Monk P, Smith EG, Walker AS, Crook DW, Peto TEA, Conlon CP.

Lancet Respir Med. 2014 Apr;2(4):285-292. doi: 10.1016/S2213-2600(14)70027-X. Epub 2014 Mar 4.


Factors affecting immunogenicity of BCG in infants, a study in Malawi, The Gambia and the UK.

Hur YG, Gorak-Stolinska P, Lalor MK, Mvula H, Floyd S, Raynes J, Ben-Smith A, Fitchett JR, Flanagan KL, Burl S, Ota MO, Crampin AC, Smith SG, Dockrell HM.

BMC Infect Dis. 2014 Apr 5;14:184. doi: 10.1186/1471-2334-14-184.


Identification of immunological biomarkers which may differentiate latent tuberculosis from exposure to environmental nontuberculous mycobacteria in children.

Hur YG, Crampin AC, Chisambo C, Kanyika J, Houben R, Ndhlovu R, Mzembe T, Lalor MK, Saul J, Branson K, Stanley C, Ngwira B, French N, Ottenhoff TH, Dockrell HM, Gorak-Stolinska P.

Clin Vaccine Immunol. 2014 Feb;21(2):133-42. doi: 10.1128/CVI.00620-13. Epub 2013 Nov 27.


Combination of cytokine responses indicative of latent TB and active TB in Malawian adults.

Hur YG, Gorak-Stolinska P, Ben-Smith A, Lalor MK, Chaguluka S, Dacombe R, Doherty TM, Ottenhoff TH, Dockrell HM, Crampin AC.

PLoS One. 2013 Nov 18;8(11):e79742. doi: 10.1371/journal.pone.0079742. eCollection 2013.


Risk factors associated with default from multi- and extensively drug-resistant tuberculosis treatment, Uzbekistan: a retrospective cohort analysis.

Lalor MK, Greig J, Allamuratova S, Althomsons S, Tigay Z, Khaemraev A, Braker K, Telnov O, du Cros P.

PLoS One. 2013 Nov 6;8(11):e78364. doi: 10.1371/journal.pone.0078364. eCollection 2013.


Analysis of host responses to Mycobacterium tuberculosis antigens in a multi-site study of subjects with different TB and HIV infection states in sub-Saharan Africa.

Sutherland JS, Lalor MK, Black GF, Ambrose LR, Loxton AG, Chegou NN, Kassa D, Mihret A, Howe R, Mayanja-Kizza H, Gomez MP, Donkor S, Franken K, Hanekom W, Klein MR, Parida SK, Boom WH, Thiel BA, Crampin AC, Ota M, Walzl G, Ottenhoff TH, Dockrell HM, Kaufmann SH; GCGH Biomarkers for TB consortium.

PLoS One. 2013 Sep 10;8(9):e74080. doi: 10.1371/journal.pone.0074080. eCollection 2013.


Variability between countries in cytokine responses to BCG vaccination: what impact might this have on protection?

Dockrell HM, Smith SG, Lalor MK.

Expert Rev Vaccines. 2012 Feb;11(2):121-4. doi: 10.1586/erv.11.186. No abstract available.


BCG vaccination induces different cytokine profiles following infant BCG vaccination in the UK and Malawi.

Lalor MK, Floyd S, Gorak-Stolinska P, Ben-Smith A, Weir RE, Smith SG, Newport MJ, Blitz R, Mvula H, Branson K, McGrath N, Crampin AC, Fine PE, Dockrell HM.

J Infect Dis. 2011 Oct 1;204(7):1075-85. doi: 10.1093/infdis/jir515.


BCG vaccination: a role for vitamin D?

Lalor MK, Floyd S, Gorak-Stolinska P, Weir RE, Blitz R, Branson K, Fine PE, Dockrell HM.

PLoS One. 2011 Jan 31;6(1):e16709. doi: 10.1371/journal.pone.0016709.


Mycobacterium tuberculosis PPD-induced immune biomarkers measurable in vitro following BCG vaccination of UK adolescents by multiplex bead array and intracellular cytokine staining.

Smith SG, Lalor MK, Gorak-Stolinska P, Blitz R, Beveridge NE, Worth A, McShane H, Dockrell HM.

BMC Immunol. 2010 Jul 7;11:35. doi: 10.1186/1471-2172-11-35.


Complex cytokine profiles induced by BCG vaccination in UK infants.

Lalor MK, Smith SG, Floyd S, Gorak-Stolinska P, Weir RE, Blitz R, Branson K, Fine PE, Dockrell HM.

Vaccine. 2010 Feb 10;28(6):1635-41. doi: 10.1016/j.vaccine.2009.11.004. Epub 2009 Nov 24.


Immunogenicity of novel DosR regulon-encoded candidate antigens of Mycobacterium tuberculosis in three high-burden populations in Africa.

Black GF, Thiel BA, Ota MO, Parida SK, Adegbola R, Boom WH, Dockrell HM, Franken KL, Friggen AH, Hill PC, Klein MR, Lalor MK, Mayanja H, Schoolnik G, Stanley K, Weldingh K, Kaufmann SH, Walzl G, Ottenhoff TH; GCGH Biomarkers for TB Consortium.

Clin Vaccine Immunol. 2009 Aug;16(8):1203-12. doi: 10.1128/CVI.00111-09. Epub 2009 Jun 24.


Population differences in immune responses to Bacille Calmette-Guérin vaccination in infancy.

Lalor MK, Ben-Smith A, Gorak-Stolinska P, Weir RE, Floyd S, Blitz R, Mvula H, Newport MJ, Branson K, McGrath N, Crampin AC, Fine PE, Dockrell HM.

J Infect Dis. 2009 Mar 15;199(6):795-800.


Differences between naive and memory T cell phenotype in Malawian and UK adolescents: a role for Cytomegalovirus?

Ben-Smith A, Gorak-Stolinska P, Floyd S, Weir RE, Lalor MK, Mvula H, Crampin AC, Wallace D, Beverley PC, Fine PE, Dockrell HM.

BMC Infect Dis. 2008 Oct 15;8:139. doi: 10.1186/1471-2334-8-139.


Persistence of the immune response induced by BCG vaccination.

Weir RE, Gorak-Stolinska P, Floyd S, Lalor MK, Stenson S, Branson K, Blitz R, Ben-Smith A, Fine PE, Dockrell HM.

BMC Infect Dis. 2008 Jan 25;8:9. doi: 10.1186/1471-2334-8-9.


Immunogenicity of Danish-SSI 1331 BCG vaccine in the UK: comparison with Glaxo-Evans 1077 BCG vaccine.

Gorak-Stolinska P, Weir RE, Floyd S, Lalor MK, Stenson S, Branson K, Blitz R, Luke S, Nazareth B, Ben-Smith A, Fine PE, Dockrell HM.

Vaccine. 2006 Jul 17;24(29-30):5726-33. Epub 2006 May 8.


The PPD-specific T-cell clonal response in UK and Malawian subjects following BCG vaccination: a new repertoire evolves over 12 months.

Bennett AR, Gorak-Stolinska P, Ben-Smith A, Floyd S, de Lara CM, Weir RE, Lalor MK, Makamo K, Msiska GK, Crampin AC, Fine PE, Dockrell HM, Beverley PC.

Vaccine. 2006 Mar 24;24(14):2617-26. Epub 2005 Dec 27.


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