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Items: 25

1.

Early antischistosomal leads identified from in vitro and in vivo screening of the Medicines for Malaria Venture Pathogen Box.

Pasche V, Laleu B, Keiser J.

ACS Infect Dis. 2018 Nov 6. doi: 10.1021/acsinfecdis.8b00220. [Epub ahead of print]

PMID:
30398059
2.

Screening a repurposing library, the Medicines for Malaria Venture Stasis Box, against Schistosoma mansoni.

Pasche V, Laleu B, Keiser J.

Parasit Vectors. 2018 May 15;11(1):298. doi: 10.1186/s13071-018-2855-z.

3.

Addressing the most neglected diseases through an open research model: The discovery of fenarimols as novel drug candidates for eumycetoma.

Lim W, Melse Y, Konings M, Phat Duong H, Eadie K, Laleu B, Perry B, Todd MH, Ioset JR, van de Sande WWJ.

PLoS Negl Trop Dis. 2018 Apr 26;12(4):e0006437. doi: 10.1371/journal.pntd.0006437. eCollection 2018 Apr.

4.

Screening of TB Actives for Activity against Nontuberculous Mycobacteria Delivers High Hit Rates.

Low JL, Wu ML, Aziz DB, Laleu B, Dick T.

Front Microbiol. 2017 Aug 15;8:1539. doi: 10.3389/fmicb.2017.01539. eCollection 2017.

5.

In vitro screening of the open source Pathogen Box identifies novel compounds with profound activities against Neospora caninum.

Müller J, Aguado A, Laleu B, Balmer V, Ritler D, Hemphill A.

Int J Parasitol. 2017 Oct;47(12):801-809. doi: 10.1016/j.ijpara.2017.06.002. Epub 2017 Jul 25.

PMID:
28751177
6.

Screening of the 'Stasis Box' identifies two kinase inhibitors under pharmaceutical development with activity against Haemonchus contortus.

Jiao Y, Preston S, Koehler AV, Stroehlein AJ, Chang BCH, Simpson KJ, Cowley KJ, Palmer MJ, Laleu B, Wells TNC, Jabbar A, Gasser RB.

Parasit Vectors. 2017 Jul 5;10(1):323. doi: 10.1186/s13071-017-2246-x.

7.

Assessing the anthelmintic activity of pyrazole-5-carboxamide derivatives against Haemonchus contortus.

Jiao Y, Preston S, Song H, Jabbar A, Liu Y, Baell J, Hofmann A, Hutchinson D, Wang T, Koehler AV, Fisher GM, Andrews KT, Laleu B, Palmer MJ, Burrows JN, Wells TNC, Wang Q, Gasser RB.

Parasit Vectors. 2017 May 31;10(1):272. doi: 10.1186/s13071-017-2191-8.

8.

Susceptibility Testing of Medically Important Parasites.

Genetu Bayih A, Debnath A, Mitre E, Huston CD, Laleu B, Leroy D, Blasco B, Campo B, Wells TNC, Willis PA, Sjö P, Van Voorhis WC, Pillai DR.

Clin Microbiol Rev. 2017 Jul;30(3):647-669. doi: 10.1128/CMR.00111-16. Review.

9.

Screening of the 'Pathogen Box' identifies an approved pesticide with major anthelmintic activity against the barber's pole worm.

Preston S, Jiao Y, Jabbar A, McGee SL, Laleu B, Willis P, Wells TNC, Gasser RB.

Int J Parasitol Drugs Drug Resist. 2016 Dec;6(3):329-334. doi: 10.1016/j.ijpddr.2016.07.004. Epub 2016 Jul 28. Review.

10.

Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond.

Van Voorhis WC, Adams JH, Adelfio R, Ahyong V, Akabas MH, Alano P, Alday A, Alemán Resto Y, Alsibaee A, Alzualde A, Andrews KT, Avery SV, Avery VM, Ayong L, Baker M, Baker S, Ben Mamoun C, Bhatia S, Bickle Q, Bounaadja L, Bowling T, Bosch J, Boucher LE, Boyom FF, Brea J, Brennan M, Burton A, Caffrey CR, Camarda G, Carrasquilla M, Carter D, Belen Cassera M, Chih-Chien Cheng K, Chindaudomsate W, Chubb A, Colon BL, Colón-López DD, Corbett Y, Crowther GJ, Cowan N, D'Alessandro S, Le Dang N, Delves M, DeRisi JL, Du AY, Duffy S, Abd El-Salam El-Sayed S, Ferdig MT, Fernández Robledo JA, Fidock DA, Florent I, Fokou PV, Galstian A, Gamo FJ, Gokool S, Gold B, Golub T, Goldgof GM, Guha R, Guiguemde WA, Gural N, Guy RK, Hansen MA, Hanson KK, Hemphill A, Hooft van Huijsduijnen R, Horii T, Horrocks P, Hughes TB, Huston C, Igarashi I, Ingram-Sieber K, Itoe MA, Jadhav A, Naranuntarat Jensen A, Jensen LT, Jiang RH, Kaiser A, Keiser J, Ketas T, Kicka S, Kim S, Kirk K, Kumar VP, Kyle DE, Lafuente MJ, Landfear S, Lee N, Lee S, Lehane AM, Li F, Little D, Liu L, Llinás M, Loza MI, Lubar A, Lucantoni L, Lucet I, Maes L, Mancama D, Mansour NR, March S, McGowan S, Medina Vera I, Meister S, Mercer L, Mestres J, Mfopa AN, Misra RN, Moon S, Moore JP, Morais Rodrigues da Costa F, Müller J, Muriana A, Nakazawa Hewitt S, Nare B, Nathan C, Narraidoo N, Nawaratna S, Ojo KK, Ortiz D, Panic G, Papadatos G, Parapini S, Patra K, Pham N, Prats S, Plouffe DM, Poulsen SA, Pradhan A, Quevedo C, Quinn RJ, Rice CA, Abdo Rizk M, Ruecker A, St Onge R, Salgado Ferreira R, Samra J, Robinett NG, Schlecht U, Schmitt M, Silva Villela F, Silvestrini F, Sinden R, Smith DA, Soldati T, Spitzmüller A, Stamm SM, Sullivan DJ, Sullivan W, Suresh S, Suzuki BM, Suzuki Y, Swamidass SJ, Taramelli D, Tchokouaha LR, Theron A, Thomas D, Tonissen KF, Townson S, Tripathi AK, Trofimov V, Udenze KO, Ullah I, Vallieres C, Vigil E, Vinetz JM, Voong Vinh P, Vu H, Watanabe NA, Weatherby K, White PM, Wilks AF, Winzeler EA, Wojcik E, Wree M, Wu W, Yokoyama N, Zollo PH, Abla N, Blasco B, Burrows J, Laleu B, Leroy D, Spangenberg T, Wells T, Willis PA.

PLoS Pathog. 2016 Jul 28;12(7):e1005763. doi: 10.1371/journal.ppat.1005763. eCollection 2016 Jul.

11.

Chiral selectivity in the binding of [4]helicene derivatives to double-stranded DNA.

Kel O, Fürstenberg A, Mehanna N, Nicolas C, Laleu B, Hammarson M, Albinsson B, Lacour J, Vauthey E.

Chemistry. 2013 May 27;19(22):7173-80. doi: 10.1002/chem.201203915. Epub 2013 Apr 9.

PMID:
23576271
12.

Nicotinamide adenine dinucleotide phosphate oxidase in experimental liver fibrosis: GKT137831 as a novel potential therapeutic agent.

Aoyama T, Paik YH, Watanabe S, Laleu B, Gaggini F, Fioraso-Cartier L, Molango S, Heitz F, Merlot C, Szyndralewiez C, Page P, Brenner DA.

Hepatology. 2012 Dec;56(6):2316-27. doi: 10.1002/hep.25938.

13.

Excited-state properties of chiral [4]helicene cations.

Kel O, Sherin P, Mehanna N, Laleu B, Lacour J, Vauthey E.

Photochem Photobiol Sci. 2012 Apr;11(4):623-31. doi: 10.1039/c2pp05361f. Epub 2012 Jan 16.

PMID:
22246477
14.

Design, synthesis and biological activity of original pyrazolo-pyrido-diazepine, -pyrazine and -oxazine dione derivatives as novel dual Nox4/Nox1 inhibitors.

Gaggini F, Laleu B, Orchard M, Fioraso-Cartier L, Cagnon L, Houngninou-Molango S, Gradia A, Duboux G, Merlot C, Heitz F, Szyndralewiez C, Page P.

Bioorg Med Chem. 2011 Dec 1;19(23):6989-99. doi: 10.1016/j.bmc.2011.10.016. Epub 2011 Oct 17.

PMID:
22041175
15.

First in class, potent, and orally bioavailable NADPH oxidase isoform 4 (Nox4) inhibitors for the treatment of idiopathic pulmonary fibrosis.

Laleu B, Gaggini F, Orchard M, Fioraso-Cartier L, Cagnon L, Houngninou-Molango S, Gradia A, Duboux G, Merlot C, Heitz F, Szyndralewiez C, Page P.

J Med Chem. 2010 Nov 11;53(21):7715-30. doi: 10.1021/jm100773e.

PMID:
20942471
16.

Vicinal diphosphoniums: electrostatic repulsion under covalent constraint.

Abdalilah M, Zurawinski R, Canac Y, Laleu B, Lacour J, Lepetit C, Magro G, Bernardinelli G, Donnadieu B, Duhayon C, Mikolajczyk M, Chauvin R.

Dalton Trans. 2009 Oct 28;(40):8493-508. doi: 10.1039/b903933c. Epub 2009 Aug 6.

PMID:
19809724
17.

Exploiting the divergent reactivity of aryl-palladium intermediates for the rapid assembly of fluorene and phenanthrene derivatives.

Zhao YB, Mariampillai B, Candito DA, Laleu B, Li M, Lautens M.

Angew Chem Int Ed Engl. 2009;48(10):1849-52. doi: 10.1002/anie.200805780.

PMID:
19173357
18.

Synthesis of annulated 2H-indazoles and 1,2,3- and 1,2,4-triazoles via a one-pot palladium-catalyzed alkylation/direct arylation reaction.

Laleu B, Lautens M.

J Org Chem. 2008 Nov 21;73(22):9164-7. doi: 10.1021/jo8017236. Epub 2008 Oct 24.

PMID:
18947186
19.

A palladium-catalyzed alkylation/direct arylation synthesis of nitrogen-containing heterocycles.

Blaszykowski C, Aktoudianakis E, Alberico D, Bressy C, Hulcoop DG, Jafarpour F, Joushaghani A, Laleu B, Lautens M.

J Org Chem. 2008 Mar 7;73(5):1888-97. doi: 10.1021/jo702052b. Epub 2008 Feb 9.

PMID:
18260672
20.

Tris(2,4,6-trimethoxyphenyl)methyl carbenium ion for charge derivatization of amines and amino acids.

Denekamp C, Lacour J, Laleu B, Rabkin E.

J Mass Spectrom. 2008 May;43(5):623-7.

PMID:
18078301
21.

Effective HPLC resolution of [4]heterohelicenium dyes on chiral stationary phases using reversed-phase eluents.

Villani C, Laleu B, Mobian P, Lacour J.

Chirality. 2007 Aug;19(8):601-6.

PMID:
17096378
22.

Pummerer fragmentation vs. pummerer rearrangement: a mechanistic analysis.

Laleu B, Machado MS, Lacour J.

Chem Commun (Camb). 2006 Jul 14;(26):2786-8.

PMID:
17009463
23.

Trimesitylmethylphosphonium cation. Supramolecular stereocontrol and simple enantiomerization mechanism determination.

Laleu B, Bernardinelli G, Chauvin R, Lacour J.

J Org Chem. 2006 Sep 15;71(19):7412-6. Erratum in: J Org Chem. 2007 Mar 16;72(6):2258.

PMID:
16958536
24.

Resolution of [4]heterohelicenium dyes with unprecedented Pummerer-like chemistry.

Laleu B, Mobian P, Herse C, Laursen BW, Hopfgartner G, Bernardinelli G, Lacour J.

Angew Chem Int Ed Engl. 2005 Mar 11;44(12):1879-83. No abstract available.

PMID:
15712308
25.

Bent structure and dynamic stereochemistry of chiral acridinium cations.

Laleu B, Herse C, Laursen BW, Bernardinelli G, Lacour J.

J Org Chem. 2003 Aug 8;68(16):6304-8.

PMID:
12895064

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