Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 34

1.

Influence of sub-chronic selective 11β-hydroxysteroid dehydrogenase 1 inhibition on the hypothalamic-pituitary-adrenal axis in female cynomolgus monkeys.

Hamilton BS, Schoelch C, Schuler-Metz A, Krosky P, Lala DS, Claremon DA, McGeehan GM.

Eur J Pharmacol. 2016 Oct 15;789:68-74. doi: 10.1016/j.ejphar.2016.07.004. Epub 2016 Jul 5.

PMID:
27393460
2.

Identification of spirooxindole and dibenzoxazepine motifs as potent mineralocorticoid receptor antagonists.

Lotesta SD, Marcus AP, Zheng Y, Leftheris K, Noto PB, Meng S, Kandpal G, Chen G, Zhou J, McKeever B, Bukhtiyarov Y, Zhao Y, Lala DS, Singh SB, McGeehan GM.

Bioorg Med Chem. 2016 Mar 15;24(6):1384-91. doi: 10.1016/j.bmc.2016.02.014. Epub 2016 Feb 9.

PMID:
26897089
3.

Pharmacological characterization of the selective 11β-hydroxysteroid dehydrogenase 1 inhibitor, BI 135585, a clinical candidate for the treatment of type 2 diabetes.

Hamilton BS, Himmelsbach F, Nar H, Schuler-Metz A, Krosky P, Guo J, Guo R, Meng S, Zhao Y, Lala DS, Zhuang L, Claremon DA, McGeehan GM.

Eur J Pharmacol. 2015 Jan 5;746:50-5. doi: 10.1016/j.ejphar.2014.10.053. Epub 2014 Nov 8.

PMID:
25445047
4.

The medicinal chemistry of liver X receptor (LXR) modulators.

Tice CM, Noto PB, Fan KY, Zhuang L, Lala DS, Singh SB.

J Med Chem. 2014 Sep 11;57(17):7182-205. doi: 10.1021/jm500442z. Epub 2014 May 28.

PMID:
24832115
5.

Regulation of sphingomyelin phosphodiesterase acid-like 3A gene (SMPDL3A) by liver X receptors.

Noto PB, Bukhtiyarov Y, Shi M, McKeever BM, McGeehan GM, Lala DS.

Mol Pharmacol. 2012 Oct;82(4):719-27. Epub 2012 Jul 18.

PMID:
22810003
6.

Discovery of a series of 2-(1H-pyrazol-1-yl)pyridines as ALK5 inhibitors with potential utility in the prevention of dermal scarring.

Boys ML, Bian F, Kramer JB, Chio CL, Ren XD, Chen H, Barrett SD, Sexton KE, Iula DM, Filzen GF, Nguyen MN, Angell P, Downs VL, Wang Z, Raheja N, Ellsworth EL, Fakhoury S, Bratton LD, Keller PR, Gowan R, Drummond EM, Maiti SN, Hena MA, Lu L, McConnell P, Knafels JD, Thanabal V, Sun F, Alessi D, McCarthy A, Zhang E, Finzel BC, Patel S, Ciotti SM, Eisma R, Payne NA, Gilbertsen RB, Kostlan CR, Pocalyko DJ, Lala DS.

Bioorg Med Chem Lett. 2012 May 15;22(10):3392-7. doi: 10.1016/j.bmcl.2012.04.013. Epub 2012 Apr 10.

PMID:
22542194
7.

An activin receptor-like kinase 5 inhibitor reduces collagen deposition in a rat dermal incision wound healing model.

Bian F, Render J, Ren XD, Chio C, Chan K, Boys M, Lala DS, Pocalyko D.

Plast Reconstr Surg. 2011 Nov;128(5):451e-459e. doi: 10.1097/PRS.0b013e31822b65c7.

PMID:
22030504
8.

The liver X receptors.

Lala DS.

Curr Opin Investig Drugs. 2005 Sep;6(9):934-43. Review.

PMID:
16187693
9.

Molecular mechanisms of mineralocorticoid receptor antagonism by eplerenone.

Hu X, Li S, McMahon EG, Lala DS, Rudolph AE.

Mini Rev Med Chem. 2005 Aug;5(8):709-18. Review.

PMID:
16101407
10.

The ligand-dependent interaction of mineralocorticoid receptor with coactivator and corepressor peptides suggests multiple activation mechanisms.

Hultman ML, Krasnoperova NV, Li S, Du S, Xia C, Dietz JD, Lala DS, Welsch DJ, Hu X.

Mol Endocrinol. 2005 Jun;19(6):1460-73. Epub 2005 Mar 10.

PMID:
15761029
11.

Liver X receptors and atherosclerosis.

Lala DS.

IDrugs. 2004 Jun;7(6):563-9. Review.

PMID:
15197661
12.

Repression of p65 transcriptional activation by the glucocorticoid receptor in the absence of receptor-coactivator interactions.

Wu J, Li Y, Dietz J, Lala DS.

Mol Endocrinol. 2004 Jan;18(1):53-62. Epub 2003 Oct 9.

PMID:
14551261
13.

Multiplexing nuclear receptors for agonist identification in a cell-based reporter gene high-throughput screen.

Grover GS, Turner BA, Parker CN, Meier J, Lala DS, Lee PH.

J Biomol Screen. 2003 Jun;8(3):239-46.

PMID:
12857377
14.

Liver X receptors interact with corepressors to regulate gene expression.

Hu X, Li S, Wu J, Xia C, Lala DS.

Mol Endocrinol. 2003 Jun;17(6):1019-26. Epub 2003 Mar 27.

PMID:
12663743
15.

The hypolipidemic natural product guggulsterone acts as an antagonist of the bile acid receptor.

Wu J, Xia C, Meier J, Li S, Hu X, Lala DS.

Mol Endocrinol. 2002 Jul;16(7):1590-7.

PMID:
12089353
16.

Steroidogenic factor 1: an essential mediator of endocrine development.

Parker KL, Rice DA, Lala DS, Ikeda Y, Luo X, Wong M, Bakke M, Zhao L, Frigeri C, Hanley NA, Stallings N, Schimmer BP.

Recent Prog Horm Res. 2002;57:19-36. Review.

PMID:
12017543
17.

Induction of human liver X receptor alpha gene expression via an autoregulatory loop mechanism.

Li Y, Bolten C, Bhat BG, Woodring-Dietz J, Li S, Prayaga SK, Xia C, Lala DS.

Mol Endocrinol. 2002 Mar;16(3):506-14.

PMID:
11875109
18.

The rexinoid LG100754 is a novel RXR:PPARgamma agonist and decreases glucose levels in vivo.

Cesario RM, Klausing K, Razzaghi H, Crombie D, Rungta D, Heyman RA, Lala DS.

Mol Endocrinol. 2001 Aug;15(8):1360-9.

PMID:
11463859
19.

Benzocaine-induced methemoglobinemia.

Gupta PM, Lala DS, Arsura EL.

South Med J. 2000 Jan;93(1):83-6.

PMID:
10653076
20.

Activation of the orphan nuclear receptor steroidogenic factor 1 by oxysterols.

Lala DS, Syka PM, Lazarchik SB, Mangelsdorf DJ, Parker KL, Heyman RA.

Proc Natl Acad Sci U S A. 1997 May 13;94(10):4895-900.

21.

Activation of specific RXR heterodimers by an antagonist of RXR homodimers.

Lala DS, Mukherjee R, Schulman IG, Koch SS, Dardashti LJ, Nadzan AM, Croston GE, Evans RM, Heyman RA.

Nature. 1996 Oct 3;383(6599):450-3.

PMID:
8837780
22.

The human medium chain acyl-CoA dehydrogenase gene promoter consists of a complex arrangement of nuclear receptor response elements and Sp1 binding sites.

Leone TC, Cresci S, Carter ME, Zhang Z, Lala DS, Strauss AW, Kelly DP.

J Biol Chem. 1995 Oct 13;270(41):24622. No abstract available.

23.
24.

A cell-specific nuclear receptor plays essential roles in adrenal and gonadal development.

Luo X, Ikeda Y, Lala DS, Baity LA, Meade JC, Parker KL.

Endocr Res. 1995 Feb-May;21(1-2):517-24.

PMID:
7588417
25.

A cell-specific nuclear receptor regulates the steroid hydroxylases.

Lala DS, Ikeda Y, Luo X, Baity LA, Meade JC, Parker KL.

Steroids. 1995 Jan;60(1):10-4. Review.

PMID:
7792792
26.

The nuclear receptor steroidogenic factor 1 acts at multiple levels of the reproductive axis.

Ingraham HA, Lala DS, Ikeda Y, Luo X, Shen WH, Nachtigal MW, Abbud R, Nilson JH, Parker KL.

Genes Dev. 1994 Oct 1;8(19):2302-12.

27.

Steroidogenic factor-1 binding and transcriptional activity of the cholesterol side-chain cleavage promoter in rat granulosa cells.

Clemens JW, Lala DS, Parker KL, Richards JS.

Endocrinology. 1994 Mar;134(3):1499-508.

PMID:
8119192
28.

Characterization of the mouse FTZ-F1 gene, which encodes a key regulator of steroid hydroxylase gene expression.

Ikeda Y, Lala DS, Luo X, Kim E, Moisan MP, Parker KL.

Mol Endocrinol. 1993 Jul;7(7):852-60.

PMID:
8413309
29.

Steroidogenic factor 1, an orphan nuclear receptor, regulates the expression of the rat aromatase gene in gonadal tissues.

Lynch JP, Lala DS, Peluso JJ, Luo W, Parker KL, White BA.

Mol Endocrinol. 1993 Jun;7(6):776-86.

PMID:
8395654
30.

Changes in gene expression during senescence of adrenocortical cells in culture.

Hornsby PJ, Cheng CY, Lala DS, Maghsoudlou SS, Raju SG, Yang L.

J Steroid Biochem Mol Biol. 1992 Dec;43(8):951-60. doi: 10.1016/0960-0760(92)90323-B. Review.

PMID:
22217840
31.

Activity of the CYP17 promoter in bovine adrenocortical cells before and after phenotypic switching.

Lala DS, Hornsby PJ.

Mol Cell Endocrinol. 1992 Nov;89(1-2):19-24.

PMID:
1338723
32.
33.

Demethylation of specific sites in the 5'-flanking region of the CYP17 genes when bovine adrenocortical cells are placed in culture.

Hornsby PJ, Yang L, Raju SG, Maghsoudlou SS, Lala DS, Nallaseth FS.

DNA Cell Biol. 1992 Jun;11(5):385-95.

PMID:
1605860
34.

A modified procedure for replica plating of mammalian cells allowing selection of clones based on gene expression.

Hornsby PJ, Yang L, Lala DS, Cheng CY, Salmons B.

Biotechniques. 1992 Feb;12(2):244-51.

PMID:
1616718

Supplemental Content

Support Center