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Items: 50

1.

Chronic MeHg exposure modifies the histone H3K4me3 epigenetic landscape in Caenorhabditis elegans.

Rudgalvyte M, Peltonen J, Lakso M, Wong G.

Comp Biochem Physiol C Toxicol Pharmacol. 2017 Jan;191:109-116. doi: 10.1016/j.cbpc.2016.10.001. Epub 2016 Oct 4.

2.

Inhibition of Excessive Oxidative Protein Folding Is Protective in MPP(+) Toxicity-Induced Parkinson's Disease Models.

Lehtonen Š, Jaronen M, Vehviläinen P, Lakso M, Rudgalvyte M, Keksa-Goldsteine V, Wong G, Courtney MJ, Koistinaho J, Goldsteins G.

Antioxid Redox Signal. 2016 Sep 10;25(8):485-97. doi: 10.1089/ars.2015.6402. Epub 2016 Jun 15.

PMID:
27139804
3.

RNA-Seq Reveals Acute Manganese Exposure Increases Endoplasmic Reticulum Related and Lipocalin mRNAs in Caenorhabditis elegans.

Rudgalvyte M, Peltonen J, Lakso M, Nass R, Wong G.

J Biochem Mol Toxicol. 2016 Feb;30(2):97-105. doi: 10.1002/jbt.21768. Epub 2015 Sep 29.

4.

Transcriptional profiling reveals differential expression of a neuropeptide-like protein and pseudogenes in aryl hydrocarbon receptor-1 mutant Caenorhabditis elegans.

Aarnio V, Heikkinen L, Peltonen J, Goldsteins G, Lakso M, Wong G.

Comp Biochem Physiol Part D Genomics Proteomics. 2014 Mar;9:40-8. doi: 10.1016/j.cbd.2013.12.001. Epub 2014 Jan 2.

5.

Methylmercury exposure increases lipocalin related (lpr) and decreases activated in blocked unfolded protein response (abu) genes and specific miRNAs in Caenorhabditis elegans.

Rudgalvyte M, VanDuyn N, Aarnio V, Heikkinen L, Peltonen J, Lakso M, Nass R, Wong G.

Toxicol Lett. 2013 Oct 24;222(2):189-96. doi: 10.1016/j.toxlet.2013.07.014. Epub 2013 Jul 18.

6.

The draft genome and transcriptome of Panagrellus redivivus are shaped by the harsh demands of a free-living lifestyle.

Srinivasan J, Dillman AR, Macchietto MG, Heikkinen L, Lakso M, Fracchia KM, Antoshechkin I, Mortazavi A, Wong G, Sternberg PW.

Genetics. 2013 Apr;193(4):1279-95. doi: 10.1534/genetics.112.148809. Epub 2013 Feb 14.

7.

Chronic ethanol exposure increases cytochrome P-450 and decreases activated in blocked unfolded protein response gene family transcripts in caenorhabditis elegans.

Peltonen J, Aarnio V, Heikkinen L, Lakso M, Wong G.

J Biochem Mol Toxicol. 2013 Mar;27(3):219-28. doi: 10.1002/jbt.21473. Epub 2013 Feb 4.

PMID:
23381935
8.

Caenorhabditis Elegans Mutants Predict Regulation of Fatty Acids and Endocannabinoids by the CYP-35A Gene Family.

Aarnio V, Lehtonen M, Storvik M, Callaway JC, Lakso M, Wong G.

Front Pharmacol. 2011 Mar 18;2:12. doi: 10.3389/fphar.2011.00012. eCollection 2011.

9.

Determination of endocannabinoids in nematodes and human brain tissue by liquid chromatography electrospray ionization tandem mass spectrometry.

Lehtonen M, Storvik M, Malinen H, Hyytiä P, Lakso M, Auriola S, Wong G, Callaway JC.

J Chromatogr B Analyt Technol Biomed Life Sci. 2011 Apr 1;879(11-12):677-94. doi: 10.1016/j.jchromb.2011.02.004. Epub 2011 Feb 28.

PMID:
21367677
10.

Trans fat diet causes decreased brood size and shortened lifespan in Caenorhabditis elegans delta-6-desaturase mutant fat-3.

Reisner K, Lehtonen M, Storvik M, Jantson T, Lakso M, Callaway JC, Wong G.

J Biochem Mol Toxicol. 2011 Sep-Oct;25(5):269-79. doi: 10.1002/jbt.20386. Epub 2011 Feb 9.

PMID:
21308896
11.

Overexpression of SUMO perturbs the growth and development of Caenorhabditis elegans.

Rytinki MM, Lakso M, Pehkonen P, Aarnio V, Reisner K, Peräkylä M, Wong G, Palvimo JJ.

Cell Mol Life Sci. 2011 Oct;68(19):3219-32. doi: 10.1007/s00018-011-0627-4. Epub 2011 Jan 21.

PMID:
21253676
12.

Global microRNA expression profiling of Caenorhabditis elegans Parkinson's disease models.

Asikainen S, Rudgalvyte M, Heikkinen L, Louhiranta K, Lakso M, Wong G, Nass R.

J Mol Neurosci. 2010 May;41(1):210-8. doi: 10.1007/s12031-009-9325-1. Epub 2010 Jan 21.

PMID:
20091141
13.

Fatty acid composition and gene expression profiles are altered in aryl hydrocarbon receptor-1 mutant Caenorhabditis elegans.

Aarnio V, Storvik M, Lehtonen M, Asikainen S, Reisner K, Callaway J, Rudgalvyte M, Lakso M, Wong G.

Comp Biochem Physiol C Toxicol Pharmacol. 2010 Apr;151(3):318-24. doi: 10.1016/j.cbpc.2009.12.006. Epub 2010 Jan 5.

PMID:
20045492
14.

1H MR spectroscopic imaging of phospholipase-mediated membrane lipid release in apoptotic rat glioma in vivo.

Liimatainen TJ, Erkkilä AT, Valonen P, Vidgren H, Lakso M, Wong G, Gröhn OH, Ylä-Herttuala S, Hakumäki JM.

Magn Reson Med. 2008 Jun;59(6):1232-8. doi: 10.1002/mrm.21607.

15.

Whole genome microarray analysis of C. elegans rrf-3 and eri-1 mutants.

Asikainen S, Storvik M, Lakso M, Wong G.

FEBS Lett. 2007 Oct 30;581(26):5050-4. Epub 2007 Sep 29.

16.
17.

Increased lifespan in transgenic Caenorhabditis elegans overexpressing human alpha-synuclein.

Vartiainen S, Aarnio V, Lakso M, Wong G.

Exp Gerontol. 2006 Sep;41(9):871-6. Epub 2006 Jun 19.

PMID:
16782295
18.

Identification of gene expression changes in transgenic C. elegans overexpressing human alpha-synuclein.

Vartiainen S, Pehkonen P, Lakso M, Nass R, Wong G.

Neurobiol Dis. 2006 Jun;22(3):477-86. Epub 2006 Apr 19.

PMID:
16626960
19.

Selective sensitivity of Caenorhabditis elegans neurons to RNA interference.

Asikainen S, Vartiainen S, Lakso M, Nass R, Wong G.

Neuroreport. 2005 Dec 19;16(18):1995-9. Erratum in: Neuroreport. 2006 Feb 6;17(2):230-1.

PMID:
16317341
20.

Overexpression of the full-length neurotrophin receptor trkB regulates the expression of plasticity-related genes in mouse brain.

Koponen E, Lakso M, Castrén E.

Brain Res Mol Brain Res. 2004 Nov 4;130(1-2):81-94.

PMID:
15519679
21.

Identification of genes regulated by memantine and MK-801 in adult rat brain by cDNA microarray analysis.

Marvanová M, Lakso M, Wong G.

Neuropsychopharmacology. 2004 Jun;29(6):1070-9.

22.

Increased expression of beta6-integrin in skin leads to spontaneous development of chronic wounds.

Häkkinen L, Koivisto L, Gardner H, Saarialho-Kere U, Carroll JM, Lakso M, Rauvala H, Laato M, Heino J, Larjava H.

Am J Pathol. 2004 Jan;164(1):229-42.

24.

Dopaminergic neuronal loss and motor deficits in Caenorhabditis elegans overexpressing human alpha-synuclein.

Lakso M, Vartiainen S, Moilanen AM, Sirviö J, Thomas JH, Nass R, Blakely RD, Wong G.

J Neurochem. 2003 Jul;86(1):165-72.

25.

Expression profiling to understand actions of NMDA/glutamate receptor antagonists in rat brain.

Törönen P, Storvik M, Lindén AM, Kontkane O, Marvanová M, Lakso M, Castrén E, Wong G.

Neurochem Res. 2002 Oct;27(10):1209-20.

PMID:
12462419
26.

Antipsychotic drug treatment induces differential gene expression in the rat cortex.

Kontkanen O, Törönen P, Lakso M, Wong G, Castrén E.

J Neurochem. 2002 Dec;83(5):1043-53.

27.

Syndecan-3-deficient mice exhibit enhanced LTP and impaired hippocampus-dependent memory.

Kaksonen M, Pavlov I, Võikar V, Lauri SE, Hienola A, Riekki R, Lakso M, Taira T, Rauvala H.

Mol Cell Neurosci. 2002 Sep;21(1):158-72.

PMID:
12359158
28.

Synexpression analysis of ESTs in the rat brain reveals distinct patterns and potential drug targets.

Marvanová M, Törönen P, Storvik M, Lakso M, Castrén E, Wong G.

Brain Res Mol Brain Res. 2002 Aug 15;104(2):176-83.

PMID:
12225872
29.
30.

The neuroprotective agent memantine induces brain-derived neurotrophic factor and trkB receptor expression in rat brain.

Marvanová M, Lakso M, Pirhonen J, Nawa H, Wong G, Castrén E.

Mol Cell Neurosci. 2001 Sep;18(3):247-58.

PMID:
11591126
31.

Increased expression of neuronal Src and tyrosine phosphorylation of NMDA receptors in rat brain after systemic treatment with MK-801.

Lindén A, Storvik M, Lakso M, Haapasalo A, Lee D, Witkin JM, Sei Y, Castrén E, Wong G.

Neuropharmacology. 2001 Mar;40(4):469-81.

PMID:
11249956
32.

Uncompetitive antagonists of the N-methyl-D-aspartate (NMDA) receptors alter the mRNA expression of proteins associated with the NMDA receptor complex.

Lindén AM, Väsänen J, Storvik M, Lakso M, Korpi ER, Wong G, Castrén E.

Pharmacol Toxicol. 2001 Feb;88(2):98-105.

PMID:
11169168
33.

A functional genomic study of the effects of antipsychotic agent chlorpromazine in PC12 cells.

Kontkanen O, Lakso M, Wong G, Castrén E.

Clin Chem Lab Med. 2000 Sep;38(9):911-5.

PMID:
11097349
35.
36.

Expression of neurotrophins BDNF and NT-3, and their receptors in rat brain after administration of antipsychotic and psychotrophic agents.

Lindén AM, Väisänen J, Lakso M, Nawa H, Wong G, Castrén E.

J Mol Neurosci. 2000 Feb-Apr;14(1-2):27-37.

PMID:
10854034
37.

Regulation of cell fate decision of undifferentiated spermatogonia by GDNF.

Meng X, Lindahl M, Hyvönen ME, Parvinen M, de Rooij DG, Hess MW, Raatikainen-Ahokas A, Sainio K, Rauvala H, Lakso M, Pichel JG, Westphal H, Saarma M, Sariola H.

Science. 2000 Feb 25;287(5457):1489-93.

38.

Excitatory actions of NMDA receptor antagonists in rat entorhinal cortex and cultured entorhinal cortical neurons.

Väisänen J, Lindén AM, Lakso M, Wong G, Heinemann U, Castrén E.

Neuropsychopharmacology. 1999 Jul;21(1):137-46.

39.

Retarded growth and deficits in the enteric and parasympathetic nervous system in mice lacking GFR alpha2, a functional neurturin receptor.

Rossi J, Luukko K, Poteryaev D, Laurikainen A, Sun YF, Laakso T, Eerikäinen S, Tuominen R, Lakso M, Rauvala H, Arumäe U, Pasternack M, Saarma M, Airaksinen MS.

Neuron. 1999 Feb;22(2):243-52.

40.

Overexpression of VEGF in testis and epididymis causes infertility in transgenic mice: evidence for nonendothelial targets for VEGF.

Korpelainen EI, Karkkainen MJ, Tenhunen A, Lakso M, Rauvala H, Vierula M, Parvinen M, Alitalo K.

J Cell Biol. 1998 Dec 14;143(6):1705-12.

41.

Targeted expression of a toxin gene to D1 dopamine receptor neurons by cre-mediated site-specific recombination.

Drago J, Padungchaichot P, Wong JY, Lawrence AJ, McManus JF, Sumarsono SH, Natoli AL, Lakso M, Wreford N, Westphal H, Kola I, Finkelstein DI.

J Neurosci. 1998 Dec 1;18(23):9845-57.

42.

Osteoblast recruitment and bone formation enhanced by cell matrix-associated heparin-binding growth-associated molecule (HB-GAM).

Imai S, Kaksonen M, Raulo E, Kinnunen T, Fages C, Meng X, Lakso M, Rauvala H.

J Cell Biol. 1998 Nov 16;143(4):1113-28.

43.

Hyperplasia of lymphatic vessels in VEGF-C transgenic mice.

Jeltsch M, Kaipainen A, Joukov V, Meng X, Lakso M, Rauvala H, Swartz M, Fukumura D, Jain RK, Alitalo K.

Science. 1997 May 30;276(5317):1423-5. Erratum in: Science 1997 Jul 25;277(5325):463.

44.

Efficient in vivo manipulation of mouse genomic sequences at the zygote stage.

Lakso M, Pichel JG, Gorman JR, Sauer B, Okamoto Y, Lee E, Alt FW, Westphal H.

Proc Natl Acad Sci U S A. 1996 Jun 11;93(12):5860-5.

45.

[Nobel Prize to a supporter of young scientists].

Lakso M, Wong G.

Duodecim. 1994;110(23-24):2184-6. Finnish. No abstract available.

PMID:
8654237
47.

Embryonic expression of nm23 during mouse organogenesis.

Lakso M, Steeg PS, Westphal H.

Cell Growth Differ. 1992 Dec;3(12):873-9.

48.

Targeted oncogene activation by site-specific recombination in transgenic mice.

Lakso M, Sauer B, Mosinger B Jr, Lee EJ, Manning RW, Yu SH, Mulder KL, Westphal H.

Proc Natl Acad Sci U S A. 1992 Jul 15;89(14):6232-6.

49.

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