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Items: 8

1.

Exploiting an Asp-Glu "switch" in glycogen synthase kinase 3 to design paralog-selective inhibitors for use in acute myeloid leukemia.

Wagner FF, Benajiba L, Campbell AJ, Weïwer M, Sacher JR, Gale JP, Ross L, Puissant A, Alexe G, Conway A, Back M, Pikman Y, Galinsky I, DeAngelo DJ, Stone RM, Kaya T, Shi X, Robers MB, Machleidt T, Wilkinson J, Hermine O, Kung A, Stein AJ, Lakshminarasimhan D, Hemann MT, Scolnick E, Zhang YL, Pan JQ, Stegmaier K, Holson EB.

Sci Transl Med. 2018 Mar 7;10(431). pii: eaam8460. doi: 10.1126/scitranslmed.aam8460.

PMID:
29515000
2.

Erratum: Non-homeostatic body weight regulation through a brainstem-restricted receptor for GDF15.

Hsu JY, Crawley S, Chen M, Ayupova DA, Lindhout DA, Higbee J, Kutach A, Joo W, Gao Z, Fu D, To C, Mondal K, Li B, Kekatpure A, Wang M, Laird T, Horner G, Chan J, McEntee M, Lopez M, Lakshminarasimhan D, White A, Wang SP, Yao J, Yie J, Matern H, Solloway M, Haldankar R, Parsons T, Tang J, Shen WD, Alice Chen Y, Tian H, Allan BB.

Nature. 2017 Nov 16;551(7680):398. doi: 10.1038/nature24481. Epub 2017 Nov 8.

PMID:
29144449
3.

Non-homeostatic body weight regulation through a brainstem-restricted receptor for GDF15.

Hsu JY, Crawley S, Chen M, Ayupova DA, Lindhout DA, Higbee J, Kutach A, Joo W, Gao Z, Fu D, To C, Mondal K, Li B, Kekatpure A, Wang M, Laird T, Horner G, Chan J, McEntee M, Lopez M, Lakshminarasimhan D, White A, Wang SP, Yao J, Yie J, Matern H, Solloway M, Haldankar R, Parsons T, Tang J, Shen WD, Alice Chen Y, Tian H, Allan BB.

Nature. 2017 Oct 12;550(7675):255-259. doi: 10.1038/nature24042. Epub 2017 Sep 27. Erratum in: Nature. 2017 Nov 16;551(7680):398.

PMID:
28953886
4.

Crystal structure of a mutant glycosylasparaginase shedding light on aspartylglycosaminuria-causing mechanism as well as on hydrolysis of non-chitobiose substrate.

Pande S, Lakshminarasimhan D, Guo HC.

Mol Genet Metab. 2017 Jun;121(2):150-156. doi: 10.1016/j.ymgme.2017.04.008. Epub 2017 Apr 19.

5.

Discovery of a new chemical series of BRD4(1) inhibitors using protein-ligand docking and structure-guided design.

Duffy BC, Liu S, Martin GS, Wang R, Hsia MM, Zhao H, Guo C, Ellis M, Quinn JF, Kharenko OA, Norek K, Gesner EM, Young PR, McLure KG, Wagner GS, Lakshminarasimhan D, White A, Suto RK, Hansen HC, Kitchen DB.

Bioorg Med Chem Lett. 2015 Jul 15;25(14):2818-23. doi: 10.1016/j.bmcl.2015.04.107. Epub 2015 May 11.

PMID:
26022843
6.

Structural basis of a point mutation that causes the genetic disease aspartylglucosaminuria.

Sui L, Lakshminarasimhan D, Pande S, Guo HC.

Structure. 2014 Dec 2;22(12):1855-1861. doi: 10.1016/j.str.2014.09.014. Epub 2014 Nov 13.

7.

Structural insights into the molecular ruler mechanism of the endoplasmic reticulum aminopeptidase ERAP1.

Gandhi A, Lakshminarasimhan D, Sun Y, Guo HC.

Sci Rep. 2011;1:186. doi: 10.1038/srep00186. Epub 2011 Dec 13.

8.

Structure of YqgQ protein from Bacillus subtilis, a conserved hypothetical protein.

Lakshminarasimhan D, Eswaramoorthy S, Burley SK, Swaminathan S.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Jan 1;66(Pt 1):8-11. doi: 10.1107/S1744309109047009. Epub 2009 Dec 25.

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