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Items: 1 to 50 of 58

1.

Aldehyde adducts inhibit 3,4-dihydroxyphenylacetaldehyde-induced α-synuclein aggregation and toxicity: Implication for Parkinson neuroprotective therapy.

Kumar VB, Hsu FF, Lakshmi VM, Gillespie KN, Burke WJ.

Eur J Pharmacol. 2019 Feb 15;845:65-73. doi: 10.1016/j.ejphar.2018.12.027. Epub 2018 Dec 21.

PMID:
30579934

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2.

Social capital as a mediator of the influence of socioeconomic position on health: Findings from a population-based cross-sectional study in Chandigarh, India.

Kaur M, Chakrapani V, Newtonraj A, Lakshmi PV, Vijin PP.

Indian J Public Health. 2018 Oct-Dec;62(4):294-298. doi: 10.4103/ijph.IJPH_274_17.

PMID:
30539892
Free Article

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3.

Effectiveness of Muskaan Ek Abhiyan (the smile campaign) for strengthening routine immunization in bihar, India.

Goel S, Dogra V, Gupta SK, Lakshmi PV, Varkey S, Pradhan N, Krishna G, Kumar R.

Indian Pediatr. 2012 Feb;49(2):103-8. Epub 2011 Mar 15.

PMID:
21555801
Free Article

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4.

Characterization of new metabolites from in vivo biotransformation of 2-amino-3-methylimidazo[4,5-f]quinoline in mouse by mass spectrometry.

Hsu FF, Lakshmi VM, Zenser TV.

J Mass Spectrom. 2009 Sep;44(9):1359-68. doi: 10.1002/jms.1620.

PMID:
19629964
Free PMC Article

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5.

Identification of new 2-amino-3-methylimidazo[4,5-f]quinoline urinary metabolites from beta-naphthoflavone-treated mice.

Lakshmi VM, Hsu FF, Zenser TV.

Drug Metab Dispos. 2009 Aug;37(8):1690-7. doi: 10.1124/dmd.109.027342. Epub 2009 May 18.

PMID:
19451400
Free PMC Article

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6.

Activation of aminoimidazole carcinogens by nitrosation: mutagenicity and nucleotide adducts.

Zenser TV, Lakshmi VM, Schut HA, Zhou HJ, Josephy P.

Mutat Res. 2009 Mar 17;673(2):109-15.

PMID:
19449459
Free PMC Article

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7.

N-Demethylation is a major route of 2-amino-3-methylimidazo[4,5-f]quinoline metabolism in mouse.

Lakshmi VM, Hsu FF, Zenser TV.

Drug Metab Dispos. 2008 Jun;36(6):1143-52. doi: 10.1124/dmd.107.019166. Epub 2008 Mar 20.

PMID:
18356269
Free PMC Article

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8.

Metabolism of a heterocyclic amine colon carcinogen in young and old rats.

Armbrecht HJ, Lakshmi VM, Wickstra J, Hsu FF, Zenser TV.

Drug Metab Dispos. 2007 Apr;35(4):633-9. Epub 2007 Jan 24.

PMID:
17251306

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9.

2-(4-Carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide potentiates nitrosation of a heterocyclic amine carcinogen by nitric oxide.

Lakshmi VM, Zenser TV.

Life Sci. 2007 Jan 23;80(7):644-9. Epub 2006 Nov 28.

PMID:
17129590

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10.

Stability and reactivity of 2-nitrosoamino-3,8-dimethylimidazo[4,5-f]quinoxaline.

Lakshmi VM, Hsu FF, Schut HA, Zenser TV.

Chem Res Toxicol. 2006 Feb;19(2):325-33.

PMID:
16485910
Free PMC Article

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11.

2-Nitrosoamino-3-methylimidazo[4,5-f]quinoline activated by the inflammatory response forms nucleotide adducts.

Lakshmi VM, Schut HA, Zenser TV.

Food Chem Toxicol. 2005 Nov;43(11):1607-17.

PMID:
15964673

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12.

Nitric oxide-mediated nitrosation of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline potentiated by hemin and myeloperoxidase.

Lakshmi VM, Hsu FF, Zenser TV.

Chem Res Toxicol. 2005 Jun;18(6):1038-47.

PMID:
15962939

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13.

Hemin potentiates nitric oxide-mediated nitrosation of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) to 2-nitrosoamino-3-methylimidazo[4,5-f]quinoline.

Lakshmi VM, Clapper ML, Chang WC, Zenser TV.

Chem Res Toxicol. 2005 Mar;18(3):528-35.

PMID:
15777093

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14.

Myeloperoxidase potentiates nitric oxide-mediated nitrosation.

Lakshmi VM, Nauseef WM, Zenser TV.

J Biol Chem. 2005 Jan 21;280(3):1746-53. Epub 2004 Nov 5.

PMID:
15531583
Free Article

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15.

2-Nitrosoamino-3-methylimidazo[4,5-f]quinoline stability and reactivity.

Lakshmi VM, Hsu FF, Zenser TV.

Chem Res Toxicol. 2004 May;17(5):709-16.

PMID:
15144229

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16.

Transformation and activation of benzidine by oxidants of the inflammatory response.

Lakshmi VM, Hsu FF, Zenser TV.

Chem Res Toxicol. 2003 Mar;16(3):367-74.

PMID:
12641437

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17.

Metabolism of N-acetylbenzidine and initiation of bladder cancer.

Zenser TV, Lakshmi VM, Hsu FF, Davis BB.

Mutat Res. 2002 Sep 30;506-507:29-40. Review.

PMID:
12351142

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18.

Nitrosation and nitration of 2-amino-3-methylimidazo[4,5-f]quinoline by reactive nitrogen oxygen species.

Lakshmi VM, Hsu FF, Zenser TV.

Chem Res Toxicol. 2002 Aug;15(8):1059-68.

PMID:
12184790

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19.

Methemoglobin oxidation of N-acetylbenzidine to form a sulfinamide.

Zenser TV, Lakshmi VM, Hsu FF, Davis BB.

Drug Metab Dispos. 2001 Apr;29(4 Pt 1):401-6.

PMID:
11259323

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20.

Reactive nitrogen oxygen species metabolize N-acetylbenzidine.

Lakshmi VM, Hsu FF, Davis BB, Zenser TV.

Chem Res Toxicol. 2001 Mar;14(3):312-8.

PMID:
11258981

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21.

Nitrating reactive nitric oxygen species transform acetaminophen to 3-nitroacetaminophen.

Lakshmi VM, Hsu FF, Davis BB, Zenser TV.

Chem Res Toxicol. 2000 Sep;13(9):891-9.

PMID:
10995262

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22.

N-Acetylbenzidine-DNA adduct formation by phorbol 12-myristate-stimulated human polymorphonuclear neutrophils.

Lakshmi VM, Hsu FF, Davis BB, Zenser TV.

Chem Res Toxicol. 2000 Aug;13(8):785-92.

PMID:
10956067

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23.

Hypochlorous acid-mediated activation of N-acetylbenzidine to form N'-(3'-monophospho-deoxyguanosin-8-yl)-N-acetylbenzidine.

Lakshmi VM, Hsu FF, McGarry AE, Davis BB, Zenser TV.

Toxicol Sci. 2000 Feb;53(2):202-12.

PMID:
10696768

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24.

Sulfinamide formation following peroxidatic metabolism of N-acetylbenzidine.

Lakshmi VM, Hsu FF, Davis BB, Zenser TV.

Chem Res Toxicol. 2000 Feb;13(2):96-102.

PMID:
10688533

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25.

Glucuronidation of benzidine and its metabolites by cDNA-expressed human UDP-glucuronosyltransferases and pH stability of glucuronides.

Ciotti M, Lakshmi VM, Basu N, Davis BB, Owens IS, Zenser TV.

Carcinogenesis. 1999 Oct;20(10):1963-9.

PMID:
10506112

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26.

Human and Escherichia coli beta-glucuronidase hydrolysis of glucuronide conjugates of benzidine and 4-aminobiphenyl, and their hydroxy metabolites.

Zenser TV, Lakshmi VM, Davis BB.

Drug Metab Dispos. 1999 Sep;27(9):1064-7.

PMID:
10460807

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27.

Peroxygenase metabolism of N-acetylbenzidine by prostaglandin H synthase. Formation of an N-hydroxylamine.

Zenser TV, Lakshmi VM, Hsu FF, Davis BB.

J Biol Chem. 1999 May 21;274(21):14850-6.

PMID:
10329684
Free Article

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28.

N-glucuronidation of benzidine and its metabolites. Role in bladder cancer.

Zenser TV, Lakshmi VM, Davis BB.

Drug Metab Dispos. 1998 Sep;26(9):856-9. Review.

PMID:
9733663

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29.

N'-(3'-monophospho-deoxyguanosin-8-yl)-N-acetylbenzidine formation by peroxidative metabolism.

Lakshmi VM, Zenser TV, Davis BB.

Carcinogenesis. 1998 May;19(5):911-7.

PMID:
9635882

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30.

Acidic urine pH is associated with elevated levels of free urinary benzidine and N-acetylbenzidine and urothelial cell DNA adducts in exposed workers.

Rothman N, Talaska G, Hayes RB, Bhatnagar VK, Bell DA, Lakshmi VM, Kashyap SK, Dosemeci M, Kashyap R, Hsu FF, Jaeger M, Hirvonen A, Parikh DJ, Davis BB, Zenser TV.

Cancer Epidemiol Biomarkers Prev. 1997 Dec;6(12):1039-42.

PMID:
9419400
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31.

Benzidine-DNA adduct levels in human peripheral white blood cells significantly correlate with levels in exfoliated urothelial cells.

Zhou Q, Talaska G, Jaeger M, Bhatnagar VK, Hayes RB, Zenzer TV, Kashyap SK, Lakshmi VM, Kashyap R, Dosemeci M, Hsu FF, Parikh DJ, Davis B, Rothman N.

Mutat Res. 1997 Oct 24;393(3):199-205.

PMID:
9393612

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32.

Rat liver cytochrome P450 metabolism of N-acetylbenzidine and N,N'-diacetylbenzidine.

Lakshmi VM, Zenser TV, Davis BB.

Drug Metab Dispos. 1997 Apr;25(4):481-8.

PMID:
9107548

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33.

The glutathione S-transferase M1 (GSTM1) null genotype and benzidine-associated bladder cancer, urine mutagenicity, and exfoliated urothelial cell DNA adducts.

Rothman N, Hayes RB, Zenser TV, DeMarini DM, Bi W, Hirvonen A, Talaska G, Bhatnagar VK, Caporaso NE, Brooks LR, Lakshmi VM, Feng P, Kashyap SK, You X, Eischen BT, Kashyap R, Shelton ML, Hsu FF, Jaeger M, Parikh DJ, Davis BB, Yin S, Bell DA.

Cancer Epidemiol Biomarkers Prev. 1996 Dec;5(12):979-83.

PMID:
8959320
Free Article

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34.

NADPH-dependent oxidation of benzidine by rat liver.

Lakshmi VM, Zenser NT, Hsu FF, Mattammal MB, Zenser TV, Davis BB.

Carcinogenesis. 1996 Sep;17(9):1941-7.

PMID:
8824518

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35.

Human N-acetylation of benzidine: role of NAT1 and NAT2.

Zenser TV, Lakshmi VM, Rustan TD, Doll MA, Deitz AC, Davis BB, Hein DW.

Cancer Res. 1996 Sep 1;56(17):3941-7.

PMID:
8752161
Free Article

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36.

Glucuronide conjugates of 4-aminobiphenyl and its N-hydroxy metabolites. pH stability and synthesis by human and dog liver.

Babu SR, Lakshmi VM, Huang GP, Zenser TV, Davis BB.

Biochem Pharmacol. 1996 Jun 28;51(12):1679-85.

PMID:
8687483

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37.

Glucuronidation of N-hydroxy metabolites of N-acetylbenzidine.

Babu SR, Lakshmi VM, Hsu FF, Zenser TV, Davis BB.

Carcinogenesis. 1995 Dec;16(12):3069-74.

PMID:
8603487

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38.

N-acetylbenzidine and N,N'-diacetylbenzidine formation by rat and human liver slices exposed to benzidine.

Lakshmi VM, Bell DA, Watson MA, Zenser TV, Davis BB.

Carcinogenesis. 1995 Jul;16(7):1565-71.

PMID:
7614690

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39.

The role of acetylation in benzidine metabolism and DNA adduct formation in dog and rat liver.

Lakshmi VM, Zenser TV, Goldman HD, Spencer GG, Gupta RC, Hsu FF, Davis BB.

Chem Res Toxicol. 1995 Jul-Aug;8(5):711-20.

PMID:
7548754

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40.

Prostaglandin H synthetase-mediated metabolism of dopamine: implication for Parkinson's disease.

Mattammal MB, Strong R, Lakshmi VM, Chung HD, Stephenson AH.

J Neurochem. 1995 Apr;64(4):1645-54.

PMID:
7891092

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41.

Glucuronidation of N-acetylbenzidine by human liver.

Babu SR, Lakshmi VM, Zenser TV, Davis BB.

Drug Metab Dispos. 1994 Nov-Dec;22(6):922-7.

PMID:
7895611

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42.

Human liver glucuronidation of benzidine.

Babu SR, Lakshmi VM, Owens IS, Zenser TV, Davis BB.

Carcinogenesis. 1994 Sep;15(9):2003-7.

PMID:
7923596

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43.

Mechanism of 3-(glutathion-S-yl)-benzidine formation.

Lakshmi VM, Zenser TV, Davis BB.

Toxicol Appl Pharmacol. 1994 Apr;125(2):256-63.

PMID:
8171433

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44.

N-acetylbenzidine-N'-glucuronidation by human, dog and rat liver.

Babu SR, Lakshmi VM, Hsu FF, Kane RE, Zenser TV, Davis BB.

Carcinogenesis. 1993 Dec;14(12):2605-11.

PMID:
8269633

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45.

Phenylbutazone peroxidatic metabolism and conjugation.

Lakshmi VM, Zenser TV, Mattammal MB, Davis BB.

J Pharmacol Exp Ther. 1993 Jul;266(1):81-8.

PMID:
8331577

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46.

Liver NADPH-dependent oxidation of the 5-nitrofurans, FANFT and ANFT, by guinea pig and rat.

Dawley RM, Lakshmi VM, Babu SR, Zenser TV, Davis BB.

Xenobiotica. 1993 Feb;23(2):193-203.

PMID:
8498082

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47.

Mechanism of formation of the thioether conjugate of the bladder carcinogen 2-amino-4-(5-nitro-2-furyl)-thiazole (ANFT).

Lakshmi VM, Zenser TV, Sohani S, Davis BB.

Carcinogenesis. 1992 Nov;13(11):2087-93.

PMID:
1423880

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48.

Role of N-glucuronidation in benzidine-induced bladder cancer in dog.

Babu SR, Lakshmi VM, Hsu FF, Zenser TV, Davis BB.

Carcinogenesis. 1992 Jul;13(7):1235-40.

PMID:
1638692

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49.

Metabolism and disposition of bladder carcinogens in rat and guinea pig: possible mechanism of guinea pig resistance to bladder cancer.

Dawley RM, Zenser TV, Mattammal MB, Lakshmi VM, Hsu FF, Davis BB.

Cancer Res. 1991 Jan 15;51(2):514-20.

PMID:
1898713
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50.

Mechanism of peroxidative activation of the bladder carcinogen 2-amino-4-(5-nitro-2-furyl)-thiazole (ANFT): comparison with benzidine.

Lakshmi VM, Mattammal MB, Zenser TV, Davis BB.

Carcinogenesis. 1990 Nov;11(11):1965-70.

PMID:
2121382

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