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When nucleoside chemistry met hypervalent iodine reagents.

Lakshman MK, Zajc B.

ARKIVOC. 2018;2018(Pt II):252-279. doi: 10.24820/ark.5550190.p010.281. Epub 2017 Dec 21.


Ethanol targets nucleoredoxin/dishevelled interactions and stimulates phosphatidylinositol 4-phosphate production in vivo and in vitro.

Arellanes-Robledo J, Reyes-Gordillo K, Ibrahim J, Leckey L, Shah R, Lakshman MR.

Biochem Pharmacol. 2018 Aug 18;156:135-146. doi: 10.1016/j.bcp.2018.08.021. [Epub ahead of print]


Thymosin β4 Prevents Oxidative Stress, Inflammation, and Fibrosis in Ethanol- and LPS-Induced Liver Injury in Mice.

Shah R, Reyes-Gordillo K, Cheng Y, Varatharajalu R, Ibrahim J, Lakshman MR.

Oxid Med Cell Longev. 2018 Jul 11;2018:9630175. doi: 10.1155/2018/9630175. eCollection 2018.


Management Practices to Build Evidence-Based Decision-Making Capacity for Chronic Disease Prevention in Georgia: A Case Study.

Allen P, O'Connor JC, Best LA, Lakshman M, Jacob RR, Brownson RC.

Prev Chronic Dis. 2018 Jul 12;15:E92. doi: 10.5888/pcd15.170482.


Pd-catalyzed versus uncatalyzed, PhI(OAc)2-mediated cyclization reactions of N6-([1,1'-biaryl]-2-yl)adenine nucleosides.

Satishkumar S, Poudapally S, Vuram PK, Gurram V, Pottabathini N, Sebastian D, Yang L, Pradhan P, Lakshman MK.

ChemCatChem. 2017 Nov 9;9(21):4058-4069. doi: 10.1002/cctc.201700918. Epub 2017 Oct 24.


Lessons Learned in Promoting Evidence-Based Public Health: Perspectives from Managers in State Public Health Departments.

Allen P, Jacob RR, Lakshman M, Best LA, Bass K, Brownson RC.

J Community Health. 2018 Oct;43(5):856-863. doi: 10.1007/s10900-018-0494-0.


A Review of Evidence Based Treatments for Transgender Youth Diagnosed with Social Anxiety Disorder.

Busa S, Janssen A, Lakshman M.

Transgend Health. 2018 Feb 1;3(1):27-33. doi: 10.1089/trgh.2017.0037. eCollection 2018. Review.


Controlling Chronic Diseases Through Evidence-Based Decision Making: A Group-Randomized Trial.

Brownson RC, Allen P, Jacob RR, deRuyter A, Lakshman M, Reis RS, Yan Y.

Prev Chronic Dis. 2017 Nov 30;14:E121. doi: 10.5888/pcd14.170326.


Cross-dehydrogenative coupling and oxidative-amination reactions of ethers and alcohols with aromatics and heteroaromatics.

Lakshman MK, Vuram PK.

Chem Sci. 2017 Sep 1;8(9):5845-5888. doi: 10.1039/c7sc01045a. Epub 2017 Jun 30.


KHF2, a mild and selective desilylating agent for phenol t-butyldimethylsilyl (TBDMS) ethers.

Lakshman MK, Tine FA, Khandaker TA, Basava V, Agyemang NB, Benavidez MSA, Gaši M, Guerrera L, Zajc B.

Synlett. 2017 Mar;28(3):381-385. doi: 10.1055/s-0036-1588350. Epub 2016 Nov 17.


Low-ω3 Fatty Acid and Soy Protein Attenuate Alcohol-Induced Fatty Liver and Injury by Regulating the Opposing Lipid Oxidation and Lipogenic Signaling Pathways.

Reyes-Gordillo K, Shah R, Varatharajalu R, Garige M, Leckey LC, Lakshman MR.

Oxid Med Cell Longev. 2016;2016:1840513. doi: 10.1155/2016/1840513. Epub 2016 Dec 18.


Benzimidazopurine nucleosides from N6-aryl adenosine derivatives by PhI(OAc)2-mediated C-N bond formation, no metal needed.

Satishkumar S, Lakshman MK.

Chem Commun (Camb). 2017 Feb 14;53(14):2226-2229. doi: 10.1039/c6cc07722f.


Ruthenium-Catalyzed C-H Bond Activation Approach to Azolyl Aminals and Hemiaminal Ethers, Mechanistic Evaluations, and Isomer Interconversion.

Singh MK, Akula HK, Satishkumar S, Stahl L, Lakshman MK.

ACS Catal. 2016 Mar 4;6(3):1921-1928. Epub 2016 Feb 18.


A novel bis(pinacolato)diboron-mediated N-O bond deoxygenative route to C6 benzotriazolyl purine nucleoside derivatives.

Basava V, Yang L, Pradhan P, Lakshman MK.

Org Biomol Chem. 2016 Aug 7;14(29):7069-83. doi: 10.1039/c6ob01170e. Epub 2016 Jul 5.


Protective Role of Dietary Curcumin in the Prevention of the Oxidative Stress Induced by Chronic Alcohol with respect to Hepatic Injury and Antiatherogenic Markers.

Varatharajalu R, Garige M, Leckey LC, Reyes-Gordillo K, Shah R, Lakshman MR.

Oxid Med Cell Longev. 2016;2016:5017460. doi: 10.1155/2016/5017460. Epub 2016 Jan 5.


Cladribine Analogues via O⁶-(Benzotriazolyl) Derivatives of Guanine Nucleosides.

Satishkumar S, Vuram PK, Relangi SS, Gurram V, Zhou H, Kreitman RJ, Montemayor MM, Yang L, Kaliyaperumal M, Sharma S, Pottabathini N, Lakshman MK.

Molecules. 2015 Oct 9;20(10):18437-63. doi: 10.3390/molecules201018437.


Reply re: "Electron Microscopic Features of Nasal Mucosa Treated with Topical and Circumostial Injection of Mitomycin-C: Implications in Dacryocystorhinostomy".

Ali MJ, Baig F, Lakshman M, Naik MN.

Ophthalmic Plast Reconstr Surg. 2015 Nov-Dec;31(6):490. doi: 10.1097/IOP.0000000000000560. No abstract available.


Cladribine Analogues via O⁶-(Benzotriazolyl) Derivatives of Guanine Nucleosides.

Satishkumar S, Vuram PK, Relangi SS, Gurram V, Zhou H, Kreitman RJ, Martínez Montemayor MM, Yang L, Kaliyaperumal M, Sharma S, Pottabathini N, Lakshman MK.

Molecules. 2015 Oct 9;20(10):18437-63. doi: 10.3390/molecules201018437.


Novel modulators of hepatosteatosis, inflammation and fibrogenesis.

Lakshman MR, Reyes-Gordillo K, Varatharajalu R, Arellanes-Robledo J, Leckey LC, Garige M, Shah R.

Hepatol Int. 2014 Sep;8 Suppl 2:413-20. doi: 10.1007/s12072-014-9526-8. Epub 2014 Mar 26.


Modular, Metal-Catalyzed Cycloisomerization Approach to Angularly Fused Polycyclic Aromatic Hydrocarbons and Their Oxidized Derivatives.

Thomson PF, Parrish D, Pradhan P, Lakshman MK.

J Org Chem. 2015 Aug 7;80(15):7435-46. doi: 10.1021/acs.joc.5b00931. Epub 2015 Jul 21.


Scanning Electron Microscopic Features of the External and Internal Surfaces of Normal Adult Lacrimal Drainage System.

Ali MJ, Baig F, Lakshman M, Naik MN.

Ophthalmic Plast Reconstr Surg. 2015 Sep-Oct;31(5):414-7. doi: 10.1097/IOP.0000000000000489.


Mild and General Access to Diverse 1H-Benzotriazoles via Diboron-Mediated N-OH Deoxygenation and Palladium-Catalyzed C-C and C-N Bond Formation.

Gurram V, Akula HK, Garlapati R, Pottabathini N, Lakshman MK.

Adv Synth Catal. 2015 Feb 9;357(2-3):451-462.


Scanning Electron Microscopic Features of Nasolacrimal Silastic Stents Retained for Prolong Durations Following Dacryocystorhinostomy.

Ali MJ, Baig F, Lakshman M, Naik MN.

Ophthalmic Plast Reconstr Surg. 2016 Jan-Feb;32(1):20-3. doi: 10.1097/IOP.0000000000000395.


Biofilms and Physical Deposits on Nasolacrimal Silastic Stents Following Dacryocystorhinostomy: Is There a Difference Between Ocular and Nasal Segments?

Ali MJ, Baig F, Lakshman M, Naik MN.

Ophthalmic Plast Reconstr Surg. 2015 Nov-Dec;31(6):452-5. doi: 10.1097/IOP.0000000000000383.


Cycloaddition of Arynes and Cyclic Enol Ethers as a Platform for Access to Stereochemically Defined 1,2-Disubstituted Benzocyclobutenes.

Yedulla VR, Pradhan P, Yang L, Lakshman MK.

European J Org Chem. 2015 Feb;2015(4):750-764. Epub 2014 Dec 22.


Facile synthesis of 1-alkoxy-1H-benzo- and 7-azabenzotriazoles from peptide coupling agents, mechanistic studies, and synthetic applications.

Lakshman MK, Singh MK, Kumar M, Chamala RR, Yedulla VR, Wagner D, Leung E, Yang L, Matin A, Ahmad S.

Beilstein J Org Chem. 2014 Aug 19;10:1919-32. doi: 10.3762/bjoc.10.200. eCollection 2014.


Electron microscopic features of nasal mucosa treated with topical and circumostial injection of mitomycin C: implications in dacryocystorhinostomy.

Ali MJ, Baig F, Lakshman M, Naik MN.

Ophthalmic Plast Reconstr Surg. 2015 Mar-Apr;31(2):103-7. doi: 10.1097/IOP.0000000000000205.


Punctal stenosis: histopathology, immunology, and electron microscopic features-a step toward unraveling the mysterious etiopathogenesis.

Ali MJ, Mishra DK, Baig F, Lakshman M, Naik MN.

Ophthalmic Plast Reconstr Surg. 2015 Mar-Apr;31(2):98-102. doi: 10.1097/IOP.0000000000000204.


Adverse signaling of scavenger receptor class B1 and PGC1s in alcoholic hepatosteatosis and steatohepatitis and protection by betaine in rat.

Varatharajalu R, Garige M, Leckey LC, Arellanes-Robledo J, Reyes-Gordillo K, Shah R, Lakshman MR.

Am J Pathol. 2014 Jul;184(7):2035-44. doi: 10.1016/j.ajpath.2014.03.005. Epub 2014 May 6.


Mechanisms of action of acetaldehyde in the up-regulation of the human α2(I) collagen gene in hepatic stellate cells: key roles of Ski, SMAD3, SMAD4, and SMAD7.

Reyes-Gordillo K, Shah R, Arellanes-Robledo J, Hernández-Nazara Z, Rincón-Sánchez AR, Inagaki Y, Rojkind M, Lakshman MR.

Am J Pathol. 2014 May;184(5):1458-67. doi: 10.1016/j.ajpath.2014.01.020. Epub 2014 Mar 15.


TGF-β1 up-regulates the expression of PDGF-β receptor mRNA and induces a delayed PI3K-, AKT-, and p70(S6K) -dependent proliferative response in activated hepatic stellate cells.

Shah R, Reyes-Gordillo K, Arellanes-Robledo J, Lechuga CG, Hernández-Nazara Z, Cotty A, Rojkind M, Lakshman MR.

Alcohol Clin Exp Res. 2013 Nov;37(11):1838-48. doi: 10.1111/acer.12167. Epub 2013 Jul 29.


Fibrogenic actions of acetaldehyde are β-catenin dependent but Wingless independent: a critical role of nucleoredoxin and reactive oxygen species in human hepatic stellate cells.

Arellanes-Robledo J, Reyes-Gordillo K, Shah R, Domínguez-Rosales JA, Hernández-Nazara ZH, Ramirez F, Rojkind M, Lakshman MR.

Free Radic Biol Med. 2013 Dec;65:1487-1496. doi: 10.1016/j.freeradbiomed.2013.07.017. Epub 2013 Jul 20.


Purinyl N1-directed aromatic C-H oxidation in 6-arylpurines and 6-arylpurine nucleosides.

Chamala RR, Parrish D, Pradhan P, Lakshman MK.

J Org Chem. 2013 Aug 2;78(15):7423-35. doi: 10.1021/jo4008282. Epub 2013 Jul 11.


Evaluation of the protective role of vitamin C in imidacloprid-induced hepatotoxicity in male Albino rats.

Soujanya S, Lakshman M, Kumar AA, Reddy AG.

J Nat Sci Biol Med. 2013 Jan;4(1):63-7. doi: 10.4103/0976-9668.107262.


CYP2E1, oxidative stress, post-translational modifications and lipid metabolism.

Lakshman MR, Garige M, Gong MA, Leckey L, Varatharajalu R, Redman RS, Seth D, Haber PS, Hirsch K, Amdur R, Shah R.

Subcell Biochem. 2013;67:199-233. doi: 10.1007/978-94-007-5881-0_7. Review.


Protective effects of thymosin β4 on carbon tetrachloride-induced acute hepatotoxicity in rats.

Reyes-Gordillo K, Shah R, Arellanes-Robledo J, Rojkind M, Lakshman MR.

Ann N Y Acad Sci. 2012 Oct;1269:61-8. doi: 10.1111/j.1749-6632.2012.06728.x.


Synthesis of deuterated 1,2,3-triazoles.

Akula HK, Lakshman MK.

J Org Chem. 2012 Oct 19;77(20):8896-904. doi: 10.1021/jo301146j. Epub 2012 Sep 27.


Synthesis and biological properties of C-2 triazolylinosine derivatives.

Lakshman MK, Kumar A, Balachandran R, Day BW, Andrei G, Snoeck R, Balzarini J.

J Org Chem. 2012 Jul 20;77(14):5870-83. doi: 10.1021/jo300628y. Epub 2012 Jul 3.


Two-step, one-pot synthesis of inosine, guanosine, and 2'-deoxyguanosine O6-ethers via intermediate O6-(benzotriazol-1-yl) derivatives.

Kokatla HP, Lakshman MK.

Curr Protoc Nucleic Acid Chem. 2012 Jun;Chapter 1:Unit1.26. doi: 10.1002/0471142700.nc0126s49.


C-C cross-coupling reactions of O6-alkyl-2-haloinosine derivatives and a one-pot cross-coupling/O6-deprotection procedure.

Gurram V, Pottabathini N, Garlapati R, Chaudhary AB, Patro B, Lakshman MK.

Chem Asian J. 2012 Aug;7(8):1853-61. doi: 10.1002/asia.201200093. Epub 2012 May 8.


Direct arylation of 6-phenylpurine and 6-arylpurine nucleosides by ruthenium-catalyzed C-H bond activation.

Lakshman MK, Deb AC, Chamala RR, Pradhan P, Pratap R.

Angew Chem Int Ed Engl. 2011 Nov 25;50(48):11400-4. doi: 10.1002/anie.201104035. Epub 2011 Sep 28. No abstract available.


Palladium-Catalyzed Aryl Amination Reactions of 6-Bromo- and 6-Chloropurine Nucleosides.

Thomson PF, Lagisetty P, Balzarini J, De Clercq E, Lakshman MK.

Adv Synth Catal. 2010 Jul 5;352(10):1728-1735.


Reduction of amine N-oxides by diboron reagents.

Kokatla HP, Thomson PF, Bae S, Doddi VR, Lakshman MK.

J Org Chem. 2011 Oct 7;76(19):7842-8. doi: 10.1021/jo201192c. Epub 2011 Aug 31.


Analysis of mitochondrial genome revealed a rare 50 bp deletion and substitutions in a family with hypertension.

Elango S, Govindaraj P, Vishwanadha VP, Reddy AG, Tamang R, Muthusami U, Kunnoth S, Koyilil VK, Lakshman M, Shanmugasundharam N, Singh L, Thangaraj K.

Mitochondrion. 2011 Nov;11(6):878-85. doi: 10.1016/j.mito.2011.07.002. Epub 2011 Jul 20.


Endoglin suppresses human prostate cancer metastasis.

Lakshman M, Huang X, Ananthanarayanan V, Jovanovic B, Liu Y, Craft CS, Romero D, Vary CP, Bergan RC.

Clin Exp Metastasis. 2011 Jan;28(1):39-53. doi: 10.1007/s10585-010-9356-6. Epub 2010 Oct 28.


Contextual synthetic lethality of cancer cell kill based on the tumor microenvironment.

Chan N, Pires IM, Bencokova Z, Coackley C, Luoto KR, Bhogal N, Lakshman M, Gottipati P, Oliver FJ, Helleday T, Hammond EM, Bristow RG.

Cancer Res. 2010 Oct 15;70(20):8045-54. doi: 10.1158/0008-5472.CAN-10-2352. Epub 2010 Oct 5.


One-pot etherification of purine nucleosides and pyrimidines.

Kokatla HP, Lakshman MK.

Org Lett. 2010 Oct 15;12(20):4478-81. doi: 10.1021/ol101655h.

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