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Items: 10

1.

Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression.

Laklai H, Miroshnikova YA, Pickup MW, Collisson EA, Kim GE, Barrett AS, Hill RC, Lakins JN, Schlaepfer DD, Mouw JK, LeBleu VS, Roy N, Novitskiy SV, Johansen JS, Poli V, Kalluri R, Iacobuzio-Donahue CA, Wood LD, Hebrok M, Hansen K, Moses HL, Weaver VM.

Nat Med. 2016 May;22(5):497-505. doi: 10.1038/nm.4082. Epub 2016 Apr 18.

2.

Force Matters: Biomechanical Regulation of Cell Invasion and Migration in Disease.

Kai F, Laklai H, Weaver VM.

Trends Cell Biol. 2016 Jul;26(7):486-497. doi: 10.1016/j.tcb.2016.03.007. Epub 2016 Apr 4. Review.

3.

Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival.

Özdemir BC, Pentcheva-Hoang T, Carstens JL, Zheng X, Wu CC, Simpson TR, Laklai H, Sugimoto H, Kahlert C, Novitskiy SV, De Jesus-Acosta A, Sharma P, Heidari P, Mahmood U, Chin L, Moses HL, Weaver VM, Maitra A, Allison JP, LeBleu VS, Kalluri R.

Cancer Cell. 2015 Dec 14;28(6):831-833. doi: 10.1016/j.ccell.2015.11.002. Epub 2015 Dec 14. No abstract available.

4.

Depletion of carcinoma-associated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survival.

Özdemir BC, Pentcheva-Hoang T, Carstens JL, Zheng X, Wu CC, Simpson TR, Laklai H, Sugimoto H, Kahlert C, Novitskiy SV, De Jesus-Acosta A, Sharma P, Heidari P, Mahmood U, Chin L, Moses HL, Weaver VM, Maitra A, Allison JP, LeBleu VS, Kalluri R.

Cancer Cell. 2014 Jun 16;25(6):719-34. doi: 10.1016/j.ccr.2014.04.005. Epub 2014 May 22. Erratum in: Cancer Cell. 2015 Dec 14;28(6):831-3.

5.

Stromally derived lysyl oxidase promotes metastasis of transforming growth factor-β-deficient mouse mammary carcinomas.

Pickup MW, Laklai H, Acerbi I, Owens P, Gorska AE, Chytil A, Aakre M, Weaver VM, Moses HL.

Cancer Res. 2013 Sep 1;73(17):5336-46. doi: 10.1158/0008-5472.CAN-13-0012. Epub 2013 Jul 15.

6.

Dual roles of hemidesmosomal proteins in the pancreatic epithelium: the phosphoinositide 3-kinase decides.

Laval S, Laklai H, Fanjul M, Pucelle M, Laurell H, Billon-Galés A, Le Guellec S, Delisle MB, Sonnenberg A, Susini C, Pyronnet S, Bousquet C.

Oncogene. 2014 Apr 10;33(15):1934-44. doi: 10.1038/onc.2013.146. Epub 2013 Apr 29.

PMID:
23624916
7.

βArrestin-1 and Mcl-1 modulate self-renewal growth of cancer stem-like side-population cells in non-small cell lung cancer.

Singh S, Bora-Singhal N, Kroeger J, Laklai H, Chellappan SP.

PLoS One. 2013;8(2):e55982. doi: 10.1371/journal.pone.0055982. Epub 2013 Feb 13.

8.

Netrin-1 mediates early events in pancreatic adenocarcinoma progression, acting on tumor and endothelial cells.

Dumartin L, Quemener C, Laklai H, Herbert J, Bicknell R, Bousquet C, Pyronnet S, Castronovo V, Schilling MK, Bikfalvi A, Hagedorn M.

Gastroenterology. 2010 Apr;138(4):1595-606, 1606.e1-8. doi: 10.1053/j.gastro.2009.12.061. Epub 2010 Jan 18.

PMID:
20080097
9.

Thrombospondin-1 is a critical effector of oncosuppressive activity of sst2 somatostatin receptor on pancreatic cancer.

Laklai H, Laval S, Dumartin L, Rochaix P, Hagedorn M, Bikfalvi A, Le Guellec S, Delisle MB, Schally AV, Susini C, Pyronnet S, Bousquet C.

Proc Natl Acad Sci U S A. 2009 Oct 20;106(42):17769-74. doi: 10.1073/pnas.0908674106. Epub 2009 Oct 1.

10.

Antitumor effects of somatostatin.

Pyronnet S, Bousquet C, Najib S, Azar R, Laklai H, Susini C.

Mol Cell Endocrinol. 2008 May 14;286(1-2):230-7. doi: 10.1016/j.mce.2008.02.002. Epub 2008 Feb 13. Review.

PMID:
18359151

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