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Cross-dressed dendritic cells sustain effector T cell responses in islet and kidney allografts.

Hughes AD, Zhao D, Dai H, Abou-Daya KI, Tieu R, Rammal R, Williams AL, Landsittel DP, Shlomchik WD, Morelli AE, Oberbarnscheidt MH, Lakkis FG.

J Clin Invest. 2019 Nov 25. pii: 125773. doi: 10.1172/JCI125773. [Epub ahead of print]


In vivo dynamics of T cells and their interactions with dendritic cells in mouse cutaneous graft-versus-host disease.

Morin-Zorman S, Wysocki C, Zhu J, Li H, Zorman S, Matte-Martone C, Kisanga E, McNiff J, Jain D, Gonzalez D, Rothstein DM, Lakkis FG, Haberman A, Shlomchik WD.

Blood Adv. 2019 Jul 23;3(14):2082-2092. doi: 10.1182/bloodadvances.2019000227.


Impact of Induction Therapy on Circulating T Follicular Helper Cells and Subsequent Donor-Specific Antibody Formation After Kidney Transplant.

Macedo C, Hadi K, Walters J, Elinoff B, Marrari M, Zeevi A, Ramaswami B, Chalasani G, Landsittel D, Shields A, Alloway R, Lakkis FG, Woodle ES, Metes D.

Kidney Int Rep. 2018 Dec 8;4(3):455-469. doi: 10.1016/j.ekir.2018.11.020. eCollection 2019 Mar.


Antibody-Mediated Rejection of Solid-Organ Allografts.

Lakkis FG, Chalasani G, Hariharan S.

N Engl J Med. 2018 Dec 27;379(26):2580. doi: 10.1056/NEJMc1813976. No abstract available.


Four-Dimensional Imaging of T Cells in Kidney Transplant Rejection.

Hughes AD, Lakkis FG, Oberbarnscheidt MH.

J Am Soc Nephrol. 2018 Jun;29(6):1596-1600. doi: 10.1681/ASN.2017070800. Epub 2018 Apr 13.


Regulatory dendritic cells for promotion of liver transplant operational tolerance: Rationale for a clinical trial and accompanying mechanistic studies.

Thomson AW, Humar A, Lakkis FG, Metes DM.

Hum Immunol. 2018 May;79(5):314-321. doi: 10.1016/j.humimm.2017.10.017. Epub 2017 Oct 31. Review.


Donor SIRPα polymorphism modulates the innate immune response to allogeneic grafts.

Dai H, Friday AJ, Abou-Daya KI, Williams AL, Mortin-Toth S, Nicotra ML, Rothstein DM, Shlomchik WD, Matozaki T, Isenberg JS, Oberbarnscheidt MH, Danska JS, Lakkis FG.

Sci Immunol. 2017 Jun 23;2(12). pii: eaam6202. doi: 10.1126/sciimmunol.aam6202.


Innate allorecognition by monocytic cells and its role in graft rejection.

Lakkis FG, Li XC.

Am J Transplant. 2018 Feb;18(2):289-292. doi: 10.1111/ajt.14436. Epub 2017 Aug 24. Review.


Phenotype, function, and differentiation potential of human monocyte subsets.

Boyette LB, Macedo C, Hadi K, Elinoff BD, Walters JT, Ramaswami B, Chalasani G, Taboas JM, Lakkis FG, Metes DM.

PLoS One. 2017 Apr 26;12(4):e0176460. doi: 10.1371/journal.pone.0176460. eCollection 2017.


Janus kinase inhibition for immunosuppression in solid organ transplantation: Is there a role in complex immunologic challenges?

Moore CA, Iasella CJ, Venkataramanan R, Lakkis FG, Smith RB, McDyer JF, Zeevi A, Ensor CR.

Hum Immunol. 2017 Feb;78(2):64-71. doi: 10.1016/j.humimm.2016.12.005. Epub 2016 Dec 18. Review.


Getting Down and Dirty: Germ-Exposed Laboratory Mice as a Model of the Adult Human Immune System.

Tieu R, Lakkis FG, Oberbarnscheidt MH.

Transplantation. 2016 Dec;100(12):2490-2491. No abstract available.


Antigen Presentation in Transplantation.

Alegre ML, Lakkis FG, Morelli AE.

Trends Immunol. 2016 Dec;37(12):831-843. doi: 10.1016/ Epub 2016 Oct 12. Review.


Graft-infiltrating host dendritic cells play a key role in organ transplant rejection.

Zhuang Q, Liu Q, Divito SJ, Zeng Q, Yatim KM, Hughes AD, Rojas-Canales DM, Nakao A, Shufesky WJ, Williams AL, Humar R, Hoffman RA, Shlomchik WD, Oberbarnscheidt MH, Lakkis FG, Morelli AE.

Nat Commun. 2016 Aug 24;7:12623. doi: 10.1038/ncomms12623.


CD8+ Effector T Cell Migration to Pancreatic Islet Grafts Is Dependent on Cognate Antigen Presentation by Donor Graft Cells.

Zhang Q, Dai H, Yatim KM, Abou-Daya K, Williams AL, Oberbarnscheidt MH, Camirand G, Rudd CE, Lakkis FG.

J Immunol. 2016 Aug 15;197(4):1471-6. doi: 10.4049/jimmunol.1600832. Epub 2016 Jun 29.


Prospective Clinical Testing of Regulatory Dendritic Cells in Organ Transplantation.

Thomson AW, Zahorchak AF, Ezzelarab MB, Butterfield LH, Lakkis FG, Metes DM.

Front Immunol. 2016 Jan 28;7:15. doi: 10.3389/fimmu.2016.00015. eCollection 2016. Review.


B Cells, Antibodies, and More.

Hoffman W, Lakkis FG, Chalasani G.

Clin J Am Soc Nephrol. 2016 Jan 7;11(1):137-54. doi: 10.2215/CJN.09430915. Epub 2015 Dec 23. Review.


Memory T Cell Migration.

Zhang Q, Lakkis FG.

Front Immunol. 2015 Oct 2;6:504. doi: 10.3389/fimmu.2015.00504. eCollection 2015. Review.


A new CJASN series: renal immunology for the clinician.

Lakkis FG, Palevsky PM.

Clin J Am Soc Nephrol. 2015 Jul 7;10(7):1273. doi: 10.2215/CJN.03870415. No abstract available.


A brief journey through the immune system.

Yatim KM, Lakkis FG.

Clin J Am Soc Nephrol. 2015 Jul 7;10(7):1274-81. doi: 10.2215/CJN.10031014. Epub 2015 Apr 6. Review.


Dendritic cells and innate immunity in kidney transplantation.

Zhuang Q, Lakkis FG.

Kidney Int. 2015 Apr;87(4):712-8. doi: 10.1038/ki.2014.430. Epub 2015 Jan 28. Review.


CD45 ligation expands Tregs by promoting interactions with DCs.

Camirand G, Wang Y, Lu Y, Wan YY, Lin Y, Deng S, Guz G, Perkins DL, Finn PW, Farber DL, Flavell RA, Shlomchik WD, Lakkis FG, Rudd CE, Rothstein DM.

J Clin Invest. 2014 Oct;124(10):4603-13. doi: 10.1172/JCI74087. Epub 2014 Sep 9.


Non-self recognition by monocytes initiates allograft rejection.

Oberbarnscheidt MH, Zeng Q, Li Q, Dai H, Williams AL, Shlomchik WD, Rothstein DM, Lakkis FG.

J Clin Invest. 2014 Aug;124(8):3579-89. doi: 10.1172/JCI74370. Epub 2014 Jul 1.


Lymphoid neogenesis in skin of human hand, nonhuman primate, and rat vascularized composite allografts.

Hautz T, Zelger BG, Nasr IW, Mundinger GS, Barth RN, Rodriguez ED, Brandacher G, Weissenbacher A, Zelger B, Cavadas P, Margreiter R, Lee WP, Pratschke J, Lakkis FG, Schneeberger S.

Transpl Int. 2014 Sep;27(9):966-76. doi: 10.1111/tri.12358. Epub 2014 Jun 24.


Immunology: TREG cells in transplantation-a double-edged sword?

Lakkis FG.

Nat Rev Nephrol. 2014 Apr;10(4):185-6. doi: 10.1038/nrneph.2014.35. Epub 2014 Mar 11.


Innate allorecognition.

Oberbarnscheidt MH, Lakkis FG.

Immunol Rev. 2014 Mar;258(1):145-9. doi: 10.1111/imr.12153. Review.


T-cell migration to vascularized organ allografts.

Walch JM, Lakkis FG.

Curr Opin Organ Transplant. 2014 Feb;19(1):28-32. doi: 10.1097/MOT.0000000000000042. Review.


Molecular analysis of transplant rejection: marching onward.

Lakkis FG, Billiar TR.

J Exp Med. 2013 Oct 21;210(11):2147-9. doi: 10.1084/jem.20131810. Review.


Post-transplant repopulation of naïve and memory T cells in blood and lymphoid tissue after alemtuzumab-mediated depletion in heart-transplanted cynomolgus monkeys.

Marco MR, Dons EM, van der Windt DJ, Bhama JK, Lu LT, Zahorchak AF, Lakkis FG, Cooper DK, Ezzelarab MB, Thomson AW.

Transpl Immunol. 2013 Dec;29(1-4):88-98. doi: 10.1016/j.trim.2013.10.002. Epub 2013 Oct 9.


Origin and biology of the allogeneic response.

Lakkis FG, Lechler RI.

Cold Spring Harb Perspect Med. 2013 Aug 1;3(8). pii: a014993. doi: 10.1101/cshperspect.a014993.


Regulatory dendritic cell infusion prolongs kidney allograft survival in nonhuman primates.

Ezzelarab MB, Zahorchak AF, Lu L, Morelli AE, Chalasani G, Demetris AJ, Lakkis FG, Wijkstrom M, Murase N, Humar A, Shapiro R, Cooper DK, Thomson AW.

Am J Transplant. 2013 Aug;13(8):1989-2005. doi: 10.1111/ajt.12310. Epub 2013 Jun 11.


Cognate antigen directs CD8+ T cell migration to vascularized transplants.

Walch JM, Zeng Q, Li Q, Oberbarnscheidt MH, Hoffman RA, Williams AL, Rothstein DM, Shlomchik WD, Kim JV, Camirand G, Lakkis FG.

J Clin Invest. 2013 Jun;123(6):2663-71. doi: 10.1172/JCI66722. Epub 2013 May 15.


Allograft outcomes in outbred mice.

Reichenbach DK, Li Q, Hoffman RA, Williams AL, Shlomchik WD, Rothstein DM, Demetris AJ, Lakkis FG.

Am J Transplant. 2013 Mar;13(3):580-8. doi: 10.1111/ajt.12056. Epub 2013 Jan 11.


Clinical islet xenotransplantation: how close are we?

van der Windt DJ, Bottino R, Kumar G, Wijkstrom M, Hara H, Ezzelarab M, Ekser B, Phelps C, Murase N, Casu A, Ayares D, Lakkis FG, Trucco M, Cooper DK.

Diabetes. 2012 Dec;61(12):3046-55. doi: 10.2337/db12-0033. Review. No abstract available.


Allorecognition triggers autophagy and subsequent necrosis in the cnidarian Hydractinia symbiolongicarpus.

Buss LW, Anderson C, Westerman E, Kritzberger C, Poudyal M, Moreno MA, Lakkis FG.

PLoS One. 2012;7(11):e48914. doi: 10.1371/journal.pone.0048914. Epub 2012 Nov 8.


Evolutionary genetics of the hydroid allodeterminant alr2.

Gloria-Soria A, Moreno MA, Yund PO, Lakkis FG, Dellaporta SL, Buss LW.

Mol Biol Evol. 2012 Dec;29(12):3921-32. doi: 10.1093/molbev/mss197. Epub 2012 Aug 1.


Early islet damage after direct exposure of pig islets to blood: has humoral immunity been underestimated?

van der Windt DJ, Marigliano M, He J, Votyakova TV, Echeverri GJ, Ekser B, Ayares D, Lakkis FG, Cooper DK, Trucco M, Bottino R.

Cell Transplant. 2012;21(8):1791-802. doi: 10.3727/096368912X653011. Epub 2012 Jul 5.


Profound depletion of host conventional dendritic cells, plasmacytoid dendritic cells, and B cells does not prevent graft-versus-host disease induction.

Li H, Demetris AJ, McNiff J, Matte-Martone C, Tan HS, Rothstein DM, Lakkis FG, Shlomchik WD.

J Immunol. 2012 Apr 15;188(8):3804-11. doi: 10.4049/jimmunol.1102795. Epub 2012 Mar 14.


Genetic Background and Allorecognition Phenotype in Hydractinia symbiolongicarpus.

Powell AE, Moreno M, Gloria-Soria A, Lakkis FG, Dellaporta SL, Buss LW.

G3 (Bethesda). 2011 Nov;1(6):499-504. doi: 10.1534/g3.111.001149. Epub 2011 Nov 1.


Long-term effects of alemtuzumab on regulatory and memory T-cell subsets in kidney transplantation.

Macedo C, Walters JT, Orkis EA, Isse K, Elinoff BD, Fedorek SP, McMichael JM, Chalasani G, Randhawa P, Demetris AJ, Zeevi A, Tan H, Shapiro R, Landsittel D, Lakkis FG, Metes D.

Transplantation. 2012 Apr 27;93(8):813-21. doi: 10.1097/TP.0b013e318247a717.


Innate immunity alone is not sufficient for chronic rejection but predisposes healed allografts to T cell-mediated pathology.

Zecher D, Li Q, Williams AL, Walters JT, Baddoura FK, Chalasani G, Rothstein DM, Shlomchik WD, Demetris AJ, Lakkis FG.

Transpl Immunol. 2012 Mar;26(2-3):113-8. doi: 10.1016/j.trim.2011.12.006. Epub 2011 Dec 24.


T-lymphocyte homeostasis and function in infant baboons: implications for transplantation.

van der Windt DJ, Dons EM, Montoya CL, Ezzelarab M, Long C, Wolf RF, Ijzermans JN, Lakkis FG, Cooper DK.

Transpl Int. 2012 Feb;25(2):218-28. doi: 10.1111/j.1432-2277.2011.01384.x. Epub 2011 Nov 17.


Carbon monoxide inhibits apoptosis during cold storage and protects kidney grafts donated after cardiac death.

Ozaki KS, Yoshida J, Ueki S, Pettigrew GL, Ghonem N, Sico RM, Lee LY, Shapiro R, Lakkis FG, Pacheco-Silva A, Murase N.

Transpl Int. 2012 Jan;25(1):107-17. doi: 10.1111/j.1432-2277.2011.01363.x. Epub 2011 Oct 15.


Multiphoton intravital microscopy of the transplanted mouse kidney.

Camirand G, Li Q, Demetris AJ, Watkins SC, Shlomchik WD, Rothstein DM, Lakkis FG.

Am J Transplant. 2011 Oct;11(10):2067-74. doi: 10.1111/j.1600-6143.2011.03671.x. Epub 2011 Aug 11.


The innate immune system in transplantation.

Oberbarnscheidt MH, Zecher D, Lakkis FG.

Semin Immunol. 2011 Aug;23(4):264-72. doi: 10.1016/j.smim.2011.06.006. Epub 2011 Jul 1. Review.


Memory T cells migrate to and reject vascularized cardiac allografts independent of the chemokine receptor CXCR3.

Oberbarnscheidt MH, Walch JM, Li Q, Williams AL, Walters JT, Hoffman RA, Demetris AJ, Gerard C, Camirand G, Lakkis FG.

Transplantation. 2011 Apr 27;91(8):827-32. doi: 10.1097/TP.0b013e31820f0856.


Regulatory T cells require mammalian target of rapamycin signaling to maintain both homeostasis and alloantigen-driven proliferation in lymphocyte-replete mice.

Wang Y, Camirand G, Lin Y, Froicu M, Deng S, Shlomchik WD, Lakkis FG, Rothstein DM.

J Immunol. 2011 Mar 1;186(5):2809-18. doi: 10.4049/jimmunol.0903805. Epub 2011 Jan 26.


Genetic diversity of the allodeterminant alr2 in Hydractinia symbiolongicarpus.

Rosengarten RD, Moreno MA, Lakkis FG, Buss LW, Dellaporta SL.

Mol Biol Evol. 2011 Feb;28(2):933-47. doi: 10.1093/molbev/msq282. Epub 2010 Oct 21.


Hydractinia allodeterminant alr1 resides in an immunoglobulin superfamily-like gene complex.

Rosa SF, Powell AE, Rosengarten RD, Nicotra ML, Moreno MA, Grimwood J, Lakkis FG, Dellaporta SL, Buss LW.

Curr Biol. 2010 Jun 22;20(12):1122-7. doi: 10.1016/j.cub.2010.04.050. Epub 2010 May 27.


NK cells delay allograft rejection in lymphopenic hosts by downregulating the homeostatic proliferation of CD8+ T cells.

Zecher D, Li Q, Oberbarnscheidt MH, Demetris AJ, Shlomchik WD, Rothstein DM, Lakkis FG.

J Immunol. 2010 Jun 15;184(12):6649-57. doi: 10.4049/jimmunol.0903729. Epub 2010 May 14.


Investigation of lymphocyte depletion and repopulation using alemtuzumab (Campath-1H) in cynomolgus monkeys.

van der Windt DJ, Smetanka C, Macedo C, He J, Lakomy R, Bottino R, Ekser B, Echeverri GJ, Metes D, Ijzermans JN, Trucco M, Cooper DK, Lakkis FG.

Am J Transplant. 2010 Apr;10(4):773-83. doi: 10.1111/j.1600-6143.2010.03050.x.

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