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Items: 1 to 50 of 65

1.

MicroRNAs in glioblastoma pathogenesis and therapy: A comprehensive review.

Ahir BK, Ozer H, Engelhard HH, Lakka SS.

Crit Rev Oncol Hematol. 2017 Dec;120:22-33. doi: 10.1016/j.critrevonc.2017.10.003. Epub 2017 Oct 7. Review.

PMID:
29198335
2.

Matrix metalloproteinases: their functional role in lung cancer.

Merchant N, Nagaraju GP, Rajitha B, Lammata S, Jella KK, Buchwald ZS, Lakka SS, Ali AN.

Carcinogenesis. 2017 Aug 1;38(8):766-780. doi: 10.1093/carcin/bgx063. Review.

PMID:
28637319
3.

SPARC overexpression alters microRNA expression profiles involved in tumor progression.

Ahir BK, Elias NM, Lakka SS.

Genes Cancer. 2017 Jan;8(1-2):453-471. doi: 10.18632/genesandcancer.130.

4.

miR-let-7f-1 regulates SPARC mediated cisplatin resistance in medulloblastoma cells.

Pannuru P, Dontula R, Khan AA, Herbert E, Ozer H, Chetty C, Lakka SS.

Cell Signal. 2014 Oct;26(10):2193-201. doi: 10.1016/j.cellsig.2014.06.014. Epub 2014 Jul 8.

PMID:
25014664
5.

Molecular mechanisms underlying the divergent roles of SPARC in human carcinogenesis.

Nagaraju GP, Dontula R, El-Rayes BF, Lakka SS.

Carcinogenesis. 2014 May;35(5):967-73. doi: 10.1093/carcin/bgu072. Epub 2014 Mar 27. Review.

PMID:
24675529
6.

MicroRNA 203 Modulates Glioma Cell Migration via Robo1/ERK/MMP-9 Signaling.

Dontula R, Dinasarapu A, Chetty C, Pannuru P, Herbert E, Ozer H, Lakka SS.

Genes Cancer. 2013 Jul;4(7-8):285-96. doi: 10.1177/1947601913500141.

7.

Blockade of SOX4 mediated DNA repair by SPARC enhances radioresponse in medulloblastoma.

Chetty C, Dontula R, Gujrati M, Dinh DH, Lakka SS.

Cancer Lett. 2012 Oct 28;323(2):188-98. doi: 10.1016/j.canlet.2012.04.014. Epub 2012 Apr 24.

8.

SPARC expression induces cell cycle arrest via STAT3 signaling pathway in medulloblastoma cells.

Chetty C, Dontula R, Ganji PN, Gujrati M, Lakka SS.

Biochem Biophys Res Commun. 2012 Jan 13;417(2):874-9. doi: 10.1016/j.bbrc.2011.12.065. Epub 2011 Dec 20.

9.

SPARC mediates Src-induced disruption of actin cytoskeleton via inactivation of small GTPases Rho-Rac-Cdc42.

Bhoopathi P, Gondi CS, Gujrati M, Dinh DH, Lakka SS.

Cell Signal. 2011 Dec;23(12):1978-87. doi: 10.1016/j.cellsig.2011.07.008. Epub 2011 Jul 23.

10.

SPARC stimulates neuronal differentiation of medulloblastoma cells via the Notch1/STAT3 pathway.

Bhoopathi P, Chetty C, Dontula R, Gujrati M, Dinh DH, Rao JS, Lakka SS.

Cancer Res. 2011 Jul 15;71(14):4908-19. doi: 10.1158/0008-5472.CAN-10-3395. Epub 2011 May 25.

11.

Suppression of MMP-2 attenuates TNF-α induced NF-κB activation and leads to JNK mediated cell death in glioma.

Kesanakurti D, Chetty C, Bhoopathi P, Lakka SS, Gorantla B, Tsung AJ, Rao JS.

PLoS One. 2011 May 4;6(5):e19341. doi: 10.1371/journal.pone.0019341.

12.

Matrix metalloproteinase pharmacogenomics in non-small-cell lung carcinoma.

Chetty C, Rao JS, Lakka SS.

Pharmacogenomics. 2011 Apr;12(4):535-46. doi: 10.2217/pgs.10.207. Review.

PMID:
21521025
13.

MMP-2 mediates mesenchymal stem cell tropism towards medulloblastoma tumors.

Bhoopathi P, Chetty C, Gogineni VR, Gujrati M, Dinh DH, Rao JS, Lakka SS.

Gene Ther. 2011 Jul;18(7):692-701. doi: 10.1038/gt.2011.14. Epub 2011 Mar 3.

14.

Suppression of uPA and uPAR attenuates angiogenin mediated angiogenesis in endothelial and glioblastoma cell lines.

Raghu H, Lakka SS, Gondi CS, Mohanam S, Dinh DH, Gujrati M, Rao JS.

PLoS One. 2010 Aug 27;5(8):e12458. doi: 10.1371/journal.pone.0012458.

15.

Urokinase plasminogen activator receptor and/or matrix metalloproteinase-9 inhibition induces apoptosis signaling through lipid rafts in glioblastoma xenograft cells.

Chetty C, Lakka SS, Bhoopathi P, Gondi CS, Veeravalli KK, Fassett D, Klopfenstein JD, Dinh DH, Gujrati M, Rao JS.

Mol Cancer Ther. 2010 Sep;9(9):2605-17. doi: 10.1158/1535-7163.MCT-10-0245. Epub 2010 Aug 17.

16.

MMP-9, uPAR and cathepsin B silencing downregulate integrins in human glioma xenograft cells in vitro and in vivo in nude mice.

Veeravalli KK, Chetty C, Ponnala S, Gondi CS, Lakka SS, Fassett D, Klopfenstein JD, Dinh DH, Gujrati M, Rao JS.

PLoS One. 2010 Jul 15;5(7):e11583. doi: 10.1371/journal.pone.0011583.

17.

Targeting MMP-9, uPAR, and cathepsin B inhibits invasion, migration and activates apoptosis in prostate cancer cells.

Nalla AK, Gorantla B, Gondi CS, Lakka SS, Rao JS.

Cancer Gene Ther. 2010 Sep;17(9):599-613. doi: 10.1038/cgt.2010.16. Epub 2010 May 7.

18.

The role of MMP-9 in the anti-angiogenic effect of secreted protein acidic and rich in cysteine.

Bhoopathi P, Chetty C, Gujrati M, Dinh DH, Rao JS, Lakka SS.

Br J Cancer. 2010 Feb 2;102(3):530-40. doi: 10.1038/sj.bjc.6605538. Epub 2010 Jan 19.

19.

MMP-2 alters VEGF expression via alphaVbeta3 integrin-mediated PI3K/AKT signaling in A549 lung cancer cells.

Chetty C, Lakka SS, Bhoopathi P, Rao JS.

Int J Cancer. 2010 Sep 1;127(5):1081-95. doi: 10.1002/ijc.25134.

20.

Stat3-siRNA induces Fas-mediated apoptosis in vitro and in vivo in breast cancer.

Kunigal S, Lakka SS, Sodadasu PK, Estes N, Rao JS.

Int J Oncol. 2009 May;34(5):1209-20.

21.
22.

Antiangiogenic therapy in brain tumors.

Lakka SS, Rao JS.

Expert Rev Neurother. 2008 Oct;8(10):1457-73. doi: 10.1586/14737175.8.10.1457. Review.

23.

Tissue inhibitor of metalloproteinase 3 suppresses tumor angiogenesis in matrix metalloproteinase 2-down-regulated lung cancer.

Chetty C, Lakka SS, Bhoopathi P, Kunigal S, Geiss R, Rao JS.

Cancer Res. 2008 Jun 15;68(12):4736-45. doi: 10.1158/0008-5472.CAN-07-6612.

24.

Matrix metalloproteinase-9 inhibition down-regulates radiation-induced nuclear factor-kappa B activity leading to apoptosis in breast tumors.

Kunigal S, Lakka SS, Joseph P, Estes N, Rao JS.

Clin Cancer Res. 2008 Jun 1;14(11):3617-26. doi: 10.1158/1078-0432.CCR-07-2060.

25.

Adenovirus-mediated transfer of siRNA against MMP-2 mRNA results in impaired invasion and tumor-induced angiogenesis, induces apoptosis in vitro and inhibits tumor growth in vivo in glioblastoma.

Kargiotis O, Chetty C, Gondi CS, Tsung AJ, Dinh DH, Gujrati M, Lakka SS, Kyritsis AP, Rao JS.

Oncogene. 2008 Aug 14;27(35):4830-40. doi: 10.1038/onc.2008.122. Epub 2008 Apr 28.

26.
27.

Blockade of tumor growth due to matrix metalloproteinase-9 inhibition is mediated by sequential activation of beta1-integrin, ERK, and NF-kappaB.

Bhoopathi P, Chetty C, Kunigal S, Vanamala SK, Rao JS, Lakka SS.

J Biol Chem. 2008 Jan 18;283(3):1545-52. Epub 2007 Nov 8.

30.

MMP-2 siRNA induced Fas/CD95-mediated extrinsic II apoptotic pathway in the A549 lung adenocarcinoma cell line.

Chetty C, Bhoopathi P, Lakka SS, Rao JS.

Oncogene. 2007 Dec 6;26(55):7675-83. Epub 2007 Jun 25.

31.
32.

Sense p16 and antisense uPAR bicistronic construct inhibits angiogenesis and induces glioma cell death.

Nalabothula N, Lakka SS, Dinh DH, Gujrati M, Olivero WC, Rao JS.

Int J Oncol. 2007 Mar;30(3):669-78.

33.

SPARC-induced migration of glioblastoma cell lines via uPA-uPAR signaling and activation of small GTPase RhoA.

Kunigal S, Gondi CS, Gujrati M, Lakka SS, Dinh DH, Olivero WC, Rao JS.

Int J Oncol. 2006 Dec;29(6):1349-57.

34.
35.
36.

Proteases and glioma angiogenesis.

Lakka SS, Gondi CS, Rao JS.

Brain Pathol. 2005 Oct;15(4):327-41. Review.

PMID:
16389945
37.
38.
39.
40.

Inhibition of matrix metalloproteinase-9 reduces in vitro invasion and angiogenesis in human microvascular endothelial cells.

Jadhav U, Chigurupati S, Lakka SS, Mohanam S.

Int J Oncol. 2004 Nov;25(5):1407-14.

PMID:
15492832
41.

RNAi-mediated inhibition of cathepsin B and uPAR leads to decreased cell invasion, angiogenesis and tumor growth in gliomas.

Gondi CS, Lakka SS, Dinh DH, Olivero WC, Gujrati M, Rao JS.

Oncogene. 2004 Nov 4;23(52):8486-96.

PMID:
15378018
42.

Adenovirus-mediated expression of antisense urokinase plasminogen activator receptor and antisense cathepsin B inhibits tumor growth, invasion, and angiogenesis in gliomas.

Gondi CS, Lakka SS, Yanamandra N, Olivero WC, Dinh DH, Gujrati M, Tung CH, Weissleder R, Rao JS.

Cancer Res. 2004 Jun 15;64(12):4069-77.

43.

Inhibition of cathepsin B and MMP-9 gene expression in glioblastoma cell line via RNA interference reduces tumor cell invasion, tumor growth and angiogenesis.

Lakka SS, Gondi CS, Yanamandra N, Olivero WC, Dinh DH, Gujrati M, Rao JS.

Oncogene. 2004 Jun 10;23(27):4681-9.

PMID:
15122332
44.

Expression of antisense uPAR and antisense uPA from a bicistronic adenoviral construct inhibits glioma cell invasion, tumor growth, and angiogenesis.

Gondi CS, Lakka SS, Yanamandra N, Siddique K, Dinh DH, Olivero WC, Gujrati M, Rao JS.

Oncogene. 2003 Sep 4;22(38):5967-75.

PMID:
12955075
45.

Promoter methylation and silencing of the tissue factor pathway inhibitor-2 (TFPI-2), a gene encoding an inhibitor of matrix metalloproteinases in human glioma cells.

Konduri SD, Srivenugopal KS, Yanamandra N, Dinh DH, Olivero WC, Gujrati M, Foster DC, Kisiel W, Ali-Osman F, Kondraganti S, Lakka SS, Rao JS.

Oncogene. 2003 Jul 17;22(29):4509-16.

PMID:
12881707
46.

Glial cell-induced endothelial morphogenesis is inhibited by interfering with extracellular signal-regulated kinase signaling.

Chandrasekar N, Mohanam S, Lakka SS, Dinh DH, Olivero WC, Gujrati M, Rao JS.

Clin Cancer Res. 2003 Jun;9(6):2342-9.

48.

Adenovirus-mediated expression of antisense MMP-9 in glioma cells inhibits tumor growth and invasion.

Lakka SS, Rajan M, Gondi C, Yanamandra N, Chandrasekar N, Jasti SL, Adachi Y, Siddique K, Gujrati M, Olivero W, Dinh DH, Kouraklis G, Kyritsis AP, Rao JS.

Oncogene. 2002 Nov 14;21(52):8011-9.

49.

Downregulation of MMP-9 in ERK-mutated stable transfectants inhibits glioma invasion in vitro.

Lakka SS, Jasti SL, Gondi C, Boyd D, Chandrasekar N, Dinh DH, Olivero WC, Gujrati M, Rao JS.

Oncogene. 2002 Aug 15;21(36):5601-8.

50.

Suppression of glioma invasion and growth by adenovirus-mediated delivery of a bicistronic construct containing antisense uPAR and sense p16 gene sequences.

Adachi Y, Chandrasekar N, Kin Y, Lakka SS, Mohanam S, Yanamandra N, Mohan PM, Fuller GN, Fang B, Fueyo J, Dinh DH, Olivero WC, Tamiya T, Ohmoto T, Kyritsis AP, Rao JS.

Oncogene. 2002 Jan 3;21(1):87-95.

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