Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 37

1.

Patterning the Geometry of Human Embryonic Stem Cell Colonies on Compliant Substrates to Control Tissue-Level Mechanics.

Muncie JM, Falcón-Banchs R, Lakins JN, Sohn LL, Weaver VM.

J Vis Exp. 2019 Sep 28;(151). doi: 10.3791/60334.

PMID:
31609314
2.

Controlled modelling of human epiblast and amnion development using stem cells.

Zheng Y, Xue X, Shao Y, Wang S, Esfahani SN, Li Z, Muncie JM, Lakins JN, Weaver VM, Gumucio DL, Fu J.

Nature. 2019 Sep;573(7774):421-425. doi: 10.1038/s41586-019-1535-2. Epub 2019 Sep 11.

PMID:
31511693
3.

A tension-mediated glycocalyx-integrin feedback loop promotes mesenchymal-like glioblastoma.

Barnes JM, Kaushik S, Bainer RO, Sa JK, Woods EC, Kai F, Przybyla L, Lee M, Lee HW, Tung JC, Maller O, Barrett AS, Lu KV, Lakins JN, Hansen KC, Obernier K, Alvarez-Buylla A, Bergers G, Phillips JJ, Nam DH, Bertozzi CR, Weaver VM.

Nat Cell Biol. 2018 Oct;20(10):1203-1214. doi: 10.1038/s41556-018-0183-3. Epub 2018 Sep 10.

4.

Fibronectin rescues estrogen receptor α from lysosomal degradation in breast cancer cells.

Sampayo RG, Toscani AM, Rubashkin MG, Thi K, Masullo LA, Violi IL, Lakins JN, Cáceres A, Hines WC, Coluccio Leskow F, Stefani FD, Chialvo DR, Bissell MJ, Weaver VM, Simian M.

J Cell Biol. 2018 Aug 6;217(8):2777-2798. doi: 10.1083/jcb.201703037. Epub 2018 Jul 6.

5.

Genetically Encoded Toolbox for Glycocalyx Engineering: Tunable Control of Cell Adhesion, Survival, and Cancer Cell Behaviors.

Shurer CR, Colville MJ, Gupta VK, Head SE, Kai F, Lakins JN, Paszek MJ.

ACS Biomater Sci Eng. 2018 Feb 12;4(2):388-399. doi: 10.1021/acsbiomaterials.7b00037. Epub 2017 Feb 28.

6.

Antisecretory Factor-Mediated Inhibition of Cell Volume Dynamics Produces Antitumor Activity in Glioblastoma.

Ilkhanizadeh S, Sabelström H, Miroshnikova YA, Frantz A, Zhu W, Idilli A, Lakins JN, Schmidt C, Quigley DA, Fenster T, Yuan E, Trzeciak JR, Saxena S, Lindberg OR, Mouw JK, Burdick JA, Magnitsky S, Berger MS, Phillips JJ, Arosio D, Sun D, Weaver VM, Weiss WA, Persson AI.

Mol Cancer Res. 2018 May;16(5):777-790. doi: 10.1158/1541-7786.MCR-17-0413. Epub 2018 Feb 5.

7.

Integrin-mediated traction force enhances paxillin molecular associations and adhesion dynamics that increase the invasiveness of tumor cells into a three-dimensional extracellular matrix.

Mekhdjian AH, Kai F, Rubashkin MG, Prahl LS, Przybyla LM, McGregor AL, Bell ES, Barnes JM, DuFort CC, Ou G, Chang AC, Cassereau L, Tan SJ, Pickup MW, Lakins JN, Ye X, Davidson MW, Lammerding J, Odde DJ, Dunn AR, Weaver VM.

Mol Biol Cell. 2017 Jun 1;28(11):1467-1488. doi: 10.1091/mbc.E16-09-0654. Epub 2017 Apr 5.

8.

Tissue mechanics promote IDH1-dependent HIF1α-tenascin C feedback to regulate glioblastoma aggression.

Miroshnikova YA, Mouw JK, Barnes JM, Pickup MW, Lakins JN, Kim Y, Lobo K, Persson AI, Reis GF, McKnight TR, Holland EC, Phillips JJ, Weaver VM.

Nat Cell Biol. 2016 Dec;18(12):1336-1345. doi: 10.1038/ncb3429. Epub 2016 Nov 7.

9.

Tissue Mechanics Orchestrate Wnt-Dependent Human Embryonic Stem Cell Differentiation.

Przybyla L, Lakins JN, Weaver VM.

Cell Stem Cell. 2016 Oct 6;19(4):462-475. doi: 10.1016/j.stem.2016.06.018. Epub 2016 Jul 21.

10.

Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression.

Laklai H, Miroshnikova YA, Pickup MW, Collisson EA, Kim GE, Barrett AS, Hill RC, Lakins JN, Schlaepfer DD, Mouw JK, LeBleu VS, Roy N, Novitskiy SV, Johansen JS, Poli V, Kalluri R, Iacobuzio-Donahue CA, Wood LD, Hebrok M, Hansen K, Moses HL, Weaver VM.

Nat Med. 2016 May;22(5):497-505. doi: 10.1038/nm.4082. Epub 2016 Apr 18.

11.

Monitoring developmental force distributions in reconstituted embryonic epithelia.

Przybyla L, Lakins JN, Sunyer R, Trepat X, Weaver VM.

Methods. 2016 Feb 1;94:101-13. doi: 10.1016/j.ymeth.2015.09.003. Epub 2015 Sep 2.

12.

Microenvironment rigidity modulates responses to the HER2 receptor tyrosine kinase inhibitor lapatinib via YAP and TAZ transcription factors.

Lin CH, Pelissier FA, Zhang H, Lakins J, Weaver VM, Park C, LaBarge MA.

Mol Biol Cell. 2015 Nov 5;26(22):3946-53. doi: 10.1091/mbc.E15-07-0456. Epub 2015 Sep 2.

13.

A 3D tension bioreactor platform to study the interplay between ECM stiffness and tumor phenotype.

Cassereau L, Miroshnikova YA, Ou G, Lakins J, Weaver VM.

J Biotechnol. 2015 Jan 10;193:66-9. doi: 10.1016/j.jbiotec.2014.11.008. Epub 2014 Nov 27.

14.

The cancer glycocalyx mechanically primes integrin-mediated growth and survival.

Paszek MJ, DuFort CC, Rossier O, Bainer R, Mouw JK, Godula K, Hudak JE, Lakins JN, Wijekoon AC, Cassereau L, Rubashkin MG, Magbanua MJ, Thorn KS, Davidson MW, Rugo HS, Park JW, Hammer DA, Giannone G, Bertozzi CR, Weaver VM.

Nature. 2014 Jul 17;511(7509):319-25. doi: 10.1038/nature13535. Epub 2014 Jun 25.

15.

Tissue mechanics modulate microRNA-dependent PTEN expression to regulate malignant progression.

Mouw JK, Yui Y, Damiano L, Bainer RO, Lakins JN, Acerbi I, Ou G, Wijekoon AC, Levental KR, Gilbert PM, Hwang ES, Chen YY, Weaver VM.

Nat Med. 2014 Apr;20(4):360-7. doi: 10.1038/nm.3497. Epub 2014 Mar 16.

16.

Oncogenic targeting of BRM drives malignancy through C/EBPβ-dependent induction of α5 integrin.

Damiano L, Stewart KM, Cohet N, Mouw JK, Lakins JN, Debnath J, Reisman D, Nickerson JA, Imbalzano AN, Weaver VM.

Oncogene. 2014 May 8;33(19):2441-53. doi: 10.1038/onc.2013.220. Epub 2013 Jun 17.

17.

A physical sciences network characterization of non-tumorigenic and metastatic cells.

Physical Sciences - Oncology Centers Network, Agus DB, Alexander JF, Arap W, Ashili S, Aslan JE, Austin RH, Backman V, Bethel KJ, Bonneau R, Chen WC, Chen-Tanyolac C, Choi NC, Curley SA, Dallas M, Damania D, Davies PC, Decuzzi P, Dickinson L, Estevez-Salmeron L, Estrella V, Ferrari M, Fischbach C, Foo J, Fraley SI, Frantz C, Fuhrmann A, Gascard P, Gatenby RA, Geng Y, Gerecht S, Gillies RJ, Godin B, Grady WM, Greenfield A, Hemphill C, Hempstead BL, Hielscher A, Hillis WD, Holland EC, Ibrahim-Hashim A, Jacks T, Johnson RH, Joo A, Katz JE, Kelbauskas L, Kesselman C, King MR, Konstantopoulos K, Kraning-Rush CM, Kuhn P, Kung K, Kwee B, Lakins JN, Lambert G, Liao D, Licht JD, Liphardt JT, Liu L, Lloyd MC, Lyubimova A, Mallick P, Marko J, McCarty OJ, Meldrum DR, Michor F, Mumenthaler SM, Nandakumar V, O'Halloran TV, Oh S, Pasqualini R, Paszek MJ, Philips KG, Poultney CS, Rana K, Reinhart-King CA, Ros R, Semenza GL, Senechal P, Shuler ML, Srinivasan S, Staunton JR, Stypula Y, Subramanian H, Tlsty TD, Tormoen GW, Tseng Y, van Oudenaarden A, Verbridge SS, Wan JC, Weaver VM, Widom J, Will C, Wirtz D, Wojtkowiak J, Wu PH.

Sci Rep. 2013;3:1449. doi: 10.1038/srep01449.

18.

Exploring the link between human embryonic stem cell organization and fate using tension-calibrated extracellular matrix functionalized polyacrylamide gels.

Lakins JN, Chin AR, Weaver VM.

Methods Mol Biol. 2012;916:317-50. doi: 10.1007/978-1-61779-980-8_24.

PMID:
22914951
19.

HOXA9 regulates BRCA1 expression to modulate human breast tumor phenotype.

Gilbert PM, Mouw JK, Unger MA, Lakins JN, Gbegnon MK, Clemmer VB, Benezra M, Licht JD, Boudreau NJ, Tsai KK, Welm AL, Feldman MD, Weber BL, Weaver VM.

J Clin Invest. 2010 May;120(5):1535-50. doi: 10.1172/JCI39534. Epub 2010 Apr 12.

20.

Matrix crosslinking forces tumor progression by enhancing integrin signaling.

Levental KR, Yu H, Kass L, Lakins JN, Egeblad M, Erler JT, Fong SF, Csiszar K, Giaccia A, Weninger W, Yamauchi M, Gasser DL, Weaver VM.

Cell. 2009 Nov 25;139(5):891-906. doi: 10.1016/j.cell.2009.10.027.

21.

alpha6beta4 integrin activates Rac-dependent p21-activated kinase 1 to drive NF-kappaB-dependent resistance to apoptosis in 3D mammary acini.

Friedland JC, Lakins JN, Kazanietz MG, Chernoff J, Boettiger D, Weaver VM.

J Cell Sci. 2007 Oct 15;120(Pt 20):3700-12. Epub 2007 Oct 2.

22.

Tensional homeostasis and the malignant phenotype.

Paszek MJ, Zahir N, Johnson KR, Lakins JN, Rozenberg GI, Gefen A, Reinhart-King CA, Margulies SS, Dembo M, Boettiger D, Hammer DA, Weaver VM.

Cancer Cell. 2005 Sep;8(3):241-54.

23.

Autocrine laminin-5 ligates alpha6beta4 integrin and activates RAC and NFkappaB to mediate anchorage-independent survival of mammary tumors.

Zahir N, Lakins JN, Russell A, Ming W, Chatterjee C, Rozenberg GI, Marinkovich MP, Weaver VM.

J Cell Biol. 2003 Dec 22;163(6):1397-407.

24.

beta4 integrin-dependent formation of polarized three-dimensional architecture confers resistance to apoptosis in normal and malignant mammary epithelium.

Weaver VM, Lelièvre S, Lakins JN, Chrenek MA, Jones JC, Giancotti F, Werb Z, Bissell MJ.

Cancer Cell. 2002 Sep;2(3):205-16.

25.

Expression of multiple forms of clusterin during light-induced retinal degeneration.

Wong P, Ulyanova T, Organisciak DT, Bennett S, Lakins J, Arnold JM, Kutty RK, Tenniswood M, vanVeen T, Darrow RM, Chader G.

Curr Eye Res. 2001 Sep;23(3):157-65.

PMID:
11803476
26.

Evidence that clusterin has discrete chaperone and ligand binding sites.

Lakins JN, Poon S, Easterbrook-Smith SB, Carver JA, Tenniswood MP, Wilson MR.

Biochemistry. 2002 Jan 8;41(1):282-91.

PMID:
11772027
27.

An antigen capture assay for the measurement of serum clusterin concentrations.

Morrissey C, Lakins J, Moquin A, Hussain M, Tenniswood M.

J Biochem Biophys Methods. 2001 Mar 28;48(1):13-21.

PMID:
11282398
28.

Expression and function of CYR61, an angiogenic factor, in breast cancer cell lines and tumor biopsies.

Tsai MS, Hornby AE, Lakins J, Lupu R.

Cancer Res. 2000 Oct 15;60(20):5603-7.

29.

Expression and regulation of estrogen receptor beta in human breast tumors and cell lines.

Vladusic EA, Hornby AE, Guerra-Vladusic FK, Lakins J, Lupu R.

Oncol Rep. 2000 Jan-Feb;7(1):157-67.

PMID:
10601611
30.

Clusterin in the male reproductive tract.

Tenniswood M, Wang Z, Lakins J, Morrissey C, O'Sullivan J, Tang H.

J Androl. 1998 Sep-Oct;19(5):508-16. Review. No abstract available.

31.

Clusterin biogenesis is altered during apoptosis in the regressing rat ventral prostate.

Lakins J, Bennett SA, Chen JH, Arnold JM, Morrissey C, Wong P, O'Sullivan J, Tenniswood M.

J Biol Chem. 1998 Oct 23;273(43):27887-95.

32.

Identification and characterization of glycosylation sites in human serum clusterin.

Kapron JT, Hilliard GM, Lakins JN, Tenniswood MP, West KA, Carr SA, Crabb JW.

Protein Sci. 1997 Oct;6(10):2120-33.

33.

Differential display RT PCR of total RNA from human foreskin fibroblasts for investigation of androgen-dependent gene expression.

Nitsche EM, Moquin A, Adams PS, Guenette RS, Lakins JN, Sinnecker GH, Kruse K, Tenniswood MP.

Am J Med Genet. 1996 May 3;63(1):231-8.

PMID:
8723115
34.

5 alpha-Reductase type 1 is localized to the outer nuclear membrane.

Savory JG, May D, Reich T, La Casse EC, Lakins J, Tenniswood M, Raymond Y, Haché RJ, Sikorska M, Lefebvre YA.

Mol Cell Endocrinol. 1995 Apr 28;110(1-2):137-47.

PMID:
7672444
35.

Molecular characterization of human TRPM-2/clusterin, a gene associated with sperm maturation, apoptosis and neurodegeneration.

Wong P, Taillefer D, Lakins J, Pineault J, Chader G, Tenniswood M.

Eur J Biochem. 1994 May 1;221(3):917-25.

36.

Genomic organization and expression of the rat TRPM-2 (clusterin) gene, a gene implicated in apoptosis.

Wong P, Pineault J, Lakins J, Taillefer D, Léger J, Wang C, Tenniswood M.

J Biol Chem. 1993 Mar 5;268(7):5021-31.

37.

Active cell death in hormone-dependent tissues.

Tenniswood MP, Guenette RS, Lakins J, Mooibroek M, Wong P, Welsh JE.

Cancer Metastasis Rev. 1992 Sep;11(2):197-220. Review.

PMID:
1356648

Supplemental Content

Loading ...
Support Center