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Items: 1 to 50 of 53

1.

Progressive multifocal leukoencephalopathy in Zambia is caused by JC virus with prototype regulatory region.

Mubanga E, Patel A, Siddiqi OK, Hanson BA, Dang X, Lakhi S, Mulundu G, Bender N, Koralnik IJ.

J Neurovirol. 2019 Aug;25(4):475-479. doi: 10.1007/s13365-019-00746-x. Epub 2019 Apr 26.

PMID:
31028690
2.

Control of the HIV-1 Load Varies by Viral Subtype in a Large Cohort of African Adults With Incident HIV-1 Infection.

Price MA, Rida W, Kilembe W, Karita E, Inambao M, Ruzagira E, Kamali A, Sanders EJ, Anzala O, Hunter E, Allen S, Edward VA, Wall KM, Tang J, Fast PE, Kaleebu P, Lakhi S, Mutua G, Bekker LG, Abu-Baker G, Tichacek A, Chetty P, Latka MH, Maenetje P, Makkan H, Kibengo F, Priddy F, Gilmour J.

J Infect Dis. 2019 Jul 2;220(3):432-441. doi: 10.1093/infdis/jiz127.

3.

Healthcare Costs and Life-years Gained From Treatments Within the Advancing Cryptococcal Meningitis Treatment for Africa (ACTA) Trial on Cryptococcal Meningitis: A Comparison of Antifungal Induction Strategies in Sub-Saharan Africa.

Chen T, Mwenge L, Lakhi S, Chanda D, Mwaba P, Molloy SF, Gheorghe A, Griffiths UK, Heyderman RS, Kanyama C, Kouanfack C, Mfinanga S, Chan AK, Temfack E, Kivuyo S, Hosseinipour MC, Lortholary O, Loyse A, Jaffar S, Harrison TS, Niessen LW; ACTA Trial Team.

Clin Infect Dis. 2019 Mar 13. pii: ciy971. doi: 10.1093/cid/ciy971. [Epub ahead of print]

4.

Addition of flucytosine to fluconazole for the treatment of cryptococcal meningitis in Africa: a multi-country cost-effectiveness analysis.

Shiri T, Loyse A, Mwenge L, Chen T, Lakhi S, Chanda D, Mwaba P, Molloy SF, Heyderman R, Kanyama C, Hosseinipour MC, Kouanfack C, Temfack E, Mfinanga S, Kivuyo S, Chan AK, Jarvis JN, Lortholary O, Jaffar S, Niessen LW, Harrison TS.

Clin Infect Dis. 2019 Feb 28. pii: ciz163. doi: 10.1093/cid/ciz163. [Epub ahead of print]

5.

VH1-69 Utilizing Antibodies Are Capable of Mediating Non-neutralizing Fc-Mediated Effector Functions Against the Transmitted/Founder gp120.

Smith SA, Burton SL, Kilembe W, Lakhi S, Karita E, Price M, Allen S, Derdeyn CA.

Front Immunol. 2019 Jan 15;9:3163. doi: 10.3389/fimmu.2018.03163. eCollection 2018.

6.

Schistosomiasis is associated with incident HIV transmission and death in Zambia.

Wall KM, Kilembe W, Vwalika B, Dinh C, Livingston P, Lee YM, Lakhi S, Boeras D, Naw HK, Brill I, Chomba E, Sharkey T, Parker R, Shutes E, Tichacek A, Secor WE, Allen S.

PLoS Negl Trop Dis. 2018 Dec 13;12(12):e0006902. doi: 10.1371/journal.pntd.0006902. eCollection 2018 Dec.

7.

Leave no one behind: response to new evidence and guidelines for the management of cryptococcal meningitis in low-income and middle-income countries.

Loyse A, Burry J, Cohn J, Ford N, Chiller T, Ribeiro I, Koulla-Shiro S, Mghamba J, Ramadhani A, Nyirenda R, Aliyu SH, Wilson D, Le T, Oladele R, Lesikari S, Muzoora C, Kalata N, Temfack E, Mapoure Y, Sini V, Chanda D, Shimwela M, Lakhi S, Ngoma J, Gondwe-Chunda L, Perfect C, Shroufi A, Andrieux-Meyer I, Chan A, Schutz C, Hosseinipour M, Van der Horst C, Klausner JD, Boulware DR, Heyderman R, Lalloo D, Day J, Jarvis JN, Rodrigues M, Jaffar S, Denning D, Migone C, Doherty M, Lortholary O, Dromer F, Stack M, Molloy SF, Bicanic T, van Oosterhout J, Mwaba P, Kanyama C, Kouanfack C, Mfinanga S, Govender N, Harrison TS.

Lancet Infect Dis. 2019 Apr;19(4):e143-e147. doi: 10.1016/S1473-3099(18)30493-6. Epub 2018 Oct 18. Review.

PMID:
30344084
8.

Effect of oral fluconazole 1200 mg/day on QT interval in African adults with HIV-associated cryptococcal meningitis.

Molloy SF, Bradley J, Karunaharan N, Mputu M, Stone N, Phulusa J, Chawinga C, Gaskell K, Segula D, Ming D, Peirse M, Chanda D, Lakhi S, Loyse A, Kanyama C, Heyderman RS, Harrison TS.

AIDS. 2018 Sep 24;32(15):2259-2261. doi: 10.1097/QAD.0000000000001961.

9.

Prediction of extended high viremia among newly HIV-1-infected persons in sub-Saharan Africa.

Powers KA, Price MA, Karita E, Kamali A, Kilembe W, Allen S, Hunter E, Bekker LG, Lakhi S, Inambao M, Anzala O, Latka MH, Fast PE, Gilmour J, Sanders EJ.

PLoS One. 2018 Apr 3;13(4):e0192785. doi: 10.1371/journal.pone.0192785. eCollection 2018.

10.

Antifungal Combinations for Treatment of Cryptococcal Meningitis in Africa.

Molloy SF, Kanyama C, Heyderman RS, Loyse A, Kouanfack C, Chanda D, Mfinanga S, Temfack E, Lakhi S, Lesikari S, Chan AK, Stone N, Kalata N, Karunaharan N, Gaskell K, Peirse M, Ellis J, Chawinga C, Lontsi S, Ndong JG, Bright P, Lupiya D, Chen T, Bradley J, Adams J, van der Horst C, van Oosterhout JJ, Sini V, Mapoure YN, Mwaba P, Bicanic T, Lalloo DG, Wang D, Hosseinipour MC, Lortholary O, Jaffar S, Harrison TS; ACTA Trial Study Team.

N Engl J Med. 2018 Mar 15;378(11):1004-1017. doi: 10.1056/NEJMoa1710922.

11.

Derivation and validation of a universal vital assessment (UVA) score: a tool for predicting mortality in adult hospitalised patients in sub-Saharan Africa.

Moore CC, Hazard R, Saulters KJ, Ainsworth J, Adakun SA, Amir A, Andrews B, Auma M, Baker T, Banura P, Crump JA, Grobusch MP, Huson MAM, Jacob ST, Jarrett OD, Kellett J, Lakhi S, Majwala A, Opio M, Rubach MP, Rylance J, Michael Scheld W, Schieffelin J, Ssekitoleko R, Wheeler I, Barnes LE.

BMJ Glob Health. 2017 Jul 28;2(2):e000344. doi: 10.1136/bmjgh-2017-000344. eCollection 2017.

12.

Differences in acute retroviral syndrome by HIV-1 subtype in a multicentre cohort study in Africa.

Sanders EJ, Price MA, Karita E, Kamali A, Kilembe W, Bekker LG, Lakhi S, Inambao M, Anzala O, Fast PE, Gilmour J, Powers KA.

AIDS. 2017 Nov 28;31(18):2541-2546. doi: 10.1097/QAD.0000000000001659.

13.

Effect of an Early Resuscitation Protocol on In-hospital Mortality Among Adults With Sepsis and Hypotension: A Randomized Clinical Trial.

Andrews B, Semler MW, Muchemwa L, Kelly P, Lakhi S, Heimburger DC, Mabula C, Bwalya M, Bernard GR.

JAMA. 2017 Oct 3;318(13):1233-1240. doi: 10.1001/jama.2017.10913.

14.

HIV infection, hypercoagulability and ischaemic stroke in adults at the University Teaching Hospital in Zambia: a case control study.

Zimba S, Ntanda PM, Lakhi S, Atadzhanov M.

BMC Infect Dis. 2017 May 18;17(1):354. doi: 10.1186/s12879-017-2455-0.

15.

Risk of heterosexual HIV transmission attributable to sexually transmitted infections and non-specific genital inflammation in Zambian discordant couples, 1994-2012.

Wall KM, Kilembe W, Vwalika B, Haddad LB, Hunter E, Lakhi S, Chavuma R, Htee Khu N, Brill I, Vwalika C, Mwananyanda L, Chomba E, Mulenga J, Tichacek A, Allen S.

Int J Epidemiol. 2017 Oct 1;46(5):1593-1606. doi: 10.1093/ije/dyx045.

16.

No Evidence for Association of β-Defensin Genomic Copy Number with HIV Susceptibility, HIV Load during Clinical Latency, or Progression to AIDS.

Abujaber R, Shea PR, McLaren PJ, Lakhi S, Gilmour J, Allen S, Fellay J, Hollox EJ; IAVI Africa HIV Prevention Partnership, Swiss HIV Cohort Study.

Ann Hum Genet. 2017 Jan;81(1):27-34. doi: 10.1111/ahg.12182.

17.

Sustained effect of couples' HIV counselling and testing on risk reduction among Zambian HIV serodiscordant couples.

Wall KM, Kilembe W, Vwalika B, Haddad LB, Lakhi S, Onwubiko U, Htee Khu N, Brill I, Chavuma R, Vwalika C, Mwananyanda L, Chomba E, Mulenga J, Tichacek A, Allen S.

Sex Transm Infect. 2017 Jun;93(4):259-266. doi: 10.1136/sextrans-2016-052743. Epub 2017 Jan 12.

18.

Developing a successful global neurology program.

Siddiqi OK, Brown M, Cooper C, Atadzhanov M, Lakhi S, Koralnik IJ.

Ann Neurol. 2017 Feb;81(2):167-170. doi: 10.1002/ana.24863. Review. No abstract available.

PMID:
28019673
19.

Pregnancy and HIV Disease Progression in an Early Infection Cohort from Five African Countries.

Wall KM, Rida W, Haddad LB, Kamali A, Karita E, Lakhi S, Kilembe W, Allen S, Inambao M, Yang AH, Latka MH, Anzala O, Sanders EJ, Bekker LG, Edward VA, Price MA.

Epidemiology. 2017 Mar;28(2):224-232. doi: 10.1097/EDE.0000000000000590.

20.

Genomic epidemiology of Cryptococcus yeasts identifies adaptation to environmental niches underpinning infection across an African HIV/AIDS cohort.

Vanhove M, Beale MA, Rhodes J, Chanda D, Lakhi S, Kwenda G, Molloy S, Karunaharan N, Stone N, Harrison TS, Bicanic T, Fisher MC.

Mol Ecol. 2017 Apr;26(7):1991-2005. doi: 10.1111/mec.13891. Epub 2016 Nov 8.

21.

Diversification in the HIV-1 Envelope Hyper-variable Domains V2, V4, and V5 and Higher Probability of Transmitted/Founder Envelope Glycosylation Favor the Development of Heterologous Neutralization Breadth.

Smith SA, Burton SL, Kilembe W, Lakhi S, Karita E, Price M, Allen S, Hunter E, Derdeyn CA.

PLoS Pathog. 2016 Nov 16;12(11):e1005989. doi: 10.1371/journal.ppat.1005989. eCollection 2016 Nov.

22.

Dynamics and Correlates of CD8 T-Cell Counts in Africans with Primary Human Immunodeficiency Virus Type 1 Infection.

Prentice HA, Lu H, Price MA, Kamali A, Karita E, Lakhi S, Sanders EJ, Anzala O, Allen S, Goepfert PA, Hunter E, Gilmour J, Tang J.

J Virol. 2016 Oct 28;90(22):10423-10430. doi: 10.1128/JVI.01467-16. Print 2016 Nov 15.

23.

A 27-Year-Old Severely Immunosuppressed Female with Misleading Clinical Features of Disseminated Cutaneous Sporotrichosis.

Patel A, Mudenda V, Lakhi S, Ngalamika O.

Case Rep Dermatol Med. 2016;2016:9403690. doi: 10.1155/2016/9403690. Epub 2016 Jan 4.

24.

Broadly Neutralizing Antibody Responses in a Large Longitudinal Sub-Saharan HIV Primary Infection Cohort.

Landais E, Huang X, Havenar-Daughton C, Murrell B, Price MA, Wickramasinghe L, Ramos A, Bian CB, Simek M, Allen S, Karita E, Kilembe W, Lakhi S, Inambao M, Kamali A, Sanders EJ, Anzala O, Edward V, Bekker LG, Tang J, Gilmour J, Kosakovsky-Pond SL, Phung P, Wrin T, Crotty S, Godzik A, Poignard P.

PLoS Pathog. 2016 Jan 14;12(1):e1005369. doi: 10.1371/journal.ppat.1005369. eCollection 2016 Jan.

25.

Hormonal Contraception, Pregnancy, Breastfeeding, and Risk of HIV Disease Progression Among Zambian Women.

Wall KM, Kilembe W, Haddad L, Vwalika B, Lakhi S, Khu NH, Brill I, Chomba E, Mulenga J, Tichacek A, Allen S.

J Acquir Immune Defic Syndr. 2016 Mar 1;71(3):345-52. doi: 10.1097/QAI.0000000000000848.

26.

HLA Class-II Associated HIV Polymorphisms Predict Escape from CD4+ T Cell Responses.

Erdmann N, Du VY, Carlson J, Schaefer M, Jureka A, Sterrett S, Yue L, Dilernia D, Lakhi S, Tang J, Sidney J, Gilmour J, Allen S, Hunter E, Heath S, Bansal A, Goepfert PA.

PLoS Pathog. 2015 Aug 24;11(8):e1005111. doi: 10.1371/journal.ppat.1005111. eCollection 2015 Aug.

27.

High Transmitter CD4+ T-Cell Count Shortly after the Time of Transmission in a Study of African Serodiscordant Couples.

Karita E, Price MA, Lakhi S, Kilembe W, Kamali A, Ruzagira E, Hunter E, Farmer P, Allen S, Stevens G, Chetty P, Welsh S, Yang A, Gilmour J, Fast P; IAVI Africa HIV Prevention Partnership.

PLoS One. 2015 Aug 20;10(8):e0134438. doi: 10.1371/journal.pone.0134438. eCollection 2015.

28.

CD4:CD8 lymphocyte ratio as a quantitative measure of immunologic health in HIV-1 infection: findings from an African cohort with prospective data.

Tang J, Li X, Price MA, Sanders EJ, Anzala O, Karita E, Kamali A, Lakhi S, Allen S, Hunter E, Kaslow RA, Gilmour J.

Front Microbiol. 2015 Jul 1;6:670. doi: 10.3389/fmicb.2015.00670. eCollection 2015.

29.

Replicative fitness of transmitted HIV-1 drives acute immune activation, proviral load in memory CD4+ T cells, and disease progression.

Claiborne DT, Prince JL, Scully E, Macharia G, Micci L, Lawson B, Kopycinski J, Deymier MJ, Vanderford TH, Nganou-Makamdop K, Ende Z, Brooks K, Tang J, Yu T, Lakhi S, Kilembe W, Silvestri G, Douek D, Goepfert PA, Price MA, Allen SA, Paiardini M, Altfeld M, Gilmour J, Hunter E.

Proc Natl Acad Sci U S A. 2015 Mar 24;112(12):E1480-9. doi: 10.1073/pnas.1421607112. Epub 2015 Feb 17.

30.

Creating an African HIV clinical research and prevention trials network: HIV prevalence, incidence and transmission.

Kamali A, Price MA, Lakhi S, Karita E, Inambao M, Sanders EJ, Anzala O, Latka MH, Bekker LG, Kaleebu P, Asiki G, Ssetaala A, Ruzagira E, Allen S, Farmer P, Hunter E, Mutua G, Makkan H, Tichacek A, Brill IK, Fast P, Stevens G, Chetty P, Amornkul PN, Gilmour J; IAVI Africa HIV Prevention Partnership.

PLoS One. 2015 Jan 20;10(1):e0116100. doi: 10.1371/journal.pone.0116100. eCollection 2015.

31.

Simplified severe sepsis protocol: a randomized controlled trial of modified early goal-directed therapy in Zambia.

Andrews B, Muchemwa L, Kelly P, Lakhi S, Heimburger DC, Bernard GR.

Crit Care Med. 2014 Nov;42(11):2315-24. doi: 10.1097/CCM.0000000000000541.

32.

Host genetics and viral load in primary HIV-1 infection: clear evidence for gene by sex interactions.

Li X, Price MA, He D, Kamali A, Karita E, Lakhi S, Sanders EJ, Anzala O, Amornkul PN, Allen S, Hunter E, Kaslow RA, Gilmour J, Tang J; IAVI Africa HIV Prevention Partnership.

Hum Genet. 2014 Sep;133(9):1187-97. doi: 10.1007/s00439-014-1465-x. Epub 2014 Jun 27.

33.

Frequency of APOE, MTHFR and ACE polymorphisms in the Zambian population.

Atadzhanov M, Mwaba MH, Mukomena PN, Lakhi S, Mwaba P, Rayaprolu S, Meschia JF, Ross OA.

BMC Res Notes. 2014 Mar 28;7:194. doi: 10.1186/1756-0500-7-194.

34.

Dynamics of viremia in primary HIV-1 infection in Africans: insights from analyses of host and viral correlates.

Prentice HA, Price MA, Porter TR, Cormier E, Mugavero MJ, Kamali A, Karita E, Lakhi S, Sanders EJ, Anzala O, Amornkul PN, Allen S, Hunter E, Kaslow RA, Gilmour J, Tang J; IAVI Africa HIV Prevention Partnership.

Virology. 2014 Jan 20;449:254-62. doi: 10.1016/j.virol.2013.11.024. Epub 2013 Dec 12.

35.

Association of the APOE, MTHFR and ACE Genes Polymorphisms and Stroke in Zambian Patients.

Atadzhanov M, Mwaba MH, Mukomena PN, Lakhi S, Rayaprolu S, Ross OA, Meschia JF.

Neurol Int. 2013 Nov 11;5(4):e20. doi: 10.4081/ni.2013.e20. eCollection 2013.

36.

Medical students' clerkship experiences and self-perceived competence in clinical skills.

Katowa-Mukwato P, Andrews B, Maimbolwa M, Lakhi S, Michelo C, Mulla Y, Banda SS.

Afr J Health Prof Educ. 2014;6(2):155-160. Epub 2014 Jul 30.

37.

Disease progression by infecting HIV-1 subtype in a seroconverter cohort in sub-Saharan Africa.

Amornkul PN, Karita E, Kamali A, Rida WN, Sanders EJ, Lakhi S, Price MA, Kilembe W, Cormier E, Anzala O, Latka MH, Bekker LG, Allen SA, Gilmour J, Fast PE; IAVI Africa HIV Prevention Partnership.

AIDS. 2013 Nov 13;27(17):2775-86. doi: 10.1097/QAD.0000000000000012.

38.

Insulin modulates the electrical activity of subfornical organ neurons.

Lakhi S, Snow W, Fry M.

Neuroreport. 2013 Apr 17;24(6):329-34. doi: 10.1097/WNR.0b013e32835ffc14.

PMID:
23481267
39.

HLA-B*57 versus HLA-B*81 in HIV-1 infection: slow and steady wins the race?

Prentice HA, Porter TR, Price MA, Cormier E, He D, Farmer PK, Kamali A, Karita E, Lakhi S, Sanders EJ, Anzala O, Amornkul PN, Allen S, Hunter E, Kaslow RA, Gilmour J, Tang J; IAVI African HIV Research Network.

J Virol. 2013 Apr;87(7):4043-51. doi: 10.1128/JVI.03302-12. Epub 2013 Jan 30.

40.

The use of Loop-mediated Isothermal Amplification (LAMP) to detect the re-emerging Human African Trypanosomiasis (HAT) in the Luangwa and Zambezi valleys.

Namangala B, Hachaambwa L, Kajino K, Mweene AS, Hayashida K, Simuunza M, Simukoko H, Choongo K, Chansa P, Lakhi S, Moonga L, Chota A, Ndebe J, Nsakashalo-Senkwe M, Chizema E, Kasonka L, Sugimoto C.

Parasit Vectors. 2012 Dec 4;5:282. doi: 10.1186/1756-3305-5-282.

41.

Cumulative impact of host and viral factors on HIV-1 viral-load control during early infection.

Yue L, Prentice HA, Farmer P, Song W, He D, Lakhi S, Goepfert P, Gilmour J, Allen S, Tang J, Kaslow RA, Hunter E.

J Virol. 2013 Jan;87(2):708-15. doi: 10.1128/JVI.02118-12. Epub 2012 Oct 31.

42.

Failure of a novel, rapid antigen and antibody combination test to detect antigen-positive HIV infection in African adults with early HIV infection.

Kilembe W, Keeling M, Karita E, Lakhi S, Chetty P, Price MA, Makkan H, Latka M, Likoti M, Ilukui K, Hurlston M, Allen S, Stevens G, Hunter E.

PLoS One. 2012;7(6):e37154. doi: 10.1371/journal.pone.0037154. Epub 2012 Jun 8.

43.

Association of interleukin-6 and interleukin-8 with poor prognosis in elderly patients with chronic lymphocytic leukemia.

Yoon JY, Lafarge S, Dawe D, Lakhi S, Kumar R, Morales C, Marshall A, Gibson SB, Johnston JB.

Leuk Lymphoma. 2012 Sep;53(9):1735-42. doi: 10.3109/10428194.2012.666662.

PMID:
22475215
44.

Differences in HIV natural history among African and non-African seroconverters in Europe and seroconverters in sub-Saharan Africa.

Pantazis N, Morrison C, Amornkul PN, Lewden C, Salata RA, Minga A, Chipato T, Jaffe H, Lakhi S, Karita E, Porter K, Meyer L, Touloumi G; CASCADE Collaboration in EuroCoord and ANRS 1220 Primo-CI Study Group.

PLoS One. 2012;7(3):e32369. doi: 10.1371/journal.pone.0032369. Epub 2012 Mar 6.

45.
46.

HIV, Hepatitis B, and Hepatitis C in Zambia.

Kapembwa KC, Goldman JD, Lakhi S, Banda Y, Bowa K, Vermund SH, Mulenga J, Chama D, Chi BH.

J Glob Infect Dis. 2011 Jul;3(3):269-74. doi: 10.4103/0974-777X.83534.

47.

Human leukocyte antigen variants B*44 and B*57 are consistently favorable during two distinct phases of primary HIV-1 infection in sub-Saharan Africans with several viral subtypes.

Tang J, Cormier E, Gilmour J, Price MA, Prentice HA, Song W, Kamali A, Karita E, Lakhi S, Sanders EJ, Anzala O, Amornkul PN, Allen S, Hunter E, Kaslow RA; IAVI African HIV Research Network.

J Virol. 2011 Sep;85(17):8894-902. doi: 10.1128/JVI.00439-11. Epub 2011 Jun 29.

48.

Transmitted HIV type 1 drug resistance among individuals with recent HIV infection in East and Southern Africa.

Price MA, Wallis CL, Lakhi S, Karita E, Kamali A, Anzala O, Sanders EJ, Bekker LG, Twesigye R, Hunter E, Kaleebu P, Kayitenkore K, Allen S, Ruzagira E, Mwangome M, Mutua G, Amornkul PN, Stevens G, Pond SL, Schaefer M, Papathanasopoulos MA, Stevens W, Gilmour J; IAVI Early Infection Cohort Study Group.

AIDS Res Hum Retroviruses. 2011 Jan;27(1):5-12. doi: 10.1089/aid.2010.0030. Epub 2010 Nov 23.

49.
50.

Affordable in-house antiretroviral drug resistance assay with good performance in non-subtype B HIV-1.

Wallis CL, Papathanasopoulos MA, Lakhi S, Karita E, Kamali A, Kaleebu P, Sanders E, Anzala O, Bekker LG, Stevens G, de Wit TF, Stevens W.

J Virol Methods. 2010 Feb;163(2):505-8. doi: 10.1016/j.jviromet.2009.11.011. Epub 2009 Nov 14.

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