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Items: 13


Ferroportin-mediated iron export from vascular endothelial cells in retina and brain.

Baumann BH, Shu W, Song Y, Simpson EM, Lakhal-Littleton S, Dunaief JL.

Exp Eye Res. 2019 Jul 16:107728. doi: 10.1016/j.exer.2019.107728. [Epub ahead of print]


Intracellular iron deficiency in pulmonary arterial smooth muscle cells induces pulmonary arterial hypertension in mice.

Lakhal-Littleton S, Crosby A, Frise MC, Mohammad G, Carr CA, Loick PAM, Robbins PA.

Proc Natl Acad Sci U S A. 2019 Jun 25;116(26):13122-13130. doi: 10.1073/pnas.1822010116. Epub 2019 May 31.


Cardiomyocyte hepcidin: From intracellular iron homeostasis to physiological function.

Lakhal-Littleton S.

Vitam Horm. 2019;110:189-200. doi: 10.1016/bs.vh.2019.01.009. Epub 2019 Feb 1. Review.


Iron-deficiency anemia reduces cardiac contraction by downregulating RyR2 channels and suppressing SERCA pump activity.

Chung YJ, Luo A, Park KC, Loonat AA, Lakhal-Littleton S, Robbins PA, Swietach P.

JCI Insight. 2019 Apr 4;4(7). pii: 125618. doi: 10.1172/jci.insight.125618. eCollection 2019 Apr 4.


Hepatic hepcidin/intestinal HIF-2α axis maintains iron absorption during iron deficiency and overload.

Schwartz AJ, Das NK, Ramakrishnan SK, Jain C, Jurkovic MT, Wu J, Nemeth E, Lakhal-Littleton S, Colacino JA, Shah YM.

J Clin Invest. 2019 Jan 2;129(1):336-348. doi: 10.1172/JCI122359. Epub 2018 Dec 10.


Mechanisms of cardiac iron homeostasis and their importance to heart function.

Lakhal-Littleton S.

Free Radic Biol Med. 2019 Mar;133:234-237. doi: 10.1016/j.freeradbiomed.2018.08.010. Epub 2018 Aug 11. Review.


The interplay between iron and oxygen homeostasis with a particular focus on the heart.

Lakhal-Littleton S, Robbins PA.

J Appl Physiol (1985). 2017 Oct 1;123(4):967-973. doi: 10.1152/japplphysiol.00237.2017. Epub 2017 Aug 3. Review.


An essential cell-autonomous role for hepcidin in cardiac iron homeostasis.

Lakhal-Littleton S, Wolna M, Chung YJ, Christian HC, Heather LC, Brescia M, Ball V, Diaz R, Santos A, Biggs D, Clarke K, Davies B, Robbins PA.

Elife. 2016 Nov 29;5. pii: e19804. doi: 10.7554/eLife.19804.


Induced Disruption of the Iron-Regulatory Hormone Hepcidin Inhibits Acute Inflammatory Hypoferraemia.

Armitage AE, Lim PJ, Frost JN, Pasricha SR, Soilleux EJ, Evans E, Morovat A, Santos A, Diaz R, Biggs D, Davies B, Gileadi U, Robbins PA, Lakhal-Littleton S, Drakesmith H.

J Innate Immun. 2016;8(5):517-28. doi: 10.1159/000447713. Epub 2016 Jul 16.


Suppression of plasma hepcidin by venesection during steady-state hypoxia.

Talbot NP, Smith TG, Lakhal-Littleton S, Gülsever C, Rivera-Ch M, Dorrington KL, Mole DR, Robbins PA.

Blood. 2016 Mar 3;127(9):1206-7. doi: 10.1182/blood-2015-05-647404. Epub 2016 Jan 15. No abstract available.


Cardiac ferroportin regulates cellular iron homeostasis and is important for cardiac function.

Lakhal-Littleton S, Wolna M, Carr CA, Miller JJ, Christian HC, Ball V, Santos A, Diaz R, Biggs D, Stillion R, Holdship P, Larner F, Tyler DJ, Clarke K, Davies B, Robbins PA.

Proc Natl Acad Sci U S A. 2015 Mar 10;112(10):3164-9. doi: 10.1073/pnas.1422373112. Epub 2015 Feb 23. Erratum in: Proc Natl Acad Sci U S A. 2015 Apr 7;112(14):E1812.


Exosome-mediated delivery of siRNA in vitro and in vivo.

El-Andaloussi S, Lee Y, Lakhal-Littleton S, Li J, Seow Y, Gardiner C, Alvarez-Erviti L, Sargent IL, Wood MJ.

Nat Protoc. 2012 Dec;7(12):2112-26. doi: 10.1038/nprot.2012.131. Epub 2012 Nov 15.


Hepcidin demonstrates a biphasic association with anemia in acute Plasmodium falciparum malaria.

Casals-Pascual C, Huang H, Lakhal-Littleton S, Thezenas ML, Kai O, Newton CR, Roberts DJ.

Haematologica. 2012 Nov;97(11):1695-8. doi: 10.3324/haematol.2012.065854. Epub 2012 Jun 11.

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