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Items: 1 to 50 of 273

1.

An evaluation of the human relevance of the liver tumors observed in female mice treated with permethrin based on mode of action.

Kondo M, Kikumoto H, Osimitz TG, Cohen SM, Lake BG, Yamada T.

Toxicol Sci. 2020 Feb 10. pii: kfaa017. doi: 10.1093/toxsci/kfaa017. [Epub ahead of print]

PMID:
32040184
2.
3.

Analysis of β-catenin gene mutations and gene expression in liver tumours of C57BL/10J mice produced by chronic administration of sodium phenobarbital.

Sidaway JE, Orton TC, Kalaitzi K, Jones HB, Foster A, Lake BG.

Toxicology. 2020 Jan 30;430:152343. doi: 10.1016/j.tox.2019.152343. Epub 2019 Dec 10.

PMID:
31836555
4.

Development and Application of a Life-Stage Physiologically Based Pharmacokinetic (PBPK) Model to the Assessment of Internal Dose of Pyrethroids in Humans.

Mallick P, Moreau M, Song G, Efremenko AY, Pendse SN, Creek MR, Osimitz TG, Hines RN, Hinderliter P, Clewell HJ, Lake BG, Yoon M.

Toxicol Sci. 2020 Jan 1;173(1):86-99. doi: 10.1093/toxsci/kfz211.

5.

Metazachlor: Mode of action analysis for rat liver tumour formation and human relevance.

Wiemann C, Goettel M, Vardy A, Elcombe BM, Elcombe CR, Chatham LR, Wang H, Li L, Buesen R, Honarvar N, Treumann S, Marxfeld H, Groeters S, Lake BG.

Toxicology. 2019 Oct 1;426:152282. doi: 10.1016/j.tox.2019.152282. Epub 2019 Aug 26.

PMID:
31465819
6.

An assay for screening xenobiotics for inhibition of rat thyroid gland peroxidase activity.

Price RJ, Burch R, Chatham LR, Higgins LG, Currie RA, Lake BG.

Xenobiotica. 2020 Mar;50(3):318-322. doi: 10.1080/00498254.2019.1629044. Epub 2019 Jun 19.

PMID:
31180273
7.

Evaluation of Age-Related Pyrethroid Pharmacokinetic Differences in Rats: Physiologically-Based Pharmacokinetic Model Development Using In Vitro Data and In Vitro to In Vivo Extrapolation.

Song G, Moreau M, Efremenko A, Lake BG, Wu H, Bruckner JV, White CA, Osimitz TG, Creek MR, Hinderliter PM, Clewell HJ, Yoon M.

Toxicol Sci. 2019 Jun 1;169(2):365-379. doi: 10.1093/toxsci/kfz042.

PMID:
30768128
8.

Involvement of Peroxisome Proliferator-Activated Receptor-Alpha in Liver Tumor Production by Permethrin in the Female Mouse.

Kondo M, Miyata K, Nagahori H, Sumida K, Osimitz TG, Cohen SM, Lake BG, Yamada T.

Toxicol Sci. 2019 Apr 1;168(2):572-596. doi: 10.1093/toxsci/kfz012.

PMID:
30629241
9.

Human relevance of rodent liver tumour formation by constitutive androstane receptor (CAR) activators.

Lake BG.

Toxicol Res (Camb). 2018 Mar 12;7(4):697-717. doi: 10.1039/c8tx00008e. eCollection 2018 Jul 1. Review.

10.

Metabolism of deltamethrin and cis- and trans-permethrin by human expressed cytochrome P450 and carboxylesterase enzymes.

Hedges L, Brown S, MacLeod AK, Vardy A, Doyle E, Song G, Moreau M, Yoon M, Osimitz TG, Lake BG.

Xenobiotica. 2019 May;49(5):521-527. doi: 10.1080/00498254.2018.1474283. Epub 2018 Jun 4.

PMID:
29779438
11.
12.

Metabolism of deltamethrin and cis- and trans-permethrin by rat and human liver microsomes, liver cytosol and plasma preparations.

Hedges L, Brown S, Vardy A, Doyle E, Yoon M, Osimitz TG, Lake BG.

Xenobiotica. 2019 Apr;49(4):388-396. doi: 10.1080/00498254.2018.1451011. Epub 2018 Apr 19.

PMID:
29537356
13.

Comparison of the effects of sodium phenobarbital in wild type and humanized constitutive androstane receptor (CAR)/pregnane X receptor (PXR) mice and in cultured mouse, rat and human hepatocytes.

Haines C, Elcombe BM, Chatham LR, Vardy A, Higgins LG, Elcombe CR, Lake BG.

Toxicology. 2018 Mar 1;396-397:23-32. doi: 10.1016/j.tox.2018.02.001. Epub 2018 Feb 6.

PMID:
29425889
14.

Comparison of the hepatic and thyroid gland effects of sodium phenobarbital and pregnenolone-16α-carbonitrile in wild-type and constitutive androstane receptor (CAR)/pregnane X receptor (PXR) knockout rats.

Haines C, Chatham LR, Vardy A, Elcombe CR, Foster JR, Lake BG.

Xenobiotica. 2019 Feb;49(2):227-238. doi: 10.1080/00498254.2018.1437300. Epub 2018 Mar 26.

PMID:
29424600
15.

Evaluation of the human relevance of the constitutive androstane receptor-mediated mode of action for rat hepatocellular tumor formation by the synthetic pyrethroid momfluorothrin.

Okuda Y, Kushida M, Kikumoto H, Nakamura Y, Higuchi H, Kawamura S, Cohen SM, Lake BG, Yamada T.

J Toxicol Sci. 2017;42(6):773-788. doi: 10.2131/jts.42.773.

16.

Editor's Highlight: Mode of Action Analysis for Rat Hepatocellular Tumors Produced by the Synthetic Pyrethroid Momfluorothrin: Evidence for Activation of the Constitutive Androstane Receptor and Mitogenicity in Rat Hepatocytes.

Okuda Y, Kushida M, Sumida K, Nagahori H, Nakamura Y, Higuchi H, Kawamura S, Lake BG, Cohen SM, Yamada T.

Toxicol Sci. 2017 Aug 1;158(2):412-430. doi: 10.1093/toxsci/kfx102.

PMID:
28520973
17.

An Evaluation of the Human Relevance of the Lung Tumors Observed in Female Mice Treated With Permethrin Based on Mode of Action.

Yamada T, Kondo M, Miyata K, Ogata K, Kushida M, Sumida K, Kawamura S, Osimitz TG, Lake BG, Cohen SM.

Toxicol Sci. 2017 Jun 1;157(2):465-486. doi: 10.1093/toxsci/kfx066.

PMID:
28431163
18.

Determination of Human Hepatic CYP2C8 and CYP1A2 Age-Dependent Expression to Support Human Health Risk Assessment for Early Ages.

Song G, Sun X, Hines RN, McCarver DG, Lake BG, Osimitz TG, Creek MR, Clewell HJ, Yoon M.

Drug Metab Dispos. 2017 May;45(5):468-475. doi: 10.1124/dmd.116.074583. Epub 2017 Feb 22.

PMID:
28228413
19.

The Mode of Action for Phenobarbital-Induced Rodent Liver Tumor Formation Is not Relevant for Humans: Recent Studies With Humanized Mice.

Yamada T, Cohen SM, Lake BG.

Toxicol Sci. 2015 Oct;147(2):298-9. doi: 10.1093/toxsci/kfv186. No abstract available.

PMID:
26408565
20.

Human hepatocytes support the hypertrophic but not the hyperplastic response to the murine nongenotoxic hepatocarcinogen sodium phenobarbital in an in vivo study using a chimeric mouse with humanized liver.

Yamada T, Okuda Y, Kushida M, Sumida K, Takeuchi H, Nagahori H, Fukuda T, Lake BG, Cohen SM, Kawamura S.

Toxicol Sci. 2014 Nov;142(1):137-57. doi: 10.1093/toxsci/kfu173. Epub 2014 Aug 21.

PMID:
25145657
21.

Mode of action analysis for pesticide-induced rodent liver tumours involving activation of the constitutive androstane receptor: relevance to human cancer risk.

Lake BG, Price RJ, Osimitz TG.

Pest Manag Sci. 2015 Jun;71(6):829-34. doi: 10.1002/ps.3854. Epub 2014 Nov 17. Review.

PMID:
25045103
22.

Mode of action and human relevance analysis for nuclear receptor-mediated liver toxicity: A case study with phenobarbital as a model constitutive androstane receptor (CAR) activator.

Elcombe CR, Peffer RC, Wolf DC, Bailey J, Bars R, Bell D, Cattley RC, Ferguson SS, Geter D, Goetz A, Goodman JI, Hester S, Jacobs A, Omiecinski CJ, Schoeny R, Xie W, Lake BG.

Crit Rev Toxicol. 2014 Jan;44(1):64-82. doi: 10.3109/10408444.2013.835786. Epub 2013 Nov 4. Review.

23.

Evaluation of the utility of the lifetime mouse bioassay in the identification of cancer hazards for humans.

Osimitz TG, Droege W, Boobis AR, Lake BG.

Food Chem Toxicol. 2013 Oct;60:550-62. doi: 10.1016/j.fct.2013.08.020. Epub 2013 Aug 15. Review.

PMID:
23954551
24.

Evaluation of the metabolism and hepatotoxicity of xenobiotics utilizing precision-cut slices.

Lake BG, Price RJ.

Xenobiotica. 2013 Jan;43(1):41-53. doi: 10.3109/00498254.2012.734643. Epub 2012 Nov 6. Review.

PMID:
23131042
25.

The search for in vitro systems. (preface).

Lake BG, Vickers AE, Ioannides C.

Xenobiotica. 2013 Jan;43(1):1. doi: 10.3109/00498254.2013.735827. Epub 2012 Oct 25. No abstract available.

PMID:
23094663
26.

Identification of human urinary biomarkers of cruciferous vegetable consumption by metabonomic profiling.

Edmands WM, Beckonert OP, Stella C, Campbell A, Lake BG, Lindon JC, Holmes E, Gooderham NJ.

J Proteome Res. 2011 Oct 7;10(10):4513-21. doi: 10.1021/pr200326k. Epub 2011 Aug 31.

27.

A comprehensive approach to the profiling of the cooked meat carcinogens 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine, and their metabolites in human urine.

Gu D, McNaughton L, Lemaster D, Lake BG, Gooderham NJ, Kadlubar FF, Turesky RJ.

Chem Res Toxicol. 2010 Apr 19;23(4):788-801. doi: 10.1021/tx900436m.

28.
29.
30.

Electronic and structural aspects of p450-mediated drug metabolism.

Lewis DF, Ito Y, Lake BG.

Drug Metab Lett. 2009 Apr;3(2):87-100.

PMID:
19601870
31.

Mode-of-action analysis for induction of rat liver tumors by pyrethrins: relevance to human cancer risk.

Osimitz TG, Lake BG.

Crit Rev Toxicol. 2009;39(6):501-11. doi: 10.1080/10408440902914014. Review.

PMID:
19463055
32.

Comparison of the effects of the synthetic pyrethroid Metofluthrin and phenobarbital on CYP2B form induction and replicative DNA synthesis in cultured rat and human hepatocytes.

Hirose Y, Nagahori H, Yamada T, Deguchi Y, Tomigahara Y, Nishioka K, Uwagawa S, Kawamura S, Isobe N, Lake BG, Okuno Y.

Toxicology. 2009 Apr 5;258(1):64-9.

PMID:
19378387
33.

Effect of chronic phenobarbitone administration on liver tumour formation in the C57BL/10J mouse.

Jones HB, Orton TC, Lake BG.

Food Chem Toxicol. 2009 Jun;47(6):1333-40. doi: 10.1016/j.fct.2009.03.014. Epub 2009 Mar 17.

PMID:
19298838
34.
35.

In vitro assays for induction of drug metabolism.

Lake BG, Price RJ, Giddings AM, Walters DG.

Methods Mol Biol. 2009;481:47-58. doi: 10.1007/978-1-59745-201-4_5. Review.

PMID:
19096794
36.

Induction of drug metabolism: species differences and toxicological relevance.

Graham MJ, Lake BG.

Toxicology. 2008 Dec 30;254(3):184-91. doi: 10.1016/j.tox.2008.09.002. Epub 2008 Sep 7. Review.

PMID:
18824059
37.

Effect of butylated hydroxytoluene, curcumin, propyl gallate and thiabendazole on cytochrome P450 forms in cultured human hepatocytes.

Price RJ, Scott MP, Giddings AM, Walters DG, Stierum RH, Meredith C, Lake BG.

Xenobiotica. 2008 Jun;38(6):574-86. doi: 10.1080/00498250802008615 .

PMID:
18570159
38.

Transcriptome analysis provides new insights into liver changes induced in the rat upon dietary administration of the food additives butylated hydroxytoluene, curcumin, propyl gallate and thiabendazole.

Stierum R, Conesa A, Heijne W, Ommen Bv, Junker K, Scott MP, Price RJ, Meredith C, Lake BG, Groten J.

Food Chem Toxicol. 2008 Aug;46(8):2616-28. doi: 10.1016/j.fct.2008.04.019. Epub 2008 Apr 25.

PMID:
18539377
39.

Effect of Pyrethrins on cytochrome P450 forms in cultured rat and human hepatocytes.

Price RJ, Giddings AM, Scott MP, Walters DG, Capen CC, Osimitz TG, Lake BG.

Toxicology. 2008 Jan 14;243(1-2):84-95. Epub 2007 Oct 7.

PMID:
18022748
40.
41.

Scaling factors for the extrapolation of in vivo metabolic drug clearance from in vitro data: reaching a consensus on values of human microsomal protein and hepatocellularity per gram of liver.

Barter ZE, Bayliss MK, Beaune PH, Boobis AR, Carlile DJ, Edwards RJ, Houston JB, Lake BG, Lipscomb JC, Pelkonen OR, Tucker GT, Rostami-Hodjegan A.

Curr Drug Metab. 2007 Jan;8(1):33-45. Review.

PMID:
17266522
42.

A mode of action for induction of liver tumors by Pyrethrins in the rat.

Price RJ, Walters DG, Finch JM, Gabriel KL, Capen CC, Osimitz TG, Lake BG.

Toxicol Appl Pharmacol. 2007 Jan 15;218(2):186-95. Epub 2006 Nov 11.

PMID:
17188729
43.

Lipophilicity relationships in inhibitors of CYP2C9 and CYP2C19 enzymes.

Lewis DF, Lake BG, Ito Y, Dickins M.

J Enzyme Inhib Med Chem. 2006 Aug;21(4):385-9.

PMID:
17059170
44.
45.
46.

A mode of action for induction of thyroid gland tumors by Pyrethrins in the rat.

Finch JM, Osimitz TG, Gabriel KL, Martin T, Henderson WJ, Capen CC, Butler WH, Lake BG.

Toxicol Appl Pharmacol. 2006 Aug 1;214(3):253-62. Epub 2006 Apr 19.

PMID:
16626768
47.

Determination of a human hepatic microsomal scaling factor for predicting in vivo drug clearance.

Hakooz N, Ito K, Rawden H, Gill H, Lemmers L, Boobis AR, Edwards RJ, Carlile DJ, Lake BG, Houston JB.

Pharm Res. 2006 Mar;23(3):533-9. Epub 2006 Feb 28.

PMID:
16505976
48.

Metabolism of coumarin by human P450s: a molecular modelling study.

Lewis DF, Ito Y, Lake BG.

Toxicol In Vitro. 2006 Mar;20(2):256-64. Epub 2005 Sep 12.

PMID:
16157466
50.

Formation of a mutagenic heterocyclic aromatic amine from creatinine in urine of meat eaters and vegetarians.

Holland RD, Gehring T, Taylor J, Lake BG, Gooderham NJ, Turesky RJ.

Chem Res Toxicol. 2005 Mar;18(3):579-90.

PMID:
15777097

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