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Items: 1 to 50 of 639

1.

Calorie Restriction Curbs Proinflammation That Accompanies Arterial Aging, Preserving a Youthful Phenotype.

Wang M, Zhang L, Zhu W, Zhang J, Kim SH, Wang Y, Ni L, Telljohann R, Monticone RE, McGraw K, Liu L, de Cabo R, Lakatta EG.

J Am Heart Assoc. 2018 Sep 18;7(18):e009112. doi: 10.1161/JAHA.118.009112.

2.

Dual Activation of Phosphodiesterases 3 and 4 Regulates Basal Spontaneous Beating Rate of Cardiac Pacemaker Cells: Role of Compartmentalization?

Vinogradova TM, Kobrinsky E, Lakatta EG.

Front Physiol. 2018 Oct 9;9:1301. doi: 10.3389/fphys.2018.01301. eCollection 2018.

3.

Dietary Sodium Restriction Reduces Arterial Stiffness, Vascular TGF-β-Dependent Fibrosis and Marinobufagenin in Young Normotensive Rats.

Grigorova YN, Wei W, Petrashevskaya N, Zernetkina V, Juhasz O, Fenner R, Gilbert C, Lakatta EG, Shapiro JI, Bagrov AY, Fedorova OV.

Int J Mol Sci. 2018 Oct 15;19(10). pii: E3168. doi: 10.3390/ijms19103168.

4.

Segment-specific associations between local haemodynamic and imaging markers of early atherosclerosis at the carotid artery: an in vivo human study.

Gallo D, Bijari PB, Morbiducci U, Qiao Y, Xie YJ, Etesami M, Habets D, Lakatta EG, Wasserman BA, Steinman DA.

J R Soc Interface. 2018 Oct 10;15(147). pii: 20180352. doi: 10.1098/rsif.2018.0352.

PMID:
30305419
5.

Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits.

Evangelou E, Warren HR, Mosen-Ansorena D, Mifsud B, Pazoki R, Gao H, Ntritsos G, Dimou N, Cabrera CP, Karaman I, Ng FL, Evangelou M, Witkowska K, Tzanis E, Hellwege JN, Giri A, Velez Edwards DR, Sun YV, Cho K, Gaziano JM, Wilson PWF, Tsao PS, Kovesdy CP, Esko T, Mägi R, Milani L, Almgren P, Boutin T, Debette S, Ding J, Giulianini F, Holliday EG, Jackson AU, Li-Gao R, Lin WY, Luan J, Mangino M, Oldmeadow C, Prins BP, Qian Y, Sargurupremraj M, Shah N, Surendran P, Thériault S, Verweij N, Willems SM, Zhao JH, Amouyel P, Connell J, de Mutsert R, Doney ASF, Farrall M, Menni C, Morris AD, Noordam R, Paré G, Poulter NR, Shields DC, Stanton A, Thom S, Abecasis G, Amin N, Arking DE, Ayers KL, Barbieri CM, Batini C, Bis JC, Blake T, Bochud M, Boehnke M, Boerwinkle E, Boomsma DI, Bottinger EP, Braund PS, Brumat M, Campbell A, Campbell H, Chakravarti A, Chambers JC, Chauhan G, Ciullo M, Cocca M, Collins F, Cordell HJ, Davies G, Borst MH, Geus EJ, Deary IJ, Deelen J, Del Greco M F, Demirkale CY, Dörr M, Ehret GB, Elosua R, Enroth S, Erzurumluoglu AM, Ferreira T, Frånberg M, Franco OH, Gandin I, Gasparini P, Giedraitis V, Gieger C, Girotto G, Goel A, Gow AJ, Gudnason V, Guo X, Gyllensten U, Hamsten A, Harris TB, Harris SE, Hartman CA, Havulinna AS, Hicks AA, Hofer E, Hofman A, Hottenga JJ, Huffman JE, Hwang SJ, Ingelsson E, James A, Jansen R, Jarvelin MR, Joehanes R, Johansson Å, Johnson AD, Joshi PK, Jousilahti P, Jukema JW, Jula A, Kähönen M, Kathiresan S, Keavney BD, Khaw KT, Knekt P, Knight J, Kolcic I, Kooner JS, Koskinen S, Kristiansson K, Kutalik Z, Laan M, Larson M, Launer LJ, Lehne B, Lehtimäki T, Liewald DCM, Lin L, Lind L, Lindgren CM, Liu Y, Loos RJF, Lopez LM, Lu Y, Lyytikäinen LP, Mahajan A, Mamasoula C, Marrugat J, Marten J, Milaneschi Y, Morgan A, Morris AP, Morrison AC, Munson PJ, Nalls MA, Nandakumar P, Nelson CP, Niiranen T, Nolte IM, Nutile T, Oldehinkel AJ, Oostra BA, O'Reilly PF, Org E, Padmanabhan S, Palmas W, Palotie A, Pattie A, Penninx BWJH, Perola M, Peters A, Polasek O, Pramstaller PP, Nguyen QT, Raitakari OT, Ren M, Rettig R, Rice K, Ridker PM, Ried JS, Riese H, Ripatti S, Robino A, Rose LM, Rotter JI, Rudan I, Ruggiero D, Saba Y, Sala CF, Salomaa V, Samani NJ, Sarin AP, Schmidt R, Schmidt H, Shrine N, Siscovick D, Smith AV, Snieder H, Sõber S, Sorice R, Starr JM, Stott DJ, Strachan DP, Strawbridge RJ, Sundström J, Swertz MA, Taylor KD, Teumer A, Tobin MD, Tomaszewski M, Toniolo D, Traglia M, Trompet S, Tuomilehto J, Tzourio C, Uitterlinden AG, Vaez A, van der Most PJ, van Duijn CM, Vergnaud AC, Verwoert GC, Vitart V, Völker U, Vollenweider P, Vuckovic D, Watkins H, Wild SH, Willemsen G, Wilson JF, Wright AF, Yao J, Zemunik T, Zhang W, Attia JR, Butterworth AS, Chasman DI, Conen D, Cucca F, Danesh J, Hayward C, Howson JMM, Laakso M, Lakatta EG, Langenberg C, Melander O, Mook-Kanamori DO, Palmer CNA, Risch L, Scott RA, Scott RJ, Sever P, Spector TD, van der Harst P, Wareham NJ, Zeggini E, Levy D, Munroe PB, Newton-Cheh C, Brown MJ, Metspalu A, Hung AM, O'Donnell CJ, Edwards TL; Million Veteran Program, Psaty BM, Tzoulaki I, Barnes MR, Wain LV, Elliott P, Caulfield MJ.

Nat Genet. 2018 Oct;50(10):1412-1425. doi: 10.1038/s41588-018-0205-x. Epub 2018 Sep 17.

PMID:
30224653
6.

Adipocytokine correlations with thyroid function and autoimmunity in euthyroid sardinians.

Delitala AP, Steri M, Fiorillo E, Marongiu M, Lakatta EG, Schlessinger D, Cucca F.

Cytokine. 2018 Aug 30;111:189-193. doi: 10.1016/j.cyto.2018.08.027. [Epub ahead of print]

PMID:
30173124
7.

Antibody to Marinobufagenin Reverses Placenta-Induced Fibrosis of Umbilical Arteries in Preeclampsia.

Fedorova OV, Ishkaraeva VV, Grigorova YN, Reznik VA, Kolodkin NI, Zazerskaya IE, Zernetkina V, Agalakova NI, Tapilskaya NI, Adair CD, Lakatta EG, Bagrov AY.

Int J Mol Sci. 2018 Aug 13;19(8). pii: E2377. doi: 10.3390/ijms19082377.

8.

Heterogeneity of calcium clock functions in dormant, dysrhythmically and rhythmically firing single pacemaker cells isolated from SA node.

Kim MS, Maltsev AV, Monfredi O, Maltseva LA, Wirth A, Florio MC, Tsutsui K, Riordon DR, Parsons SP, Tagirova S, Ziman BD, Stern MD, Lakatta EG, Maltsev VA.

Cell Calcium. 2018 Sep;74:168-179. doi: 10.1016/j.ceca.2018.07.002. Epub 2018 Jul 10.

PMID:
30092494
9.

The reality of getting old.

Lakatta EG.

Nat Rev Cardiol. 2018 Sep;15(9):499-500. doi: 10.1038/s41569-018-0068-y. No abstract available.

PMID:
30065260
10.

Characteristics of healthy vascular ageing in pooled population-based cohort studies: the global Metabolic syndrome and Artery REsearch Consortium.

Nilsson PM, Laurent S, Cunha PG, Olsen MH, Rietzschel E, Franco OH, Ryliškytė L, Strazhesko I, Vlachopoulos C, Chen CH, Boutouyrie P, Cucca F, Lakatta EG, Scuteri A; Metabolic syndrome, Arteries REsearch (MARE) Consortium.

J Hypertens. 2018 Dec;36(12):2340-2349. doi: 10.1097/HJH.0000000000001824.

PMID:
30063641
11.

PR interval genome-wide association meta-analysis identifies 50 loci associated with atrial and atrioventricular electrical activity.

van Setten J, Brody JA, Jamshidi Y, Swenson BR, Butler AM, Campbell H, Del Greco FM, Evans DS, Gibson Q, Gudbjartsson DF, Kerr KF, Krijthe BP, Lyytikäinen LP, Müller C, Müller-Nurasyid M, Nolte IM, Padmanabhan S, Ritchie MD, Robino A, Smith AV, Steri M, Tanaka T, Teumer A, Trompet S, Ulivi S, Verweij N, Yin X, Arnar DO, Asselbergs FW, Bader JS, Barnard J, Bis J, Blankenberg S, Boerwinkle E, Bradford Y, Buckley BM, Chung MK, Crawford D, den Hoed M, Denny JC, Dominiczak AF, Ehret GB, Eijgelsheim M, Ellinor PT, Felix SB, Franco OH, Franke L, Harris TB, Holm H, Ilaria G, Iorio A, Kähönen M, Kolcic I, Kors JA, Lakatta EG, Launer LJ, Lin H, Lin HJ, Loos RJF, Lubitz SA, Macfarlane PW, Magnani JW, Leach IM, Meitinger T, Mitchell BD, Munzel T, Papanicolaou GJ, Peters A, Pfeufer A, Pramstaller PP, Raitakari OT, Rotter JI, Rudan I, Samani NJ, Schlessinger D, Silva Aldana CT, Sinner MF, Smith JD, Snieder H, Soliman EZ, Spector TD, Stott DJ, Strauch K, Tarasov KV, Thorsteinsdottir U, Uitterlinden AG, Van Wagoner DR, Völker U, Völzke H, Waldenberger M, Jan Westra H, Wild PS, Zeller T, Alonso A, Avery CL, Bandinelli S, Benjamin EJ, Cucca F, Dörr M, Ferrucci L, Gasparini P, Gudnason V, Hayward C, Heckbert SR, Hicks AA, Jukema JW, Kääb S, Lehtimäki T, Liu Y, Munroe PB, Parsa A, Polasek O, Psaty BM, Roden DM, Schnabel RB, Sinagra G, Stefansson K, Stricker BH, van der Harst P, van Duijn CM, Wilson JF, Gharib SA, de Bakker PIW, Isaacs A, Arking DE, Sotoodehnia N.

Nat Commun. 2018 Jul 25;9(1):2904. doi: 10.1038/s41467-018-04766-9.

12.

Unique Ca2+-Cycling Protein Abundance and Regulation Sustains Local Ca2+ Releases and Spontaneous Firing of Rabbit Sinoatrial Node Cells.

Vinogradova TM, Tagirova Sirenko S, Lakatta EG.

Int J Mol Sci. 2018 Jul 25;19(8). pii: E2173. doi: 10.3390/ijms19082173. Review.

13.

Aldosterone, inactive matrix gla-protein, and large artery stiffness in hypertension.

Chirinos JA, Sardana M, Syed AA, Koppula MR, Varakantam S, Vasim I, Oldland HG, Phan TS, Drummen NEA, Vermeer C, Townsend RR, Akers SR, Wei W, Lakatta EG, Fedorova OV.

J Am Soc Hypertens. 2018 Sep;12(9):681-689. doi: 10.1016/j.jash.2018.06.018. Epub 2018 Jun 30.

PMID:
30033123
14.

Association of arginine vasopressin with low atrial natriuretic peptide levels, left ventricular remodelling, and outcomes in adults with and without heart failure.

Chirinos JA, Sardana M, Oldland G, Ansari B, Lee J, Hussain A, Mustafa A, Akers SR, Wei W, Lakatta EG, Fedorova OV.

ESC Heart Fail. 2018 Oct;5(5):911-919. doi: 10.1002/ehf2.12319. Epub 2018 Jul 3.

15.

Reduced vasorin enhances angiotensin II signaling within the aging arterial wall.

Pintus G, Giordo R, Wang Y, Zhu W, Kim SH, Zhang L, Ni L, Zhang J, Telljohann R, McGraw KR, Monticone RE, Ferris C, Liu L, Wang M, Lakatta EG.

Oncotarget. 2018 Jun 5;9(43):27117-27132. doi: 10.18632/oncotarget.25499. eCollection 2018 Jun 5.

16.

A coupled-clock system drives the automaticity of human sinoatrial nodal pacemaker cells.

Tsutsui K, Monfredi OJ, Sirenko-Tagirova SG, Maltseva LA, Bychkov R, Kim MS, Ziman BD, Tarasov KV, Tarasova YS, Zhang J, Wang M, Maltsev AV, Brennan JA, Efimov IR, Stern MD, Maltsev VA, Lakatta EG.

Sci Signal. 2018 Jun 12;11(534). pii: eaap7608. doi: 10.1126/scisignal.aap7608.

17.

Basal Spontaneous Firing of Rabbit Sinoatrial Node Cells Is Regulated by Dual Activation of PDEs (Phosphodiesterases) 3 and 4.

Vinogradova TM, Sirenko S, Lukyanenko YO, Yang D, Tarasov KV, Lyashkov AE, Varghese NJ, Li Y, Chakir K, Ziman B, Lakatta EG.

Circ Arrhythm Electrophysiol. 2018 Jun;11(6):e005896. doi: 10.1161/CIRCEP.117.005896.

PMID:
29880528
18.

Positive Feedback Mechanisms among Local Ca Releases, NCX, and ICaL Ignite Pacemaker Action Potentials.

Lyashkov AE, Behar J, Lakatta EG, Yaniv Y, Maltsev VA.

Biophys J. 2018 Apr 24;114(8):2024. doi: 10.1016/j.bpj.2018.03.024. No abstract available.

19.

Positive Feedback Mechanisms among Local Ca Releases, NCX, and ICaL Ignite Pacemaker Action Potentials.

Lyashkov AE, Behar J, Lakatta EG, Yaniv Y, Maltsev VA.

Biophys J. 2018 Mar 13;114(5):1176-1189. doi: 10.1016/j.bpj.2017.12.043. Erratum in: Biophys J. 2018 Apr 24;114(8):2024.

PMID:
29539403
20.

TGFβ1 reinforces arterial aging in the vascular smooth muscle cell through a long-range regulation of the cytoskeletal stiffness.

Zhu W, Kim BC, Wang M, Huang J, Isak A, Bexiga NM, Monticone R, Ha T, Lakatta EG, An SS.

Sci Rep. 2018 Feb 8;8(1):2668. doi: 10.1038/s41598-018-20763-w.

21.

Prognostic Utility of Morning Blood Pressure Surge for 20-Year All-Cause and Cardiovascular Mortalities: Results of a Community-Based Study.

Cheng HM, Wu CL, Sung SH, Lee JC, Kario K, Chiang CE, Huang CJ, Hsu PF, Chuang SY, Lakatta EG, Yin FCP, Chou P, Chen CH.

J Am Heart Assoc. 2017 Dec 9;6(12). pii: e007667. doi: 10.1161/JAHA.117.007667.

22.

Mammalian γ2 AMPK regulates intrinsic heart rate.

Yavari A, Bellahcene M, Bucchi A, Sirenko S, Pinter K, Herring N, Jung JJ, Tarasov KV, Sharpe EJ, Wolfien M, Czibik G, Steeples V, Ghaffari S, Nguyen C, Stockenhuber A, Clair JRS, Rimmbach C, Okamoto Y, Yang D, Wang M, Ziman BD, Moen JM, Riordon DR, Ramirez C, Paina M, Lee J, Zhang J, Ahmet I, Matt MG, Tarasova YS, Baban D, Sahgal N, Lockstone H, Puliyadi R, de Bono J, Siggs OM, Gomes J, Muskett H, Maguire ML, Beglov Y, Kelly M, Dos Santos PPN, Bright NJ, Woods A, Gehmlich K, Isackson H, Douglas G, Ferguson DJP, Schneider JE, Tinker A, Wolkenhauer O, Channon KM, Cornall RJ, Sternick EB, Paterson DJ, Redwood CS, Carling D, Proenza C, David R, Baruscotti M, DiFrancesco D, Lakatta EG, Watkins H, Ashrafian H.

Nat Commun. 2017 Nov 2;8(1):1258. doi: 10.1038/s41467-017-01342-5.

23.

Spontaneous, local diastolic subsarcolemmal calcium releases in single, isolated guinea-pig sinoatrial nodal cells.

Sirenko SG, Yang D, Maltseva LA, Kim MS, Lakatta EG, Maltsev VA.

PLoS One. 2017 Sep 25;12(9):e0185222. doi: 10.1371/journal.pone.0185222. eCollection 2017.

24.

Electrophysiological heterogeneity of pacemaker cells in the rabbit intercaval region, including the SA node: insights from recording multiple ion currents in each cell.

Monfredi O, Tsutsui K, Ziman B, Stern MD, Lakatta EG, Maltsev VA.

Am J Physiol Heart Circ Physiol. 2018 Mar 1;314(3):H403-H414. doi: 10.1152/ajpheart.00253.2016. Epub 2017 Sep 15.

PMID:
28916636
25.

Lower Mitochondrial Energy Production of the Thigh Muscles in Patients With Low-Normal Ankle-Brachial Index.

AlGhatrif M, Zane A, Oberdier M, Canepa M, Studenski S, Simonsick E, Spencer RG, Fishbein K, Reiter D, Lakatta EG, McDermott MM, Ferrucci L.

J Am Heart Assoc. 2017 Aug 30;6(9). pii: e006604. doi: 10.1161/JAHA.117.006604.

26.

Computer algorithms for automated detection and analysis of local Ca2+ releases in spontaneously beating cardiac pacemaker cells.

Maltsev AV, Parsons SP, Kim MS, Tsutsui K, Stern MD, Lakatta EG, Maltsev VA, Monfredi O.

PLoS One. 2017 Jul 6;12(7):e0179419. doi: 10.1371/journal.pone.0179419. eCollection 2017.

27.

Long-term low dose dietary resveratrol supplement reduces cardiovascular structural and functional deterioration in chronic heart failure in rats.

Ahmet I, Tae HJ, Lakatta EG, Talan M.

Can J Physiol Pharmacol. 2017 Mar;95(3):268-274. doi: 10.1139/cjpp-2016-0512. Epub 2016 Dec 17.

PMID:
28134561
28.

Hemodynamic Determinants of the Short-Term Blood Pressure Variability: Differential Roles of Arterial Stiffness and Wave Reflection.

Hsu PF, Cheng HM, Sung SH, Chuang SY, Lakatta EG, Yin FC, Chou P, Chen CH.

Am J Hypertens. 2017 Mar 1;30(3):256-263. doi: 10.1093/ajh/hpw144.

29.

The Systematic Evaluation of Identifying the Infarct Related Artery Utilizing Cardiac Magnetic Resonance in Patients Presenting with ST-Elevation Myocardial Infarction.

Hamo CE, Klem I, Rao SV, Songco V, Najjar S, Lakatta EG, Raman SV, Harrington RA, Heitner JF.

PLoS One. 2017 Jan 6;12(1):e0169108. doi: 10.1371/journal.pone.0169108. eCollection 2017.

30.

Arterial Stiffness and Risk of Overall Heart Failure, Heart Failure With Preserved Ejection Fraction, and Heart Failure With Reduced Ejection Fraction: The Health ABC Study (Health, Aging, and Body Composition).

Pandey A, Khan H, Newman AB, Lakatta EG, Forman DE, Butler J, Berry JD.

Hypertension. 2017 Feb;69(2):267-274. doi: 10.1161/HYPERTENSIONAHA.116.08327. Epub 2016 Dec 19.

31.

Longitudinal Association Between Serum Uric Acid and Arterial Stiffness: Results From the Baltimore Longitudinal Study of Aging.

Canepa M, Viazzi F, Strait JB, Ameri P, Pontremoli R, Brunelli C, Studenski S, Ferrucci L, Lakatta EG, AlGhatrif M.

Hypertension. 2017 Feb;69(2):228-235. doi: 10.1161/HYPERTENSIONAHA.116.08114. Epub 2016 Dec 12.

32.

The Pressure of Aging.

AlGhatrif M, Wang M, Fedorova OV, Bagrov AY, Lakatta EG.

Med Clin North Am. 2017 Jan;101(1):81-101. doi: 10.1016/j.mcna.2016.08.006. Review.

33.

The relationship between the metabolic syndrome and arterial wall thickness: A mosaic still to be interpreted.

Scuteri A, Franco OH, Majiid A, Jolita B, Sergey B, Cheng HM, Chen CH, Choi SW, Francesco C, De Buyzere ML, Alessandro D, Marcus D, Gunnar E, Albert H, Seul-Ki J, Kweon SS, Michel L, Lee YH, Mattace Raso F, Olle M, Morrell CH, Park KS, Rietzschel ER, Kristina R, Ryliskyte L, Ulf S, David S, Shin MH, Irina S, Shih-Hsien S, Olga T, Völzke H, Lakatta EG, Nilsson P; MARE Consortium.

Atherosclerosis. 2016 Dec;255:11-16. doi: 10.1016/j.atherosclerosis.2016.10.032. Epub 2016 Oct 15.

PMID:
27794213
34.

A Rat Carotid Balloon Injury Model to Test Anti-vascular Remodeling Therapeutics.

Petrasheskaya N, Tae HJ, Ahmet I, Talan MI, Lakatta EG, Lin L.

J Vis Exp. 2016 Sep 19;(115). doi: 10.3791/53777.

35.

52 Genetic Loci Influencing Myocardial Mass.

van der Harst P, van Setten J, Verweij N, Vogler G, Franke L, Maurano MT, Wang X, Mateo Leach I, Eijgelsheim M, Sotoodehnia N, Hayward C, Sorice R, Meirelles O, Lyytikäinen LP, Polašek O, Tanaka T, Arking DE, Ulivi S, Trompet S, Müller-Nurasyid M, Smith AV, Dörr M, Kerr KF, Magnani JW, Del Greco M F, Zhang W, Nolte IM, Silva CT, Padmanabhan S, Tragante V, Esko T, Abecasis GR, Adriaens ME, Andersen K, Barnett P, Bis JC, Bodmer R, Buckley BM, Campbell H, Cannon MV, Chakravarti A, Chen LY, Delitala A, Devereux RB, Doevendans PA, Dominiczak AF, Ferrucci L, Ford I, Gieger C, Harris TB, Haugen E, Heinig M, Hernandez DG, Hillege HL, Hirschhorn JN, Hofman A, Hubner N, Hwang SJ, Iorio A, Kähönen M, Kellis M, Kolcic I, Kooner IK, Kooner JS, Kors JA, Lakatta EG, Lage K, Launer LJ, Levy D, Lundby A, Macfarlane PW, May D, Meitinger T, Metspalu A, Nappo S, Naitza S, Neph S, Nord AS, Nutile T, Okin PM, Olsen JV, Oostra BA, Penninger JM, Pennacchio LA, Pers TH, Perz S, Peters A, Pinto YM, Pfeufer A, Pilia MG, Pramstaller PP, Prins BP, Raitakari OT, Raychaudhuri S, Rice KM, Rossin EJ, Rotter JI, Schafer S, Schlessinger D, Schmidt CO, Sehmi J, Silljé HHW, Sinagra G, Sinner MF, Slowikowski K, Soliman EZ, Spector TD, Spiering W, Stamatoyannopoulos JA, Stolk RP, Strauch K, Tan ST, Tarasov KV, Trinh B, Uitterlinden AG, van den Boogaard M, van Duijn CM, van Gilst WH, Viikari JS, Visscher PM, Vitart V, Völker U, Waldenberger M, Weichenberger CX, Westra HJ, Wijmenga C, Wolffenbuttel BH, Yang J, Bezzina CR, Munroe PB, Snieder H, Wright AF, Rudan I, Boyer LA, Asselbergs FW, van Veldhuisen DJ, Stricker BH, Psaty BM, Ciullo M, Sanna S, Lehtimäki T, Wilson JF, Bandinelli S, Alonso A, Gasparini P, Jukema JW, Kääb S, Gudnason V, Felix SB, Heckbert SR, de Boer RA, Newton-Cheh C, Hicks AA, Chambers JC, Jamshidi Y, Visel A, Christoffels VM, Isaacs A, Samani NJ, de Bakker PIW.

J Am Coll Cardiol. 2016 Sep 27;68(13):1435-1448. doi: 10.1016/j.jacc.2016.07.729.

36.

Mouse RAGE Variant 4 Is a Dominant Membrane Receptor that Does Not Shed to Generate Soluble RAGE.

Peng Y, Horwitz N, Lakatta EG, Lin L.

PLoS One. 2016 Sep 21;11(9):e0153657. doi: 10.1371/journal.pone.0153657. eCollection 2016.

37.

The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals.

Ehret GB, Ferreira T, Chasman DI, Jackson AU, Schmidt EM, Johnson T, Thorleifsson G, Luan J, Donnelly LA, Kanoni S, Petersen AK, Pihur V, Strawbridge RJ, Shungin D, Hughes MF, Meirelles O, Kaakinen M, Bouatia-Naji N, Kristiansson K, Shah S, Kleber ME, Guo X, Lyytikäinen LP, Fava C, Eriksson N, Nolte IM, Magnusson PK, Salfati EL, Rallidis LS, Theusch E, Smith AJP, Folkersen L, Witkowska K, Pers TH, Joehanes R, Kim SK, Lataniotis L, Jansen R, Johnson AD, Warren H, Kim YJ, Zhao W, Wu Y, Tayo BO, Bochud M; CHARGE-EchoGen consortium; CHARGE-HF consortium; Wellcome Trust Case Control Consortium, Absher D, Adair LS, Amin N, Arking DE, Axelsson T, Baldassarre D, Balkau B, Bandinelli S, Barnes MR, Barroso I, Bevan S, Bis JC, Bjornsdottir G, Boehnke M, Boerwinkle E, Bonnycastle LL, Boomsma DI, Bornstein SR, Brown MJ, Burnier M, Cabrera CP, Chambers JC, Chang IS, Cheng CY, Chines PS, Chung RH, Collins FS, Connell JM, Döring A, Dallongeville J, Danesh J, de Faire U, Delgado G, Dominiczak AF, Doney ASF, Drenos F, Edkins S, Eicher JD, Elosua R, Enroth S, Erdmann J, Eriksson P, Esko T, Evangelou E, Evans A, Fall T, Farrall M, Felix JF, Ferrières J, Ferrucci L, Fornage M, Forrester T, Franceschini N, Duran OHF, Franco-Cereceda A, Fraser RM, Ganesh SK, Gao H, Gertow K, Gianfagna F, Gigante B, Giulianini F, Goel A, Goodall AH, Goodarzi MO, Gorski M, Gräßler J, Groves C, Gudnason V, Gyllensten U, Hallmans G, Hartikainen AL, Hassinen M, Havulinna AS, Hayward C, Hercberg S, Herzig KH, Hicks AA, Hingorani AD, Hirschhorn JN, Hofman A, Holmen J, Holmen OL, Hottenga JJ, Howard P, Hsiung CA, Hunt SC, Ikram MA, Illig T, Iribarren C, Jensen RA, Kähönen M, Kang H, Kathiresan S, Keating BJ, Khaw KT, Kim YK, Kim E, Kivimaki M, Klopp N, Kolovou G, Komulainen P, Kooner JS, Kosova G, Krauss RM, Kuh D, Kutalik Z, Kuusisto J, Kvaløy K, Lakka TA, Lee NR, Lee IT, Lee WJ, Levy D, Li X, Liang KW, Lin H, Lin L, Lindström J, Lobbens S, Männistö S, Müller G, Müller-Nurasyid M, Mach F, Markus HS, Marouli E, McCarthy MI, McKenzie CA, Meneton P, Menni C, Metspalu A, Mijatovic V, Moilanen L, Montasser ME, Morris AD, Morrison AC, Mulas A, Nagaraja R, Narisu N, Nikus K, O'Donnell CJ, O'Reilly PF, Ong KK, Paccaud F, Palmer CD, Parsa A, Pedersen NL, Penninx BW, Perola M, Peters A, Poulter N, Pramstaller PP, Psaty BM, Quertermous T, Rao DC, Rasheed A, Rayner NWNWR, Renström F, Rettig R, Rice KM, Roberts R, Rose LM, Rossouw J, Samani NJ, Sanna S, Saramies J, Schunkert H, Sebert S, Sheu WH, Shin YA, Sim X, Smit JH, Smith AV, Sosa MX, Spector TD, Stančáková A, Stanton A, Stirrups KE, Stringham HM, Sundstrom J, Swift AJ, Syvänen AC, Tai ES, Tanaka T, Tarasov KV, Teumer A, Thorsteinsdottir U, Tobin MD, Tremoli E, Uitterlinden AG, Uusitupa M, Vaez A, Vaidya D, van Duijn CM, van Iperen EPA, Vasan RS, Verwoert GC, Virtamo J, Vitart V, Voight BF, Vollenweider P, Wagner A, Wain LV, Wareham NJ, Watkins H, Weder AB, Westra HJ, Wilks R, Wilsgaard T, Wilson JF, Wong TY, Yang TP, Yao J, Yengo L, Zhang W, Zhao JH, Zhu X, Bovet P, Cooper RS, Mohlke KL, Saleheen D, Lee JY, Elliott P, Gierman HJ, Willer CJ, Franke L, Hovingh GK, Taylor KD, Dedoussis G, Sever P, Wong A, Lind L, Assimes TL, Njølstad I, Schwarz PE, Langenberg C, Snieder H, Caulfield MJ, Melander O, Laakso M, Saltevo J, Rauramaa R, Tuomilehto J, Ingelsson E, Lehtimäki T, Hveem K, Palmas W, März W, Kumari M, Salomaa V, Chen YI, Rotter JI, Froguel P, Jarvelin MR, Lakatta EG, Kuulasmaa K, Franks PW, Hamsten A, Wichmann HE, Palmer CNA, Stefansson K, Ridker PM, Loos RJF, Chakravarti A, Deloukas P, Morris AP, Newton-Cheh C, Munroe PB.

Nat Genet. 2016 Oct;48(10):1171-1184. doi: 10.1038/ng.3667. Epub 2016 Sep 12.

38.

CaMKII-dependent phosphorylation regulates basal cardiac pacemaker function via modulation of local Ca2+ releases.

Li Y, Sirenko S, Riordon DR, Yang D, Spurgeon H, Lakatta EG, Vinogradova TM.

Am J Physiol Heart Circ Physiol. 2016 Sep 1;311(3):H532-44. doi: 10.1152/ajpheart.00765.2015. Epub 2016 Jul 8.

39.

Ca(2+)/calmodulin-activated phosphodiesterase 1A is highly expressed in rabbit cardiac sinoatrial nodal cells and regulates pacemaker function.

Lukyanenko YO, Younes A, Lyashkov AE, Tarasov KV, Riordon DR, Lee J, Sirenko SG, Kobrinsky E, Ziman B, Tarasova YS, Juhaszova M, Sollott SJ, Graham DR, Lakatta EG.

J Mol Cell Cardiol. 2016 Sep;98:73-82. doi: 10.1016/j.yjmcc.2016.06.064. Epub 2016 Jun 27.

40.

Electrochemical Na+ and Ca2+ gradients drive coupled-clock regulation of automaticity of isolated rabbit sinoatrial nodal pacemaker cells.

Sirenko SG, Maltsev VA, Yaniv Y, Bychkov R, Yaeger D, Vinogradova T, Spurgeon HA, Lakatta EG.

Am J Physiol Heart Circ Physiol. 2016 Jul 1;311(1):H251-67. doi: 10.1152/ajpheart.00667.2015. Epub 2016 May 20.

41.

Gender specific profiles of white coat and masked hypertension impacts on arterial structure and function in the SardiNIA study.

Scuteri A, Morrell CH, Orru' M, AlGhatrif M, Saba PS, Terracciano A, Ferreli LA, Loi F, Marongiu M, Pilia MG, Delitala A, Tarasov KV, Schlessinger D, Ganau A, Cucca F, Lakatta EG.

Int J Cardiol. 2016 Aug 15;217:92-8. doi: 10.1016/j.ijcard.2016.04.172. Epub 2016 May 3. No abstract available.

42.

Pharmacological Strategies to Retard Cardiovascular Aging.

Alfaras I, Di Germanio C, Bernier M, Csiszar A, Ungvari Z, Lakatta EG, de Cabo R.

Circ Res. 2016 May 13;118(10):1626-42. doi: 10.1161/CIRCRESAHA.116.307475. Review.

43.

Deterioration of autonomic neuronal receptor signaling and mechanisms intrinsic to heart pacemaker cells contribute to age-associated alterations in heart rate variability in vivo.

Yaniv Y, Ahmet I, Tsutsui K, Behar J, Moen JM, Okamoto Y, Guiriba TR, Liu J, Bychkov R, Lakatta EG.

Aging Cell. 2016 Aug;15(4):716-24. doi: 10.1111/acel.12483. Epub 2016 May 10.

44.

Prognostic significance of mechanical biomarkers derived from pulse wave analysis for predicting long-term cardiovascular mortality in two population-based cohorts.

Cheng HM, Chuang SY, Wang JJ, Shih YT, Wang HN, Huang CJ, Huang JT, Sung SH, Lakatta EG, Yin FC, Chou P, Yeh CJ, Bai CH, Pan WH, Chen CH.

Int J Cardiol. 2016 Jul 15;215:388-95. doi: 10.1016/j.ijcard.2016.04.070. Epub 2016 Apr 17.

PMID:
27128568
45.

High Short-Term Blood Pressure Variability Predicts Long-Term Cardiovascular Mortality in Untreated Hypertensives But Not in Normotensives.

Hsu PF, Cheng HM, Wu CH, Sung SH, Chuang SY, Lakatta EG, Yin FC, Chou P, Chen CH.

Am J Hypertens. 2016 Jul;29(7):806-13. doi: 10.1093/ajh/hpw002. Epub 2016 Feb 1.

46.

AGE-RAGE signal generates a specific NF-κB RelA "barcode" that directs collagen I expression.

Peng Y, Kim JM, Park HS, Yang A, Islam C, Lakatta EG, Lin L.

Sci Rep. 2016 Jan 5;6:18822. doi: 10.1038/srep18822.

47.

No evidence of association between subclinical thyroid disorders and common carotid intima medial thickness or atherosclerotic plaque.

Delitala AP, Filigheddu F, Orrù M, AlGhatrif M, Steri M, Pilia MG, Scuteri A, Lobina M, Piras MG, Delitala G, Lakatta EG, Schlessinger D, Cucca F.

Nutr Metab Cardiovasc Dis. 2015 Dec;25(12):1104-10. doi: 10.1016/j.numecd.2015.09.001. Epub 2015 Oct 21.

48.

Synthesis of an Endogenous Steroidal Na Pump Inhibitor Marinobufagenin, Implicated in Human Cardiovascular Diseases, Is Initiated by CYP27A1 via Bile Acid Pathway.

Fedorova OV, Zernetkina VI, Shilova VY, Grigorova YN, Juhasz O, Wei W, Marshall CA, Lakatta EG, Bagrov AY.

Circ Cardiovasc Genet. 2015 Oct;8(5):736-45. doi: 10.1161/CIRCGENETICS.115.001217. Epub 2015 Sep 15.

49.

Aortic Fibrosis, Induced by High Salt Intake in the Absence of Hypertensive Response, is Reduced by a Monoclonal Antibody to Marinobufagenin.

Grigorova YN, Juhasz O, Zernetkina V, Fishbein KW, Lakatta EG, Fedorova OV, Bagrov AY.

Am J Hypertens. 2016 May;29(5):641-6. doi: 10.1093/ajh/hpv155. Epub 2015 Sep 7.

50.

Real-time relationship between PKA biochemical signal network dynamics and increased action potential firing rate in heart pacemaker cells: Kinetics of PKA activation in heart pacemaker cells.

Yaniv Y, Ganesan A, Yang D, Ziman BD, Lyashkov AE, Levchenko A, Zhang J, Lakatta EG.

J Mol Cell Cardiol. 2015 Sep;86:168-78. doi: 10.1016/j.yjmcc.2015.07.024. Epub 2015 Aug 1.

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