Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 34

1.

A cell type-selective apoptosis-inducing small molecule for the treatment of brain cancer.

Lucki NC, Villa GR, Vergani N, Bollong MJ, Beyer BA, Lee JW, Anglin JL, Spangenberg SH, Chin EN, Sharma A, Johnson K, Sander PN, Gordon P, Skirboll SL, Wurdak H, Schultz PG, Mischel PS, Lairson LL.

Proc Natl Acad Sci U S A. 2019 Mar 26;116(13):6435-6440. doi: 10.1073/pnas.1816626116. Epub 2019 Mar 7.

2.

Biochemical Characterization and Structure-Based Mutational Analysis Provide Insight into the Binding and Mechanism of Action of Novel Aspartate Aminotransferase Inhibitors.

Holt MC, Assar Z, Beheshti Zavareh R, Lin L, Anglin J, Mashadova O, Haldar D, Mullarky E, Kremer DM, Cantley LC, Kimmelman AC, Stein AJ, Lairson LL, Lyssiotis CA.

Biochemistry. 2018 Nov 27;57(47):6604-6614. doi: 10.1021/acs.biochem.8b00914. Epub 2018 Nov 12.

PMID:
30365304
3.

A metabolite-derived protein modification integrates glycolysis with KEAP1-NRF2 signalling.

Bollong MJ, Lee G, Coukos JS, Yun H, Zambaldo C, Chang JW, Chin EN, Ahmad I, Chatterjee AK, Lairson LL, Schultz PG, Moellering RE.

Nature. 2018 Oct;562(7728):600-604. doi: 10.1038/s41586-018-0622-0. Epub 2018 Oct 15.

4.

Discovery and optimization of aspartate aminotransferase 1 inhibitors to target redox balance in pancreatic ductal adenocarcinoma.

Anglin J, Zavareh RB, Sander PN, Haldar D, Mullarky E, Cantley LC, Kimmelman AC, Lyssiotis CA, Lairson LL.

Bioorg Med Chem Lett. 2018 Sep 1;28(16):2675-2678. doi: 10.1016/j.bmcl.2018.04.061. Epub 2018 Apr 27.

5.

Metabolomics-based discovery of a metabolite that enhances oligodendrocyte maturation.

Beyer BA, Fang M, Sadrian B, Montenegro-Burke JR, Plaisted WC, Kok BPC, Saez E, Kondo T, Siuzdak G, Lairson LL.

Nat Chem Biol. 2018 Jan;14(1):22-28. doi: 10.1038/nchembio.2517. Epub 2017 Nov 13.

6.

A vimentin binding small molecule leads to mitotic disruption in mesenchymal cancers.

Bollong MJ, Pietilä M, Pearson AD, Sarkar TR, Ahmad I, Soundararajan R, Lyssiotis CA, Mani SA, Schultz PG, Lairson LL.

Proc Natl Acad Sci U S A. 2017 Nov 14;114(46):E9903-E9912. doi: 10.1073/pnas.1716009114. Epub 2017 Oct 30.

7.

Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics.

Lum KM, Sato Y, Beyer BA, Plaisted WC, Anglin JL, Lairson LL, Cravatt BF.

ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.

8.

Systems biology guided by XCMS Online metabolomics.

Huan T, Forsberg EM, Rinehart D, Johnson CH, Ivanisevic J, Benton HP, Fang M, Aisporna A, Hilmers B, Poole FL, Thorgersen MP, Adams MWW, Krantz G, Fields MW, Robbins PD, Niedernhofer LJ, Ideker T, Majumder EL, Wall JD, Rattray NJW, Goodacre R, Lairson LL, Siuzdak G.

Nat Methods. 2017 Apr 27;14(5):461-462. doi: 10.1038/nmeth.4260. No abstract available.

9.

Small molecule-mediated inhibition of myofibroblast transdifferentiation for the treatment of fibrosis.

Bollong MJ, Yang B, Vergani N, Beyer BA, Chin EN, Zambaldo C, Wang D, Chatterjee AK, Lairson LL, Schultz PG.

Proc Natl Acad Sci U S A. 2017 May 2;114(18):4679-4684. doi: 10.1073/pnas.1702750114. Epub 2017 Apr 17.

10.

A novel small-molecule inhibitor of 3-phosphoglycerate dehydrogenase.

Mullarky E, Lairson LL, Cantley LC, Lyssiotis CA.

Mol Cell Oncol. 2016 Mar 30;3(4):e1164280. doi: 10.1080/23723556.2016.1164280. eCollection 2016 Jul.

11.

High-Throughput Screening Uncovers Novel Botulinum Neurotoxin Inhibitor Chemotypes.

Bompiani KM, Caglič D, Krutein MC, Benoni G, Hrones M, Lairson LL, Bian H, Smith GR, Dickerson TJ.

ACS Comb Sci. 2016 Aug 8;18(8):461-74. doi: 10.1021/acscombsci.6b00033. Epub 2016 Jul 20.

PMID:
27314875
12.

Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancers.

Mullarky E, Lucki NC, Beheshti Zavareh R, Anglin JL, Gomes AP, Nicolay BN, Wong JC, Christen S, Takahashi H, Singh PK, Blenis J, Warren JD, Fendt SM, Asara JM, DeNicola GM, Lyssiotis CA, Lairson LL, Cantley LC.

Proc Natl Acad Sci U S A. 2016 Feb 16;113(7):1778-83. doi: 10.1073/pnas.1521548113. Epub 2016 Feb 1. Erratum in: Proc Natl Acad Sci U S A. 2016 Mar 15;113(11):E1585.

13.

A Small Molecule Inhibits Deregulated NRF2 Transcriptional Activity in Cancer.

Bollong MJ, Yun H, Sherwood L, Woods AK, Lairson LL, Schultz PG.

ACS Chem Biol. 2015 Oct 16;10(10):2193-8. doi: 10.1021/acschembio.5b00448. Epub 2015 Aug 17.

PMID:
26270491
14.

Identification of clinically viable quinolinol inhibitors of botulinum neurotoxin A light chain.

Caglič D, Krutein MC, Bompiani KM, Barlow DJ, Benoni G, Pelletier JC, Reitz AB, Lairson LL, Houseknecht KL, Smith GR, Dickerson TJ.

J Med Chem. 2014 Feb 13;57(3):669-76. doi: 10.1021/jm4012164. Epub 2014 Jan 15.

15.

A regenerative approach to the treatment of multiple sclerosis.

Deshmukh VA, Tardif V, Lyssiotis CA, Green CC, Kerman B, Kim HJ, Padmanabhan K, Swoboda JG, Ahmad I, Kondo T, Gage FH, Theofilopoulos AN, Lawson BR, Schultz PG, Lairson LL.

Nature. 2013 Oct 17;502(7471):327-332. doi: 10.1038/nature12647. Epub 2013 Oct 9.

16.

Small molecule-based approaches to adult stem cell therapies.

Lairson LL, Lyssiotis CA, Zhu S, Schultz PG.

Annu Rev Pharmacol Toxicol. 2013;53:107-25. doi: 10.1146/annurev-pharmtox-011112-140300. Review.

PMID:
23294307
17.

Structural and kinetic analysis of substrate binding to the sialyltransferase Cst-II from Campylobacter jejuni.

Lee HJ, Lairson LL, Rich JR, Lameignere E, Wakarchuk WW, Withers SG, Strynadka NC.

J Biol Chem. 2011 Oct 14;286(41):35922-32. doi: 10.1074/jbc.M111.261172. Epub 2011 Aug 5.

18.

Pan-Src family kinase inhibitors replace Sox2 during the direct reprogramming of somatic cells.

Staerk J, Lyssiotis CA, Medeiro LA, Bollong M, Foreman RK, Zhu S, Garcia M, Gao Q, Bouchez LC, Lairson LL, Charette BD, Supekova L, Janes J, Brinker A, Cho CY, Jaenisch R, Schultz PG.

Angew Chem Int Ed Engl. 2011 Jun 14;50(25):5734-6. doi: 10.1002/anie.201101042. Epub 2011 May 5. No abstract available.

19.

Chemical control of stem cell fate and developmental potential.

Lyssiotis CA, Lairson LL, Boitano AE, Wurdak H, Zhu S, Schultz PG.

Angew Chem Int Ed Engl. 2011 Jan 3;50(1):200-42. doi: 10.1002/anie.201004284. Review.

PMID:
21184400
20.

A small molecule accelerates neuronal differentiation in the adult rat.

Wurdak H, Zhu S, Min KH, Aimone L, Lairson LL, Watson J, Chopiuk G, Demas J, Charette B, Halder R, Weerapana E, Cravatt BF, Cline HT, Peters EC, Zhang J, Walker JR, Wu C, Chang J, Tuntland T, Cho CY, Schultz PG.

Proc Natl Acad Sci U S A. 2010 Sep 21;107(38):16542-7. doi: 10.1073/pnas.1010300107. Epub 2010 Sep 7. Erratum in: Proc Natl Acad Sci U S A. 2010 Dec 21;107(51):22360. Halder, Rajkumar [added].

21.

An RNAi screen identifies TRRAP as a regulator of brain tumor-initiating cell differentiation.

Wurdak H, Zhu S, Romero A, Lorger M, Watson J, Chiang CY, Zhang J, Natu VS, Lairson LL, Walker JR, Trussell CM, Harsh GR, Vogel H, Felding-Habermann B, Orth AP, Miraglia LJ, Rines DR, Skirboll SL, Schultz PG.

Cell Stem Cell. 2010 Jan 8;6(1):37-47. doi: 10.1016/j.stem.2009.11.002.

22.

NMR spectroscopic characterization of the sialyltransferase CstII from Campylobacter jejuni: histidine 188 is the general base.

Chan PH, Lairson LL, Lee HJ, Wakarchuk WW, Strynadka NC, Withers SG, McIntosh LP.

Biochemistry. 2009 Dec 1;48(47):11220-30. doi: 10.1021/bi901606n.

PMID:
19824695
23.

Reprogramming of murine fibroblasts to induced pluripotent stem cells with chemical complementation of Klf4.

Lyssiotis CA, Foreman RK, Staerk J, Garcia M, Mathur D, Markoulaki S, Hanna J, Lairson LL, Charette BD, Bouchez LC, Bollong M, Kunick C, Brinker A, Cho CY, Schultz PG, Jaenisch R.

Proc Natl Acad Sci U S A. 2009 Jun 2;106(22):8912-7. doi: 10.1073/pnas.0903860106. Epub 2009 May 15.

24.

Glycosyltransferases: structures, functions, and mechanisms.

Lairson LL, Henrissat B, Davies GJ, Withers SG.

Annu Rev Biochem. 2008;77:521-55. doi: 10.1146/annurev.biochem.76.061005.092322. Review.

PMID:
18518825
25.

S-alk(en)yl-L-cysteine sulfoxides and relative pungency measurements of photosynthetic and nonphotosynthetic tissues of Allium porrum.

Doran JA, O'Donnell JS, Lairson LL, McDonald MR, Schwan AL, Grodzinski B.

J Agric Food Chem. 2007 Oct 3;55(20):8243-50. Epub 2007 Sep 6.

PMID:
17803263
26.

Structural analysis of the alpha-2,3-sialyltransferase Cst-I from Campylobacter jejuni in apo and substrate-analogue bound forms.

Chiu CP, Lairson LL, Gilbert M, Wakarchuk WW, Withers SG, Strynadka NC.

Biochemistry. 2007 Jun 19;46(24):7196-204. Epub 2007 May 23.

PMID:
17518445
27.

Alternative donor substrates for inverting and retaining glycosyltransferases.

Lairson LL, Wakarchuk WW, Withers SG.

Chem Commun (Camb). 2007 Jan 28;(4):365-7. Epub 2006 Nov 7.

PMID:
17220972
28.

Using substrate engineering to harness enzymatic promiscuity and expand biological catalysis.

Lairson LL, Watts AG, Wakarchuk WW, Withers SG.

Nat Chem Biol. 2006 Dec;2(12):724-8. Epub 2006 Oct 22.

PMID:
17057723
29.

High-throughput screening methodology for the directed evolution of glycosyltransferases.

Aharoni A, Thieme K, Chiu CP, Buchini S, Lairson LL, Chen H, Strynadka NC, Wakarchuk WW, Withers SG.

Nat Methods. 2006 Aug;3(8):609-14.

PMID:
16862135
30.

Mutational, structural, and kinetic evidence for a dissociative mechanism in the GDP-mannose mannosyl hydrolase reaction.

Xia Z, Azurmendi HF, Lairson LL, Withers SG, Gabelli SB, Bianchet MA, Amzel LM, Mildvan AS.

Biochemistry. 2005 Jun 28;44(25):8989-97.

PMID:
15966723
31.

Mechanistic analogies amongst carbohydrate modifying enzymes.

Lairson LL, Withers SG.

Chem Commun (Camb). 2004 Oct 21;(20):2243-8. Epub 2004 Sep 27. Review.

PMID:
15489968
32.

Intermediate trapping on a mutant retaining alpha-galactosyltransferase identifies an unexpected aspartate residue.

Lairson LL, Chiu CP, Ly HD, He S, Wakarchuk WW, Strynadka NC, Withers SG.

J Biol Chem. 2004 Jul 2;279(27):28339-44. Epub 2004 Apr 9.

33.

Structural analysis of the sialyltransferase CstII from Campylobacter jejuni in complex with a substrate analog.

Chiu CP, Watts AG, Lairson LL, Gilbert M, Lim D, Wakarchuk WW, Withers SG, Strynadka NC.

Nat Struct Mol Biol. 2004 Feb;11(2):163-70. Epub 2004 Jan 18.

PMID:
14730352
34.

Surface activity of a synthetic lung surfactant containing a phospholipase-resistant phosphonolipid analog of dipalmitoyl phosphatidylcholine.

Wang Z, Schwan AL, Lairson LL, O'Donnell JS, Byrne GF, Foye A, Holm BA, Notter RH.

Am J Physiol Lung Cell Mol Physiol. 2003 Sep;285(3):L550-9.

Supplemental Content

Loading ...
Support Center