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Statistical Methods in the Journal - An Update.

Sato Y, Gosho M, Nagashima K, Takahashi S, Ware JH, Laird NM.

N Engl J Med. 2017 Mar 16;376(11):1086-1087. doi: 10.1056/NEJMc1616211. No abstract available.


Gene-based segregation method for identifying rare variants in family-based sequencing studies.

Qiao D, Lange C, Laird NM, Won S, Hersh CP, Morrow J, Hobbs BD, Lutz SM, Ruczinski I, Beaty TH, Silverman EK, Cho MH.

Genet Epidemiol. 2017 May;41(4):309-319. doi: 10.1002/gepi.22037. Epub 2017 Feb 13.


Genome-Wide Association Study of the Genetic Determinants of Emphysema Distribution.

Boueiz A, Lutz SM, Cho MH, Hersh CP, Bowler RP, Washko GR, Halper-Stromberg E, Bakke P, Gulsvik A, Laird NM, Beaty TH, Coxson HO, Crapo JD, Silverman EK, Castaldi PJ, DeMeo DL; COPDGene and ECLIPSE Investigators.

Am J Respir Crit Care Med. 2017 Mar 15;195(6):757-771. doi: 10.1164/rccm.201605-0997OC.


Exome Array Analysis Identifies a Common Variant in IL27 Associated with Chronic Obstructive Pulmonary Disease.

Hobbs BD, Parker MM, Chen H, Lao T, Hardin M, Qiao D, Hawrylkiewicz I, Sliwinski P, Yim JJ, Kim WJ, Kim DK, Castaldi PJ, Hersh CP, Morrow J, Celli BR, Pinto-Plata VM, Criner GJ, Marchetti N, Bueno R, Agustí A, Make BJ, Crapo JD, Calverley PM, Donner CF, Lomas DA, Wouters EF, Vestbo J, Paré PD, Levy RD, Rennard SI, Zhou X, Laird NM, Lin X, Beaty TH, Silverman EK, Cho MH; NETT Genetics Investigators; ECLIPSE Investigators; COPDGene Investigators; International COPD Genetics Network Investigators.

Am J Respir Crit Care Med. 2016 Jul 1;194(1):48-57. doi: 10.1164/rccm.201510-2053OC.


A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry.

Lutz SM, Cho MH, Young K, Hersh CP, Castaldi PJ, McDonald ML, Regan E, Mattheisen M, DeMeo DL, Parker M, Foreman M, Make BJ, Jensen RL, Casaburi R, Lomas DA, Bhatt SP, Bakke P, Gulsvik A, Crapo JD, Beaty TH, Laird NM, Lange C, Hokanson JE, Silverman EK; ECLIPSE Investigators; COPDGene Investigators.

BMC Genet. 2015 Dec 3;16:138. doi: 10.1186/s12863-015-0299-4.


Integrating Multiple Correlated Phenotypes for Genetic Association Analysis by Maximizing Heritability.

Zhou JJ, Cho MH, Lange C, Lutz S, Silverman EK, Laird NM.

Hum Hered. 2015;79(2):93-104. doi: 10.1159/000381641. Epub 2015 Jun 20.


A Genome-Wide Association Study of Emphysema and Airway Quantitative Imaging Phenotypes.

Cho MH, Castaldi PJ, Hersh CP, Hobbs BD, Barr RG, Tal-Singer R, Bakke P, Gulsvik A, San José Estépar R, Van Beek EJ, Coxson HO, Lynch DA, Washko GR, Laird NM, Crapo JD, Beaty TH, Silverman EK; NETT Genetics, ECLIPSE, and COPDGene Investigators.

Am J Respir Crit Care Med. 2015 Sep 1;192(5):559-69. doi: 10.1164/rccm.201501-0148OC.


A comparative analysis of family-based and population-based association tests using whole genome sequence data.

Zhou JJ, Yip WK, Cho MH, Qiao D, McDonald ML, Laird NM.

BMC Proc. 2014 Jun 17;8(Suppl 1 Genetic Analysis Workshop 18Vanessa Olmo):S33. doi: 10.1186/1753-6561-8-S1-S33. eCollection 2014.


Risk loci for chronic obstructive pulmonary disease: a genome-wide association study and meta-analysis.

Cho MH, McDonald ML, Zhou X, Mattheisen M, Castaldi PJ, Hersh CP, Demeo DL, Sylvia JS, Ziniti J, Laird NM, Lange C, Litonjua AA, Sparrow D, Casaburi R, Barr RG, Regan EA, Make BJ, Hokanson JE, Lutz S, Dudenkov TM, Farzadegan H, Hetmanski JB, Tal-Singer R, Lomas DA, Bakke P, Gulsvik A, Crapo JD, Silverman EK, Beaty TH; NETT Genetics, ICGN, ECLIPSE and COPDGene Investigators.

Lancet Respir Med. 2014 Mar;2(3):214-25. doi: 10.1016/S2213-2600(14)70002-5. Epub 2014 Feb 7.


Heritability of chronic obstructive pulmonary disease and related phenotypes in smokers.

Zhou JJ, Cho MH, Castaldi PJ, Hersh CP, Silverman EK, Laird NM.

Am J Respir Crit Care Med. 2013 Oct 15;188(8):941-7. doi: 10.1164/rccm.201302-0263OC.


Ozone exposure, vitamin C intake, and genetic susceptibility of asthmatic children in Mexico City: a cohort study.

Moreno-Macías H, Dockery DW, Schwartz J, Gold DR, Laird NM, Sienra-Monge JJ, Del Río-Navarro BE, Ramírez-Aguilar M, Barraza-Villarreal A, Li H, London SJ, Romieu I.

Respir Res. 2013 Feb 4;14:14. doi: 10.1186/1465-9921-14-14.


Prospective association of common eating disorders and adverse outcomes.

Field AE, Sonneville KR, Micali N, Crosby RD, Swanson SA, Laird NM, Treasure J, Solmi F, Horton NJ.

Pediatrics. 2012 Aug;130(2):e289-95. doi: 10.1542/peds.2011-3663. Epub 2012 Jul 16.


Identifying rare variants using a Bayesian regression approach.

Yan A, Laird NM, Li C.

BMC Proc. 2011 Nov 29;5 Suppl 9:S99. doi: 10.1186/1753-6561-5-S9-S99.


Differentiating population stratification from genotyping error using family data.

Sebro R, Lange C, Laird NM, Rogus JJ, Risch NJ.

Ann Hum Genet. 2012 Jan;76(1):42-52. doi: 10.1111/j.1469-1809.2011.00689.x. Epub 2011 Nov 23.


Alternative methods for testing treatment effects on the basis of multiple outcomes: simulation and case study.

Yoon FB, Fitzmaurice GM, Lipsitz SR, Horton NJ, Laird NM, Normand SL.

Stat Med. 2011 Jul 20;30(16):1917-32. doi: 10.1002/sim.4262. Epub 2011 May 3.


Using linkage information to weight a genome-wide association of bipolar disorder.

Howrigan DP, Laird NM, Smoller JW, Devlin B, McQueen MB.

Am J Med Genet B Neuropsychiatr Genet. 2011 Jun;156B(4):462-71. doi: 10.1002/ajmg.b.31183. Epub 2011 Apr 7.


Estimating the effect of a predictor measured by two informants on a continuous outcome: a comparison of methods.

Javaras KN, Goldsmith HH, Laird NM.

Epidemiology. 2011 May;22(3):390-9. doi: 10.1097/EDE.0b013e318212b940. Review.


Combining disease models to test for gene-environment interaction in nuclear families.

Hoffmann TJ, Vansteelandt S, Lange C, Silverman EK, DeMeo DL, Laird NM.

Biometrics. 2011 Dec;67(4):1260-70. doi: 10.1111/j.1541-0420.2011.01581.x. Epub 2011 Mar 14.


A new testing strategy to identify rare variants with either risk or protective effect on disease.

Ionita-Laza I, Buxbaum JD, Laird NM, Lange C.

PLoS Genet. 2011 Feb 3;7(2):e1001289. doi: 10.1371/journal.pgen.1001289.


Genome-wide association study on overall survival of advanced non-small cell lung cancer patients treated with carboplatin and paclitaxel.

Sato Y, Yamamoto N, Kunitoh H, Ohe Y, Minami H, Laird NM, Katori N, Saito Y, Ohnami S, Sakamoto H, Sawada J, Saijo N, Yoshida T, Tamura T.

J Thorac Oncol. 2011 Jan;6(1):132-8. doi: 10.1097/JTO.0b013e318200f415.


Multivariate logistic regression with incomplete covariate and auxiliary information.

Sinha SK, Laird NM, Fitzmaurice GM.

J Multivar Anal. 2010 Nov 1;101(10):2389-2397.


On the optimal design of genetic variant discovery studies.

Ionita-Laza I, Laird NM.

Stat Appl Genet Mol Biol. 2010;9:Article33. doi: 10.2202/1544-6115.1581. Epub 2010 Aug 27.


Tests for compositional epistasis under single interaction-parameter models.

VanderWeele TJ, Laird NM.

Ann Hum Genet. 2011 Jan;75(1):146-56. doi: 10.1111/j.1469-1809.2010.00600.x. Epub 2010 Aug 20.


Biostatistic tools in pharmacogenomics--advances, challenges, potential.

Sato Y, Laird NM, Yoshida T.

Curr Pharm Des. 2010;16(20):2232-40. Review.


Positively selected G6PD-Mahidol mutation reduces Plasmodium vivax density in Southeast Asians.

Louicharoen C, Patin E, Paul R, Nuchprayoon I, Witoonpanich B, Peerapittayamongkol C, Casademont I, Sura T, Laird NM, Singhasivanon P, Quintana-Murci L, Sakuntabhai A.

Science. 2009 Dec 11;326(5959):1546-9. doi: 10.1126/science.1178849.


Parsing the effects of individual SNPs in candidate genes with family data.

Hoffmann TJ, Lange C, Vansteelandt S, Raby BA, DeMeo DL, Silverman EK, Weiss ST, Laird NM.

Hum Hered. 2010;69(2):91-103. doi: 10.1159/000264447. Epub 2009 Dec 4.


Fitting ACE structural equation models to case-control family data.

Javaras KN, Hudson JI, Laird NM.

Genet Epidemiol. 2010 Apr;34(3):238-45. doi: 10.1002/gepi.20454.


Estimating disease prevalence using relatives of case and control probands.

Javaras KN, Laird NM, Hudson JI, Ripley BD.

Biometrics. 2010 Mar;66(1):214-21. doi: 10.1111/j.1541-0420.2009.01272.x. Epub 2009 May 18.


Genetic polymorphisms of estrogen metabolizing enzyme and breast cancer risk in Thai women.

Sangrajrang S, Sato Y, Sakamoto H, Ohnami S, Laird NM, Khuhaprema T, Brennan P, Boffetta P, Yoshida T.

Int J Cancer. 2009 Aug 15;125(4):837-43. doi: 10.1002/ijc.24434.


Gene-environment interaction tests for dichotomous traits in trios and sibships.

Hoffmann TJ, Lange C, Vansteelandt S, Laird NM.

Genet Epidemiol. 2009 Dec;33(8):691-9. doi: 10.1002/gepi.20421.


Linkage disequilibrium mapping of the chromosome 6q21-22.31 bipolar I disorder susceptibility locus.

Fan J, Ionita-Laza I, McQueen MB, Devlin B, Purcell S, Faraone SV, Allen MH, Bowden CL, Calabrese JR, Fossey MD, Friedman ES, Gyulai L, Hauser P, Ketter TB, Marangell LB, Miklowitz DJ, Nierenberg AA, Patel JK, Sachs GS, Thase ME, Molay FB, Escamilla MA, Nimgaonkar VL, Sklar P, Laird NM, Smoller JW.

Am J Med Genet B Neuropsychiatr Genet. 2010 Jan 5;153B(1):29-37. doi: 10.1002/ajmg.b.30942.


Impact of population stratification on family-based association tests with longitudinal measurements.

Ding X, Weiss S, Raby B, Lange C, Laird NM.

Stat Appl Genet Mol Biol. 2009;8:Article 17. doi: 10.2202/1544-6115.1398. Epub 2009 Feb 12.


Obesity and weight gain in relation to depression: findings from the Stirling County Study.

Murphy JM, Horton NJ, Burke JD Jr, Monson RR, Laird NM, Lesage A, Sobol AM.

Int J Obes (Lond). 2009 Mar;33(3):335-41. doi: 10.1038/ijo.2008.273. Epub 2009 Jan 13.


A new statistical screening approach for finding pharmacokinetics-related genes in genome-wide studies.

Sato Y, Laird NM, Nagashima K, Kato R, Hamano T, Yafune A, Kaniwa N, Saito Y, Sugiyama E, Kim SR, Furuse J, Ishii H, Ueno H, Okusaka T, Saijo N, Sawada JI, Yoshida T.

Pharmacogenomics J. 2009 Apr;9(2):137-46. doi: 10.1038/tpj.2008.17. Epub 2008 Dec 23.


On the frequency of copy number variants.

Ionita-Laza I, Laird NM, Raby BA, Weiss ST, Lange C.

Bioinformatics. 2008 Oct 15;24(20):2350-5. doi: 10.1093/bioinformatics/btn421. Epub 2008 Aug 8.


Penalized solutions to functional regression problems.

Harezlak J, Coull BA, Laird NM, Magari SR, Christiani DC.

Comput Stat Data Anal. 2007 Jun 15;51(10):4911-4925.


Family, peer, and media predictors of becoming eating disordered.

Field AE, Javaras KM, Aneja P, Kitos N, Camargo CA Jr, Taylor CB, Laird NM.

Arch Pediatr Adolesc Med. 2008 Jun;162(6):574-9. doi: 10.1001/archpedi.162.6.574.


FBAT-SNP-PC: an approach for multiple markers and single trait in family-based association tests.

Rakovski CS, Weiss ST, Laird NM, Lange C.

Hum Hered. 2008;66(2):122-6. doi: 10.1159/000119111. Epub 2008 Mar 31.


A structural approach to the familial coaggregation of disorders.

Hudson JI, Javaras KN, Laird NM, VanderWeele TJ, Pope HG Jr, Hernán MA.

Epidemiology. 2008 May;19(3):431-9. doi: 10.1097/EDE.0b013e31816a9de7.


Family-based methods for linkage and association analysis.

Laird NM, Lange C.

Adv Genet. 2008;60:219-52. doi: 10.1016/S0065-2660(07)00410-5. Review.


Co-occurrence of binge eating disorder with psychiatric and medical disorders.

Javaras KN, Pope HG, Lalonde JK, Roberts JL, Nillni YI, Laird NM, Bulik CM, Crow SJ, McElroy SL, Walsh BT, Tsuang MT, Rosenthal NR, Hudson JI.

J Clin Psychiatry. 2008 Feb;69(2):266-73.


Mortality associated with depression: a forty-year perspective from the Stirling County Study.

Murphy JM, Burke JD Jr, Monson RR, Horton NJ, Laird NM, Lesage A, Sobol AM, Leighton AH.

Soc Psychiatry Psychiatr Epidemiol. 2008 Aug;43(8):594-601. doi: 10.1007/s00127-008-0323-3. Epub 2008 Mar 7.


On the analysis of copy-number variations in genome-wide association studies: a translation of the family-based association test.

Ionita-Laza I, Perry GH, Raby BA, Klanderman B, Lee C, Laird NM, Weiss ST, Lange C.

Genet Epidemiol. 2008 Apr;32(3):273-84. doi: 10.1002/gepi.20302.


Familiality and heritability of binge eating disorder: results of a case-control family study and a twin study.

Javaras KN, Laird NM, Reichborn-Kjennerud T, Bulik CM, Pope HG Jr, Hudson JI.

Int J Eat Disord. 2008 Mar;41(2):174-9.


Genomewide weighted hypothesis testing in family-based association studies, with an application to a 100K scan.

Ionita-Laza I, McQueen MB, Laird NM, Lange C.

Am J Hum Genet. 2007 Sep;81(3):607-14. Epub 2007 Jul 17.


On the parsing of statistical information in family-based association testing.

McQueen MB, Weiss S, Laird NM, Lange C.

Nat Genet. 2007 Mar;39(3):281-2. No abstract available.


A study of how socioeconomic status moderates the relationship between SNPs encompassing BDNF and ADHD symptom counts in ADHD families.

Lasky-Su J, Faraone SV, Lange C, Tsuang MT, Doyle AE, Smoller JW, Laird NM, Biederman J.

Behav Genet. 2007 May;37(3):487-97. Epub 2007 Jan 10.


Approaches to handling incomplete data in family-based association testing.

Van Steen K, Laird NM, Markel P, Molenberghs G.

Ann Hum Genet. 2007 Mar;71(Pt 2):141-51. Epub 2006 Nov 10. Review.

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