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Involvement of the Gap Junction Protein, Connexin43, in the Formation and Function of Invadopodia in the Human U251 Glioblastoma Cell Line.

Chepied A, Daoud-Omar Z, Meunier-Balandre AC, Laird DW, Mesnil M, Defamie N.

Cells. 2020 Jan 3;9(1). pii: E117. doi: 10.3390/cells9010117.


Dynamic regulation of connexins in stem cell pluripotency.

Esseltine JL, Brooks CR, Edwards NA, Subasri M, Sampson J, Séguin C, Betts DH, Laird DW.

Stem Cells. 2020 Jan;38(1):52-66. doi: 10.1002/stem.3092. Epub 2019 Oct 24.


Connexin43 is Dispensable for Early Stage Human Mesenchymal Stem Cell Adipogenic Differentiation But is Protective against Cell Senescence.

Shao Q, Esseltine JL, Huang T, Novielli-Kuntz N, Ching JE, Sampson J, Laird DW.

Biomolecules. 2019 Sep 11;9(9). pii: E474. doi: 10.3390/biom9090474.


Destination and consequences of Panx1 and mutant expression in polarized MDCK cells.

Shum MG, Shao Q, Lajoie P, Laird DW.

Exp Cell Res. 2019 Aug 15;381(2):235-247. doi: 10.1016/j.yexcr.2019.05.016. Epub 2019 May 16.


Ablation of both Cx40 and Panx1 results in similar cardiovascular phenotypes exhibited in Cx40 knockout mice.

Novielli-Kuntz NM, Jelen M, Barr K, DeLalio LJ, Feng Q, Isakson BE, Gros R, Laird DW.

Biosci Rep. 2019 Feb 27;39(2). pii: BSR20182350. doi: 10.1042/BSR20182350. Print 2019 Feb 28.


The connexin 30 A88V mutant reduces cochlear gap junction expression and confers long-term protection against hearing loss.

Kelly JJ, Abitbol JM, Hulme S, Press ER, Laird DW, Allman BL.

J Cell Sci. 2019 Jan 16;132(2). pii: jcs224097. doi: 10.1242/jcs.224097.


Therapeutic strategies targeting connexins.

Laird DW, Lampe PD.

Nat Rev Drug Discov. 2018 Dec;17(12):905-921. doi: 10.1038/nrd.2018.138. Epub 2018 Oct 12. Review.


Correction to: Disease-linked connexin26 S17F promotes volar skin abnormalities and mild wound healing defects in mice.

Press E, Alaga KC, Barr K, Shao Q, Bosen F, Willecke K, Laird DW.

Cell Death Dis. 2018 May 24;9(6):630. doi: 10.1038/s41419-018-0639-1.


Mice harbouring an oculodentodigital dysplasia-linked Cx43 G60S mutation have severe hearing loss.

Abitbol JM, Kelly JJ, Barr KJ, Allman BL, Laird DW.

J Cell Sci. 2018 May 4;131(9). pii: jcs214635. doi: 10.1242/jcs.214635.


Connexins in Cardiovascular and Neurovascular Health and Disease: Pharmacological Implications.

Leybaert L, Lampe PD, Dhein S, Kwak BR, Ferdinandy P, Beyer EC, Laird DW, Naus CC, Green CR, Schulz R.

Pharmacol Rev. 2017 Oct;69(4):396-478. doi: 10.1124/pr.115.012062. Review.


SnapShot: Connexins and Disease.

Laird DW, Naus CC, Lampe PD.

Cell. 2017 Sep 7;170(6):1260-1260.e1. doi: 10.1016/j.cell.2017.08.034.


Connexins and Disease.

Delmar M, Laird DW, Naus CC, Nielsen MS, Verselis VK, White TW.

Cold Spring Harb Perspect Biol. 2018 Sep 4;10(9). pii: a029348. doi: 10.1101/cshperspect.a029348. Review.


Gap junctions and cancer: communicating for 50 years.

Aasen T, Mesnil M, Naus CC, Lampe PD, Laird DW.

Nat Rev Cancer. 2017 Jan;17(1):74. doi: 10.1038/nrc.2016.142. Epub 2016 Dec 2. No abstract available.


An update on minding the gap in cancer.

Mesnil M, Aasen T, Boucher J, Chépied A, Cronier L, Defamie N, Kameritsch P, Laird DW, Lampe PD, Lathia JD, Leithe E, Mehta PP, Monvoisin A, Pogoda K, Sin WC, Tabernero A, Yamasaki H, Yeh ES, Dagli MLZ, Naus CC.

Biochim Biophys Acta Biomembr. 2018 Jan;1860(1):237-243. doi: 10.1016/j.bbamem.2017.06.015. Epub 2017 Jun 24. Review.


Aberrant Cx43 Expression and Mislocalization in Metastatic Human Melanomas.

Alaga KC, Crawford M, Dagnino L, Laird DW.

J Cancer. 2017 Apr 9;8(7):1123-1128. doi: 10.7150/jca.18569. eCollection 2017.


Disease-linked connexin26 S17F promotes volar skin abnormalities and mild wound healing defects in mice.

Press E, Alaga KC, Barr K, Shao Q, Bosen F, Willecke K, Laird DW.

Cell Death Dis. 2017 Jun 1;8(6):e2845. doi: 10.1038/cddis.2017.234. Erratum in: Cell Death Dis. 2018 May 24;9(6):630.


Induction of cell death and gain-of-function properties of connexin26 mutants predict severity of skin disorders and hearing loss.

Press ER, Shao Q, Kelly JJ, Chin K, Alaga A, Laird DW.

J Biol Chem. 2017 Jun 9;292(23):9721-9732. doi: 10.1074/jbc.M116.770917. Epub 2017 Apr 20.


The effect of caffeine on skeletal muscle anabolic signaling and hypertrophy.

Moore TM, Mortensen XM, Ashby CK, Harris AM, Kump KJ, Laird DW, Adams AJ, Bray JK, Chen T, Thomson DM.

Appl Physiol Nutr Metab. 2017 Jun;42(6):621-629. doi: 10.1139/apnm-2016-0547. Epub 2017 Jan 26.


Connexin43 Mutant Patient-Derived Induced Pluripotent Stem Cells Exhibit Altered Differentiation Potential.

Esseltine JL, Shao Q, Brooks C, Sampson J, Betts DH, Séguin CA, Laird DW.

J Bone Miner Res. 2017 Jun;32(6):1368-1385. doi: 10.1002/jbmr.3098. Epub 2017 Apr 5.


Gap junctions and cancer: communicating for 50 years.

Aasen T, Mesnil M, Naus CC, Lampe PD, Laird DW.

Nat Rev Cancer. 2016 Dec;16(12):775-788. doi: 10.1038/nrc.2016.105. Epub 2016 Oct 21. Review. Erratum in: Nat Rev Cancer. 2017 Jan;17 (1):74.


Differential effects of pannexins on noise-induced hearing loss.

Abitbol JM, Kelly JJ, Barr K, Schormans AL, Laird DW, Allman BL.

Biochem J. 2016 Dec 15;473(24):4665-4680. Epub 2016 Oct 26.


Connexin Hemichannels: Methods for Dye Uptake and Leakage.

Johnson RG, Le HC, Evenson K, Loberg SW, Myslajek TM, Prabhu A, Manley AM, O'Shea C, Grunenwald H, Haddican M, Fitzgerald PM, Robinson T, Cisterna BA, Sáez JC, Liu TF, Laird DW, Sheridan JD.

J Membr Biol. 2016 Dec;249(6):713-741. Epub 2016 Sep 1.


Next-Generation Connexin and Pannexin Cell Biology.

Esseltine JL, Laird DW.

Trends Cell Biol. 2016 Dec;26(12):944-955. doi: 10.1016/j.tcb.2016.06.003. Epub 2016 Jun 21. Review.


Role of connexins and pannexins during ontogeny, regeneration, and pathologies of bone.

Plotkin LI, Laird DW, Amedee J.

BMC Cell Biol. 2016 May 24;17 Suppl 1:19. doi: 10.1186/s12860-016-0088-6. Review.


Specific functional pathologies of Cx43 mutations associated with oculodentodigital dysplasia.

Kelly JJ, Esseltine JL, Shao Q, Jabs EW, Sampson J, Auranen M, Bai D, Laird DW.

Mol Biol Cell. 2016 Jul 15;27(14):2172-85. doi: 10.1091/mbc.E16-01-0062. Epub 2016 May 25.


Critical Role of Cx40 in Reduced Endothelial Electrical Coupling by Lipopolysaccharide and Hypoxia-Reoxygenation.

Siddiqui M, Swarbreck S, Shao Q, Secor D, Peng T, Laird DW, Tyml K.

J Vasc Res. 2015;52(6):396-403. doi: 10.1159/000445772. Epub 2016 May 19.


A Germline Variant in the PANX1 Gene Has Reduced Channel Function and Is Associated with Multisystem Dysfunction.

Shao Q, Lindstrom K, Shi R, Kelly J, Schroeder A, Juusola J, Levine KL, Esseltine JL, Penuela S, Jackson MF, Laird DW.

J Biol Chem. 2016 Jun 10;291(24):12432-43. doi: 10.1074/jbc.M116.717934. Epub 2016 Apr 15.


Loss of Panx1 Impairs Mammary Gland Development at Lactation: Implications for Breast Tumorigenesis.

Stewart MK, Plante I, Penuela S, Laird DW.

PLoS One. 2016 Apr 21;11(4):e0154162. doi: 10.1371/journal.pone.0154162. eCollection 2016.


Gerald M. Kidder - bridging the gap in cell and developmental biology.

Laird DW, Naus CC.

Semin Cell Dev Biol. 2016 Feb;50:1-3. doi: 10.1016/j.semcdb.2016.02.017. No abstract available.


Global deletion of Panx3 produces multiple phenotypic effects in mouse humeri and femora.

Caskenette D, Penuela S, Lee V, Barr K, Beier F, Laird DW, Willmore KE.

J Anat. 2016 May;228(5):746-56. doi: 10.1111/joa.12437. Epub 2016 Jan 7.


Connexins in skeletal muscle development and disease.

Merrifield PA, Laird DW.

Semin Cell Dev Biol. 2016 Feb;50:67-73. doi: 10.1016/j.semcdb.2015.12.001. Epub 2015 Dec 10. Review.


Cx26 knockout predisposes the mammary gland to primary mammary tumors in a DMBA-induced mouse model of breast cancer.

Stewart MK, Bechberger JF, Welch I, Naus CC, Laird DW.

Oncotarget. 2015 Nov 10;6(35):37185-99. doi: 10.18632/oncotarget.5953.


Cx30 exhibits unique characteristics including a long half-life when assembled into gap junctions.

Kelly JJ, Shao Q, Jagger DJ, Laird DW.

J Cell Sci. 2015 Nov 1;128(21):3947-60. doi: 10.1242/jcs.174698. Epub 2015 Sep 10.


Manipulating Cx43 expression triggers gene reprogramming events in dermal fibroblasts from oculodentodigital dysplasia patients.

Esseltine JL, Shao Q, Huang T, Kelly JJ, Sampson J, Laird DW.

Biochem J. 2015 Nov 15;472(1):55-69. doi: 10.1042/BJ20150652. Epub 2015 Sep 8.



Laird DW, Lampe PD, Johnson RG.

Sci Am. 2015 May;312(5):70-7. No abstract available.


Deletion of Panx3 Prevents the Development of Surgically Induced Osteoarthritis.

Moon PM, Penuela S, Barr K, Khan S, Pin CL, Welch I, Attur M, Abramson SB, Laird DW, Beier F.

J Mol Med (Berl). 2015 Aug;93(8):845-56. doi: 10.1007/s00109-015-1311-1. Epub 2015 Jul 4.


Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead.

Goodson WH 3rd, Lowe L, Carpenter DO, Gilbertson M, Manaf Ali A, Lopez de Cerain Salsamendi A, Lasfar A, Carnero A, Azqueta A, Amedei A, Charles AK, Collins AR, Ward A, Salzberg AC, Colacci A, Olsen AK, Berg A, Barclay BJ, Zhou BP, Blanco-Aparicio C, Baglole CJ, Dong C, Mondello C, Hsu CW, Naus CC, Yedjou C, Curran CS, Laird DW, Koch DC, Carlin DJ, Felsher DW, Roy D, Brown DG, Ratovitski E, Ryan EP, Corsini E, Rojas E, Moon EY, Laconi E, Marongiu F, Al-Mulla F, Chiaradonna F, Darroudi F, Martin FL, Van Schooten FJ, Goldberg GS, Wagemaker G, Nangami GN, Calaf GM, Williams G, Wolf GT, Koppen G, Brunborg G, Lyerly HK, Krishnan H, Ab Hamid H, Yasaei H, Sone H, Kondoh H, Salem HK, Hsu HY, Park HH, Koturbash I, Miousse IR, Scovassi AI, Klaunig JE, Vondráček J, Raju J, Roman J, Wise JP Sr, Whitfield JR, Woodrick J, Christopher JA, Ochieng J, Martinez-Leal JF, Weisz J, Kravchenko J, Sun J, Prudhomme KR, Narayanan KB, Cohen-Solal KA, Moorwood K, Gonzalez L, Soucek L, Jian L, D'Abronzo LS, Lin LT, Li L, Gulliver L, McCawley LJ, Memeo L, Vermeulen L, Leyns L, Zhang L, Valverde M, Khatami M, Romano MF, Chapellier M, Williams MA, Wade M, Manjili MH, Lleonart ME, Xia M, Gonzalez MJ, Karamouzis MV, Kirsch-Volders M, Vaccari M, Kuemmerle NB, Singh N, Cruickshanks N, Kleinstreuer N, van Larebeke N, Ahmed N, Ogunkua O, Krishnakumar PK, Vadgama P, Marignani PA, Ghosh PM, Ostrosky-Wegman P, Thompson PA, Dent P, Heneberg P, Darbre P, Sing Leung P, Nangia-Makker P, Cheng QS, Robey RB, Al-Temaimi R, Roy R, Andrade-Vieira R, Sinha RK, Mehta R, Vento R, Di Fiore R, Ponce-Cusi R, Dornetshuber-Fleiss R, Nahta R, Castellino RC, Palorini R, Abd Hamid R, Langie SA, Eltom SE, Brooks SA, Ryeom S, Wise SS, Bay SN, Harris SA, Papagerakis S, Romano S, Pavanello S, Eriksson S, Forte S, Casey SC, Luanpitpong S, Lee TJ, Otsuki T, Chen T, Massfelder T, Sanderson T, Guarnieri T, Hultman T, Dormoy V, Odero-Marah V, Sabbisetti V, Maguer-Satta V, Rathmell WK, Engström W, Decker WK, Bisson WH, Rojanasakul Y, Luqmani Y, Chen Z, Hu Z.

Carcinogenesis. 2015 Jun;36 Suppl 1:S254-96. doi: 10.1093/carcin/bgv039. Review. Erratum in: Carcinogenesis. 2016 Mar;37(3):344.


Mechanisms of environmental chemicals that enable the cancer hallmark of evasion of growth suppression.

Nahta R, Al-Mulla F, Al-Temaimi R, Amedei A, Andrade-Vieira R, Bay SN, Brown DG, Calaf GM, Castellino RC, Cohen-Solal KA, Colacci A, Cruickshanks N, Dent P, Di Fiore R, Forte S, Goldberg GS, Hamid RA, Krishnan H, Laird DW, Lasfar A, Marignani PA, Memeo L, Mondello C, Naus CC, Ponce-Cusi R, Raju J, Roy D, Roy R, Ryan EP, Salem HK, Scovassi AI, Singh N, Vaccari M, Vento R, Vondráček J, Wade M, Woodrick J, Bisson WH.

Carcinogenesis. 2015 Jun;36 Suppl 1:S2-18. doi: 10.1093/carcin/bgv028. Review.


Functional role of a polymorphism in the Pannexin1 gene in collagen-induced platelet aggregation.

Molica F, Morel S, Meens MJ, Denis JF, Bradfield PF, Penuela S, Zufferey A, Monyer H, Imhof BA, Chanson M, Laird DW, Fontana P, Kwak BR.

Thromb Haemost. 2015 Aug;114(2):325-36. doi: 10.1160/TH14-11-0981. Epub 2015 May 7.


Insights into the role of connexins in mammary gland morphogenesis and function.

Stewart MK, Simek J, Laird DW.

Reproduction. 2015 Jun;149(6):R279-90. doi: 10.1530/REP-14-0661. Epub 2015 Mar 19. Review.


Mechanisms linking connexin mutations to human diseases.

Kelly JJ, Simek J, Laird DW.

Cell Tissue Res. 2015 Jun;360(3):701-21. doi: 10.1007/s00441-014-2024-4. Epub 2014 Nov 16. Review.


Dynamin 2 interacts with connexin 26 to regulate its degradation and function in gap junction formation.

Xiao D, Chen S, Shao Q, Chen J, Bijian K, Laird DW, Alaoui-Jamali MA.

Int J Biochem Cell Biol. 2014 Oct;55:288-97. doi: 10.1016/j.biocel.2014.09.021. Epub 2014 Sep 28.


Chemotherapeutic drugs induce ATP release via caspase-gated pannexin-1 channels and a caspase/pannexin-1-independent mechanism.

Boyd-Tressler A, Penuela S, Laird DW, Dubyak GR.

J Biol Chem. 2014 Sep 26;289(39):27246-63. doi: 10.1074/jbc.M114.590240. Epub 2014 Aug 11.


Pannexin channels and their links to human disease.

Penuela S, Harland L, Simek J, Laird DW.

Biochem J. 2014 Aug 1;461(3):371-81. doi: 10.1042/BJ20140447. Review.


Mammary gland specific knockdown of the physiological surge in Cx26 during lactation retains normal mammary gland development and function.

Stewart MK, Plante I, Bechberger JF, Naus CC, Laird DW.

PLoS One. 2014 Jul 2;9(7):e101546. doi: 10.1371/journal.pone.0101546. eCollection 2014.


An atrial-fibrillation-linked connexin40 mutant is retained in the endoplasmic reticulum and impairs the function of atrial gap-junction channels.

Sun Y, Tong X, Chen H, Huang T, Shao Q, Huang W, Laird DW, Bai D.

Dis Model Mech. 2014 May;7(5):561-9. doi: 10.1242/dmm.013813. Epub 2014 Mar 13.


Panx1 regulates cellular properties of keratinocytes and dermal fibroblasts in skin development and wound healing.

Penuela S, Kelly JJ, Churko JM, Barr KJ, Berger AC, Laird DW.

J Invest Dermatol. 2014 Jul;134(7):2026-2035. doi: 10.1038/jid.2014.86. Epub 2014 Feb 12.


Mutations in Cx30 that are linked to skin disease and non-syndromic hearing loss exhibit several distinct cellular pathologies.

Berger AC, Kelly JJ, Lajoie P, Shao Q, Laird DW.

J Cell Sci. 2014 Apr 15;127(Pt 8):1751-64. doi: 10.1242/jcs.138230. Epub 2014 Feb 12.


Syndromic and non-syndromic disease-linked Cx43 mutations.

Laird DW.

FEBS Lett. 2014 Apr 17;588(8):1339-48. doi: 10.1016/j.febslet.2013.12.022. Epub 2014 Jan 14. Review.


Diverse post-translational modifications of the pannexin family of channel-forming proteins.

Penuela S, Lohman AW, Lai W, Gyenis L, Litchfield DW, Isakson BE, Laird DW.

Channels (Austin). 2014;8(2):124-30. doi: 10.4161/chan.27422. Epub 2014 Jan 13.

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