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Items: 1 to 50 of 73

1.

Maternal phenylketonuria syndrome: studies in mice suggest a potential approach to a continuing problem.

Zeile WL, McCune HC, Musson DG, O'Donnell B, O'Neill CA, Tsuruda LS, Zori RT, Laipis PJ.

Pediatr Res. 2018 Apr;83(4):889-896. doi: 10.1038/pr.2017.323. Epub 2018 Jan 31.

2.

Partial rescue of neuropathology in the murine model of PKU following administration of recombinant phenylalanine ammonia lyase (pegvaliase).

Goldfinger M, Zeile WL, Corado CR, O'Neill CA, Tsuruda LS, Laipis PJ, Cooper JD.

Mol Genet Metab. 2017 Sep;122(1-2):33-35. doi: 10.1016/j.ymgme.2017.04.013. Epub 2017 Apr 29.

3.

Epilepsy in phenylketonuria: a complex dependence on serum phenylalanine levels.

Martynyuk AE, Ucar DA, Yang DD, Norman WM, Carney PR, Dennis DM, Laipis PJ.

Epilepsia. 2007 Jun;48(6):1143-50. Epub 2007 May 1.

4.

Structural and kinetic analysis of proton shuttle residues in the active site of human carbonic anhydrase III.

Elder I, Fisher Z, Laipis PJ, Tu C, McKenna R, Silverman DN.

Proteins. 2007 Jul 1;68(1):337-43.

PMID:
17427958
5.

PKU is a reversible neurodegenerative process within the nigrostriatum that begins as early as 4 weeks of age in Pah(enu2) mice.

Embury JE, Charron CE, Martynyuk A, Zori AG, Liu B, Ali SF, Rowland NE, Laipis PJ.

Brain Res. 2007 Jan 5;1127(1):136-50. Epub 2006 Nov 15.

6.

Impaired glutamatergic synaptic transmission in the PKU brain.

Martynyuk AE, Glushakov AV, Sumners C, Laipis PJ, Dennis DM, Seubert CN.

Mol Genet Metab. 2005 Dec;86 Suppl 1:S34-42. Epub 2005 Sep 8. Review.

PMID:
16153867
7.
8.

Human carbonic anhydrase III: structural and kinetic study of catalysis and proton transfer.

Duda DM, Tu C, Fisher SZ, An H, Yoshioka C, Govindasamy L, Laipis PJ, Agbandje-McKenna M, Silverman DN, McKenna R.

Biochemistry. 2005 Aug 2;44(30):10046-53.

PMID:
16042381
9.

Long-term changes in glutamatergic synaptic transmission in phenylketonuria.

Glushakov AV, Glushakova O, Varshney M, Bajpai LK, Sumners C, Laipis PJ, Embury JE, Baker SP, Otero DH, Dennis DM, Seubert CN, Martynyuk AE.

Brain. 2005 Feb;128(Pt 2):300-7. Epub 2005 Jan 5.

PMID:
15634735
10.
11.

Activation of carbonic anhydrase II by active-site incorporation of histidine analogs.

Elder I, Han S, Tu C, Steele H, Laipis PJ, Viola RE, Silverman DN.

Arch Biochem Biophys. 2004 Jan 15;421(2):283-9.

PMID:
14984209
12.

Direct atmospheric pressure coupling of polyacrylamide gel electrophoresis to mass spectrometry for rapid protein sequence analysis.

Coon JJ, Steele HA, Laipis PJ, Harrison WW.

J Proteome Res. 2003 Nov-Dec;2(6):610-7.

PMID:
14692454
13.

Glucose deprivation enhances targeting of GLUT1 to lipid rafts in 3T3-L1 adipocytes.

Kumar A, Xiao YP, Laipis PJ, Fletcher BS, Frost SC.

Am J Physiol Endocrinol Metab. 2004 Apr;286(4):E568-76. Epub 2003 Dec 9.

14.

Using evolutionary rates to investigate protein functional divergence and conservation. A case study of the carbonic anhydrases.

Knudsen B, Miyamoto MM, Laipis PJ, Silverman DN.

Genetics. 2003 Aug;164(4):1261-9. Erratum in: Genetics. 2003 Sep;165(1):453.

15.

Proton transfer within the active-site cavity of carbonic anhydrase III.

An H, Tu C, Ren K, Laipis PJ, Silverman DN.

Biochim Biophys Acta. 2002 Sep 23;1599(1-2):21-7.

PMID:
12484342
16.
17.

Kinetic analysis of multiple proton shuttles in the active site of human carbonic anhydrase.

Tu C, Qian M, An H, Wadhwa NR, Duda D, Yoshioka C, Pathak Y, McKenna R, Laipis PJ, Silverman DN.

J Biol Chem. 2002 Oct 11;277(41):38870-6. Epub 2002 Aug 8.

18.

Glycogen phosphorylase is activated in response to glucose deprivation but is not responsible for enhanced glucose transport activity in 3T3-L1 adipocytes.

McInerney M, Serrano Rodriguez G, Pawlina W, Hurt CB, Fletcher BS, Laipis PJ, Frost SC.

Biochim Biophys Acta. 2002 Feb 15;1570(1):53-62.

PMID:
11960689
19.

Chemical rescue in catalysis by human carbonic anhydrases II and III.

An H, Tu C, Duda D, Montanez-Clemente I, Math K, Laipis PJ, McKenna R, Silverman DN.

Biochemistry. 2002 Mar 5;41(9):3235-42.

PMID:
11863462
20.

The catalytic properties of human carbonic anhydrase IX.

Wingo T, Tu C, Laipis PJ, Silverman DN.

Biochem Biophys Res Commun. 2001 Nov 2;288(3):666-9.

PMID:
11676494
21.
22.

Carbon dioxide transport by proteic and facilitated transport membranes.

Trachtenberg MC, Tu CK, Landers RA, Willson RC, McGregor ML, Laipis PJ, Kennedy JF, Paterson M, Silverman DN, Thomas D, Smith RL, Rudolph FB.

Life Support Biosph Sci. 1999;6(4):293-302.

PMID:
11543269
23.

Effect of DNA-dependent protein kinase on the molecular fate of the rAAV2 genome in skeletal muscle.

Song S, Laipis PJ, Berns KI, Flotte TR.

Proc Natl Acad Sci U S A. 2001 Mar 27;98(7):4084-8. Epub 2001 Mar 13.

24.

Proton transfer to residues of basic pK(a) during catalysis by carbonic anhydrase.

Qian M, Earnhardt JN, Wadhwa NR, Tu C, Laipis PJ, Silverman DN.

Biochim Biophys Acta. 1999 Sep 14;1434(1):1-5.

PMID:
10556554
25.

Introduction of histidine analogs leads to enhanced proton transfer in carbonic anhydrase V.

Earnhardt JN, Wright SK, Qian M, Tu C, Laipis PJ, Viola RE, Silverman DN.

Arch Biochem Biophys. 1999 Jan 15;361(2):264-70.

PMID:
9882455
26.

The catalytic properties of murine carbonic anhydrase VII.

Earnhardt JN, Qian M, Tu C, Lakkis MM, Bergenhem NC, Laipis PJ, Tashian RE, Silverman DN.

Biochemistry. 1998 Jul 28;37(30):10837-45.

PMID:
9692974
27.

Properties of intramolecular proton transfer in carbonic anhydrase III.

Tu C, Qian M, Earnhardt JN, Laipis PJ, Silverman DN.

Biophys J. 1998 Jun;74(6):3182-9.

28.

Intramolecular proton transfer from multiple sites in catalysis by murine carbonic anhydrase V.

Earnhardt JN, Qian M, Tu C, Laipis PJ, Silverman DN.

Biochemistry. 1998 May 19;37(20):7649-55.

PMID:
9585580
29.

Isolation and expression of murine carbonic anhydrase IV.

Hurt JD, Tu C, Laipis PJ.

Protein Expr Purif. 1998 Feb;12(1):7-16.

PMID:
9473451
30.

Glutamate and aspartate as proton shuttles in mutants of carbonic anhydrase.

Qian M, Tu C, Earnhardt JN, Laipis PJ, Silverman DN.

Biochemistry. 1997 Dec 16;36(50):15758-64.

PMID:
9398305
31.

Catalytic properties of murine carbonic anhydrase IV.

Hurt JD, Tu C, Laipis PJ, Silverman DN.

J Biol Chem. 1997 May 23;272(21):13512-8.

32.

Structure-based design of an intramolecular proton transfer site in murine carbonic anhydrase V.

Heck RW, Boriack-Sjodin PA, Qian M, Tu C, Christianson DW, Laipis PJ, Silverman DN.

Biochemistry. 1996 Sep 10;35(36):11605-11.

PMID:
8794740
33.
34.

Structure determination of murine mitochondrial carbonic anhydrase V at 2.45-A resolution: implications for catalytic proton transfer and inhibitor design.

Boriack-Sjodin PA, Heck RW, Laipis PJ, Silverman DN, Christianson DW.

Proc Natl Acad Sci U S A. 1995 Nov 21;92(24):10949-53.

35.

Multiple deletions are detectable in mitochondrial DNA of aging mice.

Tanhauser SM, Laipis PJ.

J Biol Chem. 1995 Oct 20;270(42):24769-75.

36.

Proton transfer by histidine 67 in site-directed mutants of human carbonic anhydrase III.

Ren X, Tu C, Laipis PJ, Silverman DN.

Biochemistry. 1995 Jul 4;34(26):8492-8.

PMID:
7599138
37.

Catalytic properties of mouse carbonic anhydrase V.

Heck RW, Tanhauser SM, Manda R, Tu C, Laipis PJ, Silverman DN.

J Biol Chem. 1994 Oct 7;269(40):24742-6.

38.

Interactions of active-site residues and catalytic activity of human carbonic anhydrase III.

Tu C, Chen X, Ren X, LoGrasso PV, Jewell DA, Laipis PJ, Silverman DN.

J Biol Chem. 1994 Sep 16;269(37):23002-6.

39.

Analysis of expressed sequence tags from Plasmodium falciparum.

Chakrabarti D, Reddy GR, Dame JB, Almira EC, Laipis PJ, Ferl RJ, Yang TP, Rowe TC, Schuster SM.

Mol Biochem Parasitol. 1994 Jul;66(1):97-104.

PMID:
7984191
40.

Multiple copies of the bone-specific osteocalcin gene in mouse and rat.

Rahman S, Oberdorf A, Montecino M, Tanhauser SM, Lian JB, Stein GS, Laipis PJ, Stein JL.

Endocrinology. 1993 Dec;133(6):3050-3.

PMID:
8243336
41.

Rate-equilibria relationships in intramolecular proton transfer in human carbonic anhydrase III.

Silverman DN, Tu C, Chen X, Tanhauser SM, Kresge AJ, Laipis PJ.

Biochemistry. 1993 Oct 12;32(40):10757-62.

PMID:
8399223
42.

Interaction and influence of phenylalanine-198 and threonine-199 on catalysis by human carbonic anhydrase III.

Chen X, Tu C, LoGrasso PV, Laipis PJ, Silverman DN.

Biochemistry. 1993 Aug 10;32(31):7861-5.

PMID:
8347590
43.

Transcribed heteroplasmic repeated sequences in the porcine mitochondrial DNA D-loop region.

Ghivizzani SC, Mackay SL, Madsen CS, Laipis PJ, Hauswirth WW.

J Mol Evol. 1993 Jul;37(1):36-7.

PMID:
8360917
44.

Influence of amino acid replacement at position 198 on catalytic properties of zinc-bound water in human carbonic anhydrase III.

LoGrasso PV, Tu C, Chen X, Taoka S, Laipis PJ, Silverman DN.

Biochemistry. 1993 Jun 8;32(22):5786-91.

PMID:
8504098
45.

A T7 expression vector optimized for site-directed mutagenesis using oligodeoxyribonucleotide cassettes.

Tanhauser SM, Jewell DA, Tu CK, Silverman DN, Laipis PJ.

Gene. 1992 Aug 1;117(1):113-7.

PMID:
1644301
46.

Mispairing and compensational changes during the evolution of mitochondrial ribosomal RNA.

Kraus F, Jarecki L, Miyamoto MM, Tanhauser SM, Laipis PJ.

Mol Biol Evol. 1992 Jul;9(4):770-4. No abstract available.

PMID:
1378523
47.
48.

Catalytic enhancement of human carbonic anhydrase III by replacement of phenylalanine-198 with leucine.

LoGrasso PV, Tu CK, Jewell DA, Wynns GC, Laipis PJ, Silverman DN.

Biochemistry. 1991 Aug 27;30(34):8463-70.

PMID:
1909176
49.

Enhancement of the catalytic properties of human carbonic anhydrase III by site-directed mutagenesis.

Jewell DA, Tu CK, Paranawithana SR, Tanhauser SM, LoGrasso PV, Laipis PJ, Silverman DN.

Biochemistry. 1991 Feb 12;30(6):1484-90.

PMID:
1899618
50.

Enhancement of the catalytic activity of carbonic anhydrase III by phosphates.

Paranawithana SR, Tu CK, Laipis PJ, Silverman DN.

J Biol Chem. 1990 Dec 25;265(36):22270-4.

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