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Items: 1 to 50 of 103

1.

Upper Airway Cell Transcriptomics Identify a Major New Immunological Phenotype with Strong Clinical Correlates in Young Children with Acute Wheezing.

Khoo SK, Read J, Franks K, Zhang G, Bizzintino J, Coleman L, McCrae C, Öberg L, Troy NM, Prastanti F, Everard J, Oo S, Borland ML, Maciewicz RA, Le Souëf PN, Laing IA, Bosco A.

J Immunol. 2019 Mar 15;202(6):1845-1858. doi: 10.4049/jimmunol.1800178. Epub 2019 Feb 11.

PMID:
30745463
2.

Glutathione S-Transferase Genotype Protects Against In Utero Tobacco Linked Lung Function Deficits.

Owens L, Laing IA, Murdzoska J, Zhang G, Turner SW, Le Souëf PN.

Am J Respir Crit Care Med. 2019 Feb 6. doi: 10.1164/rccm.201807-1332OC. [Epub ahead of print]

PMID:
30726102
3.

Prevalence of allergic sensitization, hay fever, eczema, and asthma in a longitudinal birth cohort.

Owens L, Laing IA, Zhang G, Turner S, Le Souëf PN.

J Asthma Allergy. 2018 Aug 13;11:173-180. doi: 10.2147/JAA.S170285. eCollection 2018.

4.

The impact of respiratory viruses on lung health after preterm birth.

Townsi N, Laing IA, Hall GL, Simpson SJ.

Eur Clin Respir J. 2018 Aug 1;5(1):1487214. doi: 10.1080/20018525.2018.1487214. eCollection 2018. Review.

5.

Basophil counts in PBMC populations during childhood acute wheeze/asthma are associated with future exacerbations.

Leffler J, Jones AC, Hollams EM, Prastanti F, Le Souëf PN, Holt PG, Bosco A, Laing IA, Strickland DH.

J Allergy Clin Immunol. 2018 Nov;142(5):1639-1641.e5. doi: 10.1016/j.jaci.2018.07.003. Epub 2018 Jul 21. No abstract available.

PMID:
30036597
6.

Cord Blood IL-12 Confers Protection to Clinical Malaria in Early Childhood Life.

Song Y, Aguilar R, Guo J, Manaca MN, Nhabomba A, Berthoud TK, Khoo SK, Wiertsema S, Barbosa A, Quintó L, Laing IA, Mayor A, Guinovart C, Alonso PL, LeSouëf PN, Dobaño C, Zhang GB.

Sci Rep. 2018 Jul 18;8(1):10860. doi: 10.1038/s41598-018-29179-y.

7.

Rhinovirus is the most common virus and rhinovirus-C is the most common species in paediatric intensive care respiratory admissions.

Cox DW, Khoo SK, Zhang G, Lindsay K, Keil AD, Knight G, Gern JE, Laing IA, Bizzintino J, Le Souëf PN.

Eur Respir J. 2018 Aug 9;52(2). pii: 1800207. doi: 10.1183/13993003.00207-2018. Print 2018 Aug. No abstract available.

PMID:
29976655
8.

Airway Interleukin-33 and type 2 cytokines in adult patients with acute asthma.

Poulsen NN, Bjerregaard A, Khoo SK, Laing IA, Le Souëf P, Backer V, Rapley L, Cohen SE, Barrett L, Thompson P, Baltic S, Porsbjerg C.

Respir Med. 2018 Jul;140:50-56. doi: 10.1016/j.rmed.2018.05.016. Epub 2018 May 19.

PMID:
29957280
9.

Airway function in infancy is linked to airflow measurements and respiratory symptoms from childhood into adulthood.

Owens L, Laing IA, Zhang G, Turner S, Le Souëf PN.

Pediatr Pulmonol. 2018 Aug;53(8):1082-1088. doi: 10.1002/ppul.24062. Epub 2018 May 27.

PMID:
29806178
10.

Prospective Assessment of Rhinovirus Symptoms and Species Recurrence in Children With and Without an Acute Wheezing Exacerbation.

Lethbridge R, Prastanti F, Robertson C, Oo S, Khoo SK, Le Souëf PN, Laing IA.

Viral Immunol. 2018 May;31(4):299-305. doi: 10.1089/vim.2017.0152. Epub 2018 Feb 15.

PMID:
29446705
11.

Environmental exposure and parental collection does not affect detection or semi-quantitative load assessment of bacteria in nasal swab specimens from children.

Townsi N, Simpson SJ, Sikazwe CT, Chidlow GR, Hall GL, Pillow JJ, Wilson AC, Smith DW, Laing IA.

Infect Dis (Lond). 2018 Jun;50(6):468-471. doi: 10.1080/23744235.2017.1411607. Epub 2017 Dec 13. No abstract available.

PMID:
29237312
12.

T-cell responses against rhinovirus species A and C in asthmatic and healthy children.

Gaido CM, Granland C, Laing IA, Souëf PNL, Thomas WR, Currie AJ, Hales BJ.

Immun Inflamm Dis. 2018 Mar;6(1):143-153. doi: 10.1002/iid3.206. Epub 2017 Nov 10.

13.

Environment Changes Genetic Effects on Respiratory Conditions and Allergic Phenotypes.

Song Y, Schwager MJ, Backer V, Guo J, Porsbjerg C, Khoo SK, Laing IA, Moses EK, LeSouëf P, Zhang GB.

Sci Rep. 2017 Jul 24;7(1):6342. doi: 10.1038/s41598-017-06791-y.

14.

High fractional exhaled nitric oxide and sputum eosinophils are associated with an increased risk of future virus-induced exacerbations: A prospective cohort study.

Bjerregaard A, Laing IA, Backer V, Sverrild A, Khoo SK, Chidlow G, Sikazwe C, Smith DW, Le Souëf P, Porsbjerg C.

Clin Exp Allergy. 2017 Aug;47(8):1007-1013. doi: 10.1111/cea.12935. Epub 2017 May 9.

PMID:
28390083
15.

Characteristics associated with clinical severity and inflammatory phenotype of naturally occurring virus-induced exacerbations of asthma in adults.

Bjerregaard A, Laing IA, Poulsen N, Backer V, Sverrild A, Fally M, Khoo SK, Barrett L, Baltic S, Thompson PJ, Chidlow G, Sikazwe C, Smith DW, Bochkov YA, Le Souëf P, Porsbjerg C.

Respir Med. 2017 Feb;123:34-41. doi: 10.1016/j.rmed.2016.12.010. Epub 2016 Dec 18.

16.

Rhinovirus C is associated with wheezing and rhinovirus A is associated with pneumonia in hospitalized children in Morocco.

Annamalay AA, Jroundi I, Bizzintino J, Khoo SK, Zhang G, Lehmann D, Laing IA, Gern J, Goldblatt J, Mahraoui C, Benmessaoud R, Moraleda C, Bassat Q, Le Souëf P.

J Med Virol. 2017 Apr;89(4):582-588. doi: 10.1002/jmv.24684. Epub 2016 Sep 30.

PMID:
27677921
17.

Clinical characteristics of eosinophilic asthma exacerbations.

Bjerregaard A, Laing IA, Backer V, Fally M, Khoo SK, Chidlow G, Sikazwe C, Smith DW, Le Souëf P, Porsbjerg C.

Respirology. 2017 Feb;22(2):295-300. doi: 10.1111/resp.12905. Epub 2016 Sep 21.

PMID:
27649851
18.

Infant lung function predicts asthma persistence and remission in young adults.

Owens L, Laing IA, Zhang G, Le Souëf PN.

Respirology. 2017 Feb;22(2):289-294. doi: 10.1111/resp.12901. Epub 2016 Sep 16.

19.

Rhinovirus species and clinical features in children hospitalised with pneumonia from Mozambique.

Annamalay AA, Lanaspa M, Khoo SK, Madrid L, Acácio S, Zhang G, Laing IA, Gern J, Goldblatt J, Bizzintino J, Lehmann D, Le Souëf PN, Bassat Q.

Trop Med Int Health. 2016 Sep;21(9):1171-80. doi: 10.1111/tmi.12743. Epub 2016 Jul 26.

20.

Rhinovirus-induced asthma exacerbations and risk populations.

Coleman L, Laing IA, Bosco A.

Curr Opin Allergy Clin Immunol. 2016 Apr;16(2):179-85. doi: 10.1097/ACI.0000000000000245. Review.

PMID:
26836624
21.

Western environment/lifestyle is associated with increased genome methylation and decreased gene expression in Chinese immigrants living in Australia.

Zhang G, Wang K, Schultz E, Khoo SK, Zhang X, Annamalay A, Laing IA, Hales BJ, Goldblatt J, Le Souëf PN.

Environ Mol Mutagen. 2016 Jan;57(1):65-73. doi: 10.1002/em.21989. Epub 2015 Dec 16.

PMID:
26671525
22.

Recurrent rhinovirus detections in children following a rhinovirus-induced wheezing exacerbation: A retrospective study.

Halmø Hürdum S, Zhang G, Khoo SK, Bizzintino J, Franks KM, Lindsay K, Keil AD, Cox DW, Goldblatt J, Bochkov YA, Gern J, Ulrik CS, Souëf PN, Laing IA.

Int J Pediatr Child Health. 2015 Aug;3(1):10-18. doi: 10.12974/2311-8687.2015.03.01.2.

23.

Lower anti-echovirus antibody responses in children presenting to hospital with asthma exacerbations.

Iwasaki J, Chai LY, Khoo SK, Bizzintino J, Laing IA, Le Souëf PN, Thomas WR, Hales BJ.

Clin Exp Allergy. 2015 Oct;45(10):1523-30. doi: 10.1111/cea.12501.

PMID:
25640320
24.

Comparison of rhinovirus antibody titers in children with asthma exacerbations and species-specific rhinovirus infection.

Iwasaki J, Smith WA, Khoo SK, Bizzintino J, Zhang G, Cox DW, Laing IA, Le Souëf PN, Thomas WR, Hales BJ.

J Allergy Clin Immunol. 2014 Jul;134(1):25-32. doi: 10.1016/j.jaci.2014.03.014. Epub 2014 Apr 24.

PMID:
24767874
25.

Where should extreme preterm babies be delivered? Crucial data from EPICure.

Laing IA.

Arch Dis Child Fetal Neonatal Ed. 2014 May;99(3):F177-8. doi: 10.1136/archdischild-2014-306020. No abstract available.

PMID:
24723697
26.

Human rhinovirus species C infection in young children with acute wheeze is associated with increased acute respiratory hospital admissions.

Cox DW, Bizzintino J, Ferrari G, Khoo SK, Zhang G, Whelan S, Lee WM, Bochkov YA, Geelhoed GC, Goldblatt J, Gern JE, Laing IA, Le Souëf PN.

Am J Respir Crit Care Med. 2013 Dec 1;188(11):1358-64. doi: 10.1164/rccm.201303-0498OC.

27.

Conflict resolution in end-of-life decisions in the neonatal unit.

Laing IA.

Semin Fetal Neonatal Med. 2013 Apr;18(2):83-7. doi: 10.1016/j.siny.2012.09.005. Epub 2012 Oct 18.

PMID:
23084607
28.

Respiratory viral pathogens associated with lower respiratory tract disease among young children in the highlands of Papua New Guinea.

Chidlow GR, Laing IA, Harnett GB, Greenhill AR, Phuanukoonnon S, Siba PM, Pomat WS, Shellam GR, Smith DW, Lehmann D.

J Clin Virol. 2012 Jul;54(3):235-9. doi: 10.1016/j.jcv.2012.04.008. Epub 2012 May 16.

29.

Prevalence of and risk factors for human rhinovirus infection in healthy aboriginal and non-aboriginal Western Australian children.

Annamalay AA, Khoo SK, Jacoby P, Bizzintino J, Zhang G, Chidlow G, Lee WM, Moore HC, Harnett GB, Smith DW, Gern JE, LeSouef PN, Laing IA, Lehmann D; Kalgoorlie Otitis Media Research Project Team.

Pediatr Infect Dis J. 2012 Jul;31(7):673-9. doi: 10.1097/INF.0b013e318256ffc6.

30.

Symptomatic viral infection is associated with impaired response to treatment in children with acute asthma.

Rueter K, Bizzintino J, Martin AC, Zhang G, Hayden CM, Geelhoed GC, Goldblatt J, Laing IA, Le Souëf PN.

J Pediatr. 2012 Jan;160(1):82-7. doi: 10.1016/j.jpeds.2011.06.025. Epub 2011 Aug 19.

PMID:
21855894
31.

Regulatory role of IL10 genetic variations in determining allergen-induced T(H)2 cytokine responses in children.

Hayden CM, Zhang G, Judge PK, Khoo SK, Laing IA, Turner SW, Goldblatt J, Holt PG, Le Souëf PN.

J Allergy Clin Immunol. 2011 Jul;128(1):237-239.e8. doi: 10.1016/j.jaci.2011.02.032. Epub 2011 Mar 24. No abstract available.

PMID:
21439624
32.

The role of GSTP1 polymorphisms and tobacco smoke exposure in children with acute asthma.

Schultz EN, Devadason SG, Khoo SK, Zhang G, Bizzintino JA, Martin AC, Goldblatt J, Laing IA, Le Souëf PN, Hayden CM.

J Asthma. 2010 Nov;47(9):1049-56. doi: 10.1080/02770903.2010.508856.

PMID:
20858151
33.

Association between human rhinovirus C and severity of acute asthma in children.

Bizzintino J, Lee WM, Laing IA, Vang F, Pappas T, Zhang G, Martin AC, Khoo SK, Cox DW, Geelhoed GC, McMinn PC, Goldblatt J, Gern JE, Le Souëf PN.

Eur Respir J. 2011 May;37(5):1037-42. doi: 10.1183/09031936.00092410. Epub 2010 Aug 6.

34.

Interventions to improve rates of post-mortem examination after stillbirth.

Stock SJ, Goldsmith L, Evans MJ, Laing IA.

Eur J Obstet Gynecol Reprod Biol. 2010 Dec;153(2):148-50. doi: 10.1016/j.ejogrb.2010.07.022. Epub 2010 Aug 2.

PMID:
20674132
35.

Identifying peroxidases and their oxidants in the early pathology of cystic fibrosis.

Thomson E, Brennan S, Senthilmohan R, Gangell CL, Chapman AL, Sly PD, Kettle AJ; Australian Respiratory Early Surveillance Team for Cystic Fibrosis (AREST CF), Balding E, Berry LJ, Carlin JB, Carzino R, de Klerk N, Douglas T, Foo C, Garratt LW, Hall GL, Harrison J, Kicic A, Laing IA, Logie KM, Massie J, Mott LS, Murray C, Parsons F, Pillarisetti N, Poreddy SR, Ranganathan SC, Robertson CF, Robins-Browne R, Robinson PJ, Skoric B, Stick SM, Sutanto EN, Williamson E.

Free Radic Biol Med. 2010 Nov 15;49(9):1354-60. doi: 10.1016/j.freeradbiomed.2010.07.010. Epub 2010 Jul 18.

PMID:
20647044
36.

Normative values of substance P and neurokinin A in neonates.

Wong CM, Boyle EM, Stephen RI, Smith J, Stenson BJ, McIntosh N, Laing IA.

Ann Clin Biochem. 2010 Jul;47(Pt 4):331-5. doi: 10.1258/acb.2010.010024.

PMID:
20592332
37.

Analgesics, sedatives and neuromuscular blockers as part of end-of-life decisions in Dutch NICUs.

Laing IA, Piyasena C.

Arch Dis Child Fetal Neonatal Ed. 2010 Sep;95(5):F385. doi: 10.1136/adc.2009.178830. Epub 2010 Jun 14. No abstract available.

PMID:
20547582
38.

The importance of environment on respiratory genotype/phenotype relationships in the Inuit.

Candelaria PV, Backer V, Khoo SK, Bizzintino JA, Hayden CM, Baynam G, Laing IA, Zhang G, Porsbjerg C, Goldblatt J, Le Souëf PN; Greenlandic Study Population Group.

Allergy. 2010 Feb;65(2):229-37. doi: 10.1111/j.1398-9995.2009.02145.x. Epub 2009 Oct 1.

PMID:
19796192
39.

Interactions between innate antiviral and atopic immunoinflammatory pathways precipitate and sustain asthma exacerbations in children.

Subrata LS, Bizzintino J, Mamessier E, Bosco A, McKenna KL, Wikström ME, Goldblatt J, Sly PD, Hales BJ, Thomas WR, Laing IA, LeSouëf PN, Holt PG.

J Immunol. 2009 Aug 15;183(4):2793-800. doi: 10.4049/jimmunol.0900695. Epub 2009 Jul 20.

40.

Leukotriene pathway polymorphisms are associated with altered cysteinyl leukotriene production in children with acute asthma.

Bizzintino JA, Khoo SK, Zhang G, Martin AC, Rueter K, Geelhoed GC, Goldblatt J, Laing IA, Le Souëf PN, Hayden CM.

Prostaglandins Leukot Essent Fatty Acids. 2009 Jul;81(1):9-15. doi: 10.1016/j.plefa.2009.05.022. Epub 2009 Jun 12.

PMID:
19524426
41.

Anti-bacterial IgE in the antibody responses of house dust mite allergic children convalescent from asthma exacerbation.

Hales BJ, Martin AC, Pearce LJ, Rueter K, Zhang G, Khoo SK, Hayden CM, Bizzintino J, McMinn P, Geelhoed GC, Lee WM, Goldblatt J, Laing IA, LeSouëf PN, Thomas WR.

Clin Exp Allergy. 2009 Aug;39(8):1170-8. doi: 10.1111/j.1365-2222.2009.03252.x. Epub 2009 Apr 17.

PMID:
19400897
42.

Investigations into the role of ST2 in acute asthma in children.

Ali M, Zhang G, Thomas WR, McLean CJ, Bizzintino JA, Laing IA, Martin AC, Goldblatt J, Le Souëf PN, Hayden CM.

Tissue Antigens. 2009 Mar;73(3):206-12. doi: 10.1111/j.1399-0039.2008.01185.x.

PMID:
19254249
43.

Controlling an outbreak of MRSA in the neonatal unit: a steep learning curve.

Laing IA, Gibb AP, McCallum A.

Arch Dis Child Fetal Neonatal Ed. 2009 Jul;94(4):F307-10. doi: 10.1136/adc.2008.151290. Epub 2009 Jan 8. Review.

PMID:
19131429
44.

Cross-sectional and longitudinal association of the secretoglobin 1A1 gene A38G polymorphism with asthma phenotype in the Perth Infant Asthma Follow-up cohort.

Laing IA, de Klerk NH, Turner SW, Judge PK, Hayden CM, Landau LI, Goldblatt J, Le Souëf PN; Perth Infant Asthma Follow-up Cohort.

Clin Exp Allergy. 2009 Jan;39(1):62-71. doi: 10.1111/j.1365-2222.2008.03102.x.

PMID:
19128353
45.

Beta2-adrenoceptor polymorphisms predict response to beta2-agonists in children with acute asthma.

Martin AC, Zhang G, Rueter K, Khoo SK, Bizzintino J, Hayden CM, Geelhoed GC, Goldblatt J, Laing IA, Le Souëf PN.

J Asthma. 2008 Jun;45(5):383-8. doi: 10.1080/02770900801971792.

PMID:
18569231
46.

Reorientation of care in the NICU.

Laing IA, Freer Y.

Semin Fetal Neonatal Med. 2008 Oct;13(5):305-9. doi: 10.1016/j.siny.2008.03.009. Epub 2008 May 19.

PMID:
18486575
47.

Distinctive immunoglobulin E anti-house dust allergen-binding specificities in a tropical Australian Aboriginal community.

Hales BJ, Laing IA, Pearce LJ, Hazell LA, Mills KL, Chua KY, Thornton RB, Richmond P, Musk AW, James AL, Lesouëf PN, Thomas WR.

Clin Exp Allergy. 2007 Sep;37(9):1357-63.

PMID:
17845417
48.

TLR4 polymorphisms mediate impaired responses to respiratory syncytial virus and lipopolysaccharide.

Tulic MK, Hurrelbrink RJ, Prêle CM, Laing IA, Upham JW, Le Souef P, Sly PD, Holt PG.

J Immunol. 2007 Jul 1;179(1):132-40.

49.

Beta2-Adrenoceptor polymorphisms and asthma phenotypes: interactions with passive smoking.

Zhang G, Hayden CM, Khoo SK, Candelaria P, Laing IA, Turner S, Franklin P, Stick S, Landau L, Goldblatt J, Le Souëf PN.

Eur Respir J. 2007 Jul;30(1):48-55. Epub 2007 Apr 11.

50.

Association of haplotypes of beta2-adrenoceptor polymorphisms with lung function and airway responsiveness in a pediatric cohort.

Zhang G, Hayden CM, Khoo SK, Laing IA, Turner S, Landau L, Goldblatt J, Le Souëf PN.

Pediatr Pulmonol. 2006 Dec;41(12):1233-41.

PMID:
17068824

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