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Progressive increase of FcεRI expression across several PBMC subsets is associated with atopy and atopic asthma within school-aged children.

Leffler J, Read JF, Jones AC, Mok D, Hollams EM, Laing IA, Le Souef PN, Sly PD, Kusel MMH, de Klerk NH, Bosco A, Holt PG, Strickland DH.

Pediatr Allergy Immunol. 2019 Sep;30(6):646-653. doi: 10.1111/pai.13063. Epub 2019 May 22.


CC16 - A Biomarker of Pollutant Exposure and Future Lung Disease?

Laing IA.

Am J Respir Crit Care Med. 2019 Mar 27. doi: 10.1164/rccm.201903-0559ED. [Epub ahead of print] No abstract available.


Upper Airway Cell Transcriptomics Identify a Major New Immunological Phenotype with Strong Clinical Correlates in Young Children with Acute Wheezing.

Khoo SK, Read J, Franks K, Zhang G, Bizzintino J, Coleman L, McCrae C, Öberg L, Troy NM, Prastanti F, Everard J, Oo S, Borland ML, Maciewicz RA, Le Souëf PN, Laing IA, Bosco A.

J Immunol. 2019 Mar 15;202(6):1845-1858. doi: 10.4049/jimmunol.1800178. Epub 2019 Feb 11.


Glutathione S-Transferase Genotype Protects against In Utero Tobacco-linked Lung Function Deficits.

Owens L, Laing IA, Murdzoska J, Zhang G, Turner SW, Le Souëf PN.

Am J Respir Crit Care Med. 2019 Aug 15;200(4):462-470. doi: 10.1164/rccm.201807-1332OC.


Real-world practice level data analysis confirms link between variability within Blood Glucose Monitoring Strip (BGMS) and glycosylated haemoglobin (HbA1c) in Type 1 Diabetes.

Heald AH, Livingston M, Fryer A, Cortes G, Anderson SG, Gadsby R, Laing I, Lunt M, Young RJ, Stedman M.

Int J Clin Pract. 2018 Dec;72(12):e13252. doi: 10.1111/ijcp.13252. Epub 2018 Aug 31.


Prevalence of allergic sensitization, hay fever, eczema, and asthma in a longitudinal birth cohort.

Owens L, Laing IA, Zhang G, Turner S, Le Souëf PN.

J Asthma Allergy. 2018 Aug 13;11:173-180. doi: 10.2147/JAA.S170285. eCollection 2018.


The impact of respiratory viruses on lung health after preterm birth.

Townsi N, Laing IA, Hall GL, Simpson SJ.

Eur Clin Respir J. 2018 Aug 1;5(1):1487214. doi: 10.1080/20018525.2018.1487214. eCollection 2018. Review.


Basophil counts in PBMC populations during childhood acute wheeze/asthma are associated with future exacerbations.

Leffler J, Jones AC, Hollams EM, Prastanti F, Le Souëf PN, Holt PG, Bosco A, Laing IA, Strickland DH.

J Allergy Clin Immunol. 2018 Nov;142(5):1639-1641.e5. doi: 10.1016/j.jaci.2018.07.003. Epub 2018 Jul 21. No abstract available.


Cord Blood IL-12 Confers Protection to Clinical Malaria in Early Childhood Life.

Song Y, Aguilar R, Guo J, Manaca MN, Nhabomba A, Berthoud TK, Khoo SK, Wiertsema S, Barbosa A, Quintó L, Laing IA, Mayor A, Guinovart C, Alonso PL, LeSouëf PN, Dobaño C, Zhang GB.

Sci Rep. 2018 Jul 18;8(1):10860. doi: 10.1038/s41598-018-29179-y.


Rhinovirus is the most common virus and rhinovirus-C is the most common species in paediatric intensive care respiratory admissions.

Cox DW, Khoo SK, Zhang G, Lindsay K, Keil AD, Knight G, Gern JE, Laing IA, Bizzintino J, Le Souëf PN.

Eur Respir J. 2018 Aug 9;52(2). pii: 1800207. doi: 10.1183/13993003.00207-2018. Print 2018 Aug. No abstract available.


Airway Interleukin-33 and type 2 cytokines in adult patients with acute asthma.

Poulsen NN, Bjerregaard A, Khoo SK, Laing IA, Le Souëf P, Backer V, Rapley L, Cohen SE, Barrett L, Thompson P, Baltic S, Porsbjerg C.

Respir Med. 2018 Jul;140:50-56. doi: 10.1016/j.rmed.2018.05.016. Epub 2018 May 19.


Airway function in infancy is linked to airflow measurements and respiratory symptoms from childhood into adulthood.

Owens L, Laing IA, Zhang G, Turner S, Le Souëf PN.

Pediatr Pulmonol. 2018 Aug;53(8):1082-1088. doi: 10.1002/ppul.24062. Epub 2018 May 27.


The pattern of prescribing of glucose modulating agents for type 2 diabetes in general practices in England 2016/17.

Heald AH, Livingston M, Bien Z, Moreno GYC, Laing I, Stedman M.

Int J Clin Pract. 2018 Apr;72(4):e13080. doi: 10.1111/ijcp.13080. Epub 2018 Mar 14.


Prospective Assessment of Rhinovirus Symptoms and Species Recurrence in Children With and Without an Acute Wheezing Exacerbation.

Lethbridge R, Prastanti F, Robertson C, Oo S, Khoo SK, Le Souëf PN, Laing IA.

Viral Immunol. 2018 May;31(4):299-305. doi: 10.1089/vim.2017.0152. Epub 2018 Feb 15.


Environmental exposure and parental collection does not affect detection or semi-quantitative load assessment of bacteria in nasal swab specimens from children.

Townsi N, Simpson SJ, Sikazwe CT, Chidlow GR, Hall GL, Pillow JJ, Wilson AC, Smith DW, Laing IA.

Infect Dis (Lond). 2018 Jun;50(6):468-471. doi: 10.1080/23744235.2017.1411607. Epub 2017 Dec 13. No abstract available.


T-cell responses against rhinovirus species A and C in asthmatic and healthy children.

Gaido CM, Granland C, Laing IA, Souëf PNL, Thomas WR, Currie AJ, Hales BJ.

Immun Inflamm Dis. 2018 Mar;6(1):143-153. doi: 10.1002/iid3.206. Epub 2017 Nov 10.


Environment Changes Genetic Effects on Respiratory Conditions and Allergic Phenotypes.

Song Y, Schwager MJ, Backer V, Guo J, Porsbjerg C, Khoo SK, Laing IA, Moses EK, LeSouëf P, Zhang GB.

Sci Rep. 2017 Jul 24;7(1):6342. doi: 10.1038/s41598-017-06791-y.


Socioeconomic Deprivation as Measured by the Index of Multiple Deprivation and Its Association with Low Sex Hormone Binding Globulin in Women.

Heald A, Laing I, McLernon DJ, Donn R, Hartland AJ, Fryer AA, Livingston M.

Open Biochem J. 2017 Mar 13;11:1-7. doi: 10.2174/1874091X01711010001. eCollection 2017.


High fractional exhaled nitric oxide and sputum eosinophils are associated with an increased risk of future virus-induced exacerbations: A prospective cohort study.

Bjerregaard A, Laing IA, Backer V, Sverrild A, Khoo SK, Chidlow G, Sikazwe C, Smith DW, Le Souëf P, Porsbjerg C.

Clin Exp Allergy. 2017 Aug;47(8):1007-1013. doi: 10.1111/cea.12935. Epub 2017 May 9.


Characteristics associated with clinical severity and inflammatory phenotype of naturally occurring virus-induced exacerbations of asthma in adults.

Bjerregaard A, Laing IA, Poulsen N, Backer V, Sverrild A, Fally M, Khoo SK, Barrett L, Baltic S, Thompson PJ, Chidlow G, Sikazwe C, Smith DW, Bochkov YA, Le Souëf P, Porsbjerg C.

Respir Med. 2017 Feb;123:34-41. doi: 10.1016/j.rmed.2016.12.010. Epub 2016 Dec 18.


Severe winter asthma exacerbations can be prevented by omalizumab, but there is no carryover effect.

Sly PD, Varghese J, Noor F, Tang ML, Laing I, Oo S, Prastanti F, LeSouef PN, Holt PG.

J Allergy Clin Immunol. 2017 Feb;139(2):703-705.e4. doi: 10.1016/j.jaci.2016.07.035. Epub 2016 Sep 13. No abstract available.


Rhinovirus C is associated with wheezing and rhinovirus A is associated with pneumonia in hospitalized children in Morocco.

Annamalay AA, Jroundi I, Bizzintino J, Khoo SK, Zhang G, Lehmann D, Laing IA, Gern J, Goldblatt J, Mahraoui C, Benmessaoud R, Moraleda C, Bassat Q, Le Souëf P.

J Med Virol. 2017 Apr;89(4):582-588. doi: 10.1002/jmv.24684. Epub 2016 Sep 30.


Clinical characteristics of eosinophilic asthma exacerbations.

Bjerregaard A, Laing IA, Backer V, Fally M, Khoo SK, Chidlow G, Sikazwe C, Smith DW, Le Souëf P, Porsbjerg C.

Respirology. 2017 Feb;22(2):295-300. doi: 10.1111/resp.12905. Epub 2016 Sep 21.


Infant lung function predicts asthma persistence and remission in young adults.

Owens L, Laing IA, Zhang G, Le Souëf PN.

Respirology. 2017 Feb;22(2):289-294. doi: 10.1111/resp.12901. Epub 2016 Sep 16.


Rhinovirus species and clinical features in children hospitalised with pneumonia from Mozambique.

Annamalay AA, Lanaspa M, Khoo SK, Madrid L, Acácio S, Zhang G, Laing IA, Gern J, Goldblatt J, Bizzintino J, Lehmann D, Le Souëf PN, Bassat Q.

Trop Med Int Health. 2016 Sep;21(9):1171-80. doi: 10.1111/tmi.12743. Epub 2016 Jul 26.


Respiratory viruses in young South African children with acute lower respiratory infections and interactions with HIV.

Annamalay AA, Abbott S, Sikazwe C, Khoo SK, Bizzintino J, Zhang G, Laing I, Chidlow GR, Smith DW, Gern J, Goldblatt J, Lehmann D, Green RJ, Le Souëf PN.

J Clin Virol. 2016 Aug;81:58-63. doi: 10.1016/j.jcv.2016.06.002. Epub 2016 Jun 4.


Rhinovirus-induced asthma exacerbations and risk populations.

Coleman L, Laing IA, Bosco A.

Curr Opin Allergy Clin Immunol. 2016 Apr;16(2):179-85. doi: 10.1097/ACI.0000000000000245. Review.


Early sensitization is associated with reduced lung function from birth into adulthood.

Owens L, Laing I, Zhang G, Le Souef P.

J Allergy Clin Immunol. 2016 May;137(5):1605-1607.e2. doi: 10.1016/j.jaci.2015.10.030. Epub 2015 Dec 10. No abstract available.


Western environment/lifestyle is associated with increased genome methylation and decreased gene expression in Chinese immigrants living in Australia.

Zhang G, Wang K, Schultz E, Khoo SK, Zhang X, Annamalay A, Laing IA, Hales BJ, Goldblatt J, Le Souëf PN.

Environ Mol Mutagen. 2016 Jan;57(1):65-73. doi: 10.1002/em.21989. Epub 2015 Dec 16.


Recurrent rhinovirus detections in children following a rhinovirus-induced wheezing exacerbation: A retrospective study.

Halmø Hürdum S, Zhang G, Khoo SK, Bizzintino J, Franks KM, Lindsay K, Keil AD, Cox DW, Goldblatt J, Bochkov YA, Gern J, Ulrik CS, Souëf PN, Laing IA.

Int J Pediatr Child Health. 2015 Aug;3(1):10-18. doi: 10.12974/2311-8687.2015.03.01.2.


Lower anti-echovirus antibody responses in children presenting to hospital with asthma exacerbations.

Iwasaki J, Chai LY, Khoo SK, Bizzintino J, Laing IA, Le Souëf PN, Thomas WR, Hales BJ.

Clin Exp Allergy. 2015 Oct;45(10):1523-30. doi: 10.1111/cea.12501.


Epidemiology of Bonamia in the UK, 1982 to 2012.

Laing I, Dunn P, Peeler EJ, Feist SW, Longshaw M.

Dis Aquat Organ. 2014 Jul 24;110(1-2):101-11. doi: 10.3354/dao02647.


Comparison of rhinovirus antibody titers in children with asthma exacerbations and species-specific rhinovirus infection.

Iwasaki J, Smith WA, Khoo SK, Bizzintino J, Zhang G, Cox DW, Laing IA, Le Souëf PN, Thomas WR, Hales BJ.

J Allergy Clin Immunol. 2014 Jul;134(1):25-32. doi: 10.1016/j.jaci.2014.03.014. Epub 2014 Apr 24.


Where should extreme preterm babies be delivered? Crucial data from EPICure.

Laing IA.

Arch Dis Child Fetal Neonatal Ed. 2014 May;99(3):F177-8. doi: 10.1136/archdischild-2014-306020. No abstract available.


Insulin-like growth factor-II and insulin-like growth factor binding protein-2 prospectively predict longitudinal elevation of HDL-cholesterol in type 2 diabetes.

Narayanan RP, Fu B, Oliver RL, Siddals KW, Donn R, Hudson JE, White A, Laing I, Ollier WE, Heald AH, Gibson JM.

Ann Clin Biochem. 2014 Jul;51(Pt 4):468-75. doi: 10.1177/0004563213499145. Epub 2013 Sep 30.


Human rhinovirus species C infection in young children with acute wheeze is associated with increased acute respiratory hospital admissions.

Cox DW, Bizzintino J, Ferrari G, Khoo SK, Zhang G, Whelan S, Lee WM, Bochkov YA, Geelhoed GC, Goldblatt J, Gern JE, Laing IA, Le Souëf PN.

Am J Respir Crit Care Med. 2013 Dec 1;188(11):1358-64. doi: 10.1164/rccm.201303-0498OC.


Conflict resolution in end-of-life decisions in the neonatal unit.

Laing IA.

Semin Fetal Neonatal Med. 2013 Apr;18(2):83-7. doi: 10.1016/j.siny.2012.09.005. Epub 2012 Oct 18.


HOMA-S is associated with greater HbA1c reduction with a GLP-1 analogue in patients with type 2 diabetes.

Heald AH, Narayanan RP, Lowes D, Jarman E, Onyekwelu E, Qureshi Z, Laing I, Anderson SG.

Exp Clin Endocrinol Diabetes. 2012 Jul;120(7):420-3. doi: 10.1055/s-0032-1309046. Epub 2012 May 25.


Respiratory viral pathogens associated with lower respiratory tract disease among young children in the highlands of Papua New Guinea.

Chidlow GR, Laing IA, Harnett GB, Greenhill AR, Phuanukoonnon S, Siba PM, Pomat WS, Shellam GR, Smith DW, Lehmann D.

J Clin Virol. 2012 Jul;54(3):235-9. doi: 10.1016/j.jcv.2012.04.008. Epub 2012 May 16.


Prevalence of and risk factors for human rhinovirus infection in healthy aboriginal and non-aboriginal Western Australian children.

Annamalay AA, Khoo SK, Jacoby P, Bizzintino J, Zhang G, Chidlow G, Lee WM, Moore HC, Harnett GB, Smith DW, Gern JE, LeSouef PN, Laing IA, Lehmann D; Kalgoorlie Otitis Media Research Project Team.

Pediatr Infect Dis J. 2012 Jul;31(7):673-9. doi: 10.1097/INF.0b013e318256ffc6.


Symptomatic viral infection is associated with impaired response to treatment in children with acute asthma.

Rueter K, Bizzintino J, Martin AC, Zhang G, Hayden CM, Geelhoed GC, Goldblatt J, Laing IA, Le Souëf PN.

J Pediatr. 2012 Jan;160(1):82-7. doi: 10.1016/j.jpeds.2011.06.025. Epub 2011 Aug 19.


Measured dehydroepiandrosterone sulfate positively influences testosterone measurement in unextracted female serum: comparison of 2 immunoassays with testosterone measured by LC-MS.

Benton SC, Nuttall M, Nardo L, Laing I.

Clin Chem. 2011 Jul;57(7):1074-5. doi: 10.1373/clinchem.2010.158600. Epub 2011 Mar 28. No abstract available.


Regulatory role of IL10 genetic variations in determining allergen-induced T(H)2 cytokine responses in children.

Hayden CM, Zhang G, Judge PK, Khoo SK, Laing IA, Turner SW, Goldblatt J, Holt PG, Le Souëf PN.

J Allergy Clin Immunol. 2011 Jul;128(1):237-239.e8. doi: 10.1016/j.jaci.2011.02.032. Epub 2011 Mar 24. No abstract available.


The role of GSTP1 polymorphisms and tobacco smoke exposure in children with acute asthma.

Schultz EN, Devadason SG, Khoo SK, Zhang G, Bizzintino JA, Martin AC, Goldblatt J, Laing IA, Le Souëf PN, Hayden CM.

J Asthma. 2010 Nov;47(9):1049-56. doi: 10.1080/02770903.2010.508856.


Association between human rhinovirus C and severity of acute asthma in children.

Bizzintino J, Lee WM, Laing IA, Vang F, Pappas T, Zhang G, Martin AC, Khoo SK, Cox DW, Geelhoed GC, McMinn PC, Goldblatt J, Gern JE, Le Souëf PN.

Eur Respir J. 2011 May;37(5):1037-42. doi: 10.1183/09031936.00092410. Epub 2010 Aug 6.


Interventions to improve rates of post-mortem examination after stillbirth.

Stock SJ, Goldsmith L, Evans MJ, Laing IA.

Eur J Obstet Gynecol Reprod Biol. 2010 Dec;153(2):148-50. doi: 10.1016/j.ejogrb.2010.07.022. Epub 2010 Aug 2.


Identifying peroxidases and their oxidants in the early pathology of cystic fibrosis.

Thomson E, Brennan S, Senthilmohan R, Gangell CL, Chapman AL, Sly PD, Kettle AJ; Australian Respiratory Early Surveillance Team for Cystic Fibrosis (AREST CF), Balding E, Berry LJ, Carlin JB, Carzino R, de Klerk N, Douglas T, Foo C, Garratt LW, Hall GL, Harrison J, Kicic A, Laing IA, Logie KM, Massie J, Mott LS, Murray C, Parsons F, Pillarisetti N, Poreddy SR, Ranganathan SC, Robertson CF, Robins-Browne R, Robinson PJ, Skoric B, Stick SM, Sutanto EN, Williamson E.

Free Radic Biol Med. 2010 Nov 15;49(9):1354-60. doi: 10.1016/j.freeradbiomed.2010.07.010. Epub 2010 Jul 18.


Normative values of substance P and neurokinin A in neonates.

Wong CM, Boyle EM, Stephen RI, Smith J, Stenson BJ, McIntosh N, Laing IA.

Ann Clin Biochem. 2010 Jul;47(Pt 4):331-5. doi: 10.1258/acb.2010.010024.


Analgesics, sedatives and neuromuscular blockers as part of end-of-life decisions in Dutch NICUs.

Laing IA, Piyasena C.

Arch Dis Child Fetal Neonatal Ed. 2010 Sep;95(5):F385. doi: 10.1136/adc.2009.178830. Epub 2010 Jun 14. No abstract available.


The use of anti-Müllerian hormone and antral follicle count to predict the potential of oocytes and embryos.

Majumder K, Gelbaya TA, Laing I, Nardo LG.

Eur J Obstet Gynecol Reprod Biol. 2010 Jun;150(2):166-70. doi: 10.1016/j.ejogrb.2010.02.029. Epub 2010 Mar 11.


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