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OptiJ: Open-source optical projection tomography of large organ samples.

Vallejo Ramirez PP, Zammit J, Vanderpoorten O, Riche F, Blé FX, Zhou XH, Spiridon B, Valentine C, Spasov SE, Oluwasanya PW, Goodfellow G, Fantham MJ, Siddiqui O, Alimagham F, Robbins M, Stretton A, Simatos D, Hadeler O, Rees EJ, Ströhl F, Laine RF, Kaminski CF.

Sci Rep. 2019 Oct 30;9(1):15693. doi: 10.1038/s41598-019-52065-0.


Facile Approach to Recycling Highly Cross-Linked Thermoset Silicone Resins under Ambient Conditions.

Krug DJ, Asuncion MZ, Laine RM.

ACS Omega. 2019 Feb 20;4(2):3782-3789. doi: 10.1021/acsomega.8b02927. eCollection 2019 Feb 28.


Artificial intelligence for microscopy: what you should know.

von Chamier L, Laine RF, Henriques R.

Biochem Soc Trans. 2019 Aug 30;47(4):1029-1040. doi: 10.1042/BST20180391. Epub 2019 Jul 31. Review.


Fast Fluorescence Lifetime Imaging Reveals the Aggregation Processes of α-Synuclein and Polyglutamine in Aging Caenorhabditis elegans.

Laine RF, Sinnige T, Ma KY, Haack AJ, Poudel C, Gaida P, Curry N, Perni M, Nollen EAA, Dobson CM, Vendruscolo M, Kaminski Schierle GS, Kaminski CF.

ACS Chem Biol. 2019 Jul 19;14(7):1628-1636. doi: 10.1021/acschembio.9b00354. Epub 2019 Jun 27.


Intrinsically aggregation-prone proteins form amyloid-like aggregates and contribute to tissue aging in Caenorhabditis elegans.

Huang C, Wagner-Valladolid S, Stephens AD, Jung R, Poudel C, Sinnige T, Lechler MC, Schlörit N, Lu M, Laine RF, Michel CH, Vendruscolo M, Kaminski CF, Kaminski Schierle GS, David DC.

Elife. 2019 May 3;8. pii: e43059. doi: 10.7554/eLife.43059.


Automating multimodal microscopy with NanoJ-Fluidics.

Almada P, Pereira PM, Culley S, Caillol G, Boroni-Rueda F, Dix CL, Charras G, Baum B, Laine RF, Leterrier C, Henriques R.

Nat Commun. 2019 Mar 15;10(1):1223. doi: 10.1038/s41467-019-09231-9.


Structured illumination microscopy combined with machine learning enables the high throughput analysis and classification of virus structure.

Laine RF, Goodfellow G, Young LJ, Travers J, Carroll D, Dibben O, Bright H, Kaminski CF.

Elife. 2018 Dec 13;7. pii: e40183. doi: 10.7554/eLife.40183.


Physiology of crapemyrtle bark scale, Acanthococcus lagerstroemiae (Kuwana), associated with seasonally altered cold tolerance.

Wang Z, Chen Y, Diaz R, Laine RA.

J Insect Physiol. 2019 Jan;112:1-8. doi: 10.1016/j.jinsphys.2018.11.003. Epub 2018 Nov 13.


Thioglycosides Are Efficient Metabolic Decoys of Glycosylation that Reduce Selectin Dependent Leukocyte Adhesion.

Wang SS, Gao X, Solar VD, Yu X, Antonopoulos A, Friedman AE, Matich EK, Atilla-Gokcumen GE, Nasirikenari M, Lau JT, Dell A, Haslam SM, Laine RA, Matta KL, Neelamegham S.

Cell Chem Biol. 2018 Dec 20;25(12):1519-1532.e5. doi: 10.1016/j.chembiol.2018.09.012. Epub 2018 Oct 18.


Probing the Growth Kinetics for the Formation of Uniform 1D Block Copolymer Nanoparticles by Living Crystallization-Driven Self-Assembly.

Boott CE, Leitao EM, Hayward DW, Laine RF, Mahou P, Guerin G, Winnik MA, Richardson RM, Kaminski CF, Whittell GR, Manners I.

ACS Nano. 2018 Sep 25;12(9):8920-8933. doi: 10.1021/acsnano.8b01353. Epub 2018 Sep 12.


5,10-methenyltetrahydrofolate synthetase deficiency causes a neurometabolic disorder associated with microcephaly, epilepsy, and cerebral hypomyelination.

Rodan LH, Qi W, Ducker GS, Demirbas D, Laine R, Yang E, Walker MA, Eichler F, Rabinowitz JD, Anselm I, Berry GT; Undiagnosed Diseases Network (UDN).

Mol Genet Metab. 2018 Sep;125(1-2):118-126. doi: 10.1016/j.ymgme.2018.06.006. Epub 2018 Jun 15.


From genes to treatments: a systematic review of the pharmacogenetics in smoking cessation.

Salloum NC, Buchalter ELF, Chanani S, Espejo G, Ismail MS, Laine RO, Nageeb M, Srivastava AB, Trapp N, Trillo L, Vance E, Wenzinger M, Hartz SM, David SP, Chen LS.

Pharmacogenomics. 2018 Jul 1;19(10):861-871. doi: 10.2217/pgs-2018-0023. Epub 2018 Jun 19.


Exome-wide somatic mutation characterization of small bowel adenocarcinoma.

Hänninen UA, Katainen R, Tanskanen T, Plaketti RM, Laine R, Hamberg J, Ristimäki A, Pukkala E, Taipale M, Mecklin JP, Forsström LM, Pitkänen E, Palin K, Välimäki N, Mäkinen N, Aaltonen LA.

PLoS Genet. 2018 Mar 9;14(3):e1007200. doi: 10.1371/journal.pgen.1007200. eCollection 2018 Mar.


C-terminal calcium binding of α-synuclein modulates synaptic vesicle interaction.

Lautenschläger J, Stephens AD, Fusco G, Ströhl F, Curry N, Zacharopoulou M, Michel CH, Laine R, Nespovitaya N, Fantham M, Pinotsi D, Zago W, Fraser P, Tandon A, St George-Hyslop P, Rees E, Phillips JJ, De Simone A, Kaminski CF, Schierle GSK.

Nat Commun. 2018 Feb 19;9(1):712. doi: 10.1038/s41467-018-03111-4.


High Surface Area, Thermally Stable, Hydrophobic, Microporous, Rigid Gels Generated at Ambient from MeSi(OEt)3 /(EtO)3 SiCH2 CH2 Si(OEt)3 Mixtures by F- -Catalyzed Hydrolysis.

Furgal JC, Yamane H, Odykirk TR, Yi E, Chujo Y, Laine RM.

Chemistry. 2018 Jan 2;24(1):274-280. doi: 10.1002/chem.201704941. Epub 2017 Nov 29.


RNA Docking and Local Translation Regulate Site-Specific Axon Remodeling In Vivo.

Wong HH, Lin JQ, Ströhl F, Roque CG, Cioni JM, Cagnetta R, Turner-Bridger B, Laine RF, Harris WA, Kaminski CF, Holt CE.

Neuron. 2017 Aug 16;95(4):852-868.e8. doi: 10.1016/j.neuron.2017.07.016. Epub 2017 Aug 3.


GM2 Activator Deficiency Caused by a Homozygous Exon 2 Deletion in GM2A.

Hall PL, Laine R, Alexander JJ, Ankala A, Teot LA, Lidov HGW, Anselm I.

JIMD Rep. 2018;38:61-65. doi: 10.1007/8904_2017_31. Epub 2017 May 25.


Cyclohexylamine inexplicably induces antennae loss in Formosan subterranean termites (Coptotermes formosanus Shiraki): cyclohexylamine hydrogen phosphate salts are novel termiticides.

Grimball B, Veillon L, Calhoun T, Fronczek FR, Arceneaux E, Laine RA.

Pest Manag Sci. 2017 Oct;73(10):2039-2047. doi: 10.1002/ps.4610. Epub 2017 Aug 12.


Single Molecule Translation Imaging Visualizes the Dynamics of Local β-Actin Synthesis in Retinal Axons.

Ströhl F, Lin JQ, Laine RF, Wong HH, Urbančič V, Cagnetta R, Holt CE, Kaminski CF.

Sci Rep. 2017 Apr 6;7(1):709. doi: 10.1038/s41598-017-00695-7.


[PhSiO1.5]8,10,12 as nanoreactors for non-enzymatic introduction of ortho, meta or para-hydroxyl groups to aromatic molecules.

Bahrami M, Zhang X, Ehsani M, Jahani Y, Laine RM.

Dalton Trans. 2017 Jul 11;46(27):8797-8808. doi: 10.1039/c7dt00373k.


Durable and Hydrophobic Organic-Inorganic Hybrid Coatings via Fluoride Rearrangement of Phenyl T12 Silsesquioxane and Siloxanes.

Krug DJ, Laine RM.

ACS Appl Mater Interfaces. 2017 Mar 8;9(9):8378-8383. doi: 10.1021/acsami.6b16121. Epub 2017 Feb 21.


Facile synthesis, microstructure and photophysical properties of core-shell nanostructured (SiCN)/BN nanocomposites.

Zhang Q, Jia D, Yang Z, Cai D, Laine RM, Li Q, Zhou Y.

Sci Rep. 2017 Jan 13;7:39866. doi: 10.1038/srep39866.


Heparin acts as a structural component of β-endorphin amyloid fibrils rather than a simple aggregation promoter.

Nespovitaya N, Mahou P, Laine RF, Schierle GSK, Kaminski CF.

Chem Commun (Camb). 2017 Jan 19;53(7):1273-1276. doi: 10.1039/c6cc09770g.


De novo design of a biologically active amyloid.

Gallardo R, Ramakers M, De Smet F, Claes F, Khodaparast L, Khodaparast L, Couceiro JR, Langenberg T, Siemons M, Nyström S, Young LJ, Laine RF, Young L, Radaelli E, Benilova I, Kumar M, Staes A, Desager M, Beerens M, Vandervoort P, Luttun A, Gevaert K, Bormans G, Dewerchin M, Van Eldere J, Carmeliet P, Vande Velde G, Verfaillie C, Kaminski CF, De Strooper B, Hammarström P, Nilsson KP, Serpell L, Schymkowitz J, Rousseau F.

Science. 2016 Nov 11;354(6313). pii: aah4949.


Lower Doses of Fructose Extend Lifespan in Caenorhabditis elegans.

Zheng J, Gao C, Wang M, Tran P, Mai N, Finley JW, Heymsfield SB, Greenway FL, Li Z, Heber D, Burton JH, Johnson WD, Laine RA.

J Diet Suppl. 2017 May 4;14(3):264-277. Epub 2016 Sep 28.


From single-molecule spectroscopy to super-resolution imaging of the neuron: a review.

Laine RF, Kaminski Schierle GS, van de Linde S, Kaminski CF.

Methods Appl Fluoresc. 2016 Jun 27;4(2):022004. doi: 10.1088/2050-6120/4/2/022004. Review.


Dietary Plant Lectins Appear to Be Transported from the Gut to Gain Access to and Alter Dopaminergic Neurons of Caenorhabditis elegans, a Potential Etiology of Parkinson's Disease.

Zheng J, Wang M, Wei W, Keller JN, Adhikari B, King JF, King ML, Peng N, Laine RA.

Front Nutr. 2016 Mar 7;3:7. doi: 10.3389/fnut.2016.00007. eCollection 2016.


Nanoscopic insights into seeding mechanisms and toxicity of α-synuclein species in neurons.

Pinotsi D, Michel CH, Buell AK, Laine RF, Mahou P, Dobson CM, Kaminski CF, Kaminski Schierle GS.

Proc Natl Acad Sci U S A. 2016 Apr 5;113(14):3815-9. doi: 10.1073/pnas.1516546113. Epub 2016 Mar 18.


Escaping the Tyranny of Carbothermal Reduction: Fumed Silica from Sustainable, Green Sources without First Having to Make SiCl4.

Yi E, Hyde CE, Sun K, Laine RM.

Chemistry. 2016 Feb 12;22(7):2257-60. doi: 10.1002/chem.201505056. Epub 2016 Jan 13.


D5h [PhSiO1.5]10 synthesis via F(-) catalyzed rearrangement of [PhSiO1.5]n. An experimental/computational analysis of likely reaction pathways.

Furgal JC, Goodson T 3rd, Laine RM.

Dalton Trans. 2016 Jan 21;45(3):1025-39. doi: 10.1039/c5dt04182a.


Avoiding Carbothermal Reduction: Distillation of Alkoxysilanes from Biogenic, Green, and Sustainable Sources.

Laine RM, Furgal JC, Doan P, Pan D, Popova V, Zhang X.

Angew Chem Int Ed Engl. 2016 Jan 18;55(3):1065-9. doi: 10.1002/anie.201506838. Epub 2015 Dec 3.


In Situ Visualization of Block Copolymer Self-Assembly in Organic Media by Super-Resolution Fluorescence Microscopy.

Boott CE, Laine RF, Mahou P, Finnegan JR, Leitao EM, Webb SE, Kaminski CF, Manners I.

Chemistry. 2015 Dec 14;21(51):18539-42. doi: 10.1002/chem.201504100. Epub 2015 Nov 10.


HSV-1 Glycoproteins Are Delivered to Virus Assembly Sites Through Dynamin-Dependent Endocytosis.

Albecka A, Laine RF, Janssen AF, Kaminski CF, Crump CM.

Traffic. 2016 Jan;17(1):21-39. doi: 10.1111/tra.12340. Epub 2015 Nov 6.


myo-Inositol and Phytate Are Toxic to Formosan Subterranean Termites (Isoptera: Rhinotermitidae).

Veillon L, Bourgeois J, Leblanc A, Henderson G, Marx BD, Muniruzzaman S, Laine RA.

J Econ Entomol. 2014 Oct 1;107(5):1800-12. doi: 10.1603/EC13323.


Sugar-Based Polyamides: Self-Organization in Strong Polar Organic Solvents.

Rosu C, Russo PS, Daly WH, Cueto R, Pople JA, Laine RA, Negulescu II.

Biomacromolecules. 2015 Sep 14;16(9):3062-72. doi: 10.1021/acs.biomac.5b00977. Epub 2015 Aug 13.


A Kazal-Type Serine Protease Inhibitor from the Defense Gland Secretion of the Subterranean Termite Coptotermes formosanus Shiraki.

Negulescu H, Guo Y, Garner TP, Goodwin OY, Henderson G, Laine RA, Macnaughtan MA.

PLoS One. 2015 May 15;10(5):e0125376. doi: 10.1371/journal.pone.0125376. eCollection 2015.


A method to quantify FRET stoichiometry with phasor plot analysis and acceptor lifetime ingrowth.

Chen W, Avezov E, Schlachter SC, Gielen F, Laine RF, Harding HP, Hollfelder F, Ron D, Kaminski CF.

Biophys J. 2015 Mar 10;108(5):999-1002. doi: 10.1016/j.bpj.2015.01.012.


Structural analysis of herpes simplex virus by optical super-resolution imaging.

Laine RF, Albecka A, van de Linde S, Rees EJ, Crump CM, Kaminski CF.

Nat Commun. 2015 Jan 22;6:5980. doi: 10.1038/ncomms6980.


Retarded PDI diffusion and a reductive shift in poise of the calcium depleted endoplasmic reticulum.

Avezov E, Konno T, Zyryanova A, Chen W, Laine R, Crespillo-Casado A, Melo EP, Ushioda R, Nagata K, Kaminski CF, Harding HP, Ron D.

BMC Biol. 2015 Jan 10;13:2. doi: 10.1186/s12915-014-0112-2.


Why do the [PhSiO(1.5)](8,10,12) cages self-brominate primarily in the ortho position? Modeling reveals a strong cage influence on the mechanism.

Bahrami M, Hashemi H, Ma X, Kieffer J, Laine RM.

Phys Chem Chem Phys. 2014 Dec 21;16(47):25760-4. doi: 10.1039/c4cp03997a. Epub 2014 Oct 30.


Enhancing MS(n) mass spectrometry strategy for carbohydrate analysis: A b2 ion spectral library.

Xue J, Laine RA, Matta KL.

J Proteomics. 2015 Jan 1;112:224-49. doi: 10.1016/j.jprot.2014.07.013. Epub 2014 Aug 29.


Analyzing structure-photophysical property relationships for isolated T8, T10, and T12 stilbenevinylsilsesquioxanes.

Furgal JC, Jung JH, Goodson T 3rd, Laine RM.

J Am Chem Soc. 2013 Aug 21;135(33):12259-69. doi: 10.1021/ja4043092. Epub 2013 Aug 9.


Surface modification of titania powder P25 with phosphate and phosphonic acids--effect on thermal stability and photocatalytic activity.

Djafer L, Ayral A, Boury B, Laine RM.

J Colloid Interface Sci. 2013 Mar 1;393:335-9. doi: 10.1016/j.jcis.2012.11.002. Epub 2012 Nov 10.


Fluorescence lifetime readouts of Troponin-C-based calcium FRET sensors: a quantitative comparison of CFP and mTFP1 as donor fluorophores.

Laine R, Stuckey DW, Manning H, Warren SC, Kennedy G, Carling D, Dunsby C, Sardini A, French PM.

PLoS One. 2012;7(11):e49200. doi: 10.1371/journal.pone.0049200. Epub 2012 Nov 9.


Improving the detection of fungi in eosinophilic mucin: seeing what we could not see before.

Guo C, Ghadersohi S, Kephart GM, Laine RA, Sherris DA, Kita H, Ponikau JU.

Otolaryngol Head Neck Surg. 2012 Nov;147(5):943-9. doi: 10.1177/0194599812451010. Epub 2012 Jun 11.


Discovery of new quinoline ether inhibitors with high affinity and selectivity for PDGFR tyrosine kinases.

Plé PA, Jung F, Ashton S, Hennequin L, Laine R, Lambert-van der Brempt C, Morgentin R, Pasquet G, Taylor S.

Bioorg Med Chem Lett. 2012 May 1;22(9):3050-5. doi: 10.1016/j.bmcl.2012.03.074. Epub 2012 Mar 28.


Förster resonance energy transfer imaging in vivo with approximated radiative transfer equation.

Soloviev VY, McGinty J, Stuckey DW, Laine R, Wylezinska-Arridge M, Wells DJ, Sardini A, Hajnal JV, French PM, Arridge SR.

Appl Opt. 2011 Dec 20;50(36):6583-90. doi: 10.1364/AO.50.006583.


Ab initio calculation of the electronic absorption of functionalized octahedral silsesquioxanes via time-dependent density functional theory with range-separated hybrid functionals.

Phillips H, Zheng S, Hyla A, Laine R, Goodson T 3rd, Geva E, Dunietz BD.

J Phys Chem A. 2012 Feb 2;116(4):1137-45. doi: 10.1021/jp208316t. Epub 2012 Jan 23.


Discovery of AZD2932, a new Quinazoline Ether Inhibitor with high affinity for VEGFR-2 and PDGFR tyrosine kinases.

Plé PA, Jung F, Ashton S, Hennequin L, Laine R, Morgentin R, Pasquet G, Taylor S.

Bioorg Med Chem Lett. 2012 Jan 1;22(1):262-6. doi: 10.1016/j.bmcl.2011.11.019. Epub 2011 Nov 12.


In vivo fluorescence lifetime tomography of a FRET probe expressed in mouse.

McGinty J, Stuckey DW, Soloviev VY, Laine R, Wylezinska-Arridge M, Wells DJ, Arridge SR, French PM, Hajnal JV, Sardini A.

Biomed Opt Express. 2011 Jul 1;2(7):1907-17. doi: 10.1364/BOE.2.001907. Epub 2011 Jun 10.

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