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Topoisomerase IIβ-binding protein 1 activates expression of E2F1 and p73 in HPV-positive cells for genome amplification upon epithelial differentiation.

Hong S, Xu J, Li Y, Andrade J, Hoover P, Kaminski PJ, Laimins LA.

Oncogene. 2019 Apr;38(17):3274-3287. doi: 10.1038/s41388-018-0633-1. Epub 2019 Jan 10.


Expression of HPV-induced DNA Damage Repair Factors Correlates With CIN Progression.

Spriggs CC, Blanco LZ, Maniar KP, Laimins LA.

Int J Gynecol Pathol. 2019 Jan;38(1):1-10. doi: 10.1097/PGP.0000000000000477.


Suppression of MicroRNA 424 Levels by Human Papillomaviruses Is Necessary for Differentiation-Dependent Genome Amplification.

Hong S, Cheng S, Songock W, Bodily J, Laimins LA.

J Virol. 2017 Nov 30;91(24). pii: e01712-17. doi: 10.1128/JVI.01712-17. Print 2017 Dec 15.


Human Papillomavirus and the DNA Damage Response: Exploiting Host Repair Pathways for Viral Replication.

Spriggs CC, Laimins LA.

Viruses. 2017 Aug 18;9(8). pii: E232. doi: 10.3390/v9080232. Review.


Manipulation of the innate immune response by human papillomaviruses.

Hong S, Laimins LA.

Virus Res. 2017 Mar 2;231:34-40. doi: 10.1016/j.virusres.2016.11.004. Epub 2016 Nov 5. Review.


Human papillomaviruses: research priorities for the next decade.

Langsfeld E, Laimins LA.

Trends Cancer. 2016 May;2(5):234-240.


Post-Transcriptional Regulation of KLF4 by High-Risk Human Papillomaviruses Is Necessary for the Differentiation-Dependent Viral Life Cycle.

Gunasekharan VK, Li Y, Andrade J, Laimins LA.

PLoS Pathog. 2016 Jul 7;12(7):e1005747. doi: 10.1371/journal.ppat.1005747. eCollection 2016 Jul.


The Deacetylase Sirtuin 1 Regulates Human Papillomavirus Replication by Modulating Histone Acetylation and Recruitment of DNA Damage Factors NBS1 and Rad51 to Viral Genomes.

Langsfeld ES, Bodily JM, Laimins LA.

PLoS Pathog. 2015 Sep 25;11(9):e1005181. doi: 10.1371/journal.ppat.1005181. eCollection 2015 Sep.


Human papillomaviruses: shared and distinct pathways for pathogenesis.

Galloway DA, Laimins LA.

Curr Opin Virol. 2015 Oct;14:87-92. doi: 10.1016/j.coviro.2015.09.001. Epub 2015 Sep 20. Review.


Human papillomaviruses activate and recruit SMC1 cohesin proteins for the differentiation-dependent life cycle through association with CTCF insulators.

Mehta K, Gunasekharan V, Satsuka A, Laimins LA.

PLoS Pathog. 2015 Apr 13;11(4):e1004763. doi: 10.1371/journal.ppat.1004763. eCollection 2015 Apr.


The acetyltransferase Tip60 is a critical regulator of the differentiation-dependent amplification of human papillomaviruses.

Hong S, Dutta A, Laimins LA.

J Virol. 2015 Apr;89(8):4668-75. doi: 10.1128/JVI.03455-14. Epub 2015 Feb 11.


CD66+ cells in cervical precancers are partially differentiated progenitors with neoplastic traits.

Pattabiraman C, Hong S, Gunasekharan VK, Pranatharthi A, Bajaj J, Srivastava S, Krishnamurthy H, Ammothumkandy A, Giri VG, Laimins LA, Krishna S.

Cancer Res. 2014 Nov 15;74(22):6682-92. doi: 10.1158/0008-5472.CAN-14-1032. Epub 2014 Sep 29.


Regulation of the life cycle of HPVs by differentiation and the DNA damage response.

Hong S, Laimins LA.

Future Microbiol. 2013 Dec;8(12):1547-57. doi: 10.2217/fmb.13.127. Review.


The role of human papillomaviruses in oncogenesis.

Mighty KK, Laimins LA.

Recent Results Cancer Res. 2014;193:135-48. doi: 10.1007/978-3-642-38965-8_8. Review.


Human papillomaviruses modulate microRNA 145 expression to directly control genome amplification.

Gunasekharan V, Laimins LA.

J Virol. 2013 May;87(10):6037-43. doi: 10.1128/JVI.00153-13. Epub 2013 Mar 6.


Viral transformation of epithelial cells.

Regan JA, Laimins LA.

Methods Mol Biol. 2013;945:449-65. doi: 10.1007/978-1-62703-125-7_26.


An interaction between human papillomavirus 16 E2 and TopBP1 is required for optimum viral DNA replication and episomal genome establishment.

Donaldson MM, Mackintosh LJ, Bodily JM, Dornan ES, Laimins LA, Morgan IM.

J Virol. 2012 Dec;86(23):12806-15. doi: 10.1128/JVI.01002-12. Epub 2012 Sep 12.


Human papillomaviruses recruit cellular DNA repair and homologous recombination factors to viral replication centers.

Gillespie KA, Mehta KP, Laimins LA, Moody CA.

J Virol. 2012 Sep;86(17):9520-6. doi: 10.1128/JVI.00247-12. Epub 2012 Jun 27.


The fanconi anemia pathway limits human papillomavirus replication.

Hoskins EE, Morreale RJ, Werner SP, Higginbotham JM, Laimins LA, Lambert PF, Brown DR, Gillison ML, Nuovo GJ, Witte DP, Kim MO, Davies SM, Mehta PA, Butsch Kovacic M, Wikenheiser-Brokamp KA, Wells SI.

J Virol. 2012 Aug;86(15):8131-8. doi: 10.1128/JVI.00408-12. Epub 2012 May 23.


Suppression of STAT-1 expression by human papillomaviruses is necessary for differentiation-dependent genome amplification and plasmid maintenance.

Hong S, Mehta KP, Laimins LA.

J Virol. 2011 Sep;85(18):9486-94. doi: 10.1128/JVI.05007-11. Epub 2011 Jul 6.


Nuclear accumulation of the papillomavirus E1 helicase blocks S-phase progression and triggers an ATM-dependent DNA damage response.

Fradet-Turcotte A, Bergeron-Labrecque F, Moody CA, Lehoux M, Laimins LA, Archambault J.

J Virol. 2011 Sep;85(17):8996-9012. doi: 10.1128/JVI.00542-11. Epub 2011 Jul 6.


p63 is necessary for the activation of human papillomavirus late viral functions upon epithelial differentiation.

Mighty KK, Laimins LA.

J Virol. 2011 Sep;85(17):8863-9. doi: 10.1128/JVI.00750-11. Epub 2011 Jun 29.


The E7 open reading frame acts in cis and in trans to mediate differentiation-dependent activities in the human papillomavirus type 16 life cycle.

Bodily JM, Mehta KP, Cruz L, Meyers C, Laimins LA.

J Virol. 2011 Sep;85(17):8852-62. doi: 10.1128/JVI.00664-11. Epub 2011 Jun 22.


Human papillomavirus E7 enhances hypoxia-inducible factor 1-mediated transcription by inhibiting binding of histone deacetylases.

Bodily JM, Mehta KP, Laimins LA.

Cancer Res. 2011 Feb 1;71(3):1187-95. doi: 10.1158/0008-5472.CAN-10-2626. Epub 2010 Dec 8.


Persistence of human papillomavirus infection: keys to malignant progression.

Bodily J, Laimins LA.

Trends Microbiol. 2011 Jan;19(1):33-9. doi: 10.1016/j.tim.2010.10.002. Epub 2010 Nov 1. Review.


Nuclear export of human papillomavirus type 31 E1 is regulated by Cdk2 phosphorylation and required for viral genome maintenance.

Fradet-Turcotte A, Moody C, Laimins LA, Archambault J.

J Virol. 2010 Nov;84(22):11747-60. doi: 10.1128/JVI.01445-10. Epub 2010 Sep 15.


Human papillomavirus oncoproteins: pathways to transformation.

Moody CA, Laimins LA.

Nat Rev Cancer. 2010 Aug;10(8):550-60. doi: 10.1038/nrc2886. Epub 2010 Jul 1. Review.


Human papillomaviruses modulate expression of microRNA 203 upon epithelial differentiation to control levels of p63 proteins.

Melar-New M, Laimins LA.

J Virol. 2010 May;84(10):5212-21. doi: 10.1128/JVI.00078-10. Epub 2010 Mar 10.


Human papillomaviruses activate the ATM DNA damage pathway for viral genome amplification upon differentiation.

Moody CA, Laimins LA.

PLoS Pathog. 2009 Oct;5(10):e1000605. doi: 10.1371/journal.ppat.1000605. Epub 2009 Oct 2.


Hypoxia-specific stabilization of HIF-1alpha by human papillomaviruses.

Nakamura M, Bodily JM, Beglin M, Kyo S, Inoue M, Laimins LA.

Virology. 2009 May 10;387(2):442-8. doi: 10.1016/j.virol.2009.02.036. Epub 2009 Mar 24.


Bap31 is a novel target of the human papillomavirus E5 protein.

Regan JA, Laimins LA.

J Virol. 2008 Oct;82(20):10042-51. doi: 10.1128/JVI.01240-08. Epub 2008 Aug 6.


Human papillomaviruses activate caspases upon epithelial differentiation to induce viral genome amplification.

Moody CA, Fradet-Turcotte A, Archambault J, Laimins LA.

Proc Natl Acad Sci U S A. 2007 Dec 4;104(49):19541-6. Epub 2007 Nov 28.


Human papillomavirus E1 helicase interacts with the WD repeat protein p80 to promote maintenance of the viral genome in keratinocytes.

Côté-Martin A, Moody C, Fradet-Turcotte A, D'Abramo CM, Lehoux M, Joubert S, Poirier GG, Coulombe B, Laimins LA, Archambault J.

J Virol. 2008 Feb;82(3):1271-83. Epub 2007 Nov 21.


The full-length E1E4 protein of human papillomavirus type 18 modulates differentiation-dependent viral DNA amplification and late gene expression.

Wilson R, Ryan GB, Knight GL, Laimins LA, Roberts S.

Virology. 2007 Jun 5;362(2):453-60. Epub 2007 Feb 15.


Human papillomaviruses target the double-stranded RNA protein kinase pathway.

Hebner CM, Wilson R, Rader J, Bidder M, Laimins LA.

J Gen Virol. 2006 Nov;87(Pt 11):3183-93.


Amino acid substitutions that specifically impair the transcriptional activity of papillomavirus E2 affect binding to the long isoform of Brd4.

Sénéchal H, Poirier GG, Coulombe B, Laimins LA, Archambault J.

Virology. 2007 Feb 5;358(1):10-7. Epub 2006 Oct 3.


Analysis of the roles of E6 binding to E6TP1 and nuclear localization in the human papillomavirus type 31 life cycle.

Lee C, Wooldridge TR, Laimins LA.

Virology. 2007 Feb 5;358(1):201-10. Epub 2006 Sep 26.


Histone deacetylase 3 localizes to the plasma membrane and is a substrate of Src.

Longworth MS, Laimins LA.

Oncogene. 2006 Jul 27;25(32):4495-500. Epub 2006 Mar 13.


Human papillomaviruses: basic mechanisms of pathogenesis and oncogenicity.

Hebner CM, Laimins LA.

Rev Med Virol. 2006 Mar-Apr;16(2):83-97. Review.


HPV31 E7 facilitates replication by activating E2F2 transcription through its interaction with HDACs.

Longworth MS, Wilson R, Laimins LA.

EMBO J. 2005 May 18;24(10):1821-30. Epub 2005 Apr 28.

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