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Items: 1 to 50 of 119

1.

Equity and diversity in academic medicine: a perspective from the JCI editors.

Resar LM, Jaffee EM, Armanios M, Jackson S, Azad NS, Horton MR, Kaplan MJ, Laiho M, Maus MV, Sumner CJ, Wheelan SJ, Wills-Karp M.

J Clin Invest. 2019 Oct 1;129(10):3974-3977. doi: 10.1172/JCI130902. No abstract available.

2.

Effective targeting of RNA polymerase I in treatment-resistant prostate cancer.

Low JY, Sirajuddin P, Moubarek M, Agarwal S, Rege A, Guner G, Liu H, Yang Z, De Marzo AM, Bieberich C, Laiho M.

Prostate. 2019 Sep 16. doi: 10.1002/pros.23909. [Epub ahead of print]

PMID:
31524299
3.

Protective Effect Against Cancer of Antibodies to the Large Subunits of Both RNA Polymerases I and III in Scleroderma.

Shah AA, Laiho M, Rosen A, Casciola-Rosen L.

Arthritis Rheumatol. 2019 Sep;71(9):1571-1579. doi: 10.1002/art.40893. Epub 2019 Aug 1.

PMID:
30888702
4.

Small-Molecule Targeting of RNA Polymerase I Activates a Conserved Transcription Elongation Checkpoint.

Wei T, Najmi SM, Liu H, Peltonen K, Kucerova A, Schneider DA, Laiho M.

Cell Rep. 2018 Apr 10;23(2):404-414. doi: 10.1016/j.celrep.2018.03.066.

5.

Pharmacological inhibition of spinal cord injury-stimulated ribosomal biogenesis does not affect locomotor outcome.

Kilanczyk E, Andres KR, Hallgren J, Ohri SS, Laiho M, Whittemore SR, Hetman M.

Neurosci Lett. 2017 Mar 6;642:153-157. doi: 10.1016/j.neulet.2017.02.011. Epub 2017 Feb 7.

6.

Novel Assay to Detect RNA Polymerase I Activity In Vivo.

Guner G, Sirajuddin P, Zheng Q, Bai B, Brodie A, Liu H, Af Hällström T, Kulac I, Laiho M, De Marzo AM.

Mol Cancer Res. 2017 May;15(5):577-584. doi: 10.1158/1541-7786.MCR-16-0246. Epub 2017 Jan 23.

7.

Severe neurodegenerative disease in brothers with homozygous mutation in POLR1A.

Kara B, Köroğlu Ç, Peltonen K, Steinberg RC, Maraş Genç H, Hölttä-Vuori M, Güven A, Kanerva K, Kotil T, Solakoğlu S, Zhou Y, Olkkonen VM, Ikonen E, Laiho M, Tolun A.

Eur J Hum Genet. 2017 Feb;25(3):315-323. doi: 10.1038/ejhg.2016.183. Epub 2017 Jan 4.

8.

Deep Sequencing Analysis of Nucleolar Small RNAs: Bioinformatics.

Bai B, Laiho M.

Methods Mol Biol. 2016;1455:243-8. doi: 10.1007/978-1-4939-3792-9_19.

PMID:
27576724
9.

Deep Sequencing Analysis of Nucleolar Small RNAs: RNA Isolation and Library Preparation.

Bai B, Laiho M.

Methods Mol Biol. 2016;1455:231-41. doi: 10.1007/978-1-4939-3792-9_18.

PMID:
27576723
10.

Oncogenic Herpesvirus Utilizes Stress-Induced Cell Cycle Checkpoints for Efficient Lytic Replication.

Balistreri G, Viiliäinen J, Turunen M, Diaz R, Lyly L, Pekkonen P, Rantala J, Ojala K, Sarek G, Teesalu M, Denisova O, Peltonen K, Julkunen I, Varjosalo M, Kainov D, Kallioniemi O, Laiho M, Taipale J, Hautaniemi S, Ojala PM.

PLoS Pathog. 2016 Feb 18;12(2):e1005424. doi: 10.1371/journal.ppat.1005424. eCollection 2016 Feb.

11.

N-terminal Pro-brain Natriuretic Peptide, High-sensitivity Troponin and Pulmonary Artery Clot Score as Predictors of Right Ventricular Dysfunction in Echocardiography.

Granér M, Harjola VP, Selander T, Laiho MK, Piilonen A, Raade M, Mustonen P.

Heart Lung Circ. 2016 Jun;25(6):592-9. doi: 10.1016/j.hlc.2015.12.004. Epub 2015 Dec 19.

PMID:
26809463
12.

Sequential recovery of macromolecular components of the nucleolus.

Bai B, Laiho M.

Methods Mol Biol. 2015;1228:43-51. doi: 10.1007/978-1-4939-1680-1_5.

PMID:
25311121
13.

Small molecule BMH-compounds that inhibit RNA polymerase I and cause nucleolar stress.

Peltonen K, Colis L, Liu H, Jäämaa S, Zhang Z, Af Hällström T, Moore HM, Sirajuddin P, Laiho M.

Mol Cancer Ther. 2014 Nov;13(11):2537-46. doi: 10.1158/1535-7163.MCT-14-0256. Epub 2014 Oct 2.

14.

RNA-Seq of the nucleolus reveals abundant SNORD44-derived small RNAs.

Bai B, Yegnasubramanian S, Wheelan SJ, Laiho M.

PLoS One. 2014 Sep 9;9(9):e107519. doi: 10.1371/journal.pone.0107519. eCollection 2014.

15.

DNA damage signaling regulates age-dependent proliferative capacity of quiescent inner ear supporting cells.

Laos M, Anttonen T, Kirjavainen A, af Hällström T, Laiho M, Pirvola U.

Aging (Albany NY). 2014 Jun;6(6):496-510.

16.

DNA intercalator BMH-21 inhibits RNA polymerase I independent of DNA damage response.

Colis L, Peltonen K, Sirajuddin P, Liu H, Sanders S, Ernst G, Barrow JC, Laiho M.

Oncotarget. 2014 Jun 30;5(12):4361-9.

17.

Small RNA expression and deep sequencing analyses of the nucleolus reveal the presence of nucleolus-associated microRNAs.

Bai B, Liu H, Laiho M.

FEBS Open Bio. 2014 May 2;4:441-9. doi: 10.1016/j.fob.2014.04.010. eCollection 2014.

18.

Design, synthesis, and structure-activity relationships of pyridoquinazolinecarboxamides as RNA polymerase I inhibitors.

Colis L, Ernst G, Sanders S, Liu H, Sirajuddin P, Peltonen K, DePasquale M, Barrow JC, Laiho M.

J Med Chem. 2014 Jun 12;57(11):4950-61. doi: 10.1021/jm5004842. Epub 2014 May 30.

19.

A targeting modality for destruction of RNA polymerase I that possesses anticancer activity.

Peltonen K, Colis L, Liu H, Trivedi R, Moubarek MS, Moore HM, Bai B, Rudek MA, Bieberich CJ, Laiho M.

Cancer Cell. 2014 Jan 13;25(1):77-90. doi: 10.1016/j.ccr.2013.12.009.

20.

A tissue graft model of DNA damage response in the normal and malignant human prostate.

Af Hällström TM, Zhao H, Tian J, Rantanen V, Reese SW, Nolley R, Laiho M, Peehl DM.

J Urol. 2014 Mar;191(3):842-9. doi: 10.1016/j.juro.2013.09.007. Epub 2013 Sep 11.

21.

CRM1 and its ribosome export adaptor NMD3 localize to the nucleolus and affect rRNA synthesis.

Bai B, Moore HM, Laiho M.

Nucleus. 2013 Jul-Aug;4(4):315-25. doi: 10.4161/nucl.25342. Epub 2013 Jun 12.

22.

Proteasome activity influences UV-mediated subnuclear localization changes of NPM.

Moore HM, Bai B, Matilainen O, Colis L, Peltonen K, Laiho M.

PLoS One. 2013;8(3):e59096. doi: 10.1371/journal.pone.0059096. Epub 2013 Mar 12.

23.

Efficient sequential recovery of nucleolar macromolecular components.

Bai B, Laiho M.

Proteomics. 2012 Oct;12(19-20):3044-8. doi: 10.1002/pmic.201200071. Epub 2012 Sep 10.

24.

PSA forms complexes with α1-antichymotrypsin in prostate.

Zhu L, Jäämaa S, Af Hällström TM, Laiho M, Sankila A, Nordling S, Stenman UH, Koistinen H.

Prostate. 2013 Jan;73(2):219-26. doi: 10.1002/pros.22560. Epub 2012 Jul 16.

PMID:
22806587
25.

Maintenance of genomic integrity after DNA double strand breaks in the human prostate and seminal vesicle epithelium: the best and the worst.

Jäämaa S, Laiho M.

Mol Oncol. 2012 Oct;6(5):473-83. doi: 10.1016/j.molonc.2012.06.001. Epub 2012 Jun 18. Review.

26.

Helical computerized tomography and NT-proBNP for screening of right ventricular overload on admission and at long term follow-up of acute pulmonary embolism.

Laiho MK, Harjola VP, Graner M, Piilonen A, Raade M, Mustonen P.

Scand J Trauma Resusc Emerg Med. 2012 May 4;20:33. doi: 10.1186/1757-7241-20-33.

27.

SnoN oncoprotein enhances estrogen receptor-α transcriptional activity.

Band AM, Laiho M.

Cell Signal. 2012 Apr;24(4):922-30. doi: 10.1016/j.cellsig.2011.12.015. Epub 2011 Dec 29.

28.

LIM-domain proteins in transforming growth factor β-induced epithelial-to-mesenchymal transition and myofibroblast differentiation.

Järvinen PM, Laiho M.

Cell Signal. 2012 Apr;24(4):819-25. doi: 10.1016/j.cellsig.2011.12.004. Epub 2011 Dec 11. Review.

PMID:
22182513
29.

Contrasting DNA damage checkpoint responses in epithelium of the human seminal vesicle and prostate.

Jäämaa S, Sankila A, Rantanen V, Peltonen K, Järvinen PM, Af Hällström TM, Ruutu M, Taari K, Andersson LC, Laiho M.

Prostate. 2012 Jul 1;72(10):1060-70. doi: 10.1002/pros.21509. Epub 2011 Nov 9.

PMID:
22072329
30.

Differential epithelium DNA damage response to ATM and DNA-PK pathway inhibition in human prostate tissue culture.

Zhang Z, Yang Z, Jäämaa S, Liu H, Pellakuru LG, Iwata T, af Hällström TM, De Marzo AM, Laiho M.

Cell Cycle. 2011 Oct 15;10(20):3545-53. doi: 10.4161/cc.10.20.17841. Epub 2011 Oct 15.

31.

Cysteine-rich protein 1 is regulated by transforming growth factor-β1 and expressed in lung fibrosis.

Järvinen PM, Myllärniemi M, Liu H, Moore HM, Leppäranta O, Salmenkivi K, Koli K, Latonen L, Band AM, Laiho M.

J Cell Physiol. 2012 Jun;227(6):2605-12. doi: 10.1002/jcp.23000.

PMID:
21882188
32.

Quantitative proteomics and dynamic imaging of the nucleolus reveal distinct responses to UV and ionizing radiation.

Moore HM, Bai B, Boisvert FM, Latonen L, Rantanen V, Simpson JC, Pepperkok R, Lamond AI, Laiho M.

Mol Cell Proteomics. 2011 Oct;10(10):M111.009241. doi: 10.1074/mcp.M111.009241. Epub 2011 Jul 21.

33.

Prostate-targeted radiosensitization via aptamer-shRNA chimeras in human tumor xenografts.

Ni X, Zhang Y, Ribas J, Chowdhury WH, Castanares M, Zhang Z, Laiho M, DeWeese TL, Lupold SE.

J Clin Invest. 2011 Jun;121(6):2383-90. doi: 10.1172/JCI45109. Epub 2011 May 9.

34.

Crosstalk of TGF-β and estrogen receptor signaling in breast cancer.

Band AM, Laiho M.

J Mammary Gland Biol Neoplasia. 2011 Jun;16(2):109-15. doi: 10.1007/s10911-011-9203-7. Epub 2011 Mar 11. Review.

PMID:
21390570
35.

Reduction in membrane component of diffusing capacity is associated with the extent of acute pulmonary embolism.

Piirilä P, Laiho M, Mustonen P, Graner M, Piilonen A, Raade M, Sarna S, Harjola VP, Sovijärvi A.

Clin Physiol Funct Imaging. 2011 May;31(3):196-202. doi: 10.1111/j.1475-097X.2010.01000.x. Epub 2010 Dec 12.

36.

DNA damage recognition via activated ATM and p53 pathway in nonproliferating human prostate tissue.

Jäämaa S, Af Hällström TM, Sankila A, Rantanen V, Koistinen H, Stenman UH, Zhang Z, Yang Z, De Marzo AM, Taari K, Ruutu M, Andersson LC, Laiho M.

Cancer Res. 2010 Nov 1;70(21):8630-41. doi: 10.1158/0008-5472.CAN-10-0937. Epub 2010 Oct 26.

37.

Proteasome inhibitors induce nucleolar aggregation of proteasome target proteins and polyadenylated RNA by altering ubiquitin availability.

Latonen L, Moore HM, Bai B, Jäämaa S, Laiho M.

Oncogene. 2011 Feb 17;30(7):790-805. doi: 10.1038/onc.2010.469. Epub 2010 Oct 18.

PMID:
20956947
38.

Identification of novel p53 pathway activating small-molecule compounds reveals unexpected similarities with known therapeutic agents.

Peltonen K, Colis L, Liu H, Jäämaa S, Moore HM, Enbäck J, Laakkonen P, Vaahtokari A, Jones RJ, af Hällström TM, Laiho M.

PLoS One. 2010 Sep 27;5(9):e12996. doi: 10.1371/journal.pone.0012996.

39.

Ultraviolet B radiation regulates cysteine-rich protein 1 in human keratinocytes.

Latonen L, Järvinen PM, Suomela S, Moore HM, Saarialho-Kere U, Laiho M.

Photodermatol Photoimmunol Photomed. 2010 Apr;26(2):70-7. doi: 10.1111/j.1600-0781.2010.00488.x.

PMID:
20415737
40.

Nucleophosmin phosphorylation by v-cyclin-CDK6 controls KSHV latency.

Sarek G, Järviluoma A, Moore HM, Tojkander S, Vartia S, Biberfeld P, Laiho M, Ojala PM.

PLoS Pathog. 2010 Mar 19;6(3):e1000818. doi: 10.1371/journal.ppat.1000818.

41.

Differential sensitivity of the inner ear sensory cell populations to forced cell cycle re-entry and p53 induction.

Sulg M, Kirjavainen A, Pajusola K, Bueler H, Ylikoski J, Laiho M, Pirvola U.

J Neurochem. 2010 Mar;112(6):1513-26. doi: 10.1111/j.1471-4159.2009.06563.x. Epub 2009 Dec 26.

42.

Non-CDK-bound p27 (p27(NCDK)) is a marker for cell stress and is regulated through the Akt/PKB and AMPK-kinase pathways.

Björklund MA, Vaahtomeri K, Peltonen K, Viollet B, Mäkelä TP, Band AM, Laiho M.

Exp Cell Res. 2010 Mar 10;316(5):762-74. doi: 10.1016/j.yexcr.2009.12.014. Epub 2009 Dec 28.

PMID:
20036235
43.

The phosphatidylinositol 3-kinase/Akt pathway regulates transforming growth factor-{beta} signaling by destabilizing ski and inducing Smad7.

Band AM, Björklund M, Laiho M.

J Biol Chem. 2009 Dec 18;284(51):35441-9. doi: 10.1074/jbc.M109.029488.

44.

Genetic changes and DNA damage responses in the prostate.

Hällström TM, Laiho M.

Prostate. 2008 Jun 1;68(8):902-18. doi: 10.1002/pros.20746. Review.

PMID:
18324675
45.

Cytoskeleton-interacting LIM-domain protein CRP1 suppresses cell proliferation and protects from stress-induced cell death.

Latonen L, Järvinen PM, Laiho M.

Exp Cell Res. 2008 Feb 15;314(4):738-47. doi: 10.1016/j.yexcr.2007.11.024. Epub 2007 Dec 8.

PMID:
18177859
46.

Viral oncogene-induced DNA damage response is activated in Kaposi sarcoma tumorigenesis.

Koopal S, Furuhjelm JH, Järviluoma A, Jäämaa S, Pyakurel P, Pussinen C, Wirzenius M, Biberfeld P, Alitalo K, Laiho M, Ojala PM.

PLoS Pathog. 2007 Sep 7;3(9):1348-60.

47.

Perimän vauuriot, vanheneminen ja syöpä--erottamaton kolmikko. .

Laiho M, Saksela E.

Duodecim. 2007;123(13):1535-6. Finnish. No abstract available.

PMID:
17727144
48.

Human prostate epithelium lacks Wee1A-mediated DNA damage-induced checkpoint enforcement.

Kiviharju-af Hällström TM, Jäämaa S, Mönkkönen M, Peltonen K, Andersson LC, Medema RH, Peehl DM, Laiho M.

Proc Natl Acad Sci U S A. 2007 Apr 24;104(17):7211-6. Epub 2007 Apr 12.

49.

Reactivation of the p53 pathway as a treatment modality for KSHV-induced lymphomas.

Sarek G, Kurki S, Enbäck J, Iotzova G, Haas J, Laakkonen P, Laiho M, Ojala PM.

J Clin Invest. 2007 Apr;117(4):1019-28. Epub 2007 Mar 15.

50.

p19(Ink4d) and p21(Cip1) collaborate to maintain the postmitotic state of auditory hair cells, their codeletion leading to DNA damage and p53-mediated apoptosis.

Laine H, Doetzlhofer A, Mantela J, Ylikoski J, Laiho M, Roussel MF, Segil N, Pirvola U.

J Neurosci. 2007 Feb 7;27(6):1434-44.

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