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Items: 1 to 50 of 52

1.

Episomal minicircles persist in periods of transcriptional inactivity and can be transmitted through somatic cell nuclear transfer into bovine embryos.

Wagner S, McCracken J, Bruszies S, Broadhurst R, Wells DN, Oback B, Bode J, Laible G.

Mol Biol Rep. 2019 Apr;46(2):1737-1746. doi: 10.1007/s11033-019-04624-x. Epub 2019 Jan 29.

PMID:
30694456
2.

Cattle with a precise, zygote-mediated deletion safely eliminate the major milk allergen beta-lactoglobulin.

Wei J, Wagner S, Maclean P, Brophy B, Cole S, Smolenski G, Carlson DF, Fahrenkrug SC, Wells DN, Laible G.

Sci Rep. 2018 May 16;8(1):7661. doi: 10.1038/s41598-018-25654-8.

3.

ФC31 Integrase-Mediated Isolation and Characterization of Novel Safe Harbors for Transgene Expression in the Pig Genome.

Bi Y, Hua Z, Ren H, Zhang L, Xiao H, Liu X, Hua W, Mei S, Molenaar A, Laible G, Zheng X.

Int J Mol Sci. 2018 Jan 4;19(1). pii: E149. doi: 10.3390/ijms19010149.

4.

Taillessness in a Cloned Cow is Not Genetically Transmitted.

Wagner S, Cullum A, Wells DN, Laible G.

Cell Reprogram. 2017 Dec;19(6):331-336. doi: 10.1089/cell.2017.0018. Epub 2017 Oct 11.

5.

KDM4B-mediated reduction of H3K9me3 and H3K36me3 levels improves somatic cell reprogramming into pluripotency.

Wei J, Antony J, Meng F, MacLean P, Rhind R, Laible G, Oback B.

Sci Rep. 2017 Aug 8;7(1):7514. doi: 10.1038/s41598-017-06569-2.

6.

Development and Pre-Clinical Evaluation of Recombinant Human Myelin Basic Protein Nano Therapeutic Vaccine in Experimental Autoimmune Encephalomyelitis Mice Animal Model.

Al-Ghobashy MA, ElMeshad AN, Abdelsalam RM, Nooh MM, Al-Shorbagy M, Laible G.

Sci Rep. 2017 Apr 20;7:46468. doi: 10.1038/srep46468.

7.

Increased gene dosage for β- and κ-casein in transgenic cattle improves milk composition through complex effects.

Laible G, Smolenski G, Wheeler T, Brophy B.

Sci Rep. 2016 Nov 23;6:37607. doi: 10.1038/srep37607.

8.

Isozygous and selectable marker-free MSTN knockout cloned pigs generated by the combined use of CRISPR/Cas9 and Cre/LoxP.

Bi Y, Hua Z, Liu X, Hua W, Ren H, Xiao H, Zhang L, Li L, Wang Z, Laible G, Wang Y, Dong F, Zheng X.

Sci Rep. 2016 Aug 17;6:31729. doi: 10.1038/srep31729.

9.

Strategies to enable the adoption of animal biotechnology to sustainably improve global food safety and security.

Tizard M, Hallerman E, Fahrenkrug S, Newell-McGloughlin M, Gibson J, de Loos F, Wagner S, Laible G, Han JY, D'Occhio M, Kelly L, Lowenthal J, Gobius K, Silva P, Cooper C, Doran T.

Transgenic Res. 2016 Oct;25(5):575-95. doi: 10.1007/s11248-016-9965-1. Epub 2016 May 31. Review.

PMID:
27246007
10.

Adeno-associated-virus-mediated transduction of the mammary gland enables sustained production of recombinant proteins in milk.

Wagner S, Thresher R, Bland R, Laible G.

Sci Rep. 2015 Oct 14;5:15115. doi: 10.1038/srep15115.

11.

Efficient introgression of allelic variants by embryo-mediated editing of the bovine genome.

Wei J, Wagner S, Lu D, Maclean P, Carlson DF, Fahrenkrug SC, Laible G.

Sci Rep. 2015 Jul 9;5:11735. doi: 10.1038/srep11735.

12.

Improving livestock for agriculture - technological progress from random transgenesis to precision genome editing heralds a new era.

Laible G, Wei J, Wagner S.

Biotechnol J. 2015 Jan;10(1):109-20. doi: 10.1002/biot.201400193. Epub 2014 Dec 16. Review.

PMID:
25515661
13.

Coupled solid phase extraction and microparticle-based stability and purity-indicating immunosensor for the determination of recombinant human myelin basic protein in transgenic milk.

Al-Ghobashy MA, Williams MA, Laible G, Harding DR.

Talanta. 2013 May 15;109:7-12. doi: 10.1016/j.talanta.2013.03.043. Epub 2013 Mar 22.

PMID:
23618134
14.

Transient JMJD2B-mediated reduction of H3K9me3 levels improves reprogramming of embryonic stem cells into cloned embryos.

Antony J, Oback F, Chamley LW, Oback B, Laible G.

Mol Cell Biol. 2013 Mar;33(5):974-83. doi: 10.1128/MCB.01014-12. Epub 2012 Dec 21.

15.

Exposure to DNA is insufficient for in vitro transgenesis of live bovine sperm and embryos.

Eghbalsaied S, Ghaedi K, Laible G, Hosseini SM, Forouzanfar M, Hajian M, Oback F, Nasr-Esfahani MH, Oback B.

Reproduction. 2013 Jan 8;145(1):97-108. doi: 10.1530/REP-12-0340. Print 2013 Jan.

PMID:
23137934
16.

UC Davis transgenic animal research conference VIII.

Laible G, Fahrenkrug SC.

Transgenic Res. 2012 Dec;21(6):1375-6. doi: 10.1007/s11248-012-9670-7. No abstract available.

PMID:
23117588
17.

Targeted microRNA expression in dairy cattle directs production of β-lactoglobulin-free, high-casein milk.

Jabed A, Wagner S, McCracken J, Wells DN, Laible G.

Proc Natl Acad Sci U S A. 2012 Oct 16;109(42):16811-6. doi: 10.1073/pnas.1210057109. Epub 2012 Oct 1. Erratum in: Proc Natl Acad Sci U S A. 2016 Dec 5;:.

18.

Primary transgenic bovine cells and their rejuvenated cloned equivalents show transgene-specific epigenetic differences.

Alonso-González L, Couldrey C, Meinhardt MW, Cole SA, Wells DN, Laible G.

PLoS One. 2012;7(4):e35619. doi: 10.1371/journal.pone.0035619. Epub 2012 Apr 20.

19.

DNA oligonucleotides and plasmids perform equally as donors for targeted gene conversion.

Wagner S, McCracken J, Cole S, Laible G.

Biochem Genet. 2010 Dec;48(11-12):897-908. doi: 10.1007/s10528-010-9370-z. Epub 2010 Jul 31.

PMID:
20677020
20.

Probing the interaction between recombinant human myelin basic protein and caseins using surface plasmon resonance and diffusing wave spectroscopy.

Al-Ghobashy MA, Cucheval A, Williams MA, Laible G, Harding DR.

J Mol Recognit. 2010 Jan-Feb;23(1):84-92. doi: 10.1002/jmr.991.

PMID:
19856323
21.

Gene targeting from laboratory to livestock: current status and emerging concepts.

Laible G, Alonso-González L.

Biotechnol J. 2009 Sep;4(9):1278-92. doi: 10.1002/biot.200900006. Review.

PMID:
19606430
22.

On-line casein micelle disruption for downstream purification of recombinant human myelin basic protein produced in the milk of transgenic cows.

Al-Ghobashy MA, Williams MA, Brophy B, Laible G, Harding DR.

J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Jun 1;877(16-17):1667-77. doi: 10.1016/j.jchromb.2009.04.012. Epub 2009 Apr 9.

PMID:
19419911
23.

Site-specific modification of the bovine genome using Cre recombinase-mediated gene targeting.

Graham C, Cole S, Laible G.

Biotechnol J. 2009 Jan;4(1):108-18. doi: 10.1002/biot.200800200.

PMID:
19156732
24.

Transgenic cattle applications: the transition from promise to proof.

Laible G, Wells DN.

Biotechnol Genet Eng Rev. 2006;22:125-50. Review. No abstract available.

PMID:
18476329
25.

Enhancing livestock through genetic engineering--recent advances and future prospects.

Laible G.

Comp Immunol Microbiol Infect Dis. 2009 Mar;32(2):123-37. doi: 10.1016/j.cimid.2007.11.012. Epub 2008 Feb 19. Review.

PMID:
18243310
26.

Fetal microchimerism in normal and embryo transfer bovine pregnancies.

Turin L, Tribbioli G, Invernizzi P, Grati FR, Crema S, Laible G, Riva F.

Vet Res Commun. 2007 Aug;31 Suppl 1:205-7. No abstract available.

PMID:
17682876
27.

Bovine fetal microchimerism in normal and embryo transfer pregnancies and its implications for biotechnology applications in cattle.

Turin L, Invernizzi P, Woodcock M, Grati FR, Riva F, Tribbioli G, Laible G.

Biotechnol J. 2007 Apr;2(4):486-91.

PMID:
17285678
28.

Compositional analysis of dairy products derived from clones and cloned transgenic cattle.

Laible G, Brophy B, Knighton D, Wells DN.

Theriogenology. 2007 Jan 1;67(1):166-77. Epub 2006 Oct 18.

PMID:
17052749
29.

Reporter system for the detection of in vivo gene conversion: changing colors from blue to green using GFP variants.

Sommer JR, Alderson J, Laible G, Petters RM.

Mol Biotechnol. 2006 Jun;33(2):115-22.

PMID:
16757798
30.

Oligonucleotide-mediated gene modification and its promise for animal agriculture.

Laible G, Wagner S, Alderson J.

Gene. 2006 Jan 17;366(1):17-26. Epub 2005 Dec 5. Review.

PMID:
16330159
31.

Protamine sulfate protects exogenous DNA against nuclease degradation but is unable to improve the efficiency of bovine sperm mediated transgenesis.

Alderson J, Wilson B, Laible G, Pfeffer P, L'Huillier P.

Anim Reprod Sci. 2006 Jan;91(1-2):23-30.

PMID:
15899559
32.

Cloning livestock: a return to embryonic cells.

Wells DN, Oback B, Laible G.

Trends Biotechnol. 2003 Oct;21(10):428-32. No abstract available.

PMID:
14512228
33.

Cloned cattle derived from a novel zona-free embryo reconstruction system.

Oback B, Wiersema AT, Gaynor P, Laible G, Tucker FC, Oliver JE, Miller AL, Troskie HE, Wilson KL, Forsyth JT, Berg MC, Cockrem K, McMillan V, Tervit HR, Wells DN.

Cloning Stem Cells. 2003;5(1):3-12.

PMID:
12713696
34.

Cloned transgenic cattle produce milk with higher levels of beta-casein and kappa-casein.

Brophy B, Smolenski G, Wheeler T, Wells D, L'Huillier P, Laible G.

Nat Biotechnol. 2003 Feb;21(2):157-62. Epub 2003 Jan 27.

PMID:
12548290
35.

Coordination between donor cell type and cell cycle stage improves nuclear cloning efficiency in cattle.

Wells DN, Laible G, Tucker FC, Miller AL, Oliver JE, Xiang T, Forsyth JT, Berg MC, Cockrem K, L'Huillier PJ, Tervit HR, Oback B.

Theriogenology. 2003 Jan 1;59(1):45-59.

PMID:
12499017
36.

Over-expression of the SUV39H1 histone methyltransferase induces altered proliferation and differentiation in transgenic mice.

Czvitkovich S, Sauer S, Peters AH, Deiner E, Wolf A, Laible G, Opravil S, Beug H, Jenuwein T.

Mech Dev. 2001 Sep;107(1-2):141-53.

37.

Isolation and characterization of Suv39h2, a second histone H3 methyltransferase gene that displays testis-specific expression.

O'Carroll D, Scherthan H, Peters AH, Opravil S, Haynes AR, Laible G, Rea S, Schmid M, Lebersorger A, Jerratsch M, Sattler L, Mattei MG, Denny P, Brown SD, Schweizer D, Jenuwein T.

Mol Cell Biol. 2000 Dec;20(24):9423-33.

38.

Structure-function analysis of SUV39H1 reveals a dominant role in heterochromatin organization, chromosome segregation, and mitotic progression.

Melcher M, Schmid M, Aagaard L, Selenko P, Laible G, Jenuwein T.

Mol Cell Biol. 2000 May;20(10):3728-41.

39.

Functional mammalian homologues of the Drosophila PEV-modifier Su(var)3-9 encode centromere-associated proteins which complex with the heterochromatin component M31.

Aagaard L, Laible G, Selenko P, Schmid M, Dorn R, Schotta G, Kuhfittig S, Wolf A, Lebersorger A, Singh PB, Reuter G, Jenuwein T.

EMBO J. 1999 Apr 1;18(7):1923-38.

40.

The murine polycomb-group genes Ezh1 and Ezh2 map close to Hox gene clusters on mouse chromosomes 11 and 6.

Laible G, Haynes AR, Lebersorger A, O'Carroll D, Mattei MG, Denny P, Brown SD, Jenuwein T.

Mamm Genome. 1999 Mar;10(3):311-4. No abstract available.

PMID:
10051331
41.

SET domain proteins modulate chromatin domains in eu- and heterochromatin.

Jenuwein T, Laible G, Dorn R, Reuter G.

Cell Mol Life Sci. 1998 Jan;54(1):80-93. Review.

PMID:
9487389
42.
43.

Mammalian homologues of the Polycomb-group gene Enhancer of zeste mediate gene silencing in Drosophila heterochromatin and at S. cerevisiae telomeres.

Laible G, Wolf A, Dorn R, Reuter G, Nislow C, Lebersorger A, Popkin D, Pillus L, Jenuwein T.

EMBO J. 1997 Jun 2;16(11):3219-32.

44.

Extension of chromatin accessibility by nuclear matrix attachment regions.

Jenuwein T, Forrester WC, Fernández-Herrero LA, Laible G, Dull M, Grosschedl R.

Nature. 1997 Jan 16;385(6613):269-72.

PMID:
9000077
45.

Crystallization of a genetically engineered water-soluble primary penicillin target enzyme. The high molecular mass PBP2x of Streptococcus pneumoniae.

Charlier P, Buisson G, Dideberg O, Wierenga J, Keck W, Laible G, Hakenbeck R.

J Mol Biol. 1993 Aug 5;232(3):1007-9.

46.

Penicillin-binding protein 2x of Streptococcus pneumoniae. Expression in Escherichia coli and purification of a soluble enzymatically active derivative.

Laible G, Keck W, Lurz R, Mottl H, Frère JM, Jamin M, Hakenbeck R.

Eur J Biochem. 1992 Aug 1;207(3):943-9.

48.

Intercontinental spread of a multiresistant clone of serotype 23F Streptococcus pneumoniae.

Muñoz R, Coffey TJ, Daniels M, Dowson CG, Laible G, Casal J, Hakenbeck R, Jacobs M, Musser JM, Spratt BG, et al.

J Infect Dis. 1991 Aug;164(2):302-6.

PMID:
1856478
50.

Penicillin-binding proteins in Streptococcus pneumoniae: alterations during development of intrinsic penicillin resistance.

Hakenbeck R, Briese T, Laible G, Martin C, Schuster C.

J Chemother. 1991 Apr;3(2):86-90.

PMID:
1875238

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