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Molecular mechanism of the tree shrew's insensitivity to spiciness.

Han Y, Li B, Yin TT, Xu C, Ombati R, Luo L, Xia Y, Xu L, Zheng J, Zhang Y, Yang F, Wang GD, Yang S, Lai R.

PLoS Biol. 2018 Jul 12;16(7):e2004921. doi: 10.1371/journal.pbio.2004921. eCollection 2018 Jul.


MSC exosome works through a protein-based mechanism of action.

Toh WS, Lai RC, Zhang B, Lim SK.

Biochem Soc Trans. 2018 Jul 9. pii: BST20180079. doi: 10.1042/BST20180079. [Epub ahead of print] Review.


MicroRNA-599 suppresses glioma progression by targeting RAB27B.

Jiang Y, Wang X, Zhang J, Lai R.

Oncol Lett. 2018 Jul;16(1):1243-1252. doi: 10.3892/ol.2018.8727. Epub 2018 May 16.


Functional Plasticity of Gamma Delta T Cells and Breast Tumor Targets in Hypoxia.

Siegers GM, Dutta I, Lai R, Postovit LM.

Front Immunol. 2018 Jun 15;9:1367. doi: 10.3389/fimmu.2018.01367. eCollection 2018.


On-Surface Reactions in the Growth of High-Quality CdSe Nanocrystals in Nonpolar Solutions.

Lai R, Pu C, Peng X.

J Am Chem Soc. 2018 Jul 12. doi: 10.1021/jacs.8b04743. [Epub ahead of print]


Lipid Emulsion Pretreatment Decreased the Maximum Total and Free Plasma Concentration of Levobupivacaine for Femoral and Sciatic Nerve Block in Below-Knee Fracture Surgery.

Chen Y, Zhang J, Chen Z, Wang Q, Li B, Lai R, Xu X, Cao Z, Yu L.

Reg Anesth Pain Med. 2018 Jun 19. doi: 10.1097/AAP.0000000000000834. [Epub ahead of print]


Constitutive Activation of STAT3 in Myeloma Cells Cultured in a Three-Dimensional, Reconstructed Bone Marrow Model.

Huang YH, Molavi O, Alshareef A, Haque M, Wang Q, Chu MP, Venner CP, Sandhu I, Peters AC, Lavasanifar A, Lai R.

Cancers (Basel). 2018 Jun 16;10(6). pii: E206. doi: 10.3390/cancers10060206.


The Design of Elderly Fracture Rehabilitation Software Based on "Information-Motivation-Behavioral Skills Model".

Wu Q, Jiang Z, Su T, Dai Y, Huang D, Lai R, Zhang J, Song L.

Stud Health Technol Inform. 2018;250:234.


ERK is a negative feedback regulator for IFN-γ/STAT1 signaling by promoting STAT1 ubiquitination.

Zhang Y, Chen Y, Liu Z, Lai R.

BMC Cancer. 2018 May 31;18(1):613. doi: 10.1186/s12885-018-4539-7.


Pruritus: Progress toward Pathogenesis and Treatment.

Song J, Xian D, Yang L, Xiong X, Lai R, Zhong J.

Biomed Res Int. 2018 Apr 11;2018:9625936. doi: 10.1155/2018/9625936. eCollection 2018. Review.


Effective cardiac radiotherapy relieved life-threatening heart failure caused by advanced small cell lung cancer with cardiac metastasis: a case report.

Chen CF, Lin MH, Chu KA, Liu WS, Hsiao SH, Lai RS.

J Thorac Dis. 2018 Apr;10(4):E250-E254. doi: 10.21037/jtd.2018.03.104.


Development and Characterization of an Anti-Acne Gel Containing Siamese Crocodile (Crocodylus siamensis) Leukocyte Extract.

Phupiewkham W, Lu Q, Payoungkiattikun W, Temsiripong T, Jangpromma N, Lai R, Klaynongsruang S.

J Microbiol Biotechnol. 2018 May 28;28(5):707-717. doi: 10.4014/jmb.1802.02027.


[Relevant factors of tinnitus in the elderly: an analysis of 150 volunteers].

Han L, Ma R, Wu XQ, Lin YJ, Jin YY, Yu LS, Lai RZ, Zeng L, Ma X.

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2018 Apr;32(8):587-591. doi: 10.13201/j.issn.1001-1781.2018.08.007. Chinese.


[The investigation rate and influence factors of tinnitus with chronic suppurative otitis media].

Lin YJ, Wu XQ, Ma X, Lai RZ.

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2018 Apr;32(8):579-583. doi: 10.13201/j.issn.1001-1781.2018.08.005. Chinese.


Functionalized Caprolactone-Polyethylene Glycol Based Thermo-Responsive Hydrogels of Silibinin for the Treatment of Malignant Melanoma.

Makhmalzadeh BS, Molavi O, Vakili MR, Zhang HF, Solimani A, Abyaneh HS, Loebenberg R, Lai R, Lavasanifar A.

J Pharm Pharm Sci. 2018;21(1):143-159. doi: 10.18433/jpps29726.


Application of Calcium-Binding Motif of E-Cadherin for Electrochemical Detection of Pb(II).

Lotfi Zadeh Zhad HR, Lai RY.

Anal Chem. 2018 Jun 5;90(11):6519-6525. doi: 10.1021/acs.analchem.7b05458. Epub 2018 May 16.


[Imaging analysis of jaw defects reparation with antigen-extracted porcine cancellous bone].

Chen X, Lu L, Feng Z, Yin Z, Lai R.

Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2017 Dec 1;34(6):883-888. doi: 10.7507/1001-5515.201511047. Chinese.


Effect of prednisolone on inflammatory markers in pericardial tuberculosis: A pilot study.

Shenje J, Lai RP, Ross IL, Mayosi BM, Wilkinson RJ, Ntsekhe M, Wilkinson KA.

Int J Cardiol Heart Vasc. 2017 Nov 3;18:104-108. doi: 10.1016/j.ijcha.2017.10.002. eCollection 2018 Mar.


Proanthocyanidins against Oxidative Stress: From Molecular Mechanisms to Clinical Applications.

Yang L, Xian D, Xiong X, Lai R, Song J, Zhong J.

Biomed Res Int. 2018 Mar 12;2018:8584136. doi: 10.1155/2018/8584136. eCollection 2018. Review.


Sex-specific glioma genome-wide association study identifies new risk locus at 3p21.31 in females, and finds sex-differences in risk at 8q24.21.

Ostrom QT, Kinnersley B, Wrensch MR, Eckel-Passow JE, Armstrong G, Rice T, Chen Y, Wiencke JK, McCoy LS, Hansen HM, Amos CI, Bernstein JL, Claus EB, Il'yasova D, Johansen C, Lachance DH, Lai RK, Merrell RT, Olson SH, Sadetzki S, Schildkraut JM, Shete S, Rubin JB, Lathia JD, Berens ME, Andersson U, Rajaraman P, Chanock SJ, Linet MS, Wang Z, Yeager M; GliomaScan consortium, Houlston RS, Jenkins RB, Melin B, Bondy ML, Barnholtz-Sloan JS.

Sci Rep. 2018 May 9;8(1):7352. doi: 10.1038/s41598-018-24580-z.


Organic solute carrier 22 (SLC22) family: Potential for interactions with food, herbal/dietary supplements, endogenous compounds, and drugs.

Lai RE, Jay CE, Sweet DH.

J Food Drug Anal. 2018 Apr;26(2S):S45-S60. doi: 10.1016/j.jfda.2018.03.002. Epub 2018 Mar 24. Review.


Glioma-related seizures in relation to histopathological subtypes: a report from the glioma international case-control study.

Berntsson SG, Merrell RT, Amirian ES, Armstrong GN, Lachance D, Smits A, Zhou R, Jacobs DI, Wrensch MR, Olson SH, Il'yasova D, Claus EB, Barnholtz-Sloan JS, Schildkraut J, Sadetzki S, Johansen C, Houlston RS, Jenkins RB, Bernstein JL, Lai R, Shete S, Amos CI, Bondy ML, Melin BS.

J Neurol. 2018 Jun;265(6):1432-1442. doi: 10.1007/s00415-018-8857-0. Epub 2018 Apr 23.


A membrane disrupting toxin from wasp venom underlies the molecular mechanism of tissue damage.

Ombati R, Wang Y, Du C, Lu X, Li B, Nyachieo A, Li Y, Yang S, Lai R.

Toxicon. 2018 Jun 15;148:56-63. doi: 10.1016/j.toxicon.2018.04.011. Epub 2018 Apr 12.


Proanthocyanidins: novel treatment for psoriasis that reduces oxidative stress and modulates Th17 and Treg cells.

Lai R, Xian D, Xiong X, Yang L, Song J, Zhong J.

Redox Rep. 2018 Dec;23(1):130-135. doi: 10.1080/13510002.2018.1462027.


Mesenchymal stromal cell exosome-enhanced regulatory T-cell production through an antigen-presenting cell-mediated pathway.

Zhang B, Yeo RWY, Lai RC, Sim EWK, Chin KC, Lim SK.

Cytotherapy. 2018 May;20(5):687-696. doi: 10.1016/j.jcyt.2018.02.372. Epub 2018 Apr 2.


Oxidative stress enhances tumorigenicity and stem-like features via the activation of the Wnt/β-catenin/MYC/Sox2 axis in ALK-positive anaplastic large-cell lymphoma.

Wu C, Gupta N, Huang YH, Zhang HF, Alshareef A, Chow A, Lai R.

BMC Cancer. 2018 Apr 2;18(1):361. doi: 10.1186/s12885-018-4300-2.


A prominent air pollutant, Indeno[1,2,3-cd]pyrene, enhances allergic lung inflammation via aryl hydrocarbon receptor.

Wong TH, Lee CL, Su HH, Lee CL, Wu CC, Wang CC, Sheu CC, Lai RS, Leung SY, Lin CC, Wei YF, Wang CJ, Lin YC, Chen HL, Huang MS, Yen JH, Huang SK, Suen JL.

Sci Rep. 2018 Mar 26;8(1):5198. doi: 10.1038/s41598-018-23542-9.


Novel Sodium Channel Inhibitor From Leeches.

Wang G, Long C, Liu W, Xu C, Zhang M, Li Q, Lu Q, Meng P, Li D, Rong M, Sun Z, Luo X, Lai R.

Front Pharmacol. 2018 Mar 6;9:186. doi: 10.3389/fphar.2018.00186. eCollection 2018.


Impact of atopy on risk of glioma: a Mendelian randomisation study.

Disney-Hogg L, Cornish AJ, Sud A, Law PJ, Kinnersley B, Jacobs DI, Ostrom QT, Labreche K, Eckel-Passow JE, Armstrong GN, Claus EB, Il'yasova D, Schildkraut J, Barnholtz-Sloan JS, Olson SH, Bernstein JL, Lai RK, Schoemaker MJ, Simon M, Hoffmann P, Nöthen MM, Jöckel KH, Chanock S, Rajaraman P, Johansen C, Jenkins RB, Melin BS, Wrensch MR, Sanson M, Bondy ML, Houlston RS.

BMC Med. 2018 Mar 15;16(1):42. doi: 10.1186/s12916-018-1027-5.


The absence of a novel intron 19-retaining ALK transcript (ALK-I19) and MYCN amplification correlates with an excellent clinical outcome in neuroblastoma patients.

Alshareef A, Irwin MS, Gupta N, Zhang HF, Haque M, Findlay SD, Seong BKA, Lai J, Rayis M, Al-Dandan S, Lai R.

Oncotarget. 2018 Jan 12;9(12):10698-10713. doi: 10.18632/oncotarget.24216. eCollection 2018 Feb 13.


Influence of obesity-related risk factors in the aetiology of glioma.

Disney-Hogg L, Sud A, Law PJ, Cornish AJ, Kinnersley B, Ostrom QT, Labreche K, Eckel-Passow JE, Armstrong GN, Claus EB, Il'yasova D, Schildkraut J, Barnholtz-Sloan JS, Olson SH, Bernstein JL, Lai RK, Swerdlow AJ, Simon M, Hoffmann P, Nöthen MM, Jöckel KH, Chanock S, Rajaraman P, Johansen C, Jenkins RB, Melin BS, Wrensch MR, Sanson M, Bondy ML, Houlston RS.

Br J Cancer. 2018 Apr;118(7):1020-1027. doi: 10.1038/s41416-018-0009-x. Epub 2018 Mar 13.


Modified Lung-RADS Improves Performance of Screening LDCT in a Population with High Prevalence of Non-smoking-related Lung Cancer.

Hsu HT, Tang EK, Wu MT, Wu CC, Liang CH, Chen CS, Mar GY, Lai RS, Wang JC, Wu CL, Huang YL, Wu FZ.

Acad Radiol. 2018 Mar 9. pii: S1076-6332(18)30026-6. doi: 10.1016/j.acra.2018.01.012. [Epub ahead of print]


High serum uric acid levels are a protective factor against unfavourable neurological functional outcome in patients with ischaemic stroke.

Wang YF, Li JX, Sun XS, Lai R, Sheng WL.

J Int Med Res. 2018 May;46(5):1826-1838. doi: 10.1177/0300060517752996. Epub 2018 Mar 12.


NHR-49/HNF4 integrates regulation of fatty acid metabolism with a protective transcriptional response to oxidative stress and fasting.

Goh GYS, Winter JJ, Bhanshali F, Doering KRS, Lai R, Lee K, Veal EA, Taubert S.

Aging Cell. 2018 Jun;17(3):e12743. doi: 10.1111/acel.12743. Epub 2018 Mar 5.


Salivary factor LTRIN from Aedes aegypti facilitates the transmission of Zika virus by interfering with the lymphotoxin-β receptor.

Jin L, Guo X, Shen C, Hao X, Sun P, Li P, Xu T, Hu C, Rose O, Zhou H, Yang M, Qin CF, Guo J, Peng H, Zhu M, Cheng G, Qi X, Lai R.

Nat Immunol. 2018 Apr;19(4):342-353. doi: 10.1038/s41590-018-0063-9. Epub 2018 Mar 5.


Ectopic osteogenesis effect of antigen-extracted xenogeneic cancellous bone graft with chitosan/rhBMP-2/bFGF sequential sustained-release nanocapsules.

Li ZJ, Lu CT, Lai RF.

J Biomater Appl. 2018 Jul;33(1):23-43. doi: 10.1177/0885328218761193. Epub 2018 Mar 2.


Graded Nano Glass-Zirconia Material for Dental Applications-Part II Biocompatibility Evaluation.

Sun T, Guo M, Cheng Y, Ou L, He P, Liu X, Ma S, Lai R.

J Biomed Nanotechnol. 2017 Dec 1;13(12):1682-1693. doi: 10.1166/jbn.2017.2379.


The Immune Response to Mycobacterium tuberculosis in HIV-1-Coinfected Persons.

Esmail H, Riou C, Bruyn ED, Lai RP, Harley YXR, Meintjes G, Wilkinson KA, Wilkinson RJ.

Annu Rev Immunol. 2018 Apr 26;36:603-638. doi: 10.1146/annurev-immunol-042617-053420. Epub 2018 Feb 28.


The Changing Epidemiology of Posttransplant Lymphoproliferative Disorder in Adult Solid Organ Transplant Recipients Over 30 Years: A Single Center Experience.

Peters AC, Akinwumi MS, Cervera C, Mabilangan C, Ghosh S, Lai R, Iafollo M, Doucette K, Preiksaitis JK.

Transplantation. 2018 Feb 26. doi: 10.1097/TP.0000000000002146. [Epub ahead of print]


The Biocompatibility of Dental Graded Nano-Glass-Zirconia Material After Aging.

Sun T, Liu R, Liu X, Feng X, Zhang Y, Lai R.

Nanoscale Res Lett. 2018 Feb 23;13(1):61. doi: 10.1186/s11671-018-2479-4.


Molecular dynamics simulation of ion mobility in gases.

Lai R, Dodds ED, Li H.

J Chem Phys. 2018 Feb 14;148(6):064109. doi: 10.1063/1.4998955.


A Comment on "Anti-Psoriatic Drug Monomethylfumarate Increases Nuclear Factor Erythroid 2-Related Factor 2 Levels and Induces Aquaporin-3 mRNA and Protein Expression".

Lai R, Xian D, Yang L, Song J, Zhong J.

J Pharmacol Exp Ther. 2018 Mar;364(3):447-448. doi: 10.1124/jpet.117.246074. No abstract available.


Monitoring Two-Component Sensor Kinases with a Chemotaxis Signal Readout.

Lai RZ, Parkinson JS.

Methods Mol Biol. 2018;1729:127-135. doi: 10.1007/978-1-4939-7577-8_12.


Mendelian randomisation study of the relationship between vitamin D and risk of glioma.

Takahashi H, Cornish AJ, Sud A, Law PJ, Kinnersley B, Ostrom QT, Labreche K, Eckel-Passow JE, Armstrong GN, Claus EB, Ll'yasova D, Schildkraut J, Barnholtz-Sloan JS, Olson SH, Bernstein JL, Lai RK, Schoemaker MJ, Simon M, Hoffmann P, Nöthen MM, Jöckel KH, Chanock S, Rajaraman P, Johansen C, Jenkins RB, Melin BS, Wrensch MR, Sanson M, Bondy ML, Turnbull C, Houlston RS.

Sci Rep. 2018 Feb 5;8(1):2339. doi: 10.1038/s41598-018-20844-w.


Phosphorylation of Sox2 at Threonine 116 is a Potential Marker to Identify a Subset of Breast Cancer Cells with High Tumorigenecity and Stem-Like Features.

Gupta N, Gopal K, Wu C, Alshareef A, Chow A, Wu F, Wang P, Ye X, Bigras G, Lai R.

Cancers (Basel). 2018 Feb 3;10(2). pii: E41. doi: 10.3390/cancers10020041.


Selective Closed-State Nav1.7 Blocker JZTX-34 Exhibits Analgesic Effects against Pain.

Zeng X, Li P, Chen B, Huang J, Lai R, Liu J, Rong M.

Toxins (Basel). 2018 Feb 2;10(2). pii: E64. doi: 10.3390/toxins10020064.


Computational Redesign of Acyl-ACP Thioesterase with Improved Selectivity toward Medium-Chain-Length Fatty Acids.

Grisewood MJ, Hernandez Lozada NJ, Thoden JB, Gifford NP, Mendez-Perez D, Schoenberger HA, Allan MF, Floy ME, Lai RY, Holden HM, Pfleger BF, Maranas CD.

ACS Catal. 2017 Jun 2;7(6):3837-3849. doi: 10.1021/acscatal.7b00408. Epub 2017 Apr 20.


CD11b+ Dendritic Cell-Mediated Anti-Mycobacterium tuberculosis Th1 Activation Is Counterregulated by CD103+ Dendritic Cells via IL-10.

Lai R, Jeyanathan M, Afkhami S, Zganiacz A, Hammill JA, Yao Y, Kaushic C, Xing Z.

J Immunol. 2018 Mar 1;200(5):1746-1760. doi: 10.4049/jimmunol.1701109. Epub 2018 Jan 26.


Bimodal Seasonality and Alternating Predominance of Norovirus GII.4 and Non-GII.4, Hong Kong, China, 2014-20171.

Chan MC, Kwok K, Zhang LY, Mohammad KN, Lee N, Lui GCY, Nelson EAS, Lai RWM, Leung TF, Chan PKS.

Emerg Infect Dis. 2018 Apr 17;24(4). doi: 10.3201/eid2404.171791. [Epub ahead of print]


Centipedes subdue giant prey by blocking KCNQ channels.

Luo L, Li B, Wang S, Wu F, Wang X, Liang P, Ombati R, Chen J, Lu X, Cui J, Lu Q, Zhang L, Zhou M, Tian C, Yang S, Lai R.

Proc Natl Acad Sci U S A. 2018 Feb 13;115(7):1646-1651. doi: 10.1073/pnas.1714760115. Epub 2018 Jan 22.

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