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Items: 1 to 50 of 519

1.

Vascular age is associated with the risk of dialysis or death in chronic kidney disease.

Lin M, Chan GC, Chan KW, Lai KN, Tang SC.

Nephrology (Carlton). 2019 Jun 21. doi: 10.1111/nep.13624. [Epub ahead of print]

PMID:
31226224
2.

Amelioration of Endoplasmic Reticulum Stress by Mesenchymal Stem Cells Via Hepatocyte Growth Factor/c-Met Signaling in Obesity-Associated Kidney Injury.

Li B, Leung JCK, Chan LYY, Yiu WH, Li Y, Lok SWY, Liu WH, Chan KW, Tse HF, Lai KN, Tang SCW.

Stem Cells Transl Med. 2019 May 3. doi: 10.1002/sctm.18-0265. [Epub ahead of print]

3.

Role of Mesangial-Podocytic-Tubular Cross-Talk in IgA Nephropathy.

Leung JCK, Lai KN, Tang SCW.

Semin Nephrol. 2018 Sep;38(5):485-495. doi: 10.1016/j.semnephrol.2018.05.018. Review.

PMID:
30177020
4.

Activated renal tubular Wnt/β-catenin signaling triggers renal inflammation during overload proteinuria.

Wong DWL, Yiu WH, Chan KW, Li Y, Li B, Lok SWY, Taketo MM, Igarashi P, Chan LYY, Leung JCK, Lai KN, Tang SCW.

Kidney Int. 2018 Jun;93(6):1367-1383. doi: 10.1016/j.kint.2017.12.017. Epub 2018 Mar 28.

5.

Complement C5a inhibition moderates lipid metabolism and reduces tubulointerstitial fibrosis in diabetic nephropathy.

Yiu WH, Li RX, Wong DWL, Wu HJ, Chan KW, Chan LYY, Leung JCK, Lai KN, Sacks SH, Zhou W, Tang SCW.

Nephrol Dial Transplant. 2018 Aug 1;33(8):1323-1332. doi: 10.1093/ndt/gfx336.

PMID:
29294056
6.

Human induced pluripotent stem cell-derived mesenchymal stem cells prevent adriamycin nephropathy in mice.

Wu HJ, Yiu WH, Wong DWL, Li RX, Chan LYY, Leung JCK, Zhang Y, Lian Q, Lai KN, Tse HF, Tang SCW.

Oncotarget. 2017 Oct 10;8(61):103640-103656. doi: 10.18632/oncotarget.21760. eCollection 2017 Nov 28.

7.

Inherited mutations in BRCA1 and BRCA2 in an unselected multiethnic cohort of Asian patients with breast cancer and healthy controls from Malaysia.

Wen WX, Allen J, Lai KN, Mariapun S, Hasan SN, Ng PS, Lee DS, Lee SY, Yoon SY, Lim J, Lau SY, Decker B, Pooley K, Dorling L, Luccarini C, Baynes C, Conroy DM, Harrington P, Simard J, Yip CH, Mohd Taib NA, Ho WK, Antoniou AC, Dunning AM, Easton DF, Teo SH.

J Med Genet. 2018 Feb;55(2):97-103. doi: 10.1136/jmedgenet-2017-104947. Epub 2017 Oct 9.

8.

A placental growth factor is silenced in mouse embryos by the zinc finger protein ZFP568.

Yang P, Wang Y, Hoang D, Tinkham M, Patel A, Sun MA, Wolf G, Baker M, Chien HC, Lai KN, Cheng X, Shen CJ, Macfarlan TS.

Science. 2017 May 19;356(6339):757-759. doi: 10.1126/science.aah6895.

9.

BRCA2 Hypomorphic Missense Variants Confer Moderate Risks of Breast Cancer.

Shimelis H, Mesman RLS, Von Nicolai C, Ehlen A, Guidugli L, Martin C, Calléja FMGR, Meeks H, Hallberg E, Hinton J, Lilyquist J, Hu C, Aalfs CM, Aittomäki K, Andrulis I, Anton-Culver H, Arndt V, Beckmann MW, Benitez J, Bogdanova NV, Bojesen SE, Bolla MK, Borresen-Dale AL, Brauch H, Brennan P, Brenner H, Broeks A, Brouwers B, Brüning T, Burwinkel B, Chang-Claude J, Chenevix-Trench G, Cheng CY, Choi JY, Collée JM, Cox A, Cross SS, Czene K, Darabi H, Dennis J, Dörk T, Dos-Santos-Silva I, Dunning AM, Fasching PA, Figueroa J, Flyger H, García-Closas M, Giles GG, Glendon G, Guénel P, Haiman CA, Hall P, Hamann U, Hartman M, Hogervorst FB, Hollestelle A, Hopper JL, Ito H, Jakubowska A, Kang D, Kosma VM, Kristensen V, Lai KN, Lambrechts D, Marchand LL, Li J, Lindblom A, Lophatananon A, Lubinski J, Machackova E, Mannermaa A, Margolin S, Marme F, Matsuo K, Miao H, Michailidou K, Milne RL, Muir K, Neuhausen SL, Nevanlinna H, Olson JE, Olswold C, Oosterwijk JJC, Osorio A, Peterlongo P, Peto J, Pharoah PDP, Pylkäs K, Radice P, Rashid MU, Rhenius V, Rudolph A, Sangrajrang S, Sawyer EJ, Schmidt MK, Schoemaker MJ, Seynaeve C, Shah M, Shen CY, Shrubsole M, Shu XO, Slager S, Southey MC, Stram DO, Swerdlow A, Teo SH, Tomlinson I, Torres D, Truong T, van Asperen CJ, van der Kolk LE, Wang Q, Winqvist R, Wu AH, Yu JC, Zheng W, Zheng Y, Leary J, Walker L, Foretova L, Fostira F, Claes KBM, Varesco L, Moghadasi S, Easton DF, Spurdle A, Devilee P, Vrieling H, Monteiro ANA, Goldgar DE, Carreira A, Vreeswijk MPG, Couch FJ; for kConFab/AOCS Investigators; for NBCS Collaborators.

Cancer Res. 2017 Jun 1;77(11):2789-2799. doi: 10.1158/0008-5472.CAN-16-2568. Epub 2017 Mar 10.

10.

Characterization of BRCA1 and BRCA2 variants in multi-ethnic Asian cohort from a Malaysian case-control study.

Lai KN, Ho WK, Kang IN, Kang PC, Phuah SY, Mariapun S, Yip CH, Mohd Taib NA, Teo SH.

BMC Cancer. 2017 Feb 22;17(1):149. doi: 10.1186/s12885-017-3099-6.

11.

N-acetyl-seryl-aspartyl-lysyl-proline mediates the anti-fibrotic properties of captopril in unilateral ureteric obstructed BALB/C mice.

Chan GCW, Wu HJ, Chan KW, Yiu WH, Zou A, Huang XR, Lan HY, Lai KN, Tang SCW.

Nephrology (Carlton). 2018 Apr;23(4):297-307. doi: 10.1111/nep.13000.

PMID:
28075040
12.

Semi-individualised Chinese medicine treatment as an adjuvant management for diabetic nephropathy: a pilot add-on, randomised, controlled, multicentre, open-label pragmatic clinical trial.

Chan KW, Ip TP, Kwong AS, Lui SL, Chan GC, Cowling BJ, Yiu WH, Wong DW, Liu Y, Feng Y, Tan KC, Chan LY, Leung JC, Lai KN, Tang SC.

BMJ Open. 2016 Aug 5;6(8):e010741. doi: 10.1136/bmjopen-2015-010741.

13.

Recent advances in managing and understanding diabetic nephropathy.

Tang SC, Chan GC, Lai KN.

F1000Res. 2016 May 31;5. pii: F1000 Faculty Rev-1044. doi: 10.12688/f1000research.7693.1. eCollection 2016. Review.

14.

IgA nephropathy.

Lai KN, Tang SC, Schena FP, Novak J, Tomino Y, Fogo AB, Glassock RJ.

Nat Rev Dis Primers. 2016 Feb 11;2:16001. doi: 10.1038/nrdp.2016.1. Review.

PMID:
27189177
15.

Dent Disease in Chinese Children and Findings from Heterozygous Mothers: Phenotypic Heterogeneity, Fetal Growth, and 10 Novel Mutations.

Li F, Yue Z, Xu T, Chen M, Zhong L, Liu T, Jing X, Deng J, Hu B, Liu Y, Wang H, Lai KN, Sun L, Liu J, Maxwell PH, Wang Y.

J Pediatr. 2016 Jul;174:204-210.e1. doi: 10.1016/j.jpeds.2016.04.007. Epub 2016 May 9.

PMID:
27174143
16.

Downregulation of renal tubular Wnt/β-catenin signaling by Dickkopf-3 induces tubular cell death in proteinuric nephropathy.

Wong DW, Yiu WH, Wu HJ, Li RX, Liu Y, Chan KW, Leung JC, Chan LY, Lai KN, Tang SC.

Cell Death Dis. 2016 Mar 24;7:e2155. doi: 10.1038/cddis.2016.62.

17.

Recent advances in the understanding and management of IgA nephropathy.

Lai KN, Leung JC, Tang SC.

F1000Res. 2016 Feb 11;5. pii: F1000 Faculty Rev-161. doi: 10.12688/f1000research.7352.1. eCollection 2016. Review.

18.

In a retrospective international study, circulating miR-148b and let-7b were found to be serum markers for detecting primary IgA nephropathy.

Serino G, Pesce F, Sallustio F, De Palma G, Cox SN, Curci C, Zaza G, Lai KN, Leung JC, Tang SC, Papagianni A, Stangou M, Goumenos D, Gerolymos M, Takahashi K, Yuzawa Y, Maruyama S, Imai E, Schena FP.

Kidney Int. 2016 Mar;89(3):683-92.

PMID:
26581012
19.

Evaluation of germline BRCA1 and BRCA2 mutations in a multi-ethnic Asian cohort of ovarian cancer patients.

Hasmad HN, Lai KN, Wen WX, Park DJ, Nguyen-Dumont T, Kang PCE, Thirthagiri E, Ma'som M, Lim BK, Southey M, Woo YL, Teo SH.

Gynecol Oncol. 2016 May;141(2):318-322. doi: 10.1016/j.ygyno.2015.11.001. Epub 2015 Nov 3.

PMID:
26541979
20.

Kallistatin protects against diabetic nephropathy in db/db mice by suppressing AGE-RAGE-induced oxidative stress.

Yiu WH, Wong DW, Wu HJ, Li RX, Yam I, Chan LY, Leung JC, Lan HY, Lai KN, Tang SC.

Kidney Int. 2016 Feb;89(2):386-98.

PMID:
26536000
21.

Proteinuria is associated with sleep apnea in chronic kidney disease.

Chan GC, Lam B, Yap DY, Ip MS, Lai KN, Tang SC.

Nephrol Dial Transplant. 2016 May;31(5):772-9. doi: 10.1093/ndt/gfv306. Epub 2015 Aug 26.

PMID:
26311214
22.

Novel genes and variants associated with IgA nephropathy by co-segregating with the disease phenotypes in 10 IgAN families.

Liu R, Hu B, Li Q, Jing X, Zhong C, Chang Y, Liao Q, Lam MF, Leung JC, Lai KN, Wang Y.

Gene. 2015 Oct 15;571(1):43-51. doi: 10.1016/j.gene.2015.06.041. Epub 2015 Jun 18.

PMID:
26095808
23.

The Treatment of IgA Nephropathy.

Lai KN, Leung JC, Tang SC.

Kidney Dis (Basel). 2015 May;1(1):19-26. doi: 10.1159/000381508. Epub 2015 Apr 15. Review.

24.

Pathogenesis of renal disease in systemic lupus erythematosus--the role of autoantibodies and lymphocytes subset abnormalities.

Yap DY, Lai KN.

Int J Mol Sci. 2015 Apr 9;16(4):7917-31. doi: 10.3390/ijms16047917. Review.

25.

Combined blockade of angiotensin II and prorenin receptors ameliorates podocytic apoptosis induced by IgA-activated mesangial cells.

Leung JC, Chan LY, Saleem MA, Mathieson PW, Tang SC, Lai KN.

Apoptosis. 2015 Jul;20(7):907-20. doi: 10.1007/s10495-015-1117-1.

PMID:
25808596
26.

Diabetic nephropathy and proximal tubular damage.

Tang SC, Yiu WH, Lin M, Lai KN.

J Ren Nutr. 2015 Mar;25(2):230-3. doi: 10.1053/j.jrn.2014.10.020. Epub 2015 Jan 8. Review.

PMID:
25578352
27.

BMP7 reduces inflammation and oxidative stress in diabetic tubulopathy.

Li RX, Yiu WH, Wu HJ, Wong DW, Chan LY, Lin M, Leung JC, Lai KN, Tang SC.

Clin Sci (Lond). 2015 Feb;128(4):269-80. doi: 10.1042/CS20140401.

PMID:
25200314
28.

Albumin and glycated albumin activate KIM-1 release in tubular epithelial cells through distinct kinetics and mechanisms.

Lim AI, Chan LY, Tang SC, Lai KN, Leung JC.

Inflamm Res. 2014 Oct;63(10):831-9. doi: 10.1007/s00011-014-0757-x. Epub 2014 Jul 26.

PMID:
25063374
29.

Mesenchymal stem cells modulate albumin-induced renal tubular inflammation and fibrosis.

Wu HJ, Yiu WH, Li RX, Wong DW, Leung JC, Chan LY, Zhang Y, Lian Q, Lin M, Tse HF, Lai KN, Tang SC.

PLoS One. 2014 Mar 19;9(3):e90883. doi: 10.1371/journal.pone.0090883. eCollection 2014.

30.

Tissue kallikrein mediates pro-inflammatory pathways and activation of protease-activated receptor-4 in proximal tubular epithelial cells.

Yiu WH, Wong DW, Chan LY, Leung JC, Chan KW, Lan HY, Lai KN, Tang SC.

PLoS One. 2014 Feb 21;9(2):e88894. doi: 10.1371/journal.pone.0088894. eCollection 2014.

31.

BMP-7 represses albumin-induced chemokine synthesis in kidney tubular epithelial cells through destabilization of NF-κB-inducing kinase.

Lim AI, Chan LY, Tang SC, Yiu WH, Li R, Lai KN, Leung JC.

Immunol Cell Biol. 2014 May-Jun;92(5):427-35. doi: 10.1038/icb.2013.106. Epub 2014 Jan 14.

PMID:
24418819
32.

Effect of paricalcitol on left ventricular mass and function in CKD--the OPERA trial.

Wang AY, Fang F, Chan J, Wen YY, Qing S, Chan IH, Lo G, Lai KN, Lo WK, Lam CW, Yu CM.

J Am Soc Nephrol. 2014 Jan;25(1):175-86. doi: 10.1681/ASN.2013010103. Epub 2013 Sep 19.

33.

Hepatitis C virus-associated glomerulonephritis.

Tang SC, Lai KN.

Contrib Nephrol. 2013;181:194-206. doi: 10.1159/000348477. Epub 2013 May 8. Review.

PMID:
23689581
34.

The role of cytokines in the pathogenesis of systemic lupus erythematosus - from bench to bedside.

Yap DY, Lai KN.

Nephrology (Carlton). 2013 Apr;18(4):243-55. doi: 10.1111/nep.12047. Review.

PMID:
23452295
35.

The TLR4 antagonist CRX-526 protects against advanced diabetic nephropathy.

Lin M, Yiu WH, Li RX, Wu HJ, Wong DW, Chan LY, Leung JC, Lai KN, Tang SC.

Kidney Int. 2013 May;83(5):887-900. doi: 10.1038/ki.2013.11. Epub 2013 Feb 20.

36.

Kidney injury molecule-1: more than just an injury marker of tubular epithelial cells?

Lim AI, Tang SC, Lai KN, Leung JC.

J Cell Physiol. 2013 May;228(5):917-24. doi: 10.1002/jcp.24267. Review.

PMID:
23086807
37.

The pathogenic role of the renal proximal tubular cell in diabetic nephropathy.

Tang SC, Lai KN.

Nephrol Dial Transplant. 2012 Aug;27(8):3049-56. doi: 10.1093/ndt/gfs260. Epub 2012 Jun 25. Review.

PMID:
22734110
38.

Rare inborn errors associated with chronic hepatitis B virus infection.

Zhao Q, Peng L, Huang W, Li Q, Pei Y, Yuan P, Zheng L, Zhang Y, Deng J, Zhong C, Hu B, Ding H, Fang W, Li R, Liao Q, Lin C, Deng W, Yan H, Hou J, Wu Q, Xu T, Liu J, Hu L, Peng T, Chen S, Lai KN, Yuen MF, Wang Y, Maini MK, Li C, Li M, Wang J, Zhang X, Sham PC, Wang J, Gao ZL, Wang Y.

Hepatology. 2012 Nov;56(5):1661-70. doi: 10.1002/hep.25850. Epub 2012 Oct 14.

PMID:
22610944
39.

Distinct role of matrix metalloproteinase-3 in kidney injury molecule-1 shedding by kidney proximal tubular epithelial cells.

Lim AI, Chan LY, Lai KN, Tang SC, Chow CW, Lam MF, Leung JC.

Int J Biochem Cell Biol. 2012 Jun;44(6):1040-50. doi: 10.1016/j.biocel.2012.03.015. Epub 2012 Mar 30.

PMID:
22484054
40.

Pathogenesis of IgA nephropathy.

Lai KN.

Nat Rev Nephrol. 2012 Mar 20;8(5):275-83. doi: 10.1038/nrneph.2012.58. Review.

PMID:
22430056
41.

Quantification of BK viral load in asymptomatic renal allograft recipients.

Chan GC, Leung AY, Wong AS, Chan KW, Kwong YL, Lai KN, Tang SC.

Ren Fail. 2012;34(5):550-4. doi: 10.3109/0886022X.2012.664808. Epub 2012 Mar 6.

PMID:
22390257
42.

The role of leptin and its short-form receptor in inflammation in db/db mice infused with peritoneal dialysis fluid.

Leung JC, Chan LY, Lam MF, Tang SC, Chow CW, Lim AI, Lai KN.

Nephrol Dial Transplant. 2012 Aug;27(8):3119-29. doi: 10.1093/ndt/gfr774. Epub 2012 Jan 28.

PMID:
22287654
43.

Impact of nephrotic edema of the lower limbs on obstructive sleep apnea: gathering a unifying concept for the pathogenetic role of nocturnal rostral fluid shift.

Tang SC, Lam B, Lam JC, Chan CK, Chow CC, Ho YW, Ip MS, Lai KN.

Nephrol Dial Transplant. 2012 Jul;27(7):2788-94. doi: 10.1093/ndt/gfr759. Epub 2012 Jan 16.

PMID:
22248509
44.

A study of the clinical and biochemical profile of peritoneal dialysis fluid low in glucose degradation products.

Lai KN, Lam MF, Leung JC, Chan LY, Lam CW, Chan IH, Chan HW, Li CS, Wong SS, Ho YW, Cheuk A, Tong MK, Tang SC.

Perit Dial Int. 2012 May-Jun;32(3):280-91. doi: 10.3747/pdi.2010.00176. Epub 2011 Nov 3.

45.

Toll-like receptor 4 promotes tubular inflammation in diabetic nephropathy.

Lin M, Yiu WH, Wu HJ, Chan LY, Leung JC, Au WS, Chan KW, Lai KN, Tang SC.

J Am Soc Nephrol. 2012 Jan;23(1):86-102. doi: 10.1681/ASN.2010111210. Epub 2011 Oct 21.

46.

Oxidative damages in tubular epithelial cells in IgA nephropathy: role of crosstalk between angiotensin II and aldosterone.

Leung JC, Chan LY, Tang SC, Lam MF, Chow CW, Lim AI, Lai KN.

J Transl Med. 2011 Oct 6;9:169. doi: 10.1186/1479-5876-9-169.

47.

Immunomodulatory agents against IgA nephropathy.

Tang SC, Leung JC, Lai KN.

Adv Otorhinolaryngol. 2011;72:45-9. doi: 10.1159/000324602. Epub 2011 Aug 18. Review.

PMID:
21865687
48.

Recent advances in IgA nephropathy--the glomerulopodocytic-tubular communication.

Lai KN, Tang SC, Leung JC.

Adv Otorhinolaryngol. 2011;72:40-4. doi: 10.1159/000324593. Epub 2011 Aug 18. Review.

PMID:
21865686
49.

Clinical pictures and novel mutations of WT1-associated Denys-Drash syndrome in two Chinese children.

Yue Z, Pei Y, Sun L, Huang W, Huang H, Hu B, Yang J, Jiang X, Mo Y, Chen S, Lai KN, Wang Y.

Ren Fail. 2011;33(9):910-4. doi: 10.3109/0886022X.2011.605528. Epub 2011 Aug 18.

PMID:
21851196
50.

Streptococcus bovis peritonitis complicating peritoneal dialysis--a review of 10 years' experience.

Yap DY, To KK, Yip TP, Lui SL, Chan TM, Lai KN, Lo WK.

Perit Dial Int. 2012 Jan-Feb;32(1):55-9. doi: 10.3747/pdi.2010.00304. Epub 2011 Jul 31.

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