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Novel Antrodia cinnamomea Extract Reduced Cancer Stem-Like Phenotype Changes and Resensitized KRAS-Mutant Colorectal Cancer via a MicroRNA-27a Pathway.

Lin TJ, Lai KC, Lee AS, Chang CH, Liu CL, Chung CH.

Cancers (Basel). 2019 Oct 26;11(11). pii: E1657. doi: 10.3390/cancers11111657.


Complex oscillatory decrease with size in diffusivity of {100}-epitaxially supported 3D fcc metal nanoclusters.

Lai KC, Evans JW.

Nanoscale. 2019 Oct 7;11(37):17506-17516. doi: 10.1039/c9nr05845a. Epub 2019 Sep 18.


Gefitinib and curcumin-loaded nanoparticles enhance cell apoptosis in human oral cancer SAS cells in vitro and inhibit SAS cell xenografted tumor in vivo.

Lai KC, Chueh FS, Hsiao YT, Cheng ZY, Lien JC, Liu KC, Peng SF, Chung JG.

Toxicol Appl Pharmacol. 2019 Nov 1;382:114734. doi: 10.1016/j.taap.2019.114734. Epub 2019 Aug 27.


Effect of Linker Stereochemistry on the Activity of Indolinobenzodiazepine Containing Antibody-Drug Conjugates (ADCs).

Reid EE, Archer KE, Shizuka M, Wilhelm A, Yoder NC, Bai C, Fishkin NE, Harris L, Maloney EK, Salomon P, Hong E, Wu R, Ab O, Jin S, Lai KC, Sikka S, Chari RVJ, Miller ML.

ACS Med Chem Lett. 2019 Jul 10;10(8):1193-1197. doi: 10.1021/acsmedchemlett.9b00240. eCollection 2019 Aug 8.


Bone measurements at multiple skeletal sites in adolescent idiopathic scoliosis-an in vivo correlation study using DXA, HR-pQCT and QCT.

Cheuk KY, Hu Y, Tam EMS, Shi L, Yu FWP, Hung VWY, Lai KCY, Cheng WHW, Yip BHK, Qin L, Ng BKW, Chu WCW, Griffith J, Guo XE, Cheng JCY, Lam TP.

Arch Osteoporos. 2019 Jun 27;14(1):70. doi: 10.1007/s11657-019-0621-2.


Reshaping, Intermixing, and Coarsening for Metallic Nanocrystals: Nonequilibrium Statistical Mechanical and Coarse-Grained Modeling.

Lai KC, Han Y, Spurgeon P, Huang W, Thiel PA, Liu DJ, Evans JW.

Chem Rev. 2019 Jun 12;119(11):6670-6768. doi: 10.1021/acs.chemrev.8b00582. Epub 2019 Jun 4.


Enlarging biopsy-proven fibroadenoma: Is surgical excision necessary?

Dialani V, Chansakul T, Lai KC, Gilmore H, Sayegh NY, Slanetz PJ.

Clin Imaging. 2019 Sep - Oct;57:35-39. doi: 10.1016/j.clinimag.2019.03.014. Epub 2019 Apr 4.


Fistein Suppresses Human Osteosarcoma U-2 OS Cell Migration and Invasion via Affecting FAK, uPA and NF-ĸB Signaling Pathway In Vitro.

Chen JK, Peng SF, Lai KC, Liu HC, Huang YP, Lin CC, Huang AC, Chueh FS, Chung JG.

In Vivo. 2019 May-Jun;33(3):801-810. doi: 10.21873/invivo.11542.


Severe hypertriglyceridemia associated with everolimus drug-eluting stent placement in an infant.

Lai KC, Brothers JA, Stoller JZ.

Cardiol Young. 2019 Apr;29(4):541-543. doi: 10.1017/S1047951119000167. Epub 2019 Apr 8.


Long-Term Exposure to Oroxylin A Inhibits Metastasis by Suppressing CCL2 in Oral Squamous Cell Carcinoma Cells.

Ku WT, Tung JJ, Lee TJ, Lai KC.

Cancers (Basel). 2019 Mar 12;11(3). pii: E353. doi: 10.3390/cancers11030353.


Environmental application of three-dimensional graphene materials as adsorbents for dyes and heavy metals: Review on ice-templating method and adsorption mechanisms.

Lai KC, Lee LY, Hiew BYZ, Thangalazhy-Gopakumar S, Gan S.

J Environ Sci (China). 2019 May;79:174-199. doi: 10.1016/j.jes.2018.11.023. Epub 2018 Dec 14. Review.


The novel CD19-targeting antibody-drug conjugate huB4-DGN462 shows improved anti-tumor activity compared to SAR3419 in CD19-positive lymphoma and leukemia models.

Hicks SW, Tarantelli C, Wilhem A, Gaudio E, Li M, Arribas AJ, Spriano F, Bordone R, Cascione L, Lai KC, Qiu Q, Taborelli M, Rossi D, Stussi G, Zucca E, Stathis A, Sloss CM, Bertoni F.

Haematologica. 2019 Aug;104(8):1633-1639. doi: 10.3324/haematol.2018.211011. Epub 2019 Feb 7.


Radiological Society of North America (RSNA) 3D printing Special Interest Group (SIG): guidelines for medical 3D printing and appropriateness for clinical scenarios.

Chepelev L, Wake N, Ryan J, Althobaity W, Gupta A, Arribas E, Santiago L, Ballard DH, Wang KC, Weadock W, Ionita CN, Mitsouras D, Morris J, Matsumoto J, Christensen A, Liacouras P, Rybicki FJ, Sheikh A; RSNA Special Interest Group for 3D Printing.

3D Print Med. 2018 Nov 21;4(1):11. doi: 10.1186/s41205-018-0030-y.


Casticin Promotes Immune Responses, Enhances Macrophage and NK Cell Activities, and Increases Survival Rates of Leukemia BALB/c Mice.

Lai KC, Lu HF, Chen KB, Hsueh SC, Chung JG, Huang WW, Chen CC, Shang HS.

Am J Chin Med. 2019;47(1):223-236. doi: 10.1142/S0192415X19500113. Epub 2019 Jan 10.


Genistein induces apoptosis in vitro and has antitumor activity against human leukemia HL-60 cancer cell xenograft growth in vivo.

Hsiao YC, Peng SF, Lai KC, Liao CL, Huang YP, Lin CC, Lin ML, Liu KC, Tsai CC, Ma YS, Chung JG.

Environ Toxicol. 2019 Apr;34(4):443-456. doi: 10.1002/tox.22698. Epub 2019 Jan 7.


Maslinic Acid Enhances Immune Responses in Leukemic Mice Through Macrophage Phagocytosis and Natural Killer Cell Activities In Vivo.

Lai KC, Peng SF, Liu CC, Huang JY, Kuo JY, Cheng ZY, Wu RS, Lin CC, Chen JK, Chung JG.

In Vivo. 2019 Jan-Feb;33(1):65-73. doi: 10.21873/invivo.11440.


Ice-templated graphene oxide/chitosan aerogel as an effective adsorbent for sequestration of metanil yellow dye.

Lai KC, Hiew BYZ, Lee LY, Gan S, Thangalazhy-Gopakumar S, Chiu WS, Khiew PS.

Bioresour Technol. 2019 Feb;274:134-144. doi: 10.1016/j.biortech.2018.11.048. Epub 2018 Nov 14.


Prognostic Values of EPDR1 Hypermethylation and Its Inhibitory Function on Tumor Invasion in Colorectal Cancer.

Chu CH, Chang SC, Wang HH, Yang SH, Lai KC, Lee TC.

Cancers (Basel). 2018 Oct 22;10(10). pii: E393. doi: 10.3390/cancers10100393.


Adsorptive decontamination of diclofenac by three-dimensional graphene-based adsorbent: Response surface methodology, adsorption equilibrium, kinetic and thermodynamic studies.

Hiew BYZ, Lee LY, Lai KC, Gan S, Thangalazhy-Gopakumar S, Pan GT, Yang TC.

Environ Res. 2019 Jan;168:241-253. doi: 10.1016/j.envres.2018.09.030. Epub 2018 Sep 26.


Multilevel antimicrobial disinfectant coating in reducing the viability of multidrug-resistant organisms in hospital environment.

Leung HH, Lai CK, Yeung KL, Kwan JK, Tsang DN.

Hong Kong Med J. 2018 Oct;24 Suppl 6(5):37-39. No abstract available.


Phenethyl Isothiocyanate Inhibits In Vivo Growth of Xenograft Tumors of Human Glioblastoma Cells.

Chou YC, Chang MY, Lee HT, Shen CC, Harnod T, Liang YJ, Wu RS, Lai KC, Hsu FT, Chung JG.

Molecules. 2018 Sep 10;23(9). pii: E2305. doi: 10.3390/molecules23092305.


Berberine Inhibits Human Melanoma A375.S2 Cell Migration and Invasion via Affecting the FAK, uPA, and NF-κB Signaling Pathways and Inhibits PLX4032 Resistant A375.S2 Cell Migration In Vitro.

Liu JF, Lai KC, Peng SF, Maraming P, Huang YP, Huang AC, Chueh FS, Huang WW, Chung JG.

Molecules. 2018 Aug 13;23(8). pii: E2019. doi: 10.3390/molecules23082019.


Bisdemethoxycurcumin Suppresses Migration and Invasion of Human Cervical Cancer HeLa Cells via Inhibition of NF-ĸB, MMP-2 and -9 Pathways.

Liao CL, Chu YL, Lin HY, Chen CY, Hsu MJ, Liu KC, Lai KC, Huang AC, Chung JG.

Anticancer Res. 2018 Jul;38(7):3989-3997. doi: 10.21873/anticanres.12686.


Digoxin and Amiodarone on the Risk of Ischemic Stroke in Atrial Fibrillation: An Observational Study.

Lai KC, Chen SJ, Lin CS, Yang FC, Lin CL, Hsu CW, Huang WC, Kao CH.

Front Pharmacol. 2018 May 7;9:448. doi: 10.3389/fphar.2018.00448. eCollection 2018.


Tetrandrine suppresses adhesion, migration and invasion of human colon cancer SW620 cells via inhibition of nuclear factor-κB, matrix metalloproteinase-2 and matrix metalloproteinase-9 signaling pathways.

Juan TK, Liu KC, Kuo CL, Yang MD, Chu YL, Yang JL, Wu PP, Huang YP, Lai KC, Chung JG.

Oncol Lett. 2018 May;15(5):7716-7724. doi: 10.3892/ol.2018.8286. Epub 2018 Mar 16.


IMGN779, a Novel CD33-Targeting Antibody-Drug Conjugate with DNA-Alkylating Activity, Exhibits Potent Antitumor Activity in Models of AML.

Kovtun Y, Noordhuis P, Whiteman KR, Watkins K, Jones GE, Harvey L, Lai KC, Portwood S, Adams S, Sloss CM, Schuurhuis GJ, Ossenkoppele G, Wang ES, Pinkas J.

Mol Cancer Ther. 2018 Jun;17(6):1271-1279. doi: 10.1158/1535-7163.MCT-17-1077. Epub 2018 Mar 27.


A DNA-Interacting Payload Designed to Eliminate Cross-Linking Improves the Therapeutic Index of Antibody-Drug Conjugates (ADCs).

Miller ML, Shizuka M, Wilhelm A, Salomon P, Reid EE, Lanieri L, Sikka S, Maloney EK, Harvey L, Qiu Q, Archer KE, Bai C, Vitharana D, Harris L, Singh R, Ponte JF, Yoder NC, Kovtun Y, Lai KC, Ab O, Pinkas J, Keating TA, Chari RVJ.

Mol Cancer Ther. 2018 Mar;17(3):650-660. doi: 10.1158/1535-7163.MCT-17-0940. Epub 2018 Feb 13.


Segmentation Approach Towards Phase-Contrast Microscopic Images of Activated Sludge to Monitor the Wastewater Treatment.

Khan MB, Nisar H, Ng CA, Yeap KH, Lai KC.

Microsc Microanal. 2017 Dec;23(6):1130-1142. doi: 10.1017/S1431927617012673. Epub 2017 Dec 7.


Communication: Diverse nanoscale cluster dynamics: Diffusion of 2D epitaxial clusters.

Lai KC, Evans JW, Liu DJ.

J Chem Phys. 2017 Nov 28;147(20):201101. doi: 10.1063/1.5008424.


Effects of sonication on co-precipitation synthesis and activity of copper manganese oxide catalyst to remove methane and sulphur dioxide gases.

Yap YH, Lim MSW, Lee ZY, Lai KC, Jamaal MA, Wong FH, Ng HK, Lim SS, Tiong TJ.

Ultrason Sonochem. 2018 Jan;40(Pt A):57-67. doi: 10.1016/j.ultsonch.2017.06.032. Epub 2017 Jul 1.


Thermal Performance Study of Composite Phase Change Material with Polyacrylicand Conformal Coating.

Kee SY, Munusamy Y, Ong KS, Cornelis Metselaar HS, Chee SY, Lai KC.

Materials (Basel). 2017 Jul 28;10(8). pii: E873. doi: 10.3390/ma10080873.


Benzyl isothiocyanate and phenethyl isothiocyanate inhibit murine melanoma B16F10 cell migration and invasion in vitro.

Lai KC, Hsiao YT, Yang JL, Ma YS, Huang YP, Chiang TA, Chung JG.

Int J Oncol. 2017 Sep;51(3):832-840. doi: 10.3892/ijo.2017.4084. Epub 2017 Jul 27.


The Antitumor Activity of IMGN529, a CD37-Targeting Antibody-Drug Conjugate, Is Potentiated by Rituximab in Non-Hodgkin Lymphoma Models.

Hicks SW, Lai KC, Gavrilescu LC, Yi Y, Sikka S, Shah P, Kelly ME, Lee J, Lanieri L, Ponte JF, Sloss CM, Romanelli A.

Neoplasia. 2017 Sep;19(9):661-671. doi: 10.1016/j.neo.2017.06.001. Epub 2017 Jul 25.


Cantharidin alters the expression of genes associated with the NKG2D-associated immune response in TSGH-8301 human bladder carcinoma cells.

Kuo JH, Huang AC, Lin JJ, Lai KC, Wu RS, Yang JL, Ji BC, Yang MD, Chu YL, Chung JG.

Oncol Lett. 2017 Jul;14(1):234-240. doi: 10.3892/ol.2017.6168. Epub 2017 May 12.


Effect of Preparation Methods on the Tensile, Morphology and Solar Energy Conversion Efficiency of RGO/PMMA Nanocomposites.

Kee SY, Munusamy Y, Ong KS, Lai KC.

Polymers (Basel). 2017 Jun 18;9(6). pii: E230. doi: 10.3390/polym9060230.


Incidental finding in a young man.

Tsang WKK, Chan MK, Lai KC.

Skeletal Radiol. 2017 Sep;46(9):1259, 1301-2. doi: 10.1007/s00256-017-2679-5. No abstract available.


Validation of an Instrument to Assess the Mental Capacity to Sign an Enduring Power of Attorney.

Ko RS, Lui VW, Lai KC, Chiu CC, Lam LC.

East Asian Arch Psychiatry. 2017 Mar;27(1):11-7.


A hospital-wide screening programme to control an outbreak of vancomycin-resistant enterococci in a large tertiary hospital in Hong Kong.

Lai CK, Wong SY, Lee SS, Siu HK, Chiu CY, Tsang DN, Ip MP, Hung CT.

Hong Kong Med J. 2017 Apr;23(2):140-9. doi: 10.12809/hkmj164939. Epub 2017 Feb 24.


A prospective interventional study to examine the effect of a silver alloy and hydrogel-coated catheter on the incidence of catheter-associated urinary tract infection.

Chung PH, Wong CW, Lai CK, Siu HK, Tsang DN, Yeung KY, Ip DK, Tam PK.

Hong Kong Med J. 2017 Jun;23(3):239-45. doi: 10.12809/hkmj164906. Epub 2017 Feb 17.


Early recovery of T-cell function predicts improved survival after T-cell depleted allogeneic transplant.

Goldberg JD, Zheng J, Ratan R, Small TN, Lai KC, Boulad F, Castro-Malaspina H, Giralt SA, Jakubowski AA, Kernan NA, O'Reilly RJ, Papadopoulos EB, Young JW, van den Brink MR, Heller G, Perales MA.

Leuk Lymphoma. 2017 Aug;58(8):1859-1871. doi: 10.1080/10428194.2016.1265113. Epub 2017 Jan 10.


Sulforaphane Induces Cell Death Through G2/M Phase Arrest and Triggers Apoptosis in HCT 116 Human Colon Cancer Cells.

Liu KC, Shih TY, Kuo CL, Ma YS, Yang JL, Wu PP, Huang YP, Lai KC, Chung JG.

Am J Chin Med. 2016;44(6):1289-1310. Epub 2016 Sep 15.


A New Triglycyl Peptide Linker for Antibody-Drug Conjugates (ADCs) with Improved Targeted Killing of Cancer Cells.

Singh R, Setiady YY, Ponte J, Kovtun YV, Lai KC, Hong EE, Fishkin N, Dong L, Jones GE, Coccia JA, Lanieri L, Veale K, Costoplus JA, Skaletskaya A, Gabriel R, Salomon P, Wu R, Qiu Q, Erickson HK, Lambert JM, Chari RV, Widdison WC.

Mol Cancer Ther. 2016 Jun;15(6):1311-20. doi: 10.1158/1535-7163.MCT-16-0021. Epub 2016 Mar 29.


Casticin Induced Apoptosis in A375.S2 Human Melanoma Cells through the Inhibition of NF-[Formula: see text]B and Mitochondria-Dependent Pathways In Vitro and Inhibited Human Melanoma Xenografts in a Mouse Model In Vivo.

Shiue YW, Lu CC, Hsiao YP, Liao CL, Lin JP, Lai KC, Yu CC, Huang YP, Ho HC, Chung JG.

Am J Chin Med. 2016;44(3):637-61. doi: 10.1142/S0192415X1650035X. Epub 2016 Apr 24.


Tetrandrine induces programmed cell death in human oral cancer CAL 27 cells through the reactive oxygen species production and caspase-dependent pathways and associated with beclin-1-induced cell autophagy.

Lien JC, Lin MW, Chang SJ, Lai KC, Huang AC, Yu FS, Chung JG.

Environ Toxicol. 2017 Jan;32(1):329-343. doi: 10.1002/tox.22238. Epub 2016 Jan 29.


Antitumor effects of deguelin on H460 human lung cancer cells in vitro and in vivo: Roles of apoptotic cell death and H460 tumor xenografts model.

Hsu YC, Chiang JH, Yu CS, Hsia TC, Wu RS, Lien JC, Lai KC, Yu FS, Chung JG.

Environ Toxicol. 2017 Jan;32(1):84-98. doi: 10.1002/tox.22214. Epub 2015 Nov 23.


Blocking TNF-α inhibits angiogenesis and growth of IFIT2-depleted metastatic oral squamous cell carcinoma cells.

Lai KC, Liu CJ, Lin TJ, Mar AC, Wang HH, Chen CW, Hong ZX, Lee TC.

Cancer Lett. 2016 Jan 28;370(2):207-15. doi: 10.1016/j.canlet.2015.10.016. Epub 2015 Oct 27.


Bisdemethoxycurcumin induces DNA damage and inhibits DNA repair associated protein expressions in NCI-H460 human lung cancer cells.

Yu CC, Yang ST, Huang WW, Peng SF, Huang AC, Tang NY, Liu HC, Yang MD, Lai KC, Chung JG.

Environ Toxicol. 2016 Dec;31(12):1859-1868. doi: 10.1002/tox.22187. Epub 2015 Aug 30.


Gallic acid induces DNA damage and inhibits DNA repair-associated protein expression in human oral cancer SCC-4 cells.

Weng SW, Hsu SC, Liu HC, Ji BC, Lien JC, Yu FS, Liu KC, Lai KC, Lin JP, Chung JG.

Anticancer Res. 2015 Apr;35(4):2077-84.


Suppression of the TNF-alpha level is mediated by Gan-Lu-Yin (traditional Chinese medicine) in human oral cancer cells through the NF-kappa B, AKT, and ERK-dependent pathways.

Yang JS, Wu CC, Lee HZ, Hsieh WT, Tang FY, Bau DT, Lai KC, Lien JC, Chung JG.

Environ Toxicol. 2016 Oct;31(10):1196-205. doi: 10.1002/tox.22127. Epub 2015 Feb 26.


Cantharidin induces DNA damage and inhibits DNA repair-associated protein expressions in TSGH8301 human bladder cancer cell.

Kuo JH, Shih TY, Lin JP, Lai KC, Lin ML, Yang MD, Chung JG.

Anticancer Res. 2015 Feb;35(2):795-804.


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