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Items: 42


High concordance of a closed-system, RT-qPCR breast cancer assay for HER2 mRNA, compared to clinically determined immunohistochemistry, fluorescence in situ hybridization, and quantitative immunofluorescence.

Wasserman BE, Carvajal-Hausdorf DE, Ho K, Wong W, Wu N, Chu VC, Lai EW, Weidler JM, Bates M, Neumeister V, Rimm DL.

Lab Invest. 2017 Dec;97(12):1521-1526. doi: 10.1038/labinvest.2017.93. Epub 2017 Sep 11.


Association between acute sympathetic response, early onset vasospasm, and delayed vasospasm following spontaneous subarachnoid hemorrhage.

Moussouttas M, Lai EW, Huynh TT, James J, Stocks-Dietz C, Dombrowski K, Khoury J, Pacak K.

J Clin Neurosci. 2014 Feb;21(2):256-62. doi: 10.1016/j.jocn.2013.03.036. Epub 2013 Oct 9.


Association between sympathetic response, neurogenic cardiomyopathy, and venous thromboembolization in patients with primary subarachnoid hemorrhage.

Moussouttas M, Bhatnager M, Huynh TT, Lai EW, Khoury J, Dombrowski K, DeCaro M, Pacak K.

Acta Neurochir (Wien). 2013 Aug;155(8):1501-10. doi: 10.1007/s00701-013-1725-x. Epub 2013 May 1.


Monoamine oxidase B prompts mitochondrial and cardiac dysfunction in pressure overloaded hearts.

Kaludercic N, Carpi A, Nagayama T, Sivakumaran V, Zhu G, Lai EW, Bedja D, De Mario A, Chen K, Gabrielson KL, Lindsey ML, Pacak K, Takimoto E, Shih JC, Kass DA, Di Lisa F, Paolocci N.

Antioxid Redox Signal. 2014 Jan 10;20(2):267-80. doi: 10.1089/ars.2012.4616. Epub 2013 May 22.


High-throughput molecular and histopathologic profiling of tumor tissue in a novel transplantable model of murine neuroblastoma: new tools for pediatric drug discovery.

Stauffer JK, Orentas RJ, Lincoln E, Khan T, Salcedo R, Hixon JA, Back TC, Wei JS, Patidar R, Song Y, Hurd L, Tsokos M, Lai EW, Eisenhofer G, Weiss W, Khan J, Wigginton JM.

Cancer Invest. 2012 Jun;30(5):343-63. doi: 10.3109/07357907.2012.664670.


Determinants of central sympathetic activation in spontaneous primary subarachnoid hemorrhage.

Moussouttas M, Lai EW, Khoury J, Huynh TT, Dombrowski K, Pacak K.

Neurocrit Care. 2012 Jun;16(3):381-8. doi: 10.1007/s12028-012-9673-5.


Cerebrospinal fluid catecholamine levels as predictors of outcome in subarachnoid hemorrhage.

Moussouttas M, Huynh TT, Khoury J, Lai EW, Dombrowski K, Pello S, Pacak K.

Cerebrovasc Dis. 2012;33(2):173-81. doi: 10.1159/000334660. Epub 2012 Jan 5.


Usefulness of [18F]-DA and [18F]-DOPA for PET imaging in a mouse model of pheochromocytoma.

Martiniova L, Cleary S, Lai EW, Kiesewetter DO, Seidel J, Dawson LF, Phillips JK, Thomasson D, Chen X, Eisenhofer G, Powers JF, Kvetnansky R, Pacak K.

Nucl Med Biol. 2012 Feb;39(2):215-26. doi: 10.1016/j.nucmedbio.2011.07.007. Epub 2011 Sep 29.


Targeting GLUT1 and the Warburg effect in renal cell carcinoma by chemical synthetic lethality.

Chan DA, Sutphin PD, Nguyen P, Turcotte S, Lai EW, Banh A, Reynolds GE, Chi JT, Wu J, Solow-Cordero DE, Bonnet M, Flanagan JU, Bouley DM, Graves EE, Denny WA, Hay MP, Giaccia AJ.

Sci Transl Med. 2011 Aug 3;3(94):94ra70. doi: 10.1126/scitranslmed.3002394.


SAR studies of 4-pyridyl heterocyclic anilines that selectively induce autophagic cell death in von Hippel-Lindau-deficient renal cell carcinoma cells.

Bonnet M, Flanagan JU, Chan DA, Lai EW, Nguyen P, Giaccia AJ, Hay MP.

Bioorg Med Chem. 2011 Jun 1;19(11):3347-56. doi: 10.1016/j.bmc.2011.04.042. Epub 2011 Apr 24.


CSF catecholamine profile in subarachnoid hemorrhage patients with neurogenic cardiomyopathy.

Moussouttas M, Lai EW, Dombrowski K, Huynh TT, Khoury J, Carmona G, DeCaro M, Pacak K.

Neurocrit Care. 2011 Jun;14(3):401-6. doi: 10.1007/s12028-011-9527-6.


Minimal changes in environmental temperature result in a significant increase in energy expenditure and changes in the hormonal homeostasis in healthy adults.

Celi FS, Brychta RJ, Linderman JD, Butler PW, Alberobello AT, Smith S, Courville AB, Lai EW, Costello R, Skarulis MC, Csako G, Remaley A, Pacak K, Chen KY.

Eur J Endocrinol. 2010 Dec;163(6):863-72. doi: 10.1530/EJE-10-0627. Epub 2010 Sep 8.


G(s)alpha deficiency in adipose tissue leads to a lean phenotype with divergent effects on cold tolerance and diet-induced thermogenesis.

Chen M, Chen H, Nguyen A, Gupta D, Wang J, Lai EW, Pacak K, Gavrilova O, Quon MJ, Weinstein LS.

Cell Metab. 2010 Apr 7;11(4):320-30. doi: 10.1016/j.cmet.2010.02.013.


Monoamine oxidase A-mediated enhanced catabolism of norepinephrine contributes to adverse remodeling and pump failure in hearts with pressure overload.

Kaludercic N, Takimoto E, Nagayama T, Feng N, Lai EW, Bedja D, Chen K, Gabrielson KL, Blakely RD, Shih JC, Pacak K, Kass DA, Di Lisa F, Paolocci N.

Circ Res. 2010 Jan 8;106(1):193-202. doi: 10.1161/CIRCRESAHA.109.198366. Epub 2009 Nov 12.


Radiofrequency ablation of metastatic pheochromocytoma.

Venkatesan AM, Locklin J, Lai EW, Adams KT, Fojo AT, Pacak K, Wood BJ.

J Vasc Interv Radiol. 2009 Nov;20(11):1483-90. doi: 10.1016/j.jvir.2009.07.031.


Animal model of metastatic pheochromocytoma: evaluation by MRI and PET.

Martiniova L, Lai EW, Thomasson D, Kiesewetter DO, Seidel J, Merino MJ, Kvetnansky R, Pacak K.

Endocr Regul. 2009 Apr;43(2):59-64.


Successful chemotherapy of hepatic metastases in a case of succinate dehydrogenase subunit B-related paraganglioma.

He J, Makey D, Fojo T, Adams KT, Havekes B, Eisenhofer G, Sullivan P, Lai EW, Pacak K.

Endocrine. 2009 Oct;36(2):189-93. doi: 10.1007/s12020-009-9219-6. Epub 2009 Jul 18.


In vivo micro-CT imaging of liver lesions in small animal models.

Martiniova L, Schimel D, Lai EW, Limpuangthip A, Kvetnansky R, Pacak K.

Methods. 2010 Jan;50(1):20-5. doi: 10.1016/j.ymeth.2009.05.016. Epub 2009 Jun 9. Review.


New imaging approaches to phaeochromocytomas and paragangliomas.

Havekes B, King K, Lai EW, Romijn JA, Corssmit EP, Pacak K.

Clin Endocrinol (Oxf). 2010 Feb;72(2):137-45. doi: 10.1111/j.1365-2265.2009.03648.x. Epub 2009 Jun 8. Review.


Overexpression of interleukin-13 receptor-alpha2 in neuroendocrine malignant pheochromocytoma: a novel target for receptor directed anti-cancer therapy.

Lai EW, Joshi BH, Martiniova L, Dogra R, Fujisawa T, Leland P, de Krijger RR, Lubensky IA, Elkahloun AG, Morris JC, Puri RK, Pacak K.

J Clin Endocrinol Metab. 2009 Aug;94(8):2952-7. doi: 10.1210/jc.2009-0309. Epub 2009 Jun 2.


Central nervous system imprinting of the G protein G(s)alpha and its role in metabolic regulation.

Chen M, Wang J, Dickerson KE, Kelleher J, Xie T, Gupta D, Lai EW, Pacak K, Gavrilova O, Weinstein LS.

Cell Metab. 2009 Jun;9(6):548-55. doi: 10.1016/j.cmet.2009.05.004.


A reduction in Pten tumor suppressor activity promotes ErbB-2-induced mouse prostate adenocarcinoma formation through the activation of signaling cascades downstream of PDK1.

Rodriguez OC, Lai EW, Vissapragada S, Cromelin C, Avetian M, Salinas P, Ramos H, Kallakury B, Casimiro M, Lisanti MP, Tanowitz HB, Pacak K, Glazer RI, Avantaggiati M, Albanese C.

Am J Pathol. 2009 Jun;174(6):2051-60. doi: 10.2353/ajpath.2009.080859. Epub 2009 May 14.


Noninvasive monitoring of a murine model of metastatic pheochromocytoma: a comparison of contrast-enhanced microCT and nonenhanced MRI.

Martiniova L, Kotys MS, Thomasson D, Schimel D, Lai EW, Bernardo M, Merino MJ, Powers JF, Ruzicka J, Kvetnansky R, Choyke PL, Pacak K.

J Magn Reson Imaging. 2009 Mar;29(3):685-91. doi: 10.1002/jmri.21654.


Mechanisms of enhanced beta-adrenergic reserve from cardiac resynchronization therapy.

Chakir K, Daya SK, Aiba T, Tunin RS, Dimaano VL, Abraham TP, Jaques-Robinson KM, Lai EW, Pacak K, Zhu WZ, Xiao RP, Tomaselli GF, Kass DA.

Circulation. 2009 Mar 10;119(9):1231-40. doi: 10.1161/CIRCULATIONAHA.108.774752. Epub 2009 Feb 23. Erratum in: Circulation. 2009 May 19;119(19):e533. Jacques, Kathryn [corrected to Jaques-Robinson, Kathryn M].


Characterization of an animal model of aggressive metastatic pheochromocytoma linked to a specific gene signature.

Martiniova L, Lai EW, Elkahloun AG, Abu-Asab M, Wickremasinghe A, Solis DC, Perera SM, Huynh TT, Lubensky IA, Tischler AS, Kvetnansky R, Alesci S, Morris JC, Pacak K.

Clin Exp Metastasis. 2009;26(3):239-50. doi: 10.1007/s10585-009-9236-0. Epub 2009 Jan 25.


Brief communication: radiographic contrast infusion and catecholamine release in patients with pheochromocytoma.

Baid SK, Lai EW, Wesley RA, Ling A, Timmers HJ, Adams KT, Kozupa A, Pacak K.

Ann Intern Med. 2009 Jan 6;150(1):27-32. Erratum in: Ann Intern Med. 2009 Feb 17;150(4):292.


Detection and treatment of pheochromocytomas and paragangliomas: current standing of MIBG scintigraphy and future role of PET imaging.

Havekes B, Lai EW, Corssmit EP, Romijn JA, Timmers HJ, Pacak K.

Q J Nucl Med Mol Imaging. 2008 Dec;52(4):419-29. Review.


Gender-related differences in the clinical presentation of malignant and benign pheochromocytoma.

Lai EW, Perera SM, Havekes B, Timmers HJ, Brouwers FM, McElroy B, Adams KT, Ohta S, Wesley RA, Eisenhofer G, Pacak K.

Endocrine. 2008 Aug-Dec;34(1-3):96-100. doi: 10.1007/s12020-008-9108-4. Epub 2008 Nov 4.


Severe obesity and insulin resistance due to deletion of the maternal Gsalpha allele is reversed by paternal deletion of the Gsalpha imprint control region.

Xie T, Chen M, Gavrilova O, Lai EW, Liu J, Weinstein LS.

Endocrinology. 2008 May;149(5):2443-50. doi: 10.1210/en.2007-1458. Epub 2008 Jan 17.


Metastasis-associated gene expression profile of liver and subcutaneous lesions derived from mouse pheochromocytoma cells.

Ohta S, Lai EW, Morris JC, Pang AL, Watanabe M, Yazawa H, Zhang R, Green JE, Chan WY, Sirajuddin P, Taniguchi S, Powers JF, Tischler AS, Pacak K.

Mol Carcinog. 2008 Apr;47(4):245-51.


ErbB-2 induces bilateral adrenal pheochromocytoma formation in mice.

Lai EW, Rodriguez OC, Aventian M, Cromelin C, Fricke ST, Martiniova L, Lubensky IA, Lisanti MP, Picard KL, Powers JF, Tischler AS, Pacak K, Albanese C.

Cell Cycle. 2007 Aug 1;6(15):1946-50. Epub 2007 May 31.


Adenoviral gene transfer in bovine adrenomedullary and murine pheochromocytoma cells: potential clinical and therapeutic relevance.

Alesci S, Perera SM, Lai EW, Kukura C, Abu-Asab M, Tsokos M, Morris JC, Pacak K.

Endocrinology. 2007 Aug;148(8):3900-7. Epub 2007 May 24.


The role of 6-[18F]fluorodopamine positron emission tomography in the localization of adrenal pheochromocytoma associated with von Hippel-Lindau syndrome.

Kaji P, Carrasquillo JA, Linehan WM, Chen CC, Eisenhofer G, Pinto PA, Lai EW, Pacak K.

Eur J Endocrinol. 2007 Apr;156(4):483-7.


Anatomical and functional imaging of tumors in animal models: focus on pheochromocytoma.

Martiniova L, Ohta S, Guion P, Schimel D, Lai EW, Klaunberg B, Jagoda E, Pacak K.

Ann N Y Acad Sci. 2006 Aug;1073:392-404. Review.


Animal models of pheochromocytoma including NIH initial experience.

Ohta S, Lai EW, Taniguchi S, Tischler AS, Alesci S, Pacak K.

Ann N Y Acad Sci. 2006 Aug;1073:300-5.


MicroCT for high-resolution imaging of ectopic pheochromocytoma tumors in the liver of nude mice.

Ohta S, Lai EW, Morris JC, Bakan DA, Klaunberg B, Cleary S, Powers JF, Tischler AS, Abu-Asab M, Schimel D, Pacak K.

Int J Cancer. 2006 Nov 1;119(9):2236-41.


The alternative stimulatory G protein alpha-subunit XLalphas is a critical regulator of energy and glucose metabolism and sympathetic nerve activity in adult mice.

Xie T, Plagge A, Gavrilova O, Pack S, Jou W, Lai EW, Frontera M, Kelsey G, Weinstein LS.

J Biol Chem. 2006 Jul 14;281(28):18989-99. Epub 2006 May 2.


Increased lipolysis of subcutaneous abdominal adipose tissue and altered noradrenergic activity in patients with Cushing's syndrome: an in-vivo microdialysis study.

Krsek M, Rosická M, Nedvídková J, Kvasnicková H, Hána V, Marek J, Haluzík M, Lai EW, Pacák K.

Physiol Res. 2006;55(4):421-8. Epub 2005 Oct 17.


Biochemical and clinical manifestations of dopamine-producing paragangliomas: utility of plasma methoxytyramine.

Eisenhofer G, Goldstein DS, Sullivan P, Csako G, Brouwers FM, Lai EW, Adams KT, Pacak K.

J Clin Endocrinol Metab. 2005 Apr;90(4):2068-75. Epub 2005 Jan 11.


Downregulation of metastasis suppressor genes in malignant pheochromocytoma.

Ohta S, Lai EW, Pang AL, Brouwers FM, Chan WY, Eisenhofer G, de Krijger R, Ksinantova L, Breza J, Blazicek P, Kvetnansky R, Wesley RA, Pacak K.

Int J Cancer. 2005 Mar 10;114(1):139-43.


The role of MAP kinases in trauma and ischemia-reperfusion.

Lai EW, Toledo-Pereyra LH, Walsh J, Lopez-Neblina F, Anaya-Prado R.

J Invest Surg. 2004 Jan-Feb;17(1):45-53. Review.


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