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New therapeutic targets in pancreatic cancer.

Lai E, Puzzoni M, Ziranu P, Pretta A, Impera V, Mariani S, Liscia N, Soro P, Musio F, Persano M, Donisi C, Tolu S, Balconi F, Pireddu A, Demurtas L, Pusceddu V, Camera S, Sclafani F, Scartozzi M.

Cancer Treat Rev. 2019 Nov 11;81:101926. doi: 10.1016/j.ctrv.2019.101926. [Epub ahead of print] Review.


The TOMMORROW study: Design of an Alzheimer's disease delay-of-onset clinical trial.

Burns DK, Chiang C, Welsh-Bohmer KA, Brannan SK, Culp M, O'Neil J, Runyan G, Harrigan P, Plassman BL, Lutz M, Lai E, Haneline S, Yarnall D, Yarbrough D, Metz C, Ponduru S, Sundseth S, Saunders AM.

Alzheimers Dement (N Y). 2019 Oct 28;5:661-670. doi: 10.1016/j.trci.2019.09.010. eCollection 2019.


A Geospatial Analysis of Health, Mental Health, and Stressful Community Contexts in Los Angeles County.

Robles B, Thomas CS, Lai ES, Kuo T.

Prev Chronic Dis. 2019 Nov 7;16:E150. doi: 10.5888/pcd16.190138.


Use of hydrochlorothiazide and risk of skin cancer: a nationwide Taiwanese case-control study.

Pottegård A, Pedersen SA, Schmidt SAJ, Lee CN, Hsu CK, Liao TC, Shao SC, Lai EC.

Br J Cancer. 2019 Nov 1. doi: 10.1038/s41416-019-0613-4. [Epub ahead of print]


Deciphering How the Viscoelastic Properties of Mussel-Inspired Metal-Coordinate Transiently Cross-Linked Gels Dictate Their Tack Behavior.

Lai E, Keshavarz B, Holten-Andersen N.

Langmuir. 2019 Oct 24. doi: 10.1021/acs.langmuir.9b02772. [Epub ahead of print]


Three-Dimensional Graphene-Based Composite Hydrogel Materials for Flexible Supercapacitor Electrodes.

Lai E, Yue X, Ning W, Huang J, Ling X, Lin H.

Front Chem. 2019 Oct 1;7:660. doi: 10.3389/fchem.2019.00660. eCollection 2019. Review.


Assessing the impact of rising child poverty on the unprecedented rise in infant mortality in England, 2000-2017: time trend analysis.

Taylor-Robinson D, Lai ETC, Wickham S, Rose T, Norman P, Bambra C, Whitehead M, Barr B.

BMJ Open. 2019 Oct 2;9(10):e029424. doi: 10.1136/bmjopen-2019-029424.


Will esports result in a higher prevalence of problematic gaming? A review of the global situation.

Chung T, Sum S, Chan M, Lai E, Cheng N.

J Behav Addict. 2019 Sep 1;8(3):384-394. doi: 10.1556/2006.8.2019.46. Epub 2019 Sep 25.


Comparative risk evaluation for cardiovascular events associated with dapagliflozin vs. empagliflozin in real-world type 2 diabetes patients: a multi-institutional cohort study.

Shao SC, Chang KC, Hung MJ, Yang NI, Chan YY, Chen HY, Kao Yang YH, Lai EC.

Cardiovasc Diabetol. 2019 Sep 24;18(1):120. doi: 10.1186/s12933-019-0919-9.


Closed system RT-qPCR as a potential companion diagnostic test for immunotherapy outcome in metastatic melanoma.

Gupta S, McCann L, Chan YGY, Lai EW, Wei W, Wong PF, Smithy JW, Weidler J, Rhees B, Bates M, Kluger HM, Rimm DL.

J Immunother Cancer. 2019 Sep 18;7(1):254. doi: 10.1186/s40425-019-0731-9.


Prevalence and predictors of influenza vaccination among residents of long-term care facilities.

Tan HY, Lai E, Kunasekaran M, Chughtai AA, Trent M, Poulos CJ, MacIntyre CR.

Vaccine. 2019 Oct 8;37(43):6329-6335. doi: 10.1016/j.vaccine.2019.09.021. Epub 2019 Sep 13.


NaHCO3 Dilates Mouse Afferent Arteriole Via Na+/HCO3- Cotransporters NBCs.

Jiang S, Wang X, Wei J, Zhang G, Zhang J, Xie P, Xu L, Wang L, Zhao L, Li L, Wilcox CS, Chen J, Lai EY, Liu R.

Hypertension. 2019 Nov;74(5):1104-1112. doi: 10.1161/HYPERTENSIONAHA.119.13235. Epub 2019 Sep 16.


Interactions between psychiatric and physical disorders and their effects on the risks of suicide: a nested case-control study.

Chang CF, Yeh MK, Chien WC, Chung CH, Li TT, Lai EC.

Ann N Y Acad Sci. 2019 Sep 8. doi: 10.1111/nyas.14216. [Epub ahead of print]


How do early-life factors explain social inequalities in adolescent mental health? Findings from the UK Millennium Cohort Study.

Straatmann VS, Lai E, Lange T, Campbell MC, Wickham S, Andersen AN, Strandberg-Larsen K, Taylor-Robinson D.

J Epidemiol Community Health. 2019 Nov;73(11):1049-1060. doi: 10.1136/jech-2019-212367. Epub 2019 Sep 6. Review.


Effects of sodium-glucose co-transporter-2 inhibitors on serum alanine aminotransferase levels in people with type 2 diabetes: A multi-institutional cohort study.

Shao SC, Chang KC, Chien RN, Lin SJ, Hung MJ, Chan YY, Kao Yang YH, Lai EC.

Diabetes Obes Metab. 2019 Sep 4. doi: 10.1111/dom.13875. [Epub ahead of print]


Neutralizing Activity of Anti-interferon-γ Autoantibodies in Adult-Onset Immunodeficiency Is Associated With Their Binding Domains.

Yasamut U, Thongkum W, Moonmuang S, Sakkhachornphop S, Chaiwarith R, Praparattanapan J, Wipasa J, Chawansuntati K, Supparatpinyo K, Lai E, Tayapiwatana C.

Front Immunol. 2019 Aug 14;10:1905. doi: 10.3389/fimmu.2019.01905. eCollection 2019.


Pharmacokinetic-Pharmacodynamic (Dipeptidyl Peptidase-4 Inhibition) Model to Support Dose Rationale in Diabetes Patients, Including Those with Renal Impairment, for the Once-Weekly Administered Omarigliptin.

Jain L, Chain ASY, Tatosian DA, Hing J, Passarell JA, Kauh EA, Lai E.

Br J Clin Pharmacol. 2019 Aug 27. doi: 10.1111/bcp.14103. [Epub ahead of print]


Cancer-associated mutations in DICER1 RNase IIIa and IIIb domains exert similar effects on miRNA biogenesis.

Vedanayagam J, Chatila WK, Aksoy BA, Majumdar S, Skanderup AJ, Demir E, Schultz N, Sander C, Lai EC.

Nat Commun. 2019 Aug 15;10(1):3682. doi: 10.1038/s41467-019-11610-1.


Reply by Authors.

Stefanova V, Buckley R, Flax S, Spevack L, Hajek D, Tunis A, Lai E, Loblaw A.

J Urol. 2019 Dec;202(6):1273. doi: 10.1097/JU.0000000000000473. Epub 2019 Aug 7. No abstract available.


Differentiations in Gene Content and Expression Response to Virulence Induction Between Two Agrobacterium Strains.

Haryono M, Cho ST, Fang MJ, Chen AP, Chou SJ, Lai EM, Kuo CH.

Front Microbiol. 2019 Jul 9;10:1554. doi: 10.3389/fmicb.2019.01554. eCollection 2019.


Three-phase treatment concept for skeletal Class III growing patients with severe space deficiency: A report of three cases with skeletally anchored maxillary protraction.

Lin HY, Yang H, Lai EH, Lin SY, Chang JZ.

J Formos Med Assoc. 2019 Jul 19. pii: S0929-6646(19)30485-1. doi: 10.1016/j.jfma.2019.07.002. [Epub ahead of print]


Structures of SCCmec elements in methicillin-resistant Staphylococcus lugdunensis are closely related to those harboured by community-associated methicillin-resistant Staphylococcus aureus.

Liu MC, Cao H, Lau A, Chow KH, Lai EL, Tse CW, Wu AK, Ho PL.

J Med Microbiol. 2019 Sep;68(9):1367-1372. doi: 10.1099/jmm.0.001013.


Racial Disparities in Total Knee Replacement Failure As Related to Poverty.

Bass AR, Mehta B, Szymonifka J, Finik J, Lyman S, Lai EY, Parks M, Figgie M, Mandl LA, Goodman SM.

Arthritis Care Res (Hoboken). 2019 Nov;71(11):1488-1494. doi: 10.1002/acr.24028.


DNA Methylation Markers for Breast Cancer Detection in the Developing World.

Downs BM, Mercado-Rodriguez C, Cimino-Mathews A, Chen C, Yuan JP, Van Den Berg E, Cope LM, Schmitt F, Tse GM, Ali SZ, Meir-Levi D, Sood R, Li J, Richardson AL, Mosunjac MB, Rizzo M, Tulac S, Kocmond KJ, de Guzman T, Lai EW, Rhees B, Bates M, Wolff AC, Gabrielson E, Harvey SC, Umbricht CB, Visvanathan K, Fackler MJ, Sukumar S.

Clin Cancer Res. 2019 Nov 1;25(21):6357-6367. doi: 10.1158/1078-0432.CCR-18-3277. Epub 2019 Jul 12.


Poverty dynamics and health in late childhood in the UK: evidence from the Millennium Cohort Study.

Lai ETC, Wickham S, Law C, Whitehead M, Barr B, Taylor-Robinson D.

Arch Dis Child. 2019 Nov;104(11):1049-1055. doi: 10.1136/archdischild-2018-316702. Epub 2019 Jun 11.


Letter: contraindicated drug-drug interactions before and after initiation of direct-acting anti-viral agents in chronic hepatitis C patients in Taiwan.

Shao SC, Lai EC, Chang KC, Chan YY, Chen HY, Chien RN.

Aliment Pharmacol Ther. 2019 Jul;50(1):113-115. doi: 10.1111/apt.15303. No abstract available.


Ten-year fracture risk by FRAX and osteoporotic fractures in patients with systemic autoimmune diseases.

Lai EL, Huang WN, Chen HH, Hsu CY, Chen DY, Hsieh TY, Hung WT, Lin CT, Lai KL, Tang KT, Chen YM, Chen YH.

Lupus. 2019 Jul;28(8):945-953. doi: 10.1177/0961203319855122. Epub 2019 Jun 9.


Chemical screen for epigenetic barriers to single allele activation of Oct4.

Headley KM, Kedziora KM, Alejo A, Lai EZ, Purvis JE, Hathaway NA.

Stem Cell Res. 2019 Jul;38:101470. doi: 10.1016/j.scr.2019.101470. Epub 2019 May 24.


Extra-Glissonian Approach for Laparoscopic Liver Right Anterior Sectionectomy.

Chen HW, Wang FJ, Li JY, Deng FW, Lai ECH, Lau WY.

JSLS. 2019 Apr-Jun;23(2). pii: e2019.00009. doi: 10.4293/JSLS.2019.00009.


Understanding social inequalities in children being bullied: UK Millennium Cohort Study findings.

Campbell M, Straatmann VS, Lai ETC, Potier J, Pinto Pereira SM, Wickham SL, Taylor-Robinson DC.

PLoS One. 2019 May 29;14(5):e0217162. doi: 10.1371/journal.pone.0217162. eCollection 2019.


Taiwan's National Health Insurance Research Database: past and future.

Hsieh CY, Su CC, Shao SC, Sung SF, Lin SJ, Kao Yang YH, Lai EC.

Clin Epidemiol. 2019 May 3;11:349-358. doi: 10.2147/CLEP.S196293. eCollection 2019. Review.


Dual Sinus Nodes With Donor Sinus Node Dysfunction in Biatrial Heart Transplantation.

Lai E, Ray R, Hongo R.

JAMA Intern Med. 2019 Jul 1;179(7):975-976. doi: 10.1001/jamainternmed.2019.0640. No abstract available.


Cyclic di-GMP inactivates T6SS and T4SS activity in Agrobacterium tumefaciens.

McCarthy RR, Yu M, Eilers K, Wang YC, Lai EM, Filloux A.

Mol Microbiol. 2019 Aug;112(2):632-648. doi: 10.1111/mmi.14279. Epub 2019 Jun 4.


Understanding pathways to social inequalities in childhood unintentional injuries: findings from the UK millennium cohort study.

Campbell M, Lai ETC, Pearce A, Orton E, Kendrick D, Wickham S, Taylor-Robinson DC.

BMC Pediatr. 2019 May 15;19(1):150. doi: 10.1186/s12887-019-1514-7.


Transcriptional Regulation of the Glutamate/GABA/Glutamine Cycle in Adult Glia Controls Motor Activity and Seizures in Drosophila.

Mazaud D, Kottler B, Gonçalves-Pimentel C, Proelss S, Tüchler N, Deneubourg C, Yuasa Y, Diebold C, Jungbluth H, Lai EC, Hirth F, Giangrande A, Fanto M.

J Neurosci. 2019 Jul 3;39(27):5269-5283. doi: 10.1523/JNEUROSCI.1833-18.2019. Epub 2019 May 7.


Erratum: Deep experimental profiling of microRNA diversity, deployment, and evolution across the Drosophila genus.

Mohammed J, Flynt AS, Panzarino AM, Mondal MMH, DeCruz M, Siepel A, Lai EC.

Genome Res. 2019 May;29(5):881. doi: 10.1101/gr.250654.119. No abstract available.


Staged orthodontic treatment in preparation for immediate implant placement: A clinical report with a 5-year follow-up.

Lin IP, Lai EH, Chang JZ, Wang CY.

J Prosthet Dent. 2019 Apr 23. pii: S0022-3913(18)30691-7. doi: 10.1016/j.prosdent.2018.10.027. [Epub ahead of print]


Chronic kidney disease in patients infected with human immunodeficiency virus (HIV) in an urban cohort.

Brito RM, Nguyen DT, Johnson JR, Lai EJ, Castro RE, Albert AM, Barnes AS, Graviss EA, Suki WN.

PLoS One. 2019 Apr 17;14(4):e0215575. doi: 10.1371/journal.pone.0215575. eCollection 2019.


Incidence of type 2 diabetes mellitus in men receiving steroid 5α-reductase inhibitors: population based cohort study.

Wei L, Lai EC, Kao-Yang YH, Walker BR, MacDonald TM, Andrew R.

BMJ. 2019 Apr 10;365:l1204. doi: 10.1136/bmj.l1204.


A Digital Game and School-Based Intervention for Students in Hong Kong: Quasi-Experimental Design.

Shum AK, Lai ES, Leung WG, Cheng MN, Wong HK, So SW, Law YW, Yip PS.

J Med Internet Res. 2019 Apr 5;21(4):e12003. doi: 10.2196/12003.


Increased risk of coronary heart disease among patients with idiopathic inflammatory myositis: a nationwide population study in Taiwan.

Weng MY, Lai EC, Kao Yang YH.

Rheumatology (Oxford). 2019 Nov 1;58(11):1935-1941. doi: 10.1093/rheumatology/kez076.


The RNase YbeY Is Vital for Ribosome Maturation, Stress Resistance, and Virulence of the Natural Genetic Engineer Agrobacterium tumefaciens.

Möller P, Busch P, Sauerbrei B, Kraus A, Förstner KU, Wen TN, Overlöper A, Lai EM, Narberhaus F.

J Bacteriol. 2019 May 8;201(11). pii: e00730-18. doi: 10.1128/JB.00730-18. Print 2019 Jun 1.


Linking Sleep to Externalizing Behavioral Difficulties: A Longitudinal Psychometric Survey in a Cohort of Italian School-Age Children.

Muratori P, Menicucci D, Lai E, Battaglia F, Bontempelli L, Chericoni N, Gemignani A.

J Prim Prev. 2019 Apr;40(2):231-241. doi: 10.1007/s10935-019-00547-2.


Child health unravelling in UK.

Taylor-Robinson DC, Lai ET, Whitehead M, Barr B.

BMJ. 2019 Mar 5;364:l963. doi: 10.1136/bmj.l963. No abstract available.


Transperineal Prostate Biopsies Using Local Anesthesia: Experience with 1,287 Patients. Prostate Cancer Detection Rate, Complications and Patient Tolerability.

Stefanova V, Buckley R, Flax S, Spevack L, Hajek D, Tunis A, Lai E, Loblaw A; Collaborators.

J Urol. 2019 Jun;201(6):1121-1126. doi: 10.1097/JU.0000000000000156.


Plant-Pathogenic Agrobacterium tumefaciens Strains Have Diverse Type VI Effector-Immunity Pairs and Vary in In-Planta Competitiveness.

Wu CF, Santos MNM, Cho ST, Chang HH, Tsai YM, Smith DA, Kuo CH, Chang JH, Lai EM.

Mol Plant Microbe Interact. 2019 Aug;32(8):961-971. doi: 10.1094/MPMI-01-19-0021-R. Epub 2019 Jun 27.


Higher pricing of fresh produce is more likely in SNAP-Ed eligible neighborhoods when adjacent non-program eligible neighborhoods are mixed income.

Jewell MP, Lai ES, Thompson J, Fox M, Kuo T.

Prev Med Rep. 2019 Feb 8;14:100817. doi: 10.1016/j.pmedr.2019.01.021. eCollection 2019 Jun.


Efficient Generation of an Fah/Rag2 Dual-Gene Knockout Porcine Cell Line Using CRISPR/Cas9 and Adenovirus.

Gao M, Zhang B, He Y, Yang Q, Deng L, Zhu Y, Lai E, Wang M, Wang L, Yang G, Liao G, Bao J, Bu H.

DNA Cell Biol. 2019 Apr;38(4):314-321. doi: 10.1089/dna.2018.4493. Epub 2019 Feb 14.


"Healthcare for Society"-a column featuring outstanding community contributions.

Wong MCS, Lai ECH.

Hong Kong Med J. 2019 Feb;25(1):4-5. doi: 10.12809/hkmj195086. No abstract available.

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